[Objective]The research aimed to discuss shallowly the application of L-band sounding seconds data in the artificial precipitation.[Method]The characteristics,getting manner and displaying method of L-band sounding se...[Objective]The research aimed to discuss shallowly the application of L-band sounding seconds data in the artificial precipitation.[Method]The characteristics,getting manner and displaying method of L-band sounding seconds data were introduced briefly.Moreover,its application prospect in the artificial precipitation operation was analyzed initially.We aimed to improve its application rate in the artificial precipitation operation.[Result]L-band sounding seconds data had the great improvement in the time-space resolution and the space positioning accuracy aspects when compared with the previous sounding data,and the precision reached the second level.It could provide the high-precision data basis for the assimilation of artificial precipitation numerical model initial field,and improve the numerical model.Moreover,the sounding product could provide the accurate scientific basis for the selection of artificial precipitation operation tool,the determination of operation height and range,and guide the artificial precipitation operation,and improve the operation efficiency.[Conclusion]The research provided the analysis and reference basis for the command of artificial precipitation operation.展开更多
The space gravitational wave detection aims to detect gravitational waves in the mHz band in order to study supermassive black hole mergers,galaxy evolution and the structure of the early universe.One of its core payl...The space gravitational wave detection aims to detect gravitational waves in the mHz band in order to study supermassive black hole mergers,galaxy evolution and the structure of the early universe.One of its core payloads is a transponder-type interstellar laser interferometer,designed to measure relative displacement changes at the pico-meter level.Among its components,phasemeter is tasked with extracting the phase and frequency of the interference signal.Currently,phase-locked loop(PLL)phasemeters are commonly employed.However,the second harmonic signal generated by the mixer can restrict both the dynamic range and phase measurement accuracy of the phasemeter.This paper analyzes the interstellar laser interferometer and the impact of the second harmonic signal on the phasemeter's performance.To address these challenges,a phasemeter incorporating a second harmonic signal filter is proposed.This new design mitigates second harmonic disturbances within the phasemeter's bandwidth by dynamically adjusting the filter's cutoff frequency to track the input signal frequency,thereby suppressing the second harmonic signal in real time.Theoretical and simulation analyses demonstrate that the proposed phasemeter with a second harmonic filter significantly enhances the dynamic range.Finally,experimental results verify that the phasemeter can achieve the tracking of sudden frequency changes up to4.8 MHz.展开更多
This interview examines the theoretical foundations,pedagogical applications,developmental trajectory,and future directions of the xu-argument.Professor Wang Chuming offers a comprehensive account of the xu-argument,c...This interview examines the theoretical foundations,pedagogical applications,developmental trajectory,and future directions of the xu-argument.Professor Wang Chuming offers a comprehensive account of the xu-argument,clarifying its theoretical framework,the learning mechanisms underlying xu,and its interface with international theories of second language acquisition(SLA).From the perspective of the xu-argument,he proposes novel interpretations of core issues in SLA.Drawing on the development of the xu-argument,Wang further discusses the essence,directions,and methodology of innovation in SLA theory.He emphasizes that theoretical advances must capture and illuminate underlying natural laws,arguing that innovative approaches are typically rooted in deep reflection on common sense.He also calls for theoretical innovation in SLA in the Chinese context,advocating a robust research paradigm that shifts from local observation to global theoretical generalization,thereby promoting bottom-up theoretical development.In closing,he highlights the promising prospects for SLA theory in the era of artificial intelligence.展开更多
The level of glutathione(GSH)is significantly associated with numerous pathological processes,thus,real-time detection of the GSH level is of significance for early diagnosis of GSH-related diseases.Herein,we develope...The level of glutathione(GSH)is significantly associated with numerous pathological processes,thus,real-time detection of the GSH level is of significance for early diagnosis of GSH-related diseases.Herein,we developed in vivo second near-infrared(NIR-II)window fluorescence(FL)and ratiometric photoacoustic(RPA)dual-modality imaging of GSH using a GSH-activatable probe(LET-14).LET-14 was synthesized based on a rhodamine hybrid xanthene skeleton with a FL shielding 2,4-dinitrobenzene sulfonyl group that can be specifically cleaved by GSH,thus resulting in a markedly bathochromic-shift absorption,a 6.5-fold increase in NIR-II FL intensity(FL920)and a 13-fold increase in RPA signal(PA880/PA705)in vitro.Intriguingly,LET-14 exhibits good selectivity and sensitivity for NIR-II FL and RPA dual-modality imaging of GSH in 4T1 tumor-bearing mouse model.Our findings develop an in vivo detection tool of GSH,which has great potential in the field of cancer diagnosis.展开更多
