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Remimazolam reduces State-Trait Anxiety Inventory-State Scale scores in hemorrhoid surgery with spinal-epidural anesthesia:A randomized trial
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作者 Tao Hu Qian Huang +2 位作者 Lai Wei Shi Zhong Jing Wang 《World Journal of Gastrointestinal Surgery》 2025年第9期343-354,共12页
BACKGROUND In the field of anesthesia for procedure for prolapse and hemorrhoids(PPH)surgery,combined spinal-epidural(CSE)anesthesia has been a common approach.However,exploring new combinations to optimize patient ou... BACKGROUND In the field of anesthesia for procedure for prolapse and hemorrhoids(PPH)surgery,combined spinal-epidural(CSE)anesthesia has been a common approach.However,exploring new combinations to optimize patient outcomes remains crucial.Remimazolam,a short-acting benzodiazepine,shows potential for improving sedation and reducing patient anxiety.The effects of combining remimazolam with CSE anesthesia,compared to traditional CSE anesthesia alone,on patient anxiety,sedation depth,and hemodynamics during PPH surgery have not been fully elucidated.AIM To compare remimazolam-CSE vs CSE alone on State-Trait Anxiety Inventory-State scale(STAI-S)scores,sedation,and hemodynamics in PPH surgery.METHODS This study is a single-center,prospective,randomized controlled trial.Between November 23,2022,and August 6,2024,60 eligible patients were randomly assigned to the CSE anesthesia group or the remimazolam-combined CSE anesthesia group(30 patients each).STAI-S scores,Ramsay sedation scores,and hemodynamic parameters(systolic blood pressure,diastolic blood pressure,heart rate)were measured at multiple time points.Two-way mixed-effects ANOVA and posthoc analyses were performed.RESULTS The Combined group demonstrated significantly lower STAI-S scores before leaving the operating room[mean:28.80 vs 54.03,mean difference(95%CI):25.23(21.24-29.23),P<0.001]and 24 hours post-operation[mean:45.07 vs 54.53,mean difference(95%CI):9.47(6.29-12.64),P<0.001]than the CSE group.Moreover,the Combined group achieved a deeper sedation level during intraoperative maintenance[median:5.00(IQR:5.00-5.00)vs 2.00(IQR:2.00-2.00);median difference(95%CI):3.00(3.00-3.00),P<0.001].Regarding hemodynamics,a significant intergroup difference in systolic blood pressure was observed at the start of the surgery[mean:128.8 vs 114.7 for the Combined and CSE groups,mean difference(95%CI):14.17(0.77-27.57),adjusted P=0.033].CONCLUSION Remimazolam-combined anesthesia outperformed CSE anesthesia in reducing STAI-S scores,enhancing intraoperative sedation,and stabilizing systolic blood pressure at a critical stage,indicating its superiority in perioperative management. 展开更多
关键词 Procedure for prolapse and hemorrhoids surgery Combined spinal-epidural anesthesia Remimazolam-based combined anesthesia State-Trait Anxiety Inventory-State scale scores Sedation depth Hemodynamics
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Scoring the Clinical Application of a Novel Scale in a Hybrid Operating Room for Neurosurgery
