期刊文献+
共找到45,395篇文章
< 1 2 250 >
每页显示 20 50 100
Rediscovering Analytical Rigor in Traditional Economic Thought:The“Second Integration”and the Making of a Chinese School of Economics
1
作者 Cheng Lin Zhou Rui Chen Xudong 《China Economist》 2026年第1期54-90,共37页
Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understandi... Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition. 展开更多
关键词 traditional Chinese economic thought analytical rigor second Integration Chinese economics
在线阅读 下载PDF
基于油气润滑的TPS高速球轴承腔温升研究
2
作者 尚春民 关欣雨 +1 位作者 邱李杰 张心明 《机械设计与制造》 北大核心 2025年第6期268-273,279,共7页
针对涡轮动力模拟器(TPS)系统中主轴轴承在油气润滑的条件下转速升高温升加剧的问题,以主轴角接触球轴承腔为研究对象,在考虑自旋因素下进行摩擦力矩热功率的数值计算。采用Eulerian多相流模型进行轴承腔温度场仿真分析,并与试验测得的... 针对涡轮动力模拟器(TPS)系统中主轴轴承在油气润滑的条件下转速升高温升加剧的问题,以主轴角接触球轴承腔为研究对象,在考虑自旋因素下进行摩擦力矩热功率的数值计算。采用Eulerian多相流模型进行轴承腔温度场仿真分析,并与试验测得的数据进行对比研究。结果表明:随供气压力的增大轴承腔温度降低,但持续增大供气压力会导致轴承腔温度不稳定,因此TPS系统最佳供气压力在(0.3~0.4)MPa之间;在入口倾角的作用下,内滚道壁面温度变化稳定,内外滚道最高温度差达到10℃以上;随转速升高,轴承腔内最高温度位置越接近润滑点,油气两相流降温程度越明显。 展开更多
关键词 油气润滑 tps 角接触球轴承 温度场 仿真 供气压力
在线阅读 下载PDF
MDT模式结合TPS教学法在妇科恶性肿瘤临床教学中的应用探讨
3
作者 熊晶 谭朝霞 张文 《长沙民政职业技术学院学报》 2025年第3期107-111,共5页
本研究运用MDT模式结合TPS教学法探讨在临床医学八年制学生妇科恶性肿瘤教学中的应用效果和价值。选取在中南大学湘雅二医院妇产科学习的八年制学生共36人,随机分配至观察组与对照组,每组各有18名学生。以卵巢恶性肿瘤为教学内容,观察... 本研究运用MDT模式结合TPS教学法探讨在临床医学八年制学生妇科恶性肿瘤教学中的应用效果和价值。选取在中南大学湘雅二医院妇产科学习的八年制学生共36人,随机分配至观察组与对照组,每组各有18名学生。以卵巢恶性肿瘤为教学内容,观察组采用MDT模式结合TPS教学法,对照组采用传统教学方法。学习结束后,通过试卷考核及教学满意度问卷调查来了解36名同学的学习效果和教学满意度,并通过对比分析来判断教学效果及教学满意度。在试卷考核中,观察组学生在理论题、病案分析题的得分及总成绩上均明显优于对照组,差异具有统计学意义(P均<0.05)。在教学满意度问卷调查中,观察组同学在提高学习兴趣、提高自学能力、提高临床适应能力、多学科知识运用能力以及愿意继续接受该教学模式等方面的满意度均高于对照组(P均<0.05)。 展开更多
关键词 多学科协作诊疗 tps教学 妇科肿瘤
暂未订购
葡萄TPS基因家族全基因组鉴定及VvTPS4在单萜形成中的功能验证
4
作者 杨彩丽 李永洲 +5 位作者 贺亮亮 宋银花 章鹏 刘肇先 李鹏慧 刘三军 《中国农业科学》 北大核心 2025年第7期1397-1417,共21页
【目的】基于葡萄基因组信息,通过生物信息学手段对葡萄TPS基因家族成员进行鉴定及表达分析,为后续VvTPSs的生物学功能研究和葡萄育种提供科学依据。【方法】根据拟南芥AtTPS基因家族成员蛋白序列和TPS对应的隐尔马可夫文件PF01397和PF0... 【目的】基于葡萄基因组信息,通过生物信息学手段对葡萄TPS基因家族成员进行鉴定及表达分析,为后续VvTPSs的生物学功能研究和葡萄育种提供科学依据。【方法】根据拟南芥AtTPS基因家族成员蛋白序列和TPS对应的隐尔马可夫文件PF01397和PF03936,对VvTPS基因家族进行鉴定。利用Expasy、TBtools、MEME、MEGA、MCScanX、SPOMA、WoLF PSORT和PlantCARE等工具分析家族成员的理化性质、系统进化树、染色体定位、基因结构、蛋白质二级结构、启动子顺式作用元件和预测亚细胞定位。运用qPCR分析基因家族成员在无香型(‘红地球’)和玫瑰香型(‘玫瑰香’)葡萄成熟果实中的表达情况,并通过番茄转基因功能验证,分析转基因番茄果实挥发性代谢组学,以明确VvTPS4在单萜生物合成方面的功能。【结果】鉴定获得65个VvTPS基因家族成员,编码蛋白的氨基酸数目为339—840,平均分子质量为64.13 kDa,理论等电点为4.93—7.65,大多数成员具有7个外显子结构。经系统进化树分析,将葡萄TPS家族划分为TPS-a、TPS-b、TPS-c、TPS-e/f和TPS-g亚家族。VvTPS成员多定位于叶绿体和细胞质,其中,定位于质体的成员有10个属于TPS-g亚家族。在启动子区域发现含有大量响应光照、温度、干旱、激素和防御相关的顺式作用元件。克隆到29个VvTPSs,绝大多数VvTPSs在玫瑰香型葡萄果实中的表达高于无香型葡萄果实。转基因结果表明,过表达VvTPS4能够增加番茄果实中挥发性单萜物质的积累,其中,芳樟醇是最显著上调的化合物,是野生型的20.73倍,其次是L-α-松油醇(14.55倍),风味特征分析表明,这两种物质具有花香味,是影响‘玫瑰香’香气的主要特征物质。【结论】从葡萄基因组中鉴定到65个VvTPSs,成员之间具有高度的保守性,且在不同香气类型的葡萄中表达模式不同。过表达VvTPS4能显著增加挥发性单萜物质的积累,可能与玫瑰香气形成密切相关。 展开更多