BEIJING,Feb.22(Xinhua)-The second volume of a book about the interactions between Xi Jinping,General Secretary of the Communist Party of China Central Committee,and the people during his domestic inspection tours has ...BEIJING,Feb.22(Xinhua)-The second volume of a book about the interactions between Xi Jinping,General Secretary of the Communist Party of China Central Committee,and the people during his domestic inspection tours has been published by the China Women Publishing House.展开更多
This study proposes a class of augmented subspace schemes for the weak Galerkin(WG)finite element method used to solve eigenvalue problems.The augmented subspace is built with the conforming linear finite element spac...This study proposes a class of augmented subspace schemes for the weak Galerkin(WG)finite element method used to solve eigenvalue problems.The augmented subspace is built with the conforming linear finite element space defined on the coarse mesh and the eigen-function approximations in the WG finite element space defined on the fine mesh.Based on this augmented subspace,solving the eigenvalue problem in the fine WG finite element space can be reduced to the solution of the linear boundary value problem in the same WG finite element space and a low dimensional eigenvalue problem in the augmented sub-space.The proposed augmented subspace techniques have the second order convergence rate with respect to the coarse mesh size,as demonstrated by the accompanying error esti-mates.Finally,a few numerical examples are provided to validate the proposed numerical techniques.展开更多
Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understandi...Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.展开更多
In 2021,we published our first special issue on the xu-argument in Chinese Journal of Applied Linguistics.Five years have passed since then.Over this period,second language acquisition(SLA)has undergone substantial ch...In 2021,we published our first special issue on the xu-argument in Chinese Journal of Applied Linguistics.Five years have passed since then.Over this period,second language acquisition(SLA)has undergone substantial changes.For example,the emergence of Large Language Models(LLMs)such as ChatGPT and DeepSeek has begun to reshape language teaching and learning.During the same period,the xu-argument has advanced considerably,both theoretically and methodologically.The present special issue brings together an interview and seven empirical studies,which collectively exemplify these developments.展开更多
BACKGROUND Repeated application of the Pringle maneuver is a key obstacle to safe minimally invasive repeat liver resection(MISRLR).However,limited technical guidance is available.AIM To study the utility of newly dev...BACKGROUND Repeated application of the Pringle maneuver is a key obstacle to safe minimally invasive repeat liver resection(MISRLR).However,limited technical guidance is available.AIM To study the utility of newly developed Pringle taping method guided by liver surface in MISRLR.METHODS We retrospectively reviewed 72 cases of MISRLR performed by a single surgeon at two centers from August 2015 to July 2024.Beginning in October 2019,a liver surface-guided encirclement of hepatoduodenal ligament(LSEH)was used for repeat Pringle taping.Perioperative outcomes including Pringle taping success,operative time,blood loss,conversion rate,morbidity,and mortality were assessed.RESULTS Laparoscopic and robotic approaches were used in 63 patients and 9 patients,respectively.The median operative time,blood loss,and hospital stay were 331.5 minutes,70 mL,and 8 days,respectively.Open conversion occurred in two cases(2.8%)due to severe adhesions and right renal vein injury.Clavien-Dindo grade≥III complications occurred in 5.6%of cases with no mortality.Anti-adhesion barriers were used in 54 patients(75.0%).LSEH was attempted in 57 cases,improving Pringle taping success from 33.0%to 91.4%(P<0.001).LSEH succeeded in all patients with prior open liver resection(n=11).Among 6 patients in whom LSEH failed,3 patients(50.0%)had undergone a third liver resection,and 1 patient had a history of distal gastrectomy with choledochoduodenostomy.CONCLUSION The newly developed LSEH technique for Pringle taping in MISRLR was feasible,enhancing safety and reproducibility even in patients with a history of open liver resection.展开更多
When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,whi...When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.展开更多
