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Information Diffusion Models and Fuzzing Algorithms for a Privacy-Aware Data Transmission Scheduling in 6G Heterogeneous ad hoc Networks
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作者 Borja Bordel Sánchez Ramón Alcarria Tomás Robles 《Computer Modeling in Engineering & Sciences》 2026年第2期1214-1234,共21页
In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic h... In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic heterogeneous infrastructures,unstable links and non-uniform hardware capabilities create critical issues regarding security and privacy.Traditional protocols are often too computationally heavy to allow 6G services to achieve their expected Quality-of-Service(QoS).As the transport network is built of ad hoc nodes,there is no guarantee about their trustworthiness or behavior,and transversal functionalities are delegated to the extreme nodes.However,while security can be guaranteed in extreme-to-extreme solutions,privacy cannot,as all intermediate nodes still have to handle the data packets they are transporting.Besides,traditional schemes for private anonymous ad hoc communications are vulnerable against modern intelligent attacks based on learning models.The proposed scheme fulfills this gap.Findings show the probability of a successful intelligent attack reduces by up to 65%compared to ad hoc networks with no privacy protection strategy when used the proposed technology.While congestion probability can remain below 0.001%,as required in 6G services. 展开更多
关键词 6G networks ad hoc networks PRIVACY scheduling algorithms diffusion models fuzzing algorithms
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Multi-Label Classification Model Using Graph Convolutional Neural Network for Social Network Nodes
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作者 Junmin Lyu Guangyu Xu +4 位作者 Feng Bao Yu Zhou Yuxin Liu Siyu Lu Wenfeng Zheng 《Computer Modeling in Engineering & Sciences》 2026年第2期1235-1256,共22页
Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relati... Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks. 展开更多
关键词 GNN social networks nodes multi-label classification model graphic convolution neural network coupling principle
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Dual Layer Source Grid Load Storage Collaborative Planning Model Based on Benders Decomposition: Distribution Network Optimization Considering Low-Carbon and Economy
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作者 Jun Guo Maoyuan Chen +2 位作者 Yuyang Li Sibo Feng Guangyu Fu 《Energy Engineering》 2026年第2期104-133,共30页
Theauthor proposes a dual layer source grid load storage collaborative planning model based on Benders decomposition to optimize the low-carbon and economic performance of the distribution network.The model plans the ... Theauthor proposes a dual layer source grid load storage collaborative planning model based on Benders decomposition to optimize the low-carbon and economic performance of the distribution network.The model plans the configuration of photovoltaic(3.8 MW),wind power(2.5 MW),energy storage(2.2 MWh),and SVC(1.2 Mvar)through interaction between upper and lower layers,and modifies lines 2–3,8–9,etc.to improve transmission capacity and voltage stability.The author uses normal distribution and Monte Carlo method to model load uncertainty,and combines Weibull distribution to describe wind speed characteristics.Compared to the traditional three-layer model(TLM),Benders decomposition-based two-layer model(BLBD)has a 58.1%reduction in convergence time(5.36 vs.12.78 h),a 51.1%reduction in iteration times(23 vs.47 times),a 8.07%reduction in total cost(12.436 vs.13.528 million yuan),and a 9.62%reduction in carbon emissions(12,456 vs.13,782 t).After optimization,the peak valley difference decreased from4.1 to 2.9MW,the renewable energy consumption rate reached 93.4%,and the energy storage efficiency was 87.6%.Themodel has been validated in the IEEE 33 node system,demonstrating its superiority in terms of economy,low-carbon,and reliability. 展开更多
关键词 Benders decomposition source grid load storage distribution network planning low-carbon economy optimization model
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Anisotropy of Phase Transformation in Aluminum and Copper under Shock Compression:Atomistic Simulations and Neural Network Model
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作者 Evgenii V.Fomin Ilya A.Bryukhanov +1 位作者 Natalya A.Grachyova Alexander E.Mayer 《Computers, Materials & Continua》 2026年第4期548-577,共30页
