Editor's Note:As a unique system of succession in Tibetan Buddhism,the reincarnation of Living Buddhas is governed by standardized religious rituals,historical conventions,and established principles.Since the Karm...Editor's Note:As a unique system of succession in Tibetan Buddhism,the reincarnation of Living Buddhas is governed by standardized religious rituals,historical conventions,and established principles.Since the Karma Kagyu sect pioneered the reincarnation system of Living Buddhas in the 13th century,this tradition has continued for more than 700 years.Since the Gelug sect adopted the reincarnation practice in the 16th century,resulting in major lineages such as the Dalai Lama and Panchen Erdeni reincarnations,the system has now held a history of over 400 years.Since the Yuan Dynasty(1271-1368),successive central governments of China have,without exception,strengthened administration over reincarnation matters.In the 57th year of the reign of Emperor Qianlong(1792)of the Qing Dynasty,the Golden Urn Lot-Drawing System was formally established.This system has remained in place up to the present day.Demonstrating national sovereignty,governmental authority,as well as the sacredness and impartiality of Buddhism,it has effectively prevented corruption and malpractice during the reincarnation process.展开更多
伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)是一种常染色体显性遗传性脑小血管疾病。多发性硬化是一种中枢神经系统...伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)是一种常染色体显性遗传性脑小血管疾病。多发性硬化是一种中枢神经系统的炎症性脱髓鞘疾病。两者在临床表现和影像学特征上有较多类似之处,易造成误诊。本文报道1例因颅内和脊髓同时发生病变,最初诊断为多发性硬化,最终经基因检测明确诊断为Notch受体3(Notch receptor 3,Notch3)p.Arg544Cys(c.1630C>T)纯合错义突变的CADASIL患者,旨在通过对该病例的分析,减少CADASIL的误诊和漏诊,丰富Notch3在该突变位点上的临床表型,并提高对该疾病的认识与诊疗水平。展开更多
文摘Editor's Note:As a unique system of succession in Tibetan Buddhism,the reincarnation of Living Buddhas is governed by standardized religious rituals,historical conventions,and established principles.Since the Karma Kagyu sect pioneered the reincarnation system of Living Buddhas in the 13th century,this tradition has continued for more than 700 years.Since the Gelug sect adopted the reincarnation practice in the 16th century,resulting in major lineages such as the Dalai Lama and Panchen Erdeni reincarnations,the system has now held a history of over 400 years.Since the Yuan Dynasty(1271-1368),successive central governments of China have,without exception,strengthened administration over reincarnation matters.In the 57th year of the reign of Emperor Qianlong(1792)of the Qing Dynasty,the Golden Urn Lot-Drawing System was formally established.This system has remained in place up to the present day.Demonstrating national sovereignty,governmental authority,as well as the sacredness and impartiality of Buddhism,it has effectively prevented corruption and malpractice during the reincarnation process.
文摘目的探讨成人非偏头痛症状与卵圆孔未闭(patent foramen ovale,PFO)的相关性。方法回顾分析我院心血管内科超声心动图室2024年2~12月经胸超声心动图右心声学造影(contrast transthoracic echocardiography,cTTE)检查患者的临床资料,根据症状分为偏头痛症状组(n=527)、非偏头痛症状组(包括不明原因的头晕、耳鸣、一过性听力减退、晕厥、肢体麻木、一过性视野缺损症状,n=144)和无症状对照组(n=87)。比较3组PFO阳性率、PFO阳性患者右向左分流(right to left shunt,RLS)的差异;多因素logistic回归分析PFO阳性的独立相关因素。结果偏头痛症状组、非偏头痛症状组和无症状对照组PFO阳性率分别为85.0%(448/527)、84.0%(121/144)和26.4%(23/87),3组差异有显著性(χ^(2)=153.434,P=0.000),偏头痛症状组和非偏头痛症状组PFO阳性率显著高于无症状对照组(均P=0.000)。592例诊断PFO,3组RLS分级差异有显著性(H=18.762,P=0.000),偏头痛症状组和非偏头痛症状组RLS分级显著高于无症状对照组(均P=0.000)。多因素logistic回归分析显示,年龄≤40岁(OR=2.221,95%CI:1.515~3.256,P=0.000)、偏头痛(OR=3.373,95%CI:2.322~4.899,P=0.000)、头晕(OR=2.499,95%CI:1.694~3.685,P=0.000)和肢体麻木(OR=1.981,95%CI:1.052~3.729,P=0.034)与PFO阳性独立相关。结论头晕、肢体麻木等非偏头痛症状与成人PFO相关,对这些症状的患者进行cTTE检查是必要的。