Increasing the hole expansion ratio is significant for developing high formability parts.Hole expansion tests were carried out on low carbon hot-rolled steel containing 0.11%Ti,0.072%Ti–0.03%Nb and 0.097%Ti–0.059%Nb...Increasing the hole expansion ratio is significant for developing high formability parts.Hole expansion tests were carried out on low carbon hot-rolled steel containing 0.11%Ti,0.072%Ti–0.03%Nb and 0.097%Ti–0.059%Nb,respectively.The effects of microstructure,texture,crack propagation behavior and second phase precipitation behavior on hole expansion ratio were investigated.The precipitation behavior of TiC and(Ti,Nb)C in austenite and ferrite in three groups of steel samples was calculated theoretically.The results showed that the hole expansion ratios of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 51.73%,51.17%and 66.24%following simulated coiling at 600℃,respectively.The microstructure was mainly polygonal ferrite with a small amount of pearlite.The grain refinement of 0.097Ti–0.059Nb test steel and the low texture ratio of{110}//ND improved the hole expansion ratio.The low overall hole expansion ratio was due to the microstructure inhomogeneity.The microstructure uniformity was improved by the quenching and tempering treatment,and the hole expansion ratio of the three test steels was greatly increased.The fastest precipitation temperatures in the austenitic region of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 880,860 and 830℃,while those in the ferrite region were 680,675 and 675℃,respectively.The addition of Nb element increased the volume free energy,so that the critical core size of the nucleation on the dislocation line increased,resulting in the decrease in the fastest precipitation temperature.展开更多
The mechanism of strength and toughness variation in Ti microalloyed steel within the range of 0.04–0.157 wt.%was investigated.By adding 0.13 wt.%Ti,the steel achieves higher strength while maintaining a certain leve...The mechanism of strength and toughness variation in Ti microalloyed steel within the range of 0.04–0.157 wt.%was investigated.By adding 0.13 wt.%Ti,the steel achieves higher strength while maintaining a certain level of elongation and low-temperature impact toughness.With increasing Ti content,the grain size in the steel decreased from 17.7 to 8.9μm.This decrease in grain size is accompanied by an increase in the percentage of low-angle grain boundaries and dislocations,which act as barriers to hinder crack propagation.The Ti microalloyed steel exhibits a 20%increase in yield strength and a 14%increase in tensile strength.The transformation of steel plasticity occurs when the Ti content exceeds 0.102 wt.%.The low-temperature impact toughness of the steel gradually decreases with increasing Ti content.At low Ti content,the low-temperature impact toughness is reduced due to crack initiation by large-size inclusions.At high Ti content,the low-temperature impact toughness of the steel deteriorates due to several factors.These include the narrower tough–brittle transition zone,grain boundary embrittlement caused by small-sized grains,and the decrease in the solid solution strengthening effect.展开更多
Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-ter...Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health.Currently,several surgical techniques have been validated for their effectiveness in increasing PIKM.However,the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques,variations in clinical scenarios,and anatomical differences.Therefore,clear guidelines and considerations for PIKM augmentation are needed.This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery.It aims to establish a standardized framework for assessing,planning,and executing PIKM augmentation procedures,with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation.展开更多
二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提...二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提升;二语写作研究领域暂未形成明显的核心作者和机构的合作网络;研究主题主要聚焦二语写作教学方法的多元化、二语写作反馈的多焦点、二语写作评估与测试的科学化,以及学习者个体差异的多维影响等方面。基于此,提出未来该领域发展需加强学者、机构之间的相互合作;关注个体学习者写作过程的认知特征与情感因素,尤其重视青少年二语学习过程的研究;扩大二语写作纵向研究规模,推动研究的深入发展。展开更多
Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was ...Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness.展开更多
Fluorescence lateral flow immunoassay(LFA)has emerged as a powerful tool for rapid screening of various biomarkers owing to its simplicity,sensitivity and flexibility.It is noteworthy that fluorescent probe mainly det...Fluorescence lateral flow immunoassay(LFA)has emerged as a powerful tool for rapid screening of various biomarkers owing to its simplicity,sensitivity and flexibility.It is noteworthy that fluorescent probe mainly determines the analytical performance of LFA.Due to the emission and excitation wavelengths are located in the visible region,most fluorophores are inevitably subject to light scattering and background autofluorescence.Herein,we reported a novel LFA sensor based on the second near-infrared(NIR-Ⅱ)fluorescent probe with excellent anti-interference capability.The designed