It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range ... It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range of crystallographic directions of shock loading has not been revealed.In this work,we calculated the shock Hugoniot for aluminum and copper in different crystallographic directions([100],[110],[111],[112],[102],[114],[123],[134],[221]and[401])of shock compression using molecular dynamics(MD)simulations.The results showed a high pressure(>160 GPa for Cu and>40 GPa for Al)of the FCC-to-BCC transition.In copper,different characteristics of the phase transition are observed depending on the loading direction with the[100]compression direction being the weakest.The FCC-to-BCC transition for copper is in the range of 150–220 GPa,which is consistent with the existing experimental data.Due to the high transition pressure,the BCC phase transition in copper competes with melting.In aluminum,the FCC-to-BCC transition is observed for all studied directions at pressures between 40 and 50 GPa far beyond the melting.In all considered cases we observe the coexistence of HCP and BCC phases during the FCC-to-BCC transition,which is consistent with the experimental data and atomistic calculations;this HCP phase forms in the course of accompanying plastic deformation with dislocation activity in the parent FCC phase.The plasticity incipience is also anisotropic in bothmetals,which is due to the difference in the projections of stress on the slip plane for different orientations of the FCC crystal.MD modeling results demonstrate a strong dependence of the FCC-to-BCC transition on the crystallographic direction,in which the material is loaded in the copper crystals.However,MD simulations data can only be obtained for specific points in the stereographic direction space;therefore,for more comprehensive understanding of the phase transition process,a feed-forward neural network was trained using MD modeling data.The trained machine learning model allowed us to construct continuous stereographic maps of phase transitions as a function of stress in the shock-compressed state of metal.Due to appearance and growth of multiple centers of new phase,the FCC-to-BCC transition leads to formation of a polycrystalline structure from the parent single crystal. 展开更多
关键词 Molecular dynamics(MD) ALUMINUM COPPER shock wave polymorphic phase transformation polycrystalline structure neural network model
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The Interaction Mechanism Between Urban Scale Hierarchy and Urban Networks in China:An Analysis Based on A Spatial Simultaneous Equation Model
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作者 ZHOU Ying ZHENG Wensheng WANG Xiaofang 《Chinese Geographical Science》 2026年第1期19-33,共15页
Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefor... Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefore,this paper analyzes the spatial interaction between urban scale hierarchy and urban networks in China from 2019 to 2023,drawing on Baidu migration data and employing a spatial simultaneous equation model.The results reveal a significant positive spatial correlation between cities with higher hierarchy and those with greater network centrality.Within a static framework,we identify a positive interaction between urban scale hierarchy and urban network centrality,while their spatial cross-effects manifest as negative neighborhood interactions based on geographical distance and positive cross-scale interactions shaped by network connections.Within a dynamic framework,changes in urban scale hierarchy and urban networks are mutually reinforcing,thereby widening disparities within the urban hierarchy.Furthermore,an increase in a city’s network centrality had a dampening effect on the population growth of neighboring cities and network-connected cities.This study enhances understanding of the spatial organisation of urban systems and offers insights for coordinated regional development. 展开更多
关键词 urban scale hierarchy urban networks spatial interaction spatial spillover effect Baidu migration data spatial simultaneous equation model China
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NUMERICAL SIMULATION OF METHANE-AIR TURBULENT JET FLAME USING A NEW SECOND-ORDER MOMENT MODEL 被引量:4
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作者 陈兴隆 周力行 张健 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2000年第1期41-47,共7页
A new second-order moment model for turbulent combustion is applied in the simulation of methane-air turbulent jet flame. The predicted results are compared with the experimental results and with those predicted using... A new second-order moment model for turbulent combustion is applied in the simulation of methane-air turbulent jet flame. The predicted results are compared with the experimental results and with those predicted using the well-known EBU-Arrhenius model and the original second-order moment model. The comparison shows the advantage of the new model that it requires almost the same computational storage and time as that of the original second-order moment model, but its modeling results are in better agreement with experiments than those using other models. Hence, the new second-order moment model is promising in modeling turbulent combustion with NOx formation with finite reaction rate for engineering application. 展开更多