关键词 葡萄 tps基因家族 表达分析 香气 代谢组学
在线阅读 下载PDF
紫花含笑TPS基因家族鉴定及与萜烯类物质代谢关系分析
5
作者 及浩楠 肖宇光 +4 位作者 牛小云 张志龙 刘军 姜景民 刁姝 《林业科学研究》 北大核心 2025年第3期29-38,共10页
[目的]探究紫花含笑花朵萜烯类物含量和TPS基因家族表达模式的相关性,为解析萜烯类物质合成途径的关键基因提供重要参考。[方法]基于紫花含笑无参转录组数据,采用生物信息学方法鉴定紫花含笑TPS基因家族成员,并对基因家族成员进行理化... [目的]探究紫花含笑花朵萜烯类物含量和TPS基因家族表达模式的相关性,为解析萜烯类物质合成途径的关键基因提供重要参考。[方法]基于紫花含笑无参转录组数据,采用生物信息学方法鉴定紫花含笑TPS基因家族成员,并对基因家族成员进行理化性质、保守基序及系统进化分析;利用实时荧光定量PCR技术揭示不同发育时期TPS基因表达模式,并结合顶空固相微萃取和气相色谱-质谱联用技术获取的不同发育阶段萜烯类物质含量,分析TPS基因表达和萜类物质含量的变化关系。[结果]本研究共鉴定到10个TPS成员,其编码氨基酸数量在511~987 aa,蛋白分子质量在57810.20~113803.45 Da。系统进化分析结果显示,紫花含笑TPS基因家族分为3个基因亚家族,TPS-e/f基因亚家族成员缺少Motif 1、Motif 3、Motif 5,TPS-b基因亚家族成员C41348.3缺少Motif 3,其余TPS基因含有6个Motif。C41348.6、C41348.3在时期Ⅴ显著性高表达,C31983.0和C40582.0在时期Ⅴ高表达。甜香型物质Α-罗勒烯、α-石竹烯、罗勒烯、卡地那二烯在时期IV含量上升,甜香型物质β-榄香烯、α-石竹烯、δ-榄香烯在时期V含量上升。对基因表达量变化与萜烯类物质含量变化进行相关性分析,紫花含笑TPS-b基因亚家族成员C41348.3和C41348.6均与单萜1,2-二[(E)-丙-1-烯基]环丁烷合成正相关。紫花含笑TPS-e/f基因亚家族中的C31983.0与3种甜果香型物质正相关。[结论]Α-罗勒烯、α-石竹烯、罗勒烯、卡地那二烯这几种甜果香型物质可能与紫花含笑时期IV花的果香形成有关。β-榄香烯、α-石竹烯、δ-榄香烯这几种甜果香型物质可能与紫花含笑时期V花的果香形成有关。C41348.6和C41348.3可能与成分1,2-二[(E)-丙-1-烯基]环丁烷合成有关。C31983.0可能参与调控紫花含笑甜果香型物质β-榄香烯、δ-榄香烯、α-石竹烯的形成。TPS基因家族可能在萜烯类物质的合成过程中发挥作用。本研究对紫花含笑TPS基因家族成员进行了深入挖掘,为未来探索紫花含笑花朵中重要萜类成分合成的关键基因功能提供理论基础。 展开更多
关键词 紫花含笑 生物信息学 tps基因家族 表达分析 挥发性萜类物质
在线阅读 下载PDF
莲萜类合成酶(TPS)基因家族鉴定与分析
6
作者 秦莉莉 杨宁宁 +4 位作者 张晨 唐佳伟 邓开宇 张克轩 董臣 《分子植物育种》 北大核心 2025年第4期1278-1284,共7页
萜类化合物是植物界中数量最多的天然代谢物,具有多种重要的生物学功能,萜类合成酶(terpenoid synthase,TPS)在萜类物质合成中起着关键作用。莲(Nelumbo nucifera)是中国重要的药食两用的植物,关于其萜类物质及TPS基因家族的研究相对较... 萜类化合物是植物界中数量最多的天然代谢物,具有多种重要的生物学功能,萜类合成酶(terpenoid synthase,TPS)在萜类物质合成中起着关键作用。莲(Nelumbo nucifera)是中国重要的药食两用的植物,关于其萜类物质及TPS基因家族的研究相对较少,本研究利用生物信息学技术鉴定莲的TPS基因家族,并分析了其基因结构、保守结构域、理化性质、蛋白质结构、基因表达特性等。结果表明,莲的TPS家族共有8个成员,分别命名为NnTPS01~NnTPS08。NnTPSs分为4个亚族,分布在3条染色体上,且均含有1个TPS和1个TPP结构域。理化性质分析表明,莲的TPS家族成员编码的蛋白均为酸性亲水蛋白。二级结构预测显示莲TPS基因家族编码的蛋白均以α-螺旋和无规卷曲为主。有6个蛋白亚细胞定位于叶绿体。顺式作用元件分析发现NnTPSs含有多种生物与非生物胁迫的作用元件。基因表达特性分析显示有7个基因可以表达,有5个基因在叶中表达量出现了上调,并且发现大多数基因在茎中都不表达。本研究结果为后续研究莲TPS基因家族功能特性提供科学依据。 展开更多
关键词 萜类化合物 tps基因家族 生物信息学 基因表达
原文传递
TPS教学模式在新护士门诊轮转培训中的应用
7
作者 冯丽菲 朱晓秋 +2 位作者 沈莹 张苗苗 金琳娜 《中国高等医学教育》 2025年第8期145-146,F0003,共3页
目的:探讨TPS教学模式在新护士门诊轮转培训中的应用效果。方法:选择我院参加门诊轮转的166名新护士作为研究对象,2021年9~12月期间轮转的83名新护士为对照组,2022年1~4月期间轮转的83名新护士为试验组。对照组采用常规教学模式,试验组... 目的:探讨TPS教学模式在新护士门诊轮转培训中的应用效果。方法:选择我院参加门诊轮转的166名新护士作为研究对象,2021年9~12月期间轮转的83名新护士为对照组,2022年1~4月期间轮转的83名新护士为试验组。对照组采用常规教学模式,试验组采用TPS教学模式。对比两组培训满意度和人文执业能力。结果:试验组培训满意度和人文执业能力均高于对照组,差异具有统计学意义(P<0.05)。结论:TPS教学模式能够提高门诊轮转新护士的人文执业能力,具有一定的推广意义。 展开更多
关键词 tps教学模式 新护士 人文执业能力
在线阅读 下载PDF
忍冬TPS基因家族鉴定及其在蚜虫危害下的表达分析
8
作者 王刚 崔媛 +3 位作者 李启东 黄璐瑶 刘振华 李佳 《中国中药杂志》 北大核心 2025年第8期2116-2129,共14页