NIR-Ⅱprobe was the Nd^(3+)and Yb^(3+)doped rare earth nanoparticles(RENPs)by employing Nd^(3+)as energy donor and Yb^(3+)as energy acceptor,which of the donor-acceptor energy transfer(ET)efficiency reached up to 80.7%.Meanwhile,relying on the convenient and effective encapsulation strategy of poly(lactic-co-glycolic acid)(PLGA)microspheres to RENPs,the surface functionalized NIR-Ⅱprobe(RE@PLGA)was obtained for subsequent bioconjugation.Benefiting from the optical advantages of NIR-Ⅱprobe,this proposed NIR-ⅡLFA displayed a good linear relationship ranging from 7 ng/mL to 200 ng/mL for the detection ofα-fetoprotein(AFP),an important biomarker of hepatocellular carcinoma(HCC).The limit of detection(LOD)was determined as low as 3.0 ng/m L,which was of 8.3 times lower than clinical cutoff value.It is promising that LFA sensor based on this efficient RENPs probe provides new opportunities for high sensitive detection of various biomarkers in biological samples.展开更多
The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue a...The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.展开更多
The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex...The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex beams for various applications.In this work,the second harmonic(SH)optical vortex beams generated from nonlinear fork gratings under Gaussian beam illumination are numerically investigated.The far-field intensity and phase distributions,as well as the orbital angular momentum(OAM)spectra of the SH beams,are analyzed for different structural topological charges and diffraction orders.Results reveal that higher-order diffraction and larger structural topological charges lead to angular interference patterns and non-uniform intensity distributions,deviating from the standard vortex profile.To optimize the SH vortex quality,the effects of the fundamental wave beam waist,crystal thickness,and grating duty cycle are explored.It is shown that increasing the beam waist can effectively suppress diffraction order interference and improve the beam’s quality.This study provides theoretical guidance for enhancing the performance of nonlinear optical devices based on NPCs.展开更多
文摘[Objective]The research aimed to discuss shallowly the application of L-band sounding seconds data in the artificial precipitation.[Method]The characteristics,getting manner and displaying method of L-band sounding seconds data were introduced briefly.Moreover,its application prospect in the artificial precipitation operation was analyzed initially.We aimed to improve its application rate in the artificial precipitation operation.[Result]L-band sounding seconds data had the great improvement in the time-space resolution and the space positioning accuracy aspects when compared with the previous sounding data,and the precision reached the second level.It could provide the high-precision data basis for the assimilation of artificial precipitation numerical model initial field,and improve the numerical model.Moreover,the sounding product could provide the accurate scientific basis for the selection of artificial precipitation operation tool,the determination of operation height and range,and guide the artificial precipitation operation,and improve the operation efficiency.[Conclusion]The research provided the analysis and reference basis for the command of artificial precipitation operation.
基金the National Key Research&Development Program of China(Grant No.2022YFC2203901)the State Key Laboratory of Spatial Datum(Grant No.SKLSD2025-KF-03)+1 种基金Fundamental Research Funds for the Central UniversitiesSun Yat-sen University for the support。
文摘The space gravitational wave detection aims to detect gravitational waves in the mHz band in order to study supermassive black hole mergers,galaxy evolution and the structure of the early universe.One of its core payloads is a transponder-type interstellar laser interferometer,designed to measure relative displacement changes at the pico-meter level.Among its components,phasemeter is tasked with extracting the phase and frequency of the interference signal.Currently,phase-locked loop(PLL)phasemeters are commonly employed.However,the second harmonic signal generated by the mixer can restrict both the dynamic range and phase measurement accuracy of the phasemeter.This paper analyzes the interstellar laser interferometer and the impact of the second harmonic signal on the phasemeter's performance.To address these challenges,a phasemeter incorporating a second harmonic signal filter is proposed.This new design mitigates second harmonic disturbances within the phasemeter's bandwidth by dynamically adjusting the filter's cutoff frequency to track the input signal frequency,thereby suppressing the second harmonic signal in real time.Theoretical and simulation analyses demonstrate that the proposed phasemeter with a second harmonic filter significantly enhances the dynamic range.Finally,experimental results verify that the phasemeter can achieve the tracking of sudden frequency changes up to4.8 MHz.