关键词 turbulent combustion second-order moment model numerical simulation
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Second-order consensus in networks of dynamic agents with communication time-delays 被引量:5
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作者 Bo Yang Huajing Fang Hua Wang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第1期88-94,共7页
This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics.By employin... This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics.By employing a frequency domain method,it is proven that the information states and their time derivatives of all the agents in the network achieve consensus asymptotically,respectively,for appropriate communication timedelay if the topology of weighted network is connected.Particularly,a tight upper bound on the communication time-delay that can be tolerated in the dynamic network is found.The consensus protocols are distributed in the sense that each agent only needs information from its neighboring agents,which reduces the complexity of connections between neighboring agents significantly.Numerical simulation results are provided to demonstrate the effectiveness and the sharpness of the theoretical results for second-order consensus in networks in the presence of communication time-delays. 展开更多
关键词 second-order consensus protocols dynamic networks algebraic graph theory frequency domain analysis com-munication constraints.
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Distributed Containment Control of Networked Nonlinear Second-order Systems With Unknown Parameters 被引量:4
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作者 Long Ma Haibo Min +2 位作者 Shicheng Wang Yuan Liu Zhiguo Liu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第1期232-239,共8页
In this paper, we study the containment control problem for nonlinear second-order systems with unknown parameters and multiple stationary/dynamic leaders. The topologies that characterize the interaction among the le... In this paper, we study the containment control problem for nonlinear second-order systems with unknown parameters and multiple stationary/dynamic leaders. The topologies that characterize the interaction among the leaders and the followers are directed graphs. Necessary and sufficient criteria which guarantee the control objectives are established for both stationary leaders(regulation case) and dynamic leaders(dynamic tracking case) based protocols. The final states of all the followers are exclusively determined by the initial values of the leaders and the topology structures. In the regulation case, all the followers converge into the convex hull spanned by the leaders,while in the dynamic tracking case, not only the positions of the followers converge into the convex hull but also the velocities of the followers converge into the velocity convex hull of the leaders.Finally, all the theoretical results are illustrated by numerical simulations. 展开更多
关键词 Containment control directed network topology multi-agent systems nonlinear second-order systems
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Comparison of a Full Second-Order Moment Model and an Algebraic Stress Two-Phase Turbulence Model for Simulating Bubble-Liquid Flows in a Bubble Column 被引量:3
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作者 周力行 杨玟 +2 位作者 廉春英 L.S.Fan D.J.Lee 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2002年第2期142-148,共7页
A full second-order moment (FSM) model and an algebraic stress (ASM) two-phase turbulence modelare proposed and applied to predict turbulent bubble-liquid flows in a 2D rectangular bubble column. Predictiongives the b... A full second-order moment (FSM) model and an algebraic stress (ASM) two-phase turbulence modelare proposed and applied to predict turbulent bubble-liquid flows in a 2D rectangular bubble column. Predictiongives the bubble and liquid velocities, bubble volume fraction, bubble and liquid Reynolds stresses and bubble-liquidvelocity correlation. For predicted two-phase velocities and bubble volume fraction there is only slight differencebetween these two models, and the simulation results using both two models are in good agreement with the particleimage velocimetry (PIV) measurements. Although the predicted two-phase Reynolds stresses using the FSM are insomewhat better agreement with the PIV measurements than those predicted using the ASM, the Reynolds stressespredicted using both two models are in general agreement with the experiments. Therefore, it is suggested to usethe ASM two-phase turbulence model in engineering application for saving the computation time. 展开更多
关键词 second-order moment model two-phase turbulence bubble-liquid flow bubble column
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Distributed Time Synchronization in Wireless Sensor Networks via Second-Order Consensus Algorithms 被引量:2
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作者 吴杰 白煜 张立毅 《Transactions of Tianjin University》 EI CAS 2015年第2期113-121,共9页
