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Transgressive Lacustrine Shale Sedimentary Environment,Enrichment Model and Mechanisms for Organic Matter in the Paleocene Funing Formation,China
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作者 SUN Biao LIU Xiaoping +5 位作者 SHU Honglin WANG Gaocheng LIU Tian HUA Zuxian PENG Wendi YUAN Yu 《Acta Geologica Sinica(English Edition)》 2025年第4期1119-1133,共15页
The relationship between marine transgression and the distribution of lacustrine organic matter has restricted shale oil and gas exploration for decades.In this study,the research objective is to analyze the sedimenta... The relationship between marine transgression and the distribution of lacustrine organic matter has restricted shale oil and gas exploration for decades.In this study,the research objective is to analyze the sedimentary environment and evaluate its influence on organic matter in transgressive lacustrine shale.The study uses various analyses including total organic carbon(TOC),Rock-Eval pyrolysis,gas chromatography-mass spectrometry(GC-MS),trace element and isotope analysis.Finally,the study proposes an enrichment model for organic matter.The lacustrine shale of the second member of the Funing Formation(E_(1)f^(2))is divided into three sequences.The results indicate that the depositional environment of the organic matter during this period was an arid and humid,reduced,closed,rift lake basin.In the first sequence,high salinity resulted from increased evaporation,leading to low primary biological productivity.At this time,the lake basin belonged to a salinized closed lake basin.Intermittent transgressions began in the second sequence,with the deep lake area still being dominated by a reducing environment.The third sequence saw the environment evolve into a closed lake basin characterized by a warm and humid freshwater environment with high primary productivity.Marine transgressions introduce a substantial amount of marine plankton,nutrient elements,as well as more CO_(2) and CO_(3)^(2−)into the lake,leading to increased primary productivity.The sedimentary model for transgressive lacustrine source rocks proposed here serves as an example for similar transgressive lake basins. 展开更多
关键词 lacustrine shale organic-matter enrichment model sedimentary environment TRANSGRESSION Subei basin
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Sedimentary Controls on Migration Patterns and Developmental Model of Black Shales in the Foreland Lake Basin: Insights from the Middle Jurassic Lianggaoshan Formation in the Sichuan Basin, China
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作者 LIN Sichen ZHU Haihua +5 位作者 WANG Minglei ZHANG Benjian ZHANG Fuyuan YANG Xilin HONG Haitao LI Yucong 《Acta Geologica Sinica(English Edition)》 2025年第5期1423-1441,共19页
Research on the distribution and development of black shales in the Lianggaoshan Formation has been deficient,which has hindered exploration for lacustrine shale oil in the Sichuan Basin.Our study characterized the we... Research on the distribution and development of black shales in the Lianggaoshan Formation has been deficient,which has hindered exploration for lacustrine shale oil in the Sichuan Basin.Our study characterized the well logging data,core samples,outcrops,and geochemistry of black shales in the Lianggaoshan Formation in the Sichuan Basin.Our analysis focused on the lake basin evolution and the migration characteristics,paleoenvironmental features,formation mechanisms,and developmental model of the black shales.The results indicated that black shales in the Lianggaoshan Formation exhibited significant lateral migration,with an overall thickening trend from east to west.Within the 1st Member of the formation,black shale occurred as a single thick layer in the eastern region that gradually thinned toward the central region.Multiple sets of shale developed within the 2nd and 3rd members,and these had lower thicknesses than the 1st Member and migrated toward central Sichuan.Paleoproductivity and terrigenous input were the main factors controlling the deposition of black shales.A semi-humid climate influenced the deposition of black shales,bringing abundant freshwater,terrigenous debris,and nutrients into the basin.Decomposition of organic matter consumed oxygen in sediment and bottom water,causing localized oxygen deficiency in the strata. 展开更多
关键词 black shale shale migration PALEOENVIRONMENT development model Lianggaoshan Formation Sichuan Basin
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Multi-parameter modeling and analysis of ground motion amplification in the Quaternary sedimentary basin of the Beijing-Tianjin-Hebei region
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作者 Hong Zhou 《Earthquake Science》 2025年第2期136-151,共16页