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作者 Wei-yu Sun Yu Feng +8 位作者 Jin Yu Ting-bao Zhang Yi-hui Ma Kun-xian Zhang Xi-qian Gu Min Niu Xiang Li Jin-cao Chen Wen-yuan Zhao 《Current Medical Science》 2025年第2期349-362,共14页
Objective The lack of clarity regarding the application performance of a hybrid operating room(HOR)and the uncertainty of surgical scheduling often lead to its inefficient application.This study aimed to review the cl... Objective The lack of clarity regarding the application performance of a hybrid operating room(HOR)and the uncertainty of surgical scheduling often lead to its inefficient application.This study aimed to review the clinical application of our neurosurgical HOR and propose a scale to score cases clearly.Methods We reviewed the operating procedures and duration of stay in 1865 HOR cases.The actual procedures of each case were summarized into 5 application types,and numerical assignment was used to distinguish the dependence of each type on our HOR:surgical procedures combined with interventional procedures(4 points,the highest dependence),surgical procedures combined with imaging procedures(3 points),interventional procedures(2 points),imaging procedures(1 point),and surgical procedures(0 points,the lowest dependence).Results A novel scale that could score 1865 cases into those 5 grades was developed.The percentages by grade were as follows:4 points,4.24%;3 points,4.88%;2 points,20.75%;1 point,69.38%;and 0 points,0.75%.The cumulative usage time was 4241.9 h,the duration of which was as follows:4 points,16.17%;3 points,15.50%;2 points,31.32%;1 point,35.62%;and 0 points,1.39%.Conclusions The HOR serves as a multifunctional room to treat neurosurgical diseases.The scale helps to quickly prioritize cases that rely more on HOR,providing guidelines for surgical scheduling.Although our HOR is unsuitable for emergency cases,it clearly shows the application performance of our HOR to provide a reference for promoting its efficient application. 展开更多
关键词 Hybrid operating room score scale Neurosurgical diseases Open surgical procedures Interventional procedures Imaging procedures
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Influence of Continuous Care Intervention on Wound Stomy and Improvement of ECSA Scale Score
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作者 ZHA Xiaoying 《外文科技期刊数据库(文摘版)医药卫生》 2021年第6期293-294,共4页
Objective: to explore the effect of continuous nursing intervention on wound stomy and the improvement of ECSA scale score. Methods: 100 cases of rectal cancer patients in our hospital from January 2020 to January 202... Objective: to explore the effect of continuous nursing intervention on wound stomy and the improvement of ECSA scale score. Methods: 100 cases of rectal cancer patients in our hospital from January 2020 to January 2021 were collected and randomly divided into two groups. The control group received routine nursing, and the observation group received continuous nursing intervention. The score of ECSA scale and the complication rate of wound stomy were compared between the two groups. Results: the score of ECSA scale in observation group was higher than that in control group, and the incidence of complications in wound stomy was lower than that in control group, with significant difference (P < 0.05). Conclusion: the effect of continuous nursing intervention on wound ostomy and the improvement of ECSA scale score are accurate. It can improve patients' self-management ability and reduce complications of wound ostomy. It is a continuous nursing mode worthy of promotion and application. 展开更多