This paper proposes a distributed second-order consensus time synchronization, which incorporates the second-order consensus algorithm into wireless sensor networks. Since local clocks may have different skews and off... This paper proposes a distributed second-order consensus time synchronization, which incorporates the second-order consensus algorithm into wireless sensor networks. Since local clocks may have different skews and offsets, the algorithm is designed to include offset compensation and skew compensation. The local clocks are not directly modified, thus the virtual clocks are built according to the local clocks via the compensation parameters. Each node achieves a virtual consensus clock by periodically updated compensation parameters. Finally, the effectiveness of the proposed algorithm is verified through a number of simulations in a mesh network. It is proved that the proposed algorithm has the advantage of being distributed, asymptotic convergence, and robust to new node joining. 展开更多
关键词 wireless sensor network time SYNCHRONIZATION second-order CONSENSUS CLOCK SKEW CLOCK OFFSET
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A hybrid data-driven approach for rainfall-induced landslide susceptibility mapping:Physically-based probabilistic model with convolutional neural network 被引量:1
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作者 Hong-Zhi Cui Bin Tong +2 位作者 Tao Wang Jie Dou Jian Ji 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期4933-4951,共19页
Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with region... Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with regional-scale geotechnical parameters.To explore rainfall-induced LSM,this study proposes a hybrid model that combines the physically-based probabilistic model(PPM)with convolutional neural network(CNN).The PPM is capable of effectively capturing the spatial distribution of landslides by incorporating the probability of failure(POF)considering the slope stability mechanism under rainfall conditions.This significantly characterizes the variation of POF caused by parameter uncertainties.CNN was used as a binary classifier to capture the spatial and channel correlation between landslide conditioning factors and the probability of landslide occurrence.OpenCV image enhancement technique was utilized to extract non-landslide points based on the POF of landslides.The proposed model comprehensively considers physical mechanics when selecting non-landslide samples,effectively filtering out samples that do not adhere to physical principles and reduce the risk of overfitting.The results indicate that the proposed PPM-CNN hybrid model presents a higher prediction accuracy,with an area under the curve(AUC)value of 0.85 based on the landslide case of the Niangniangba area of Gansu Province,China compared with the individual CNN model(AUC=0.61)and the PPM(AUC=0.74).This model can also consider the statistical correlation and non-normal probability distributions of model parameters.These results offer practical guidance for future research on rainfall-induced LSM at the regional scale. 展开更多
关键词 Rainfall landslides Landslide susceptibility mapping Hybrid model Physically-based model Convolution neural network(CNN) Probability of failure(POF)
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Regional Storm Surge Forecast Method Based on a Neural Network and the Coupled ADCIRC-SWAN Model 被引量:1
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作者 Yuan SUN Po HU +2 位作者 Shuiqing LI Dongxue MO Yijun HOU 《Advances in Atmospheric Sciences》 2025年第1期129-145,共17页
Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many ... Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many resources and takes too long to compute,while neural network forecasting lacks regional data to train regional forecasting models.In this study,we used the DUAL wind model to build typhoon wind fields,and constructed a typhoon database of 75 processes in the northern South China Sea using the coupled Advanced Circulation-Simulating Waves Nearshore(ADCIRC-SWAN)model.Then,a neural network with a Res-U-Net structure was trained using the typhoon database to forecast the typhoon processes in the validation dataset,and an excellent storm surge forecasting effect was achieved in the Pearl River Estuary region.The storm surge forecasting effect of stronger typhoons was improved by adding a branch structure and transfer learning. 展开更多
关键词 regional storm surge forecast coupled ADCIRC-SWAN model neural network Res-U-Net structure
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Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach
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作者 Ghaliah Alhamzi Badr Saad TAlkahtani +1 位作者 Ravi Shanker Dubey Mati ur Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期609-633,共25页
This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV i... This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately. 展开更多