Basin effect was first described following the analysis of seismic ground motion associated with the 1985 MW8.1 earthquake in Mexico.Basins affect the propagation of seismic waves through various mechanisms,and severa... Basin effect was first described following the analysis of seismic ground motion associated with the 1985 MW8.1 earthquake in Mexico.Basins affect the propagation of seismic waves through various mechanisms,and several unique phenomena,such as the basin edge effect,basin focusing effect,and basin-induced secondary waves,have been observed.Understanding and quantitatively predicting these phenomena are crucial for earthquake disaster reduction.Some pioneering studies in this field have proposed a quantitative relationship between the basin effect on ground motion and basin depth.Unfortunately,basin effect phenomena predicted using a model based only on basin depth exhibit large deviations from actual distributions,implying the severe shortcomings of single-parameter basin effect modeling.Quaternary sediments are thick and widely distributed in the Beijing-Tianjin-Hebei region.The seismic media inside and outside of this basin have significantly different physical properties,and the basin bottom forms an interface with strong seismic reflections.In this study,we established a three-dimensional structure model of the Quaternary sedimentary basin based on the velocity structure model of the North China Craton and used it to simulate the ground motion under a strong earthquake following the spectral element method,obtaining the spatial distribution characteristics of the ground motion amplification ratio throughout the basin.The back-propagation(BP)neural network algorithm was then introduced to establish a multi-parameter mathematical model for predicting ground motion amplification ratios,with the seismic source location,physical property ratio of the media inside and outside the basin,seismic wave frequency,and basin shape as the input parameters.We then examined the main factors influencing the amplification of seismic ground motion in basins based on the prediction results,and concluded that the main factors influencing the basin effect are basin shape and differences in the physical properties of media inside and outside the basin. 展开更多
关键词 three-dimensional basin effect ground motion modeling BP neural network algorithm spectral element method
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Sedimentary facies and depositional model of lower member of Dalazi Formation(Lower Cretaceous),Songjiang Basin
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作者 GAO Ningning ZHENG Xiaoping SHAN Xuanlong 《Global Geology》 2025年第3期206-216,共11页
The lower member of Dalazi Formation is an important oil reservoir in the Songjiang Basin.Based on the research on its field-measured geological profiles,lithological combination characteristics and grain size distrib... The lower member of Dalazi Formation is an important oil reservoir in the Songjiang Basin.Based on the research on its field-measured geological profiles,lithological combination characteristics and grain size distribution characteristics,combined with the analysis of the spatial distribution characteristics,sedimentary structural characteristics and hydrodynamic conditions of the sediments in this member,nine sedimentary microfacies of the fan delta plain subfacies,fan delta front subfacies and littoral-shallow lacustrine subfacies have been identified.The study reveals that lower member of Dalazi Formation in the research area follows a fan delta–shallow lacustrine depositional model in the steep slope zone of a rift lake basin.The sediments primarily originate from the Pre-Mesozoic strata in the steep southeastern and eastern margins.The basin center migrated from the early Xiaoshahe area to the Yangmucun–Shenglicun area,and the sedimentary system gradually transitioned from fan delta to littoral-shallow lacustrine facies. 展开更多
关键词 Songjiang Basin lower member of Dalazi Formation fan delta shore shallow lake depositional model
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Modeling of Precipitation over Africa:Progress,Challenges,and Prospects
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作者 A.A.AKINSANOLA C.N.WENHAJI +21 位作者 R.BARIMALALA P.-A.MONERIE R.D.DIXON A.T.TAMOFFO M.O.ADENIYI V.ONGOMA I.DIALLO M.GUDOSHAVA C.M.WAINWRIGHT R.JAMES K.C.SILVERIO A.FAYE S.S.NANGOMBE M.W.POKAM D.A.VONDOU N.C.G.HART I.PINTO M.KILAVI S.HAGOS E.N.RAJAGOPAL R.K.KOLLI S.JOSEPH 《Advances in Atmospheric Sciences》 2026年第1期59-86,共28页
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha... In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain. 展开更多
关键词 RAINFALL MONSOON climate modeling CORDEX CMIP6 convection-permitting models
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Do Higher Horizontal Resolution Models Perform Better?
