BACKGROUND Patients with major depression(MD)exhibit conditional reasoning dysfunction;however,no studies on the event-related potential(ERP)characteristics of conditional reasoning in MD have been reported.AIM To inv...BACKGROUND Patients with major depression(MD)exhibit conditional reasoning dysfunction;however,no studies on the event-related potential(ERP)characteristics of conditional reasoning in MD have been reported.AIM To investigate the ERP characteristics of conditional reasoning in MD patients and explore the neural mechanism of cognitive processing.METHODS Thirty-four patients with MD and 34 healthy controls(HCs)completed ERP measurements while performing the Wason selection task(WST).The clusterbased permutation test in FieldTrip was used to compare the differences in the mean amplitudes between the patients with MD and HCs on the ERP components under different experimental conditions.Behavioral data[accuracy(ACC)and reaction times(RTs)],the ERP P100 and late positive potentials(LPPs)were analyzed.RESULTS Although the mean ACC was greater and the mean of RTs was shorter in HCs than in MD patients,the differences were not statistically significant.However,across both groups,the ACC in the precautionary WST was greater than that in the other tasks,and the RTs in the abstract task were greater than those in the other tasks.Importantly,compared with that of HCs,the P100 of the left centroparietal sites was significantly increased,and the early LPP was attenuated at parietal sites and increased at left frontocentral sites;the medium LPP and late LPP were increased at the left frontocentral sites.CONCLUSION Patients with MD have conditional reasoning dysfunction and exhibit abnormal ERP characteristics evoked by the WST,which suggests neural correlates of abnormalities in conditional reasoning function in MD patients.展开更多
We devise an approach to Bayesian statistics and their applications in the analysis of the Monty Hall problem. We combine knowledge gained through applications of the Maximum Entropy Principle and Nash equilibrium str...We devise an approach to Bayesian statistics and their applications in the analysis of the Monty Hall problem. We combine knowledge gained through applications of the Maximum Entropy Principle and Nash equilibrium strategies to provide results concerning the use of Bayesian approaches unique to the Monty Hall problem. We use a model to describe Monty’s decision process and clarify that Bayesian inference results in an “irrelevant, therefore invariant” hypothesis. We discuss the advantages of Bayesian inference over the frequentist inference in tackling the uneven prior probability Monty Hall variant. We demonstrate that the use of Bayesian statistics conforms to the Maximum Entropy Principle in information theory and Bayesian approach successfully resolves dilemmas in the uneven probability Monty Hall variant. Our findings have applications in the decision making, information theory, bioinformatics, quantum game theory and beyond.展开更多
基金Supported by Wuxi Taihu Talent Project,No.WXTTP 2021the General Scientific Research Program of Wuxi Municipal Health Commission,No.M202447.
文摘BACKGROUND Patients with major depression(MD)exhibit conditional reasoning dysfunction;however,no studies on the event-related potential(ERP)characteristics of conditional reasoning in MD have been reported.AIM To investigate the ERP characteristics of conditional reasoning in MD patients and explore the neural mechanism of cognitive processing.METHODS Thirty-four patients with MD and 34 healthy controls(HCs)completed ERP measurements while performing the Wason selection task(WST).The clusterbased permutation test in FieldTrip was used to compare the differences in the mean amplitudes between the patients with MD and HCs on the ERP components under different experimental conditions.Behavioral data[accuracy(ACC)and reaction times(RTs)],the ERP P100 and late positive potentials(LPPs)were analyzed.RESULTS Although the mean ACC was greater and the mean of RTs was shorter in HCs than in MD patients,the differences were not statistically significant.However,across both groups,the ACC in the precautionary WST was greater than that in the other tasks,and the RTs in the abstract task were greater than those in the other tasks.Importantly,compared with that of HCs,the P100 of the left centroparietal sites was significantly increased,and the early LPP was attenuated at parietal sites and increased at left frontocentral sites;the medium LPP and late LPP were increased at the left frontocentral sites.CONCLUSION Patients with MD have conditional reasoning dysfunction and exhibit abnormal ERP characteristics evoked by the WST,which suggests neural correlates of abnormalities in conditional reasoning function in MD patients.
文摘We devise an approach to Bayesian statistics and their applications in the analysis of the Monty Hall problem. We combine knowledge gained through applications of the Maximum Entropy Principle and Nash equilibrium strategies to provide results concerning the use of Bayesian approaches unique to the Monty Hall problem. We use a model to describe Monty’s decision process and clarify that Bayesian inference results in an “irrelevant, therefore invariant” hypothesis. We discuss the advantages of Bayesian inference over the frequentist inference in tackling the uneven prior probability Monty Hall variant. We demonstrate that the use of Bayesian statistics conforms to the Maximum Entropy Principle in information theory and Bayesian approach successfully resolves dilemmas in the uneven probability Monty Hall variant. Our findings have applications in the decision making, information theory, bioinformatics, quantum game theory and beyond.