探究忍冬萜类合成酶(terpene synthase,TPS)基因家族成员的基本特征及其潜在功能。采用生物信息学方法对忍冬TPS基因家族进行鉴定和功能分析。结果表明,忍冬中LjTPS基因家族共鉴定出70个成员,蛋白长度在130~1437 aa,多为亲水性蛋白,不... 探究忍冬萜类合成酶(terpene synthase,TPS)基因家族成员的基本特征及其潜在功能。采用生物信息学方法对忍冬TPS基因家族进行鉴定和功能分析。结果表明,忍冬中LjTPS基因家族共鉴定出70个成员,蛋白长度在130~1437 aa,多为亲水性蛋白,不均匀地分布于9条染色体上。系统发育分析显示LjTPS基因家族成员分为6个亚族,主要为TPS-a、TPS-b和TPS-e亚族成员。启动子顺式作用元件分析表明LjTPS成员含有大量响应胁迫的顺式作用元件。通过蚜虫接种实验发现忍冬在蚜虫危害下萜类化合物骨架合成MVA途径关键酶基因HMGS、HMGR、MK、MPD和DXP途径关键酶基因DXS均呈现先增后降的趋势。qRT-PCR结果显示α-法尼烯合成酶基因LjTPS34和LjTPS39表达量下调;(E)-β-石竹烯合成酶基因LjTPS15和LjTPS17的表达量在取食前12 h上调,随后开始下降。与之有相互作用的法尼基焦磷酸合酶FPS亦呈先增后降的趋势。芳樟醇合成酶基因LjTPS12和LjTPS33的表达量在蚜虫取食72 h后显著上调(P<0.0001),分别可达初始表达量的24.39、22.64倍,与忍冬芳樟醇相对含量的趋势基本一致。该研究为后续忍冬与害虫的相互作用及LjTPS基因家族的功能研究提供理论基础。 展开更多
关键词 忍冬 萜类合成酶(tps) 生物信息学分析 蚜虫胁迫
原文传递
血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌曲妥珠单抗敏感性的相关性
9
作者 陈柯 牛萍 王芳 《实用癌症杂志》 2025年第1期9-12,共4页
目的探讨血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌曲妥珠单抗敏感性的关系。方法选取Her-2阳性乳腺癌患者100例,均接受曲妥珠单抗治疗,根据RECIST1.1标准评价疗效,将CR+PR纳入敏感组,SD+PD纳入耐药组。同时期选取健康人群30名纳入对照... 目的探讨血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌曲妥珠单抗敏感性的关系。方法选取Her-2阳性乳腺癌患者100例,均接受曲妥珠单抗治疗,根据RECIST1.1标准评价疗效,将CR+PR纳入敏感组,SD+PD纳入耐药组。同时期选取健康人群30名纳入对照组。比较3组血清Her-2-ECD、TPS水平。分析Her-2-ECD、TPS水平与乳腺癌患者临床病理参数和疗效的关系。结果CR+PR共79例,SD+PD共21例。3组血清Her-2-ECD、TPS水平比较,差异有统计学意义(P<0.05),其中耐药组血清Her-2-ECD、TPS水平最高,敏感组次之,对照组最低。不同组织学分级、肿瘤转移部位数量患者血清Her-2-ECD、TPS水平比较,差异有统计学意义(P<0.05);不同年龄、月经状态、ECOG评分患者血清Her-2-ECD、TPS水平比较,差异无统计学意义(P>0.05)。血清Her-2-ECD、TPS水平联合预测靶向治疗疗效灵敏度84.69%、特异度78.49%、AUC 0.841,均较单一检测更高(P<0.05)。耐药组中血清Her-2-ECD>41.55 ng/ml、血清TPS>118.47 U/L的患者占比均高于敏感组(P<0.05)。结论血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌患者对曲妥珠单抗治疗的敏感性具有一定关系,联合检测可以提高对靶向治疗疗效的预测能力。 展开更多
关键词 乳腺癌 HER-2阳性 Her-2-ECD tps 曲妥珠单抗 敏感性
暂未订购
加工温度对PBAT/TPS共混体系性能的影响 被引量:3
10
作者 李宇飞 《化工管理》 2025年第2期140-143,共4页
聚对苯二甲酸-己二酸-丁二醇酯(PBAT)与热塑性淀粉(TPS)共混,可降低PBAT的自身成本,同时增强其机械性能。PBAT与TPS对温度均较为敏感,适当的加工温度可以促进聚酯材料在吹膜过程中的流动性和成型性,进而影响材料制品的性能。文章在相同... 聚对苯二甲酸-己二酸-丁二醇酯(PBAT)与热塑性淀粉(TPS)共混,可降低PBAT的自身成本,同时增强其机械性能。PBAT与TPS对温度均较为敏感,适当的加工温度可以促进聚酯材料在吹膜过程中的流动性和成型性,进而影响材料制品的性能。文章在相同配方、不同温度下进行加工改性、挤出、吹塑成膜以及注塑成条后,并对共混体系进行力学性能、结晶行为、热变形温度和维卡软化点分析对比。结果表明,当双螺杆挤出机加工温度为140℃时,共混切片的熔融温度(Tm)最高,有利于结晶成核以及共混体系分子链的重新排布,从而加快结晶速度;共混切片的结晶起始温度也最高,在该加工温度下,结晶过程更缓慢,稳定性更强,且拉伸强度、断裂伸长率等力学性能最优。 展开更多
关键词 聚对苯二甲酸-己二酸-丁二醇酯(PBAT) 热塑性淀粉(tps) 拉伸强度 结晶行为 温度
在线阅读 下载PDF
TPS教学模式在基础化学课程教学中的实践探究——以碱金属教学设计为例 被引量:1
11
作者 王丽霞 李敏 +2 位作者 吴晓燕 叶东 梁仕健 《邢台学院学报》 2025年第2期151-158,共8页
完备的化学知识对地理科学专业后续课程的学习具有重要作用,但生源多元化带来的学情差异给基础化学的教学带来巨大困难。以碱金属的教学设计为例,将TPS教学模式引入课程中,旨在帮助拥有不同教育背景的学生学习好基础化学,提高学生对化... 完备的化学知识对地理科学专业后续课程的学习具有重要作用,但生源多元化带来的学情差异给基础化学的教学带来巨大困难。以碱金属的教学设计为例,将TPS教学模式引入课程中,旨在帮助拥有不同教育背景的学生学习好基础化学,提高学生对化学学习的积极性与自主性,增强学生的学习自信,最终实现基础化学的有效教学和学生综合化学素质的“双提升”。成绩数据对比分析及调查问卷统计表明,这种教学方法对地理科学专业中的基础化学教学有积极意义。 展开更多
