To the Editor:Sepsis is the leading cause of death in hospitalized patients.[1]Organ dysfunction is a central feature of sepsis.The sequential organ failure assessment(SOFA)score,which is most commonly used in the dia...To the Editor:Sepsis is the leading cause of death in hospitalized patients.[1]Organ dysfunction is a central feature of sepsis.The sequential organ failure assessment(SOFA)score,which is most commonly used in the diagnosis and treatment of sepsis,is based on the assessment of organ function.[2]The study of organ injury is currently a hot topic in the field of sepsis research.[3]Clarifying the distribution status of multiple organ dysfunction and mortality in sepsis is highly important for further research in these fields.We designed this study to analyze the distribution of multiple organ dysfunction syndrome(MODS)in sepsis patients based on SOFA scores.The diagnosis of sepsis was based on the third international consensus definition of sepsis and septic shock.[4]Each patient was reevaluated and given a SOFA score based on the raw data.In this survey,patients with sepsis in eICU database,Medical Information Mart for Intensive Care(MIMIC)-IV database and admitted to Peking Union Medical College Hospital(PUMCH)were enrolled.The exclusion criteria were as follows:patients aged less than 18 years,patients not at first admission,and patients who were unable to have SOFA scores.The data in the PUMCH database were collected from June 8,2013 to October 12,2022.MIMIC is the largest free clinical database in critical care medicine.展开更多
基金supported by grants from the Beijing Municipal Natural Science Foundation(No.L222019)College Innovation Fund for Medical Sciences(No.2024-I2M-C&T-C-002)+3 种基金National High Level Hospital Clinical Research Funding(No.2022-PUMCH-B-115)National High Level Hospital Clinical Research Funding(No.2022-PUMCH-D-005)National Key R&D Program of China(No.2024YFF1207104)National Natural Science Foundation of China(No.81801901).
文摘To the Editor:Sepsis is the leading cause of death in hospitalized patients.[1]Organ dysfunction is a central feature of sepsis.The sequential organ failure assessment(SOFA)score,which is most commonly used in the diagnosis and treatment of sepsis,is based on the assessment of organ function.[2]The study of organ injury is currently a hot topic in the field of sepsis research.[3]Clarifying the distribution status of multiple organ dysfunction and mortality in sepsis is highly important for further research in these fields.We designed this study to analyze the distribution of multiple organ dysfunction syndrome(MODS)in sepsis patients based on SOFA scores.The diagnosis of sepsis was based on the third international consensus definition of sepsis and septic shock.[4]Each patient was reevaluated and given a SOFA score based on the raw data.In this survey,patients with sepsis in eICU database,Medical Information Mart for Intensive Care(MIMIC)-IV database and admitted to Peking Union Medical College Hospital(PUMCH)were enrolled.The exclusion criteria were as follows:patients aged less than 18 years,patients not at first admission,and patients who were unable to have SOFA scores.The data in the PUMCH database were collected from June 8,2013 to October 12,2022.MIMIC is the largest free clinical database in critical care medicine.
