BACKGROUND Cognitive decline is common among older patients with cardiovascular disease(CVD) and can decrease their self-management abilities. However, the instruments for identifying mild cognitive impairment(MCI) ar...BACKGROUND Cognitive decline is common among older patients with cardiovascular disease(CVD) and can decrease their self-management abilities. However, the instruments for identifying mild cognitive impairment(MCI) are not always feasible in clinical practice. Therefore, this study evaluated whether MCI could be detected using the Japanese version of the Rapid Dementia Screening Test(RDST-J), which is a simple screening tool for identifying cognitive decline.METHODS This retrospective single-center study included patients who were ≥ 65 years old and hospitalized because of CVD.Patients with a pre-hospitalization diagnosis of dementia were excluded. Each patient's cognitive function had been measured at discharge using the RDST-J and the Japanese version of the Montreal Cognitive Assessment(Mo CA-J), which is a standard tool for MCI screening. The correlation between the two scores was evaluated using Spearman's rank correlation coefficient. Receiver operating characteristic(ROC) analysis was also to evaluate whether the RDST-J could identify MCI, which was defined as a Mo CA-J score of ≤ 25 points.RESULTS The study included 78 patients(mean age: 77.2 ± 8.9 years). The RDST-J and Mo CA-J scores were strongly correlated(r = 0.835, P < 0.001). The ROC analysis revealed that an RDST-J score of ≤ 9 points provided 75.4% sensitivity and 95.2% specificity for identifying MCI, with an area under the curve of 0.899(95% CI: 0.835-0.964). The same cut-off value was identified when excluding patients with a high probability of dementia(RDST-J score of ≤ 4 points).CONCLUSIONS The RDST-J may be a simple and effective tool for identifying MCI in older patients with CVD.展开更多
The differential hybridization technique hasbeen widely used to identify genes that are dif-ferentially expressed.However,this approachhas several drawbacks.First,the screeningprocedures are rather labor-intensive and...The differential hybridization technique hasbeen widely used to identify genes that are dif-ferentially expressed.However,this approachhas several drawbacks.First,the screeningprocedures are rather labor-intensive and time-consuming.Second,the amount of phageDNAs transferred onto the two filters may notbe equivalent,which leads to an inaccurate se-lection of a positive clone.Third,isolation ofphage DNA is slow and cumbersome.Here,aPCR based differential screening method that展开更多
Introduction:Premature depletion of hyperopic reserve has been demonstrated to associate with subsequent myopia development.However,the relationship between screen use and insufficient hyperopic reserve(defined as sph...Introduction:Premature depletion of hyperopic reserve has been demonstrated to associate with subsequent myopia development.However,the relationship between screen use and insufficient hyperopic reserve(defined as spherical equivalent refraction below age-specific thresholds)remains unclear,and regional heterogeneity in this association warrants investigation.Methods:This cross-sectional study(2020–2024)included 28,993 children from 9 provincial-level administrative divisions(PLADs).We assessed associations between screen exposure(time and habits)and hyperopic reserve status.Multivariable logistic regression analyses were conducted with stratified analyses based on regional gross domestic product(GDP)levels.Results:Among screened children,49.0%exhibited insufficient hyperopic reserve.High screen time[odds ratio(OR)=1.21,95%confidence interval(95%CI):1.14,1.29]and poor screen habits(OR=1.19,95%CI:1.12,1.27)were independently associated with insufficient hyperopic reserve.Low-GDP regions demonstrated significantly higher detection rates among children aged 6–9 years,whereas high-GDP regions showed accelerated increases in detection rates after age 11.Low-GDP regions exhibited heightened risks for both high screen time and poor screen habits,with this association most pronounced among girls in low-GDP areas.Conclusions:Screen exposure associates with insufficient hyperopic reserve,exhibiting notable regional and gender differences.High screen time and poor screen habits represent key risk factors for insufficient hyperopic reserve,particularly among girls residing in low-GDP areas.展开更多
文摘BACKGROUND Cognitive decline is common among older patients with cardiovascular disease(CVD) and can decrease their self-management abilities. However, the instruments for identifying mild cognitive impairment(MCI) are not always feasible in clinical practice. Therefore, this study evaluated whether MCI could be detected using the Japanese version of the Rapid Dementia Screening Test(RDST-J), which is a simple screening tool for identifying cognitive decline.METHODS This retrospective single-center study included patients who were ≥ 65 years old and hospitalized because of CVD.Patients with a pre-hospitalization diagnosis of dementia were excluded. Each patient's cognitive function had been measured at discharge using the RDST-J and the Japanese version of the Montreal Cognitive Assessment(Mo CA-J), which is a standard tool for MCI screening. The correlation between the two scores was evaluated using Spearman's rank correlation coefficient. Receiver operating characteristic(ROC) analysis was also to evaluate whether the RDST-J could identify MCI, which was defined as a Mo CA-J score of ≤ 25 points.RESULTS The study included 78 patients(mean age: 77.2 ± 8.9 years). The RDST-J and Mo CA-J scores were strongly correlated(r = 0.835, P < 0.001). The ROC analysis revealed that an RDST-J score of ≤ 9 points provided 75.4% sensitivity and 95.2% specificity for identifying MCI, with an area under the curve of 0.899(95% CI: 0.835-0.964). The same cut-off value was identified when excluding patients with a high probability of dementia(RDST-J score of ≤ 4 points).CONCLUSIONS The RDST-J may be a simple and effective tool for identifying MCI in older patients with CVD.
文摘The differential hybridization technique hasbeen widely used to identify genes that are dif-ferentially expressed.However,this approachhas several drawbacks.First,the screeningprocedures are rather labor-intensive and time-consuming.Second,the amount of phageDNAs transferred onto the two filters may notbe equivalent,which leads to an inaccurate se-lection of a positive clone.Third,isolation ofphage DNA is slow and cumbersome.Here,aPCR based differential screening method that
基金the Ministry of Science and Technology of the People’s Republic of China through the National Key Research and Development Program of China(Grant No.2021YFC2702102)the Beijing Municipal Health Commission High-level Public Health Technical Talent Construction Project(Leading Talent-01-09).
文摘Introduction:Premature depletion of hyperopic reserve has been demonstrated to associate with subsequent myopia development.However,the relationship between screen use and insufficient hyperopic reserve(defined as spherical equivalent refraction below age-specific thresholds)remains unclear,and regional heterogeneity in this association warrants investigation.Methods:This cross-sectional study(2020–2024)included 28,993 children from 9 provincial-level administrative divisions(PLADs).We assessed associations between screen exposure(time and habits)and hyperopic reserve status.Multivariable logistic regression analyses were conducted with stratified analyses based on regional gross domestic product(GDP)levels.Results:Among screened children,49.0%exhibited insufficient hyperopic reserve.High screen time[odds ratio(OR)=1.21,95%confidence interval(95%CI):1.14,1.29]and poor screen habits(OR=1.19,95%CI:1.12,1.27)were independently associated with insufficient hyperopic reserve.Low-GDP regions demonstrated significantly higher detection rates among children aged 6–9 years,whereas high-GDP regions showed accelerated increases in detection rates after age 11.Low-GDP regions exhibited heightened risks for both high screen time and poor screen habits,with this association most pronounced among girls in low-GDP areas.Conclusions:Screen exposure associates with insufficient hyperopic reserve,exhibiting notable regional and gender differences.High screen time and poor screen habits represent key risk factors for insufficient hyperopic reserve,particularly among girls residing in low-GDP areas.