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作者 Shoji KUSUNOKI 《Advances in Atmospheric Sciences》 2026年第1期259-262,共4页
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(... Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)]. 展开更多
关键词 enhancing model resolution refinement data assimilation systems section climate model climate projection higher horizontal resolution seasonal forecasting simulation seasonal migration rain bands model resolution
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An Optimized Customer Churn Prediction Approach Based on Regularized Bidirectional Long Short-Term Memory Model
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作者 Adel Saad Assiri 《Computers, Materials & Continua》 2026年第1期1783-1803,共21页
Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying ... Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying issues with services,products,or customer experience,resulting in considerable income loss.Prediction of customer churn is a crucial task aimed at retaining customers and maintaining revenue growth.Traditional machine learning(ML)models often struggle to capture complex temporal dependencies in client behavior data.To address this,an optimized deep learning(DL)approach using a Regularized Bidirectional Long Short-Term Memory(RBiLSTM)model is proposed to mitigate overfitting and improve generalization error.The model integrates dropout,L2-regularization,and early stopping to enhance predictive accuracy while preventing over-reliance on specific patterns.Moreover,this study investigates the effect of optimization techniques on boosting the training efficiency of the developed model.Experimental results on a recent public customer churn dataset demonstrate that the trained model outperforms the traditional ML models and some other DL models,such as Long Short-Term Memory(LSTM)and Deep Neural Network(DNN),in churn prediction performance and stability.The proposed approach achieves 96.1%accuracy,compared with LSTM and DNN,which attain 94.5%and 94.1%accuracy,respectively.These results confirm that the proposed approach can be used as a valuable tool for businesses to identify at-risk consumers proactively and implement targeted retention strategies. 展开更多
关键词 Customer churn prediction deep learning RBiLSTM DROPOUT baseline models
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When Large Language Models and Machine Learning Meet Multi-Criteria Decision Making: Fully Integrated Approach for Social Media Moderation
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作者 Noreen Fuentes Janeth Ugang +4 位作者 Narcisan Galamiton Suzette Bacus Samantha Shane Evangelista Fatima Maturan Lanndon Ocampo 《Computers, Materials & Continua》 2026年第1期2137-2162,共26页
This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to use... This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities. 展开更多
关键词 Self-moderation user-generated content k-means clustering TODIM large language models
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A Boundary Element Reconstruction (BER) Model for Moving Morphable Component Topology Optimization
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作者 Zhao Li Hongyu Xu +2 位作者 Shuai Zhang Jintao Cui Xiaofeng Liu 《Computers, Materials & Continua》 2026年第1期2213-2230,共18页
The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is m... The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is mainly used for finite element analysis at present,and the effectiveness of the surrogate material model has been fully confirmed.However,there are some accuracy problems when dealing with boundary elements using the surrogate material model,which will affect the topology optimization results.In this study,a boundary element reconstruction(BER)model is proposed based on the surrogate material model under the MMC topology optimization framework to improve the accuracy of topology optimization.The proposed BER model can reconstruct the boundary elements by refining the local meshes and obtaining new nodes in boundary elements.Then the density of boundary elements is recalculated using the new node information,which is more accurate than the original model.Based on the new density of boundary elements,the material properties and volume information of the boundary elements are updated.Compared with other finite element analysis methods,the BER model is simple and feasible and can improve computational accuracy.Finally,the effectiveness and superiority of the proposed method are verified by comparing it with the optimization results of the original surrogate material model through several numerical examples. 展开更多
关键词 Topology optimization MMC method boundary element reconstruction surrogate material model local mesh
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Face-Pedestrian Joint Feature Modeling with Cross-Category Dynamic Matching for Occlusion-Robust Multi-Object Tracking
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作者 Qin Hu Hongshan Kong 《Computers, Materials & Continua》 2026年第1期870-900,共31页
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba... To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions. 展开更多
关键词 Cross-category dynamic binding joint feature modeling face-pedestrian association multi object tracking occlusion robustness
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Motion In-Betweening via Frequency-Domain Diffusion Model
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作者 Qiang Zhang Shuo Feng +2 位作者 Shanxiong Chen Teng Wan Ying Qi 《Computers, Materials & Continua》 2026年第1期275-296,共22页