文摘This interview examines the theoretical foundations,pedagogical applications,developmental trajectory,and future directions of the xu-argument.Professor Wang Chuming offers a comprehensive account of the xu-argument,clarifying its theoretical framework,the learning mechanisms underlying xu,and its interface with international theories of second language acquisition(SLA).From the perspective of the xu-argument,he proposes novel interpretations of core issues in SLA.Drawing on the development of the xu-argument,Wang further discusses the essence,directions,and methodology of innovation in SLA theory.He emphasizes that theoretical advances must capture and illuminate underlying natural laws,arguing that innovative approaches are typically rooted in deep reflection on common sense.He also calls for theoretical innovation in SLA in the Chinese context,advocating a robust research paradigm that shifts from local observation to global theoretical generalization,thereby promoting bottom-up theoretical development.In closing,he highlights the promising prospects for SLA theory in the era of artificial intelligence.
基金supported by the National Natural Science Foundation of China(Nos.82372116,U23A2097)Guangdong Basic and Applied Basic Research Foundation(No.2022A1515010620)+2 种基金Shenzhen Medical Research Fund(Nos.B2302047,A2302047)Shenzhen Science and Technology Program(No.JCYJ20220818095806014)Research Team Cultivation Program of Shenzhen University(No.2023QNT019).
文摘The level of glutathione(GSH)is significantly associated with numerous pathological processes,thus,real-time detection of the GSH level is of significance for early diagnosis of GSH-related diseases.Herein,we developed in vivo second near-infrared(NIR-II)window fluorescence(FL)and ratiometric photoacoustic(RPA)dual-modality imaging of GSH using a GSH-activatable probe(LET-14).LET-14 was synthesized based on a rhodamine hybrid xanthene skeleton with a FL shielding 2,4-dinitrobenzene sulfonyl group that can be specifically cleaved by GSH,thus resulting in a markedly bathochromic-shift absorption,a 6.5-fold increase in NIR-II FL intensity(FL920)and a 13-fold increase in RPA signal(PA880/PA705)in vitro.Intriguingly,LET-14 exhibits good selectivity and sensitivity for NIR-II FL and RPA dual-modality imaging of GSH in 4T1 tumor-bearing mouse model.Our findings develop an in vivo detection tool of GSH,which has great potential in the field of cancer diagnosis.
文摘BEIJING,Feb.22(Xinhua)-The second volume of a book about the interactions between Xi Jinping,General Secretary of the Communist Party of China Central Committee,and the people during his domestic inspection tours has been published by the China Women Publishing House.
基金partly supported by the Beijing Natural Science Foundation(Grant No.Z200003)by the National Natural Science Foundation of China(Grant Nos.12331015,12301475,12301465)+1 种基金by the National Center for Mathematics and Interdisciplinary Science,Chinese Academy of Sciencesby the Research Foundation for the Beijing University of Technology New Faculty(Grant No.006000514122516).
文摘This study proposes a class of augmented subspace schemes for the weak Galerkin(WG)finite element method used to solve eigenvalue problems.The augmented subspace is built with the conforming linear finite element space defined on the coarse mesh and the eigen-function approximations in the WG finite element space defined on the fine mesh.Based on this augmented subspace,solving the eigenvalue problem in the fine WG finite element space can be reduced to the solution of the linear boundary value problem in the same WG finite element space and a low dimensional eigenvalue problem in the augmented sub-space.The proposed augmented subspace techniques have the second order convergence rate with respect to the coarse mesh size,as demonstrated by the accompanying error esti-mates.Finally,a few numerical examples are provided to validate the proposed numerical techniques.
基金supported by the National Social Science Fund of China(NSSFC):NSSFC Major Project“Exploration and Practice in the Development of Chinese Economics Since the Modern Era”(Grant No.17ZDA034)NSSFC Key Project“The Status and Value of Traditional Chinese Economic Thought”(Grant No.17AJL006)NSSFC General Project“The Transformation and Evolution of Chinese Economic Thought During the Republican Era”(Grant No.22BJL130).
文摘Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.
文摘In 2021,we published our first special issue on the xu-argument in Chinese Journal of Applied Linguistics.Five years have passed since then.Over this period,second language acquisition(SLA)has undergone substantial changes.For example,the emergence of Large Language Models(LLMs)such as ChatGPT and DeepSeek has begun to reshape language teaching and learning.During the same period,the xu-argument has advanced considerably,both theoretically and methodologically.The present special issue brings together an interview and seven empirical studies,which collectively exemplify these developments.