关键词 continuous nursing intervention wound stomy INFLUENCE ECSA scale score IMPROVEMENT
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科博肽与地佐辛在胸部肿瘤切除术后镇痛中的疗效与安全性对比
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作者 聂晶 胡培娟 +1 位作者 钱玮 谈宇龙 《中国现代药物应用》 2026年第1期70-73,共4页
目的对比科博肽与地佐辛用于胸部肿瘤切除术后镇痛的疗效和安全性。方法将124例接受胸部肿瘤切除术患者按照治疗方法不同分为科博肽组(56例)和地佐辛组(68例)。科博肽组术毕给予注射用科博肽肌内注射进行镇痛,地佐辛组术毕给予地佐辛注... 目的对比科博肽与地佐辛用于胸部肿瘤切除术后镇痛的疗效和安全性。方法将124例接受胸部肿瘤切除术患者按照治疗方法不同分为科博肽组(56例)和地佐辛组(68例)。科博肽组术毕给予注射用科博肽肌内注射进行镇痛,地佐辛组术毕给予地佐辛注射液静脉注射进行镇痛。对比两组术后镇痛疗效指标、术后不良反应发生情况。结果术后6、24 h,科博肽组视觉模拟评分法(VAS)评分(3.8±0.4)、(2.3±0.3)分明显低于地佐辛组的(4.3±0.5)、(2.8±0.4)分,差异均具有统计学意义(P<0.05);科博肽组术后24 h内辅助镇痛需求率为19.6%(11/56),低于地佐辛组的25.0%(17/68),但差异无统计学意义(P>0.05);两组术后住院时间对比差异无统计学意义(P>0.05)。两组术后均未出现严重不良反应,常见不良反应主要为轻度的胃肠道反应和神经系统症状。科博肽组术后不良反应总发生率为7.1%(4/56),略低于地佐辛组的7.4%(5/68),但差异无统计学意义(P>0.05)。结论科博肽用于胸部肿瘤切除术后镇痛具有良好的效果和安全性。与地佐辛相比,科博肽镇痛效果更佳,患者术后VAS评分更低,且不良反应发生率略低,提示科博肽可作为术后镇痛的有效选择之一。 展开更多
关键词 科博肽 地佐辛 术后镇痛 视觉模拟评分法评分 不良反应
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急性脑梗死患者出院时NIHSS评分影响因素分析
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作者 张会玲 高素颖 +2 位作者 张娜 张广波 王志超 《中国现代药物应用》 2026年第1期6-9,共4页
目的探讨急性脑梗死患者出院时美国国立卫生研究院卒中量表(NIHSS)评分的影响因素。方法回顾性分析4048例急性脑梗死患者的临床资料,依据NIHSS评分分为轻型组(NIHSS评分≤7分,3696例)、中型组(7分<NIHSS评分<15分,278例)、重型组(... 目的探讨急性脑梗死患者出院时美国国立卫生研究院卒中量表(NIHSS)评分的影响因素。方法回顾性分析4048例急性脑梗死患者的临床资料,依据NIHSS评分分为轻型组(NIHSS评分≤7分,3696例)、中型组(7分<NIHSS评分<15分,278例)、重型组(NIHSS评分≥15分,74例)。对比三组基线资料,采用单因素及多因素Logistic回归分析急性脑梗死患者出院时NIHSS评分的影响因素。结果三组年龄、脑卒中史、心房颤动史、收缩压、舒张压、空腹血糖(FPG)、尿酸比较,差异有统计学意义(P<0.05)。分别以轻型组为参照,中型组和重型组为因变量,以年龄、脑卒中史、心房颤动史、抗血小板药物使用、收缩压、舒张压、FPG、尿酸为自变量,分别进行单因素分析显示,年龄、脑卒中史、心房颤动史、收缩压、抗血小板药物使用是中型组的危险因素(P<0.05),尿酸是中型组的保护因素(P<0.05)。年龄、脑卒中史、心房颤动史、抗血小板药物使用、收缩压、舒张压、FPG是重型组的危险因素(P<0.05),尿酸是重型组的保护因素(P<0.05)。以轻型组为参照,中型组、重型组为因变量,在校正了其他影响因素后,进行多因素Logistic回归分析显示,年龄[OR=1.038,95%CI=(1.025,1.050)]、脑卒中史[OR=1.351,95%CI=(1.034,1.767)]、收缩压[OR=1.007,95%CI=(1.002,1.012)]是中型组的独立危险因素(P<0.05)。年龄[OR=1.089,95%CI=(1.061,1.118)]、脑卒中史[OR=1.548,95%CI=(1.025,2.593)]、心房颤动史[OR=2.983,95%CI=(1.249,7.120)]、舒张压[OR=1.053,95%CI=(1.032,1.075)]、FPG[OR=1.240,95%CI=(1.151,1.335)]是重型组的独立危险因素(P<0.05),尿酸[OR=0.997,95%CI=(0.995,1.000)]是重型组的独立保护因素(P<0.05)。结论年龄、脑卒中史、心房颤动史、血压、FPG、尿酸是急性脑梗死患者出院时NIHSS评分的影响因素。 展开更多
关键词 急性脑梗死 美国国立卫生研究院卒中量表评分 影响因素
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Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores 被引量:14
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作者 Chan-chan Li Xiao-zhu Hao +3 位作者 Jia-qi Tian Zhen-wei Yao Xiao-yuan Feng Yan-mei Yang 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第1期69-76,共8页
Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the p... Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the present study was to assess a FVH score and explore its relationship with clinical outcomes. Patients with acute ischemic stroke due to middle cerebral artery M1 occlusion underwent magnetic resonance imaging and were followed up at 10 days (National Institutes of Health Stroke Scale) and 90 days (modified Rankin Scale) to determine short-term clinical outcomes. Effective collateral circulation indirectly improved recovery of neurological function and short-term clinical outcome by extending the size of the pial penumbra and reducing infarct lesions. FVH score showed no correlation with 90-day functional clinical outcome and was not sufficient as an independent predictor of short-term clinical outcome. 展开更多
关键词 nerve regeneration National Institutes of Health Stroke scale middle cerebral artery occlusion collateral circulation modified Rankin scale score cerebral ischemia acute stroke diffusion-weighted imaging fluid-attenuated inversion recovery neural regeneration
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Logistic分布位置-尺度参数联合回归建模及其Score检验 被引量:1
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作者 房钦钦 赵为华 《南通大学学报(自然科学版)》 CAS 2017年第1期81-86,共6页
Logistic分布是一种重要的位置-尺度分布,与正态分布比较,Logistic分布是一种厚尾分布.为刻画数据的异方差性,提出了基于Logistic分布的位置-尺度参数联合回归建模问题,利用牛顿迭代法得到了参数估计算法.为检验解释变量的重要性,基于Sc... Logistic分布是一种重要的位置-尺度分布,与正态分布比较,Logistic分布是一种厚尾分布.为刻画数据的异方差性,提出了基于Logistic分布的位置-尺度参数联合回归建模问题,利用牛顿迭代法得到了参数估计算法.为检验解释变量的重要性,基于Score检验方法研究了相关的假设检验问题,并通过数值模拟研究其检验功效问题.最后,利用AIC和BIC信息准则对基于Logistic回归模型和线性回归进行拟合优度分析.大量数值模拟和实例数据分析验证了所提方法的有效性. 展开更多
关键词 Logistic分布 位置-尺度分布 score检验 厚尾分布 回归
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Diabetes empowerment scores among type 2 diabetes mellitus patients and its correlated factors: A cross-sectional study in a primary care setting in Malaysia 被引量:5
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作者 Thew Hui Zhu Ching Siew Mooi +1 位作者 Nurainul Hana Shamsuddin Ching Siew Mooi 《World Journal of Diabetes》 SCIE CAS 2019年第7期403-413,共11页
BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type ... BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type 2 diabetes patients in a primary care clinic in Malaysia.METHODS This is a cross sectional study involving 322 patients with type 2 diabetes mellitus(DM)followed up in a primary care clinic.Systematic sampling method was used for patient recruitment.The Diabetes Empowerment Scale(DES)questionnaire was used to measure patient empowerment.It consists of three domains:(1)Managing the psychosocial aspect of diabetes(9 items);(2)Assessing dissatisfaction and readiness to change(9 items);and(3)Setting and achieving diabetes goal(10 items).A score was considered high if it ranged from 100 to 140.Data analysis was performed using SPSS version 25 and multiple linear regressions was used to identify the predictors of total diabetes empowerment scores.RESULTS The median age of the study population was 55 years old.56%were male and the mean duration of diabetes was 4 years.The total median score of the DES was 110[interquartile range(IQR)=10].The median scores of the three subscales were 40 with(IQR=4)for"Managing the psychosocial aspect of diabetes";36 with(IQR=3)for"Assessing dissatisfaction and readiness to change";and 34 with(IQR=5)for"Setting and