Dear Editor,In patients with early-stage non-small cell lung cancer(NSCLC),the risk of post-surgical recurrence(REC)is 20%–50%,[1]and the risk of developing a second primary lung cancer(2P)is 3–4 times higher than i...Dear Editor,In patients with early-stage non-small cell lung cancer(NSCLC),the risk of post-surgical recurrence(REC)is 20%–50%,[1]and the risk of developing a second primary lung cancer(2P)is 3–4 times higher than in the general population[2].Distinguishing between REC and 2P can be challenging,complicating treatment of these so called“equivocal”(EQU)cases.展开更多
Gastrointestinal stromal tumor （GIST） is the most common mesenchymal malignancy of the gastrointestinal tract.GISTs may coexist with different types of cancer,either synchronous or metachronous （1）.Most GISTs deve...Gastrointestinal stromal tumor （GIST） is the most common mesenchymal malignancy of the gastrointestinal tract.GISTs may coexist with different types of cancer,either synchronous or metachronous （1）.Most GISTs develop in a sporadic fashion,but familial occurrence,such as neurofibromatosis and Carney-triad,has also been reported （2）.The overall frequency of second tumors in different series varied from 4.5% to 33%.The most frequent types of GIST-associated cancers were gastrointestinal carcinomas （47%）,lymphoma/leukemia （7%）,carcinomas of prostate （9%）,breast （7%）,kidney （6%）,lung （5%）,female genital tract （5%）,carcinoid tumors （3%）,soft tissue and bone sarcomas （3%）,malignant melanoma （2%） and seminoma （1%） （1,3-5）.展开更多
基金supported by the National Cancer Institute(Grants No.R01-80127,Yang and R01-84354,P.Y.)the National Institutes of Health(Grant No.LM-R01-13438,L.L.,J.W.,and P.Y.).
文摘Dear Editor,In patients with early-stage non-small cell lung cancer(NSCLC),the risk of post-surgical recurrence(REC)is 20%–50%,[1]and the risk of developing a second primary lung cancer(2P)is 3–4 times higher than in the general population[2].Distinguishing between REC and 2P can be challenging,complicating treatment of these so called“equivocal”(EQU)cases.
文摘Gastrointestinal stromal tumor （GIST） is the most common mesenchymal malignancy of the gastrointestinal tract.GISTs may coexist with different types of cancer,either synchronous or metachronous （1）.Most GISTs develop in a sporadic fashion,but familial occurrence,such as neurofibromatosis and Carney-triad,has also been reported （2）.The overall frequency of second tumors in different series varied from 4.5% to 33%.The most frequent types of GIST-associated cancers were gastrointestinal carcinomas （47%）,lymphoma/leukemia （7%）,carcinomas of prostate （9%）,breast （7%）,kidney （6%）,lung （5%）,female genital tract （5%）,carcinoid tumors （3%）,soft tissue and bone sarcomas （3%）,malignant melanoma （2%） and seminoma （1%） （1,3-5）.