关键词 HIV infection model qualitative scheme approximate solution piecewise global operator neural network
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A two-scale second-order moment two-phase turbulence model for simulating dense gas-particle flows 被引量:5
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作者 Zhuoxiong Zeng Lixing Zhou Jian Zhang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2005年第5期425-429,共5页
A two-scale second-order moment two-phase turbulence model accounting for inter-particle collision is developed, based on the concepts of particle large-scale fluctuation due to turbulence and particle small-scale flu... A two-scale second-order moment two-phase turbulence model accounting for inter-particle collision is developed, based on the concepts of particle large-scale fluctuation due to turbulence and particle small-scale fluctuation due to collision and through a unified treatment of these two kinds of fluctuations. The proposed model is used to simulate gas-particle flows in a channel and in a downer. Simulation results are in agreement with the experimental results reported in references and are near the results obtained using the sin- gle-scale second-order moment two-phase turbulence model superposed with a particle collision model (USM-θ model) in most regions. 展开更多
关键词 Gas-particle flows .second-order moment model . Two-scale fluctuation
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Static output feedback stabilization for second-order singular systems using model reduction methods 被引量:1
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作者 Zheng WANG Yuhao CONG Xiulin HU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2021年第3期457-466,共10页
In this paper,the static output feedback stabilization for large-scale unstable second-order singular systems is investigated.First,the upper bound of all unstable eigenvalues of second-order singular systems is deriv... In this paper,the static output feedback stabilization for large-scale unstable second-order singular systems is investigated.First,the upper bound of all unstable eigenvalues of second-order singular systems is derived.Then,by using the argument principle,a computable stability criterion is proposed to check the stability of secondorder singular systems.Furthermore,by applying model reduction methods to original systems,a static output feedback design algorithm for stabilizing second-order singular systems is presented.A simulation example is provided to illustrate the effectiveness of the design algorithm. 展开更多
关键词 second-order singular system static output feedback model reduction method argument principle
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Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures
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作者 Muhammad Qasim Khan Fazal Malik +1 位作者 Fahad Alturise Noor Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期123-153,共31页
Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important a... Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject. 展开更多
关键词 Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication
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Age-and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging 被引量:1
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作者 Dilara Yilmaz Francisco C.Marques +9 位作者 Lorena Gregorio Jérôme Schlatter Christian Gehre Thurgadevi Pararajasingam Wanwan Qiu Neashan Mathavan Xiao-Hua Qin Esther Wehrle Gisela A.Kuhn Ralph Müller 《Bone Research》 2025年第4期957-967,共11页
Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better under... Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms.Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss.Our study uses the prematurely aged PolgD257A/D257A(PolgA)mouse model to scrutinize age-and sex-related alterations in musculoskeletal health parameters(frailty,grip strength,gait data),bone and particularly the osteocyte lacuno-canalicular network(LCN).Moreover,a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging.Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters,bone,and osteocyte LCN in PolgA mice as early as 40 weeks,with more prominent alterations evident in aged males.Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss,given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans. 展开更多
关键词 molecular cellular mechanismsemerging osteocyte lacuno canalicular network bone remodeling therapeutic targets premature aging polgd d mouse model reduced bone density age related osteoporosis
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Genome-scale metabolic network model-guided genetic modification of Escherichia coli for pyruvate accumulation
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作者 LI Xuefei GUO Chaohao +4 位作者 TONG Wenyue YANG Sen LIU Xiaoyun LI Jingchen KANG Ming 《微生物学报》 北大核心 2025年第10期4374-4391,共18页