关键词 tps教学模式 拼图游戏教学法 地理科学 化学
在线阅读 下载PDF
二语写作研究的现状、反思与展望——基于Journal of Second Language Writing近十年载文分析
12
作者 孙云帆 孙玲 《西部学刊》 2025年第5期164-168,共5页
二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提... 二语写作是二语习得研究领域的重要组成部分。运用CiteSpace软件对近十年发表在Journal of Second Language Writing的231篇实证研究论文进行可视化分析,研究发现:二语写作研究整体呈波动性上升趋势,研究规模较为稳定,研究关注度逐渐提升;二语写作研究领域暂未形成明显的核心作者和机构的合作网络;研究主题主要聚焦二语写作教学方法的多元化、二语写作反馈的多焦点、二语写作评估与测试的科学化,以及学习者个体差异的多维影响等方面。基于此,提出未来该领域发展需加强学者、机构之间的相互合作;关注个体学习者写作过程的认知特征与情感因素,尤其重视青少年二语学习过程的研究;扩大二语写作纵向研究规模,推动研究的深入发展。 展开更多
关键词 二语写作研究 Journal of second Language Writing 可视化分析 现状 反思与展望
在线阅读 下载PDF
TPS联合PCMC模式在中医外科学临床教学的应用
13
作者 韩娜娜 尹戈 +2 位作者 孙道永 王海水 任东 《中国中医药现代远程教育》 2025年第4期7-9,共3页
目的 观察思考-交流-分享(Think-pair-share,TPS)联合启发式临床医学课程(Problem-originated clinical medical curriculum,PCMC)教学模式在中医外科临床教学中的应用效果。方法 选取日照市中医医院外科/血管外科2021年1月—2021年12... 目的 观察思考-交流-分享(Think-pair-share,TPS)联合启发式临床医学课程(Problem-originated clinical medical curriculum,PCMC)教学模式在中医外科临床教学中的应用效果。方法 选取日照市中医医院外科/血管外科2021年1月—2021年12月接收的42名实习生为对照组,采用传统教学法;2022年1月—2022年12月接收的40名实习生为研究组,采用TPS联合PCMC教学模式。观察两组学习效果,自制“一分钟问卷”评估教学效果。结果 研究组理论考核和临床技能考核成绩均明显高于对照组(P<0.05)。调查问卷显示,研究组在学习能力、激发热情、人文关怀、思维拓展、团队协作、临床能力、技能操作和总体印象方面均优于对照组(P<0.05)。结论 应用TPS联合PCMC教学模式可发挥互动式、主动性学习的优势,能显著提高学生的临床学习和适应能力。 展开更多
关键词 中医外科 思考-交流-分享 启发式临床医学课程教学模式 临床教学
在线阅读 下载PDF
Second chance in fertility: a comprehensive narrative review of redo micro-TESE outcomes after initial failure 被引量:1
14
作者 Haitham Elbardisi Emre Bakircioglu +1 位作者 Wen Liu Darren Katz 《Asian Journal of Andrology》 2025年第3期409-415,共7页
When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,whi... When microdissection testicular sperm extraction(micro-TESE)fails,a redo procedure may be the only option for patients who want a biological child.However,there are many gaps of knowledge surrounding the procedure,which need to be addressed to help clinicians and patients make informed decisions.This review explores redo micro-TESE in the context of nonobstructive azoospermia(NOA).Literature was searched using Google Scholar,Medline,and PubMed.Search terms were“NOA”AND“second microdissection testicular sperm extractions”AND“redo microdissection testicles sperm extraction”AND“repeat microdissection testicular sperm extractions”AND“failed microdissection testicular sperm extractions”AND“salvage microdissection testicular sperm extractions”.Only original articles in English were included.A total of nine articles were included,consisting of four retrospective and five prospective studies.The time gap between the first and second micro-TESE varied from 6 months to 24 months.Most of the included studies reported successful surgical sperm