Patients with unresectable colorectal liver metastases(u-CRLM)exhibit a poor prognosis,with the 5-year overall survival(OS)rate remaining below 10%when treated with first-line chemotherapy alone.Liver transplantation(...Patients with unresectable colorectal liver metastases(u-CRLM)exhibit a poor prognosis,with the 5-year overall survival(OS)rate remaining below 10%when treated with first-line chemotherapy alone.Liver transplantation(LT)has emerged as a promising therapeutic option for carefully selected patients,achieving 5-year OS rates of up to 60%,despite a relatively high recurrence rate(1-3).However,the critical challenge of organ shortage continues to limit its broader application.展开更多
基金supported by the Original Exploration Program Project of the National Natural Science Foundation of China(No.82150004).
文摘Patients with unresectable colorectal liver metastases(u-CRLM)exhibit a poor prognosis,with the 5-year overall survival(OS)rate remaining below 10%when treated with first-line chemotherapy alone.Liver transplantation(LT)has emerged as a promising therapeutic option for carefully selected patients,achieving 5-year OS rates of up to 60%,despite a relatively high recurrence rate(1-3).However,the critical challenge of organ shortage continues to limit its broader application.