[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a... [Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a guide,we simulated pyruvate production of E.coli,screened key genes in metabolic pathways,and developed gene editing procedures accordingly.We knocked out the acetate kinase gene ackA,phosphate acetyltransferase gene pta,alcohol dehydrogenase adhE,glycogen synthase gene glgA,glycogen phosphorylase gene glgP,phosphoribosyl pyrophosphate(PRPP)synthase gene prs,ribose 1,5-bisphosphate phosphokinase gene phnN,and transporter encoding gene proP.Furthermore,we knocked in the transporter encoding gene ompC,flavonoid toxin gene fldA,and D-serine ammonia lyase gene dsdA.[Results]A shake flask process with the genetically edited mutant strain MG1655-6-2 under anaerobic conditions produced pyruvate at a titer of 10.46 g/L and a yield of 0.69 g/g.Metabolomic analysis revealed a significant increase in the pyruvate level in the fermentation broth,accompanied by notable decreases in the levels of certain related metabolic byproducts.Through 5 L fed-batch fermentation and an adaptive laboratory evolution,the strain finally achieved a pyruvate titer of 45.86 g/L.[Conclusion]This study illustrated the efficacy of a gene editing strategy predicted by a genome-scale metabolic network model in enhancing pyruvate accumulation in E.coli under anaerobic conditions and provided novel insights for microbial metabolic engineering. 展开更多
关键词 Escherichia coli PYRUVATE genome-scale metabolic network model CRISPR-Cas9 adaptive laboratory evolution
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A method for modeling and evaluating the interoperability of multi-agent systems based on hierarchical weighted networks
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作者 DONG Jingwei TANG Wei YU Minggang 《Journal of Systems Engineering and Electronics》 2025年第3期754-767,共14页
Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weight... Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weighted scale-free community network and susceptible-infected-recovered(SIR)model.To solve the problem of difficulty in describing the changes in the structure and collaboration mode of the system under external factors,a two-dimensional Monte Carlo method and an improved dynamic Bayesian network are used to simulate the impact of external environmental factors on multi-agent systems.A collaborative information flow path optimization algorithm for agents under environmental factors is designed based on the Dijkstra algorithm.A method for evaluating system interoperability is designed based on simulation experiments,providing reference for the construction planning and optimization of organizational application of the system.Finally,the feasibility of the method is verified through case studies. 展开更多
关键词 complex network agent INTEROPERABILITY susceptible-infected-recovered model dynamic Bayesian network
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Data Gathering Based on Hybrid Energy Efficient Clustering Algorithm and DCRNN Model in Wireless Sensor Network
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作者 Li Cuiran Liu Shuqi +1 位作者 Xie Jianli Liu Li 《China Communications》 2025年第3期115-131,共17页
In order to solve the problems of short network lifetime and high data transmission delay in data gathering for wireless sensor network(WSN)caused by uneven energy consumption among nodes,a hybrid energy efficient clu... In order to solve the problems of short network lifetime and high data transmission delay in data gathering for wireless sensor network(WSN)caused by uneven energy consumption among nodes,a hybrid energy efficient clustering routing base on firefly and pigeon-inspired algorithm(FF-PIA)is proposed to optimise the data transmission path.After having obtained the optimal number of cluster head node(CH),its result might be taken as the basis of producing the initial population of FF-PIA algorithm.The L′evy flight mechanism and adaptive inertia weighting are employed in the algorithm iteration to balance the contradiction between the global search and the local search.Moreover,a Gaussian perturbation strategy is applied to update the optimal solution,ensuring the algorithm can jump out of the local optimal solution.And,in the WSN data gathering,a onedimensional signal reconstruction algorithm model is developed by dilated convolution and residual neural networks(DCRNN).We conducted experiments on the National Oceanic and Atmospheric Administration(NOAA)dataset.It shows that the DCRNN modeldriven data reconstruction algorithm improves the reconstruction accuracy as well as the reconstruction time performance.FF-PIA and DCRNN clustering routing co-simulation reveals that the proposed algorithm can effectively improve the performance in extending the network lifetime and reducing data transmission delay. 展开更多
关键词 CLUSTERING data gathering DCRNN model network lifetime wireless sensor network
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