retrieval(SSR)in the second micro-TESE in the range of 10%–21%,except in one study where it reached 42%.It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE.Patients with hypospermatogenesis and Klinefelter syndrome(KS)had the highest chance of success in redo surgery.In conclusion,redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%.Patients with hypospermatogenesis and KS have a higher chance of success.There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery. 展开更多
关键词 nonobstructive azoospermia redo micro-TESE repeat micro-TESE salvage micro-TESE second micro-TESE
原文传递
Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery 被引量:1
15
作者 Shiwen Zhang Rui Sheng +26 位作者 Zhen Fan Fang Wang Ping Di Junyu Shi Duohong Zou Dehua Li Yufeng Zhang Zhuofan Chen Guoli Yang Wei Geng Lin Wang Jian Zhang Yuanding Huang Baohong Zhao Chunbo Tang Dong Wu Shulan Xu Cheng Yang Yongbin Mou Jiacai He Xingmei Yang Zhen Tan Xiaoxiao Cai Jiang Chen Hongchang Lai Zuolin Wang Quan Yuan 《International Journal of Oral Science》 2025年第5期608-616,共9页
Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-ter... Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health.Currently,several surgical techniques have been validated for their effectiveness in increasing PIKM.However,the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques,variations in clinical scenarios,and anatomical differences.Therefore,clear guidelines and considerations for PIKM augmentation are needed.This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery.It aims to establish a standardized framework for assessing,planning,and executing PIKM augmentation procedures,with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation. 展开更多
关键词 surgical procedures second stage surgery surgical techniques heterogeneity dental practitioners peri implant keratinized mucosa augmentation surgical techniquesvariations
暂未订购
A Study on the Mechanisms by Which AGEs and RAG Promote Wound Healing in Patients with Second-Degree Burns undergoing Eschar Grinding Combined with Drug Therapy
16
作者 Weijie He Zhi Liu +5 位作者 Lujun Yang Sitian Xie Zhan Ouyang Yao Lin Fuhua Huang Shijie Tang 《Modern Plastic Surgery》 2025年第1期1-20,共20页
Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects o... Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects on the expression level of (advanced glycation end products) AGEs in wound tissue, so as to provide a basis for the application of AGEs expression level in wound tissue in the future clinical treatment of second-degree burns. Methods: Patients with second-degree burns admitted to the Department of Burns and Plastic Surgery of the Second Affiliated