Human motion modeling is a core technology in computer animation,game development,and humancomputer interaction.In particular,generating natural and coherent in-between motion using only the initial and terminal frame... Human motion modeling is a core technology in computer animation,game development,and humancomputer interaction.In particular,generating natural and coherent in-between motion using only the initial and terminal frames remains a fundamental yet unresolved challenge.Existing methods typically rely on dense keyframe inputs or complex prior structures,making it difficult to balance motion quality and plausibility under conditions such as sparse constraints,long-term dependencies,and diverse motion styles.To address this,we propose a motion generation framework based on a frequency-domain diffusion model,which aims to better model complex motion distributions and enhance generation stability under sparse conditions.Our method maps motion sequences to the frequency domain via the Discrete Cosine Transform(DCT),enabling more effective modeling of low-frequency motion structures while suppressing high-frequency noise.A denoising network based on self-attention is introduced to capture long-range temporal dependencies and improve global structural awareness.Additionally,a multi-objective loss function is employed to jointly optimize motion smoothness,pose diversity,and anatomical consistency,enhancing the realism and physical plausibility of the generated sequences.Comparative experiments on the Human3.6M and LaFAN1 datasets demonstrate that our method outperforms state-of-the-art approaches across multiple performance metrics,showing stronger capabilities in generating intermediate motion frames.This research offers a new perspective and methodology for human motion generation and holds promise for applications in character animation,game development,and virtual interaction. 展开更多
关键词 Motion generation diffusion model frequency domain human motion synthesis self-attention network 3D motion interpolation
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Effects of noninvasive brain stimulation on motor functions in animal models of ischemia and trauma in the central nervous system
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作者 Seda Demir Gereon R.Fink +1 位作者 Maria A.Rueger Stefan J.Blaschke 《Neural Regeneration Research》 2026年第4期1264-1276,共13页
Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of kn... Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of knowledge about the underlying modes of action and optimal treatment modalities,a thorough translational investigation of noninvasive brain stimulation in preclinical animal models is urgently needed.Thus,we reviewed the current literature on the mechanistic underpinnings of noninvasive brain stimulation in models of central nervous system impairment,with a particular emphasis on traumatic brain injury and stroke.Due to the lack of translational models in most noninvasive brain stimulation techniques proposed,we found this review to the most relevant techniques used in humans,i.e.,transcranial magnetic stimulation and transcranial direct current stimulation.We searched the literature in Pub Med,encompassing the MEDLINE and PMC databases,for studies published between January 1,2020 and September 30,2024.Thirty-five studies were eligible.Transcranial magnetic stimulation and transcranial direct current stimulation demonstrated distinct strengths in augmenting rehabilitation post-stroke and traumatic brain injury,with emerging mechanistic evidence.Overall,we identified neuronal,inflammatory,microvascular,and apoptotic pathways highlighted in the literature.This review also highlights a lack of translational surrogate parameters to bridge the gap between preclinical findings and their clinical translation. 展开更多
关键词 noninvasive brain stimulation preclinical modeling STROKE transcranial direct current stimulation transcranial magnetic stimulation traumatic brain injury
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Sedimentary Characteristics and Model of Gravity Flow Depositional System for the First Member of Upper Miocene Huangliu Formation in Dongfang Area, Yinggehai Basin, Northwestern South China Sea 被引量:13
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作者 Ming Sun Hua Wang +4 位作者 Jihua Liao Huajun Gan Jun Xiao Jinfeng Ren Shu'e Zhao 《Journal of Earth Science》 SCIE CAS CSCD 2014年第3期506-518,共13页
The gravity flow deposit were mainly developed in the lowstand systems tract(LST) of the first member of Upper Miocene Huangliu Formation(Ehl1) in Dongfang area, Yinggehai Basin, has become a valuable target for g... The gravity flow deposit were mainly developed in the lowstand systems tract(LST) of the first member of Upper Miocene Huangliu Formation(Ehl1) in Dongfang area, Yinggehai Basin, has become a valuable target for gas exploration and production. The gravity flow sedimentary characteristics of lithofacies associations, sedimentary texture, seismic facies and logging facies were described in detail on the basis of integrated analysis of cores, logging and seismic data. The sedimentary microfacies types composed of neritic sandbar, continental shelf mud, main channel, bifurcated or cross-cutting distributary channel, overspill, and natural levee are revealed under the constraint of high resolution sequence stratigraphic framework in the Ehl1. The gravity flow deposit system in the LST is divided into three evolution stages corresponding to periods of three parasequence sets. The gravity flow deposit was induced in the early LST, expanded rapidly in the middle LST and decreased slightly in the late LST. But its developing scale decreased sharply in the transgression systems tract(TST) and finally vanished in the highstand systems tract(HST). This spatial evolution rule is constrained by the integrated function of sediments supply of the Vietnam Blue River in the LST, the development of local gradient change in sea floor(micro-topography, i.e., flexure slope break), and the fall in relative sea level. On the basics of the deep study of the coupling relationship among the three main control factors, the sedimentary model is established as an optimal component of "source-channel-sink" for shallow marine turbidite submarine fan. 展开更多
关键词 Yinggehai Basin Dongfang area the first member of Upper Miocene Huangliu Formation(Ehl1) sedimentation characteristics gravity flow sedimentary model.
