There are different types of membrane proteins in a cellular membrane,and most of them must correctly assemble into appropriate clusters for their cellular functions.In this work,we suggest a physical mechanism for se...There are different types of membrane proteins in a cellular membrane,and most of them must correctly assemble into appropriate clusters for their cellular functions.In this work,we suggest a physical mechanism for selective aggregation of different membrane proteins without specific protein-protein attraction by dissipative particle dynamics method.A membrane-mediated interaction may result in different protein clusters with ideal mixing,nonideal mixing and demixing of different types of membrane proteins,depending on the extent of the similarity of membrane deformations by those proteins.展开更多
基金supported by the National Natural Science Foundation of China(20736005,20876004)the support of the Research Foundation for Youth Scholars of Beijing Technology and Business Universitythe"Chemical Grid Project"of Beijing University of Chemical Technology for the generous allocations of computer time and excellent technical assistance
文摘There are different types of membrane proteins in a cellular membrane,and most of them must correctly assemble into appropriate clusters for their cellular functions.In this work,we suggest a physical mechanism for selective aggregation of different membrane proteins without specific protein-protein attraction by dissipative particle dynamics method.A membrane-mediated interaction may result in different protein clusters with ideal mixing,nonideal mixing and demixing of different types of membrane proteins,depending on the extent of the similarity of membrane deformations by those proteins.