Hospital of Shantou University Medical College from July 2023 to July 2024 were selected as the research subjects. This study was a non-double-blind study, and both patients and researchers were aware of the treatment methods. They were randomly divided into Group A (control group) and Group B (study group). According to the order of their visits, the patients were numbered in advance;then the seed number was taken, and 70 random numbers were generated on the computer using SAS, the first 35 corresponding to group A, and the last 35 corresponding to group B;the random numbers were arranged from small to large, and the rank of the random numbers was the patient number;finally, the patient numbers were arranged from small to large, and the corresponding groups were the grouping scheme. 1) Wound healing time: The wound healing was observed every day, and the wound healing time was calculated when the wound was completely epithelialized. 2) Wound healing: The wound healing area was measured 1, 7, and 14 days after treatment, and transparent paper was used to record combined with a computer-assisted imaging system. Wound healing rate = wound healing area (cm2)/total wound area before treatment (cm2) × 100%. The time for complete wound healing was recorded in the two groups of patients. 3) Pain: The pain was evaluated at 1, 7, and 14 days after treatment using the visual analogue scale (VAS). The higher the score, the more severe the pain. 4) Scar condition: Scar formation was evaluated 1, 3, and 6 months after wound healing using the VAS scale, with a total score of 15 points. The higher the score, the more severe the scar. 5) Detect the expression of AGEs in wound tissue. Results: The wound healed 14.03 ± 2.28 days after eschar removal, with a cure rate of 97.8%. No infection occurred in the wound after eschar removal in all patients. The wound healing time ranged from 9 to 23 days, with an average healing time of 28.41 ± 1.45 days. The healing quality was satisfactory. The Vancouver Scar Scale scored the wound healing scar as 0.81 ± 0.73 points. Western blot was used to detect the expression of AGEs, (receptor for advanced glycation end products) RAGE, and protein in the wound tissue. Results After 7, 14, and 28 days of medication, the wounds of diabetic patients healed well. The drug treatment efficacy and hydroxyproline content showed an upward trend, and the expression levels of AGEs, RAGE, and HIF-1a proteins showed a downward trend. Compared with day 0, the hydroxyproline content of the wound granulation tissue on days 7, 14, and 28 was significantly increased (P< 0.01), and the expression levels of AGEs, RAGE, and