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Novel therapies for myasthenia gravis:Translational research from animal models to clinical application
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作者 Benedetta Sorrenti Christian Laurini +4 位作者 Luca Bosco Camilla Mirella Maria Strano Adele Ratti Yuri Matteo Falzone Stefano Carlo Previtali 《Neural Regeneration Research》 2026年第5期1834-1848,共15页
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in ... Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors. 展开更多
关键词 acetylcholine receptor(AChR) animal models B-cell depletion biological therapies COMPLEMENT IMMUNOTHERAPY muscle-specific kinase(Mu SK) neonatal Fc receptor
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Human cerebral organoids:Complex,versatile,and human-relevant models of neural development and brain diseases
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作者 Raquel Coronel Rosa González-Sastre +8 位作者 Patricia Mateos-Martínez Laura Maeso Elena Llorente-Beneyto Sabela Martín-Benito Viviana S.Costa Gagosian Leonardo Foti Ma Carmen González-Caballero Victoria López-Alonso Isabel Liste 《Neural Regeneration Research》 2026年第3期837-854,共18页
The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cereb... The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering. 展开更多
关键词 assembloids BIOENGINEERING challenges disease modeling drug screening and toxicology human brain organoids human pluripotent stem cells neurodegenerative diseases NEURODEVELOPMENT VASCULARIZATION
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Basin-Scale Sand Deposition in the Upper Triassic Xujiahe Formation of the Sichuan Basin, Southwest China: Sedimentary Framework and Conceptual Model 被引量:10
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作者 谭秀成 夏青松 +5 位作者 陈景山 李凌 刘宏 罗冰 夏吉文 杨家静 《Journal of Earth Science》 SCIE CAS CSCD 2013年第1期89-103,共15页
The Upper Triassic Xujiahe (须家河) Formation in the Sichuan (四川) Basin, Southwest China is distinctive for the basin-scale sand deposition. This relatively rare sedimentary phenomenon has not been well interpre... The Upper Triassic Xujiahe (须家河) Formation in the Sichuan (四川) Basin, Southwest China is distinctive for the basin-scale sand deposition. This relatively rare sedimentary phenomenon has not been well interpreted. Here we addressed this issue by discussing sedimentary framework and conceptual model. Analysis of sedimentary setting implied that the basin received transgression during the deposition. It had multiple provenance supplies and river networks, as being surrounded by old- lands in multiple directions including the north, east and south. Thus, the basin was generally charac-terized by coastal and widely open and shallow lacustrine deposition during the Late Triassic Xujiahe period. This is similar to the modern well-known Poyang (鄱阳) Lake. Therefore, we investigated the framework and conceptual model of the Sichuan Basin during the Xujiahe period with an analogue to the Poyang Lake. Results show that the conceptual model of the deposition can be divided into transgressive and regressive stages. The first, third and fifth mem- bers of the formation are in transgressive stage and the deposits are dominated by shore and shallow lacustrine mud. In contrast, the deposition is mainly of braided river channel sand deposits during the regressive stage, mainly including the second, fourth and sixth members of the formation. The sand deposited in almost the entire basin because of the lateral migration and forward moving of the cross networks of the braided rivers. The multiple alternations of short and rapid transgression and relatively long regression are beneficial to the basin-scale sand deposition. Thus, the main channel of the braided river and its extensional areas are favorable for the development of hydrocarbon reservoir. This provides practical significance to the reservoir evaluation and exploration. In addition, the results also justify the relatively distinctive sedimentary phenomenon in the study area and may also have im- plications for understanding the large-scale sand deposition elsewhere. 展开更多
关键词 basin-scale sand deposition coastal and widely open lake sedimentary framework sedimentary conceptual model channel of braided river Upper Triassic Xujiahe Formation Sichuan Basin.