文摘BACKGROUND Repeated application of the Pringle maneuver is a key obstacle to safe minimally invasive repeat liver resection(MISRLR).However,limited technical guidance is available.AIM To study the utility of newly developed Pringle taping method guided by liver surface in MISRLR.METHODS We retrospectively reviewed 72 cases of MISRLR performed by a single surgeon at two centers from August 2015 to July 2024.Beginning in October 2019,a liver surface-guided encirclement of hepatoduodenal ligament(LSEH)was used for repeat Pringle taping.Perioperative outcomes including Pringle taping success,operative time,blood loss,conversion rate,morbidity,and mortality were assessed.RESULTS Laparoscopic and robotic approaches were used in 63 patients and 9 patients,respectively.The median operative time,blood loss,and hospital stay were 331.5 minutes,70 mL,and 8 days,respectively.Open conversion occurred in two cases(2.8%)due to severe adhesions and right renal vein injury.Clavien-Dindo grade≥III complications occurred in 5.6%of cases with no mortality.Anti-adhesion barriers were used in 54 patients(75.0%).LSEH was attempted in 57 cases,improving Pringle taping success from 33.0%to 91.4%(P<0.001).LSEH succeeded in all patients with prior open liver resection(n=11).Among 6 patients in whom LSEH failed,3 patients(50.0%)had undergone a third liver resection,and 1 patient had a history of distal gastrectomy with choledochoduodenostomy.CONCLUSION The newly developed LSEH technique for Pringle taping in MISRLR was feasible,enhancing safety and reproducibility even in patients with a history of open liver resection.
文摘When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.
基金financially supported by the CITIC niobium steel development award Fund(M1656-2021)Central Iron and Steel Research Institute for its independent research and development fund(No.21G62460ZD).
文摘Increasing the hole expansion ratio is significant for developing high formability parts.Hole expansion tests were carried out on low carbon hot-rolled steel containing 0.11%Ti,0.072%Ti–0.03%Nb and 0.097%Ti–0.059%Nb,respectively.The effects of microstructure,texture,crack propagation behavior and second phase precipitation behavior on hole expansion ratio were investigated.The precipitation behavior of TiC and(Ti,Nb)C in austenite and ferrite in three groups of steel samples was calculated theoretically.The results showed that the hole expansion ratios of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 51.73%,51.17%and 66.24%following simulated coiling at 600℃,respectively.The microstructure was mainly polygonal ferrite with a small amount of pearlite.The grain refinement of 0.097Ti–0.059Nb test steel and the low texture ratio of{110}//ND improved the hole expansion ratio.The low overall hole expansion ratio was due to the microstructure inhomogeneity.The microstructure uniformity was improved by the quenching and tempering treatment,and the hole expansion ratio of the three test steels was greatly increased.The fastest precipitation temperatures in the austenitic region of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 880,860 and 830℃,while those in the ferrite region were 680,675 and 675℃,respectively.The addition of Nb element increased the volume free energy,so that the critical core size of the nucleation on the dislocation line increased,resulting in the decrease in the fastest precipitation temperature.
基金supported by the National Natural Science Foundation of China(Nos.52174311 and 51974020).
文摘The mechanism of strength and toughness variation in Ti microalloyed steel within the range of 0.04–0.157 wt.%was investigated.By adding 0.13 wt.%Ti,the steel achieves higher strength while maintaining a certain level of elongation and low-temperature impact toughness.With increasing Ti content,the grain size in the steel decreased from 17.7 to 8.9μm.This decrease in grain size is accompanied by an increase in the percentage of low-angle grain boundaries and dislocations,which act as barriers to hinder crack propagation.The Ti microalloyed steel exhibits a 20%increase in yield strength and a 14%increase in tensile strength.The transformation of steel plasticity occurs when the Ti content exceeds 0.102 wt.%.The low-temperature impact toughness of the steel gradually decreases with increasing Ti content.At low Ti content,the low-temperature impact toughness is reduced due to crack initiation by large-size inclusions.At high Ti content,the low-temperature impact toughness of the steel deteriorates due to several factors.These include the narrower tough–brittle transition zone,grain boundary embrittlement caused by small-sized grains,and the decrease in the solid solution strengthening effect.
基金supported by the Natural Science Foundation of Sichuan Province(grant number:25NSFSC0265).