HIF-1α proteins were significantly downregulated (P< 0.05 or P< 0.01). Conclusion: Monitoring the expression levels of AGEs and RAGE can reflect the wound-healing effect of patients with second-degree burns, and the prognosis of the wound is closely related to the expression levels of AGEs, RAGE, and scab abrasion. In the treatment of second-degree burn wounds, scab abrasion can grasp the level of necrotic scab removal, can achieve “relatively accurate” removal of necrotic tissue, maximally protect the ecological tissue between wounds and retaining normal tissue, and can play a positive role in promoting the healing process of burn wounds;at the same time, nanosilver dressings have good antibacterial properties and high safety, and mussel mucin has anti-inflammatory and antioxidant activities and the characteristics of blocking nerve endings, which can effectively relieve the burning, stinging, and itching of sensitive skin and effectively promote wound healing. 展开更多
关键词 AGES RAG DERMABRASION second Degree Burns
暂未订购
Second-Order Topological Insulators in 2D Electronic Materials
17
作者 FENG Xiao-ran NIU Cheng-wang +1 位作者 HUANG Bai-biao DAI Ying 《物理学进展》 北大核心 2025年第1期1-31,共31页
Higher-order band topology not only enriches our understanding of topological phases but also unveils pioneering lower-dimensional boundary states,which harbors substantial potential for next-generation device applica... Higher-order band topology not only enriches our understanding of topological phases but also unveils pioneering lower-dimensional boundary states,which harbors substantial potential for next-generation device applications.The distinct electronic configurations and tunable attributes of two-dimensional materials position them as a quintessential platform for the realization of second-order topological insulators(SOTIs).This article provides an overview of the research progress in SOTIs within the field of two-dimensional electronic materials,focusing on the characterization of higher-order topological properties and the numerous candidate materials proposed in theoretical studies.These endeavors not only enhance our understanding of higher-order topological states but also highlight potential material systems that could be experimentally realized. 展开更多
关键词 second order topological insulator corner state 2D electronic material
在线阅读 下载PDF
Accumulation mechanism and enrichment model of deep tight sandstone gas in second member of Upper Triassic Xujiahe Formation,Xinchang structural belt,Sichuan Basin,SW China 被引量:1
18
作者 XIONG Liang CHEN Dongxia +3 位作者 YANG Yingtao ZHANG Ling LI Sha WANG Qiaochu 《Petroleum Exploration and Development》 2025年第4期907-920,共14页
Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was ... Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness. 展开更多
关键词 Upper Triassic second member of the Xujiahe Formation tight sandstone gas reservoir enrichment mechanism hydrocarbon accumulation model Xinchang structural belt Sichuan Basin
在线阅读 下载PDF
Optimizing the generation of second harmonic optical vortices from nonlinear photonic crystals
19
作者 LIU Shiqiang ZHANG Xinyu +4 位作者 CHEN Yan LI Shifeng ZHAO Gang ZHU Shining HU Xiaopeng 《物理学进展》 北大核心 2025年第4期161-168,共8页
The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex... The generation of optical vortices from nonlinear photonic crystals(NPCs)with spatially modulated second-order nonlinearity offers a promising approach to extend the working wavelength and topological charge of vortex beams for various applications.In this work,the second harmonic(SH)optical vortex beams generated from nonlinear fork gratings under Gaussian beam illumination are numerically investigated.The far-field intensity and phase distributions,as well as the orbital angular momentum(OAM)spectra of the SH beams,are analyzed for different structural topological charges and diffraction orders.Results reveal that higher-order diffraction and larger structural topological charges lead to angular interference patterns and non-uniform intensity distributions,deviating from the standard vortex profile.To optimize the SH vortex quality,the effects of the fundamental wave beam waist,crystal thickness,and grating duty cycle are explored.It is shown that increasing the beam waist can effectively suppress diffraction order interference and improve the beam’s quality.This study provides theoretical guidance for enhancing the performance of nonlinear optical devices based on NPCs. 展开更多
关键词 optical vortex nonlinear photonic crystal second harmonic generation orbital angular momentum
在线阅读 下载PDF
TPS-1诱导化疗对局部晚期鼻咽癌的长期疗效观察 被引量:1
20
作者 李依婷 吴峥 +8 位作者 何倩 罗乐 刘林 马宏志 李云 韩宸 周钰娟 肖锋 韩亚骞 《肿瘤药学》 2025年第1期99-105,共7页
目的评估多西他塞+顺铂+替吉奥(TPS-1)诱导化疗方案在局部晚期鼻咽癌(LANPC)中的长期疗效及安全性,并探讨其替代TPF方案的可能性。方法回顾性分析2018年1月—2019年12月在本院接受TPS-1方案诱导化疗并完成根治性放化疗的71例LANPC患者... 目的评估多西他塞+顺铂+替吉奥(TPS-1)诱导化疗方案在局部晚期鼻咽癌(LANPC)中的长期疗效及安全性,并探讨其替代TPF方案的可能性。方法回顾性分析2018年1月—2019年12月在本院接受TPS-1方案诱导化疗并完成根治性放化疗的71例LANPC患者的资料,采用Kaplan-Meier法对患者生存情况进行分析,并记录不良反应。结果全组患者的客观缓解率(ORR)为97.2%,中位随访时间68个月,5年总生存(OS)率、局部无复发生存(LRFS)率、区域无复发生存(RRFS)率和无远处转移生存(DMFS)率分别为91.3%、86.7%、90.0%和79.8%。TPS-1方案诱导化疗后不良反应发生率低,全组无4级不良反应,3级不良反应发生率为4.2%。结论TPS-1诱导化疗方案对LANPC患者显示出良好的短期疗效和长期生存获益,且安全性良好,但其在远处转移控制方面仍有待改善。该方案作为TPF替代方案的可行性仍需进一步随机对照研究验证。 展开更多
关键词 tps-1 诱导化疗 鼻咽癌 长期疗效 不良反应
暂未订购
上一页 1 2 250 下一页 到第
使用帮助 返回顶部