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Formation Conditions and Sedimentary Model of Over-Flooding Lake Deltas within Continental Lake Basins: An Example from the Paleogene in the Jiyang Subbasin, Bohai Bay Basin 被引量:3
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作者 WANG Jian CAO Yingchang +1 位作者 LIU Huimin GAO Yongjin 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2015年第1期270-284,共15页
A large quantity of drilling core, paleontology, geochemistry and geophysics data revealed several features of the Jiyang subbasin during the deposition of the Ekl-ES4x members: (1) the paleotopography of the gentl... A large quantity of drilling core, paleontology, geochemistry and geophysics data revealed several features of the Jiyang subbasin during the deposition of the Ekl-ES4x members: (1) the paleotopography of the gentle slope belt had an extremely low gradient; (2) the paleoclimate frequently alternated between dry and wet periods in a generally arid setting; (3) there was strong weathering around the periphery of the basin; (4) the lake was very shallow; (5) the lake level frequently rose and fell; and (6) the sedimentary environment of the gentle slope belt was an over- flooding lake. All of these factors provided favorable geological conditions for the development of an over-flooding lake delta. The lithologies of the continental over-flooding lake delta deposits are complex and diverse. The compositional maturity is moderate to low, and the grain size distribution curves and sedimentary structures indicate the presence of both gravity and traction currents. The sedimentary microfacies associations consist of a combination of ordered superposition of flood channels, distributary channels and sheet sands. The delta exhibits a weak foreset seismic reflection. The over-flooding lake delta deposits are laterally extensive. The sandstone content is high, and the individual sandstone beds are thin. The flood channel and distributary channel deposits exhibit evidence of bifurcation and lateral migration. The distribution of the sandbodies and the oxidation color of the mudstones provide evidence of cyclic deposition. The paleoclimate was the dominant factor controlling the development of the over-flooding lake delta. Due to the frequently alternating wet and dry paleoclimates, the over-flooding lake delta is characterized by the development of a broad upper plain and a lower delta plain. The upper delta plain is characterized by flood channel deposits, whereas the lower delta plain is represented by distributary channel deposits. The transition zone is characterized by the interaction of flood channels and distributary channels. Due to fault activity, the sandbodies of the over-flooding lake delta were juxtaposed against hydrocarbon source rocks, which was favorable for the development of lithologic reservoirs or structural-lithologic reservoirs. The lower delta plain deposits comprise the most favorable reservoirs. 展开更多
关键词 Jiyang subbasin continental basin over-flooding lake delta sedimentary model oil andgas exploration
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Sedimentary facies and depositional model of shallow water delta dominated by fluvial for Chang 8 oil-bearing group of Yanchang Formation in southwestern Ordos Basin,China 被引量:12
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作者 陈林 陆永潮 +5 位作者 吴吉元 邢凤存 刘璐 马义权 饶丹 彭丽 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第12期4749-4763,共15页
A systematic analysis of southwestern Ordos Basin's sedimentary characteristics,internal architectural element association styles and depositional model was illustrated through core statistics,well logging data an... A systematic analysis of southwestern Ordos Basin's sedimentary characteristics,internal architectural element association styles and depositional model was illustrated through core statistics,well logging data and outcrop observations in Chang 8 oil-bearing group.This analysis indicates that shallow water delta sediments dominated by a fluvial system is the primary sedimentary system of the Chang 8 oil-bearing group of the Yanchang Formation in southwestern Ordos Basin.Four microfacies with fine grain sizes are identified: distributary channels,sheet sandstone,mouth