文摘Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health.Currently,several surgical techniques have been validated for their effectiveness in increasing PIKM.However,the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques,variations in clinical scenarios,and anatomical differences.Therefore,clear guidelines and considerations for PIKM augmentation are needed.This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery.It aims to establish a standardized framework for assessing,planning,and executing PIKM augmentation procedures,with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation.
文摘二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提升;二语写作研究领域暂未形成明显的核心作者和机构的合作网络;研究主题主要聚焦二语写作教学方法的多元化、二语写作反馈的多焦点、二语写作评估与测试的科学化,以及学习者个体差异的多维影响等方面。基于此,提出未来该领域发展需加强学者、机构之间的相互合作;关注个体学习者写作过程的认知特征与情感因素,尤其重视青少年二语学习过程的研究;扩大二语写作纵向研究规模,推动研究的深入发展。
基金Supported by the National Natural Science Foundation of China(42302141).
文摘Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness.
基金supported by the National Natural Science Foundation of China(Nos.U2267221,22107029,22377135)the Bohai Rim Advanced Research Institute for Drug Discovery(No.LX215002)+5 种基金the Natural Science Foundation of Shandong Province(No.ZR2022QH212)the Taishan Scholars Program(No.tsqn202312305)the Young Elite Scientists Sponsorship Program by Chinese Chemical Societythe Fundamental Research Projects of Science&Technology Innovation and development Plan in Yantai City(No.2023JCYJ059)the Shandong Laboratory Program(No.SYS202205)the Shanghai Postdoctoral Excellence Program(No.2023704)。
文摘Fluorescence lateral flow immunoassay(LFA)has emerged as a powerful tool for rapid screening of various biomarkers owing to its simplicity,sensitivity and flexibility.It is noteworthy that fluorescent probe mainly determines the analytical performance of LFA.Due to the emission and excitation wavelengths are located in the visible region,most fluorophores are inevitably subject to light scattering and background autofluorescence.Herein,we reported a novel LFA sensor based on the second near-infrared(NIR-Ⅱ)fluorescent probe with excellent anti-interference capability.The designed NIR-Ⅱprobe was the Nd^(3+)and Yb^(3+)doped rare earth nanoparticles(RENPs)by employing Nd^(3+)as energy donor and Yb^(3+)as energy acceptor,which of the donor-acceptor energy transfer(ET)efficiency reached up to 80.7%.Meanwhile,relying on the convenient and effective encapsulation strategy of poly(lactic-co-glycolic acid)(PLGA)microspheres to RENPs,the surface functionalized NIR-Ⅱprobe(RE@PLGA)was obtained for subsequent bioconjugation.Benefiting from the optical advantages of NIR-Ⅱprobe,this proposed NIR-ⅡLFA displayed a good linear relationship ranging from 7 ng/mL to 200 ng/mL for the detection ofα-fetoprotein(AFP),an important biomarker of hepatocellular carcinoma(HCC).The limit of detection(LOD)was determined as low as 3.0 ng/m L,which was of 8.3 times lower than clinical cutoff value.It is promising that LFA sensor based on this efficient RENPs probe provides new opportunities for high sensitive detection of various biomarkers in biological samples.
基金Supported by National Natural Science Foundation of China(81874059 and 82102105)the Natural Science Foundation of Zhejiang Province(LQ22H160017)the China Postdoctoral Science Foundation(2021M702825).
文摘The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.
基金supported by the National Nat-ural Science Foundation of China(Nos.12192251,12174185,92163216,and 62288101).
文摘The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex beams for various applications.In this work,the second harmonic(SH)optical vortex beams generated from nonlinear fork gratings under Gaussian beam illumination are numerically investigated.The far-field intensity and phase distributions,as well as the orbital angular momentum(OAM)spectra of the SH beams,are analyzed for different structural topological charges and diffraction orders.Results reveal that higher-order diffraction and larger structural topological charges lead to angular interference patterns and non-uniform intensity distributions,deviating from the standard vortex profile.To optimize the SH vortex quality,the effects of the fundamental wave beam waist,crystal thickness,and grating duty cycle are explored.It is shown that increasing the beam waist can effectively suppress diffraction order interference and improve the beam’s quality.This study provides theoretical guidance for enhancing the performance of nonlinear optical devices based on NPCs.