bar and interdistributary fines.According to the sandbody's spatial distribution and internal architecture,two types of sandbody architectural element associations are identified: amalgamated distributary channels and thin-layer lobate sandstone.In this sedimentary system,net-like distributary channels at the delta with a narrow ribbon shape compose the skeleton of the sandbody that extends further into the delta front and shades into contiguous lobate distribution sheet sandstone in the distal delta front.The mouth bar is largely absent in this system.By analyzing the palaeogeomorphology,the palaeostructure background,sedimentary characteristics,sedimentary facies types and spatial distribution of sedimentary facies during the Chang 8 period,a distinctive depositional model of the Chang 8 shallow water fluvial-dominated delta was established,which primarily consists of straight multi-phase amalgamated distributary channels in the delta plain,net-like distributary channels frequently diverting and converging in the proximal delta front,sheet sandstones with dispersing contiguous lobate shapes in the distal delta front,and prodelta or shallow lake mudstones. 展开更多
关键词 sedimentary facies architectural element DEPOSITIONAL model shallow water delta CHANG 8 oil-bearing GROUP ORDOS Basin
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基于Hybrid Model的浙江省太阳总辐射估算及其时空分布特征
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作者 顾婷婷 潘娅英 张加易 《气象科学》 2025年第2期176-181,共6页
利用浙江省两个辐射站的观测资料,对地表太阳辐射模型Hybrid Model在浙江省的适用性进行评估分析。在此基础上,利用Hybrid Model重建浙江省71个站点1971—2020年的地表太阳辐射日数据集,并分析其时空变化特征。结果表明:Hybrid Model模... 利用浙江省两个辐射站的观测资料,对地表太阳辐射模型Hybrid Model在浙江省的适用性进行评估分析。在此基础上,利用Hybrid Model重建浙江省71个站点1971—2020年的地表太阳辐射日数据集,并分析其时空变化特征。结果表明:Hybrid Model模拟效果良好,和A-P模型计算结果进行对比,杭州站的平均误差、均方根误差、平均绝对百分比误差分别为2.01 MJ·m^(-2)、2.69 MJ·m^(-2)和18.02%,而洪家站的平均误差、均方根误差、平均绝对百分比误差分别为1.41 MJ·m^(-2)、1.85 MJ·m^(-2)和11.56%,误差均低于A-P模型,且Hybrid Model在各月模拟的误差波动较小。浙江省近50 a平均地表总辐射在3733~5060 MJ·m^(-2),高值区主要位于浙北平原及滨海岛屿地区。1971—2020年浙江省太阳总辐射呈明显减少的趋势,气候倾向率为-72 MJ·m^(-2)·(10 a)^(-1),并在1980s初和2000年中期发生了突变减少。 展开更多
关键词 Hybrid model 太阳总辐射 误差分析 时空分布
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Cenozoic tectono-sedimentary characteristics and extension model of the Northwest Sub-basin,South China Sea 被引量:8
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作者 Weiwei Ding Mingbi Li +2 位作者 Lihong Zhao Aiguo Ruan Zhenli Wu 《Geoscience Frontiers》 SCIE CAS 2011年第4期509-517,共9页
Based on the interpretations of three seismic profiles and one wide-angle seismic profile across the Northwest Sub-basin,South China Sea.stratigraphic sequences,deformation characteristics and an extension model for t... Based on the interpretations of three seismic profiles and one wide-angle seismic profile across the Northwest Sub-basin,South China Sea.stratigraphic sequences,deformation characteristics and an extension model for this sub-basin have been worked out.Three tectonic-stratigraphic units are determined.Detailed analyses of extension show that the event occurred mainly during the Paleogene and resulted in the formation of half-grabens or grabens distributed symmetrically around the spreading center.Sediments are characterized by chaotic and discontinuous reflectors,indicating clastic sediments. Farther to the southwest,the sub-basin features mainly continental rifting instead of sea-floor spreading. The rifting would have been controlled by the shape of the massif and developed just along the northern edge of the Zhongsha-Xisha Block,rather than joined the Xisha Trough.After 25 Ma.a southward ridge jump triggered the opening of the Southwest Sub-basin.The NW-directed stress caused by the sea-floor spreading of the Northwest Sub-basin may have prevented the continuous opening of the sub-basin.After that the Northwest Sub-basin experienced thermal cooling and exhibited broad subsidence.The deep crustal structure shown by the velocity model from a wide-angle seismic profile is also symmetrical around the spreading center,which indicates that the Northwest Sub-basin might have opened in a pure shear model. 展开更多
关键词 Continental rifting CENOZOIC Tectono-sedimentary characteristics Extension model Northwest Sub-basin Marginal sea
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