achieving diabetes goal".According to multiple linear regressions,factors that had significant correlation with higher empowerment scores among type 2 diabetes patients included an above secondary education level(P<0.001),diabetes education exposure(P=0.003),lack of ischemic heart disease(P=0.017),and lower glycated hemoglobin(HbA1c)levels(P<0.001).CONCLUSION Diabetes empowerment scores were high among type 2 diabetes patients in this study population.Predictors for high empowerment scores included above secondary education level,diabetes education exposure,lack of ischemic heart disease status and lower HbA1c. 展开更多
关键词 DIABETES EMPOWERMENT scoreS DIABETES EMPOWERMENT scale Type 2 DIABETES Primary care MALAYSIA
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Likert Scale计分系统在磁共振成像预测胎盘植入深度中的应用价值 被引量:10
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作者 孟砺实 杨正强 +1 位作者 严雨 严建春 《中国医学装备》 2020年第8期79-84,共6页
目的:评价LikertScale计分系统在磁共振成像(MRI)预测胎盘植入深度中的应用价值。方法:选取150例经产前MRI检查的前置胎盘孕妇,其中非胎盘植入63例,粘连性胎盘植入46例,植入性胎盘植入27例,穿透性胎盘植入14例,所有患者均经临床手术及... 目的:评价LikertScale计分系统在磁共振成像(MRI)预测胎盘植入深度中的应用价值。方法:选取150例经产前MRI检查的前置胎盘孕妇,其中非胎盘植入63例,粘连性胎盘植入46例,植入性胎盘植入27例,穿透性胎盘植入14例,所有患者均经临床手术及病理证实。采用LikertScale计分系统对胎盘植入7个MRI征象进行评分,再累加得出总评分,由两名具有高级职称放射科医师盲法阅片。采用组内相关系数、方差分析以及最小显著性差异法进行统计学分析,并绘制受试者工作曲线,计算不同类型评分的界值。结果:两名阅片医师在非胎盘植入、粘连性胎盘植入、植入性胎盘植入及穿透性胎盘植入评分方面一致性均表现较好,组内相关系数(ICC)≥0.60,可以取两名阅片医师评分均值进行分析。穿透性胎盘植入总评分为(31.46±2.29)分,高于植入性胎盘植入总评分(27.27±1.66)分,植入性胎盘植入的总评分高于粘连性胎盘植入的总评分(22.03±2.45)分,粘连性胎盘植入的总评分高于非胎盘植入总评分(15.98±3.06)分,差异均有统计学意义(Z=205.253,P<0.05)。受试者工作曲线显示,非胎盘植入与粘连性胎盘植入之间、粘连性胎盘植入与植入性胎盘植入之间以及植入性胎盘植入与穿透性胎盘植入之间评分界值分别为20分、25分和30分。结论:Likert Scale计分系统可以预测胎盘植入深度,为MRI诊断胎盘植入深度建立了一种量化模式,从而帮助临床医师制定合理的治疗方案。 展开更多
关键词 Likert scale计分系统 磁共振成像(MRI) 胎盘植入 预测
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Performance of a Score-Stove with a Kerosene Burner and the Effect of Pressurization of the Working Fluid
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作者 Md Ehsan Manabendra Sarker +1 位作者 Rifath Mahmud Paul H. Riley 《Journal of Power and Energy Engineering》 2015年第4期458-466,共9页
Score-StoveTM a clean-burning cooking stove that also generates electricity was tested using a pressurized kerosene burner. The Score-Stove works on the principle of thermo-acoustics to gen- erate small-scale electric... Score-StoveTM a clean-burning cooking stove that also generates electricity was tested using a pressurized kerosene burner. The Score-Stove works on the principle of thermo-acoustics to gen- erate small-scale electricity. The device having hot-end, cold-end and regenerator acts in a way similar to a stirling cycle generating acoustic power, which is then converted to electricity using a linear actuator. It can supply small power for applications such as LED lighting, mobile phone charging and radios particularly in rural areas without grid electricity as well as improving house- hold air pollution. After assessing the needs of the rural communities through a survey, tea-stalls and small restaurants owners were identified as clients with the most potential of using the stove in Bangladesh. Bangladesh University of Engineering and Technology ((BUET) modified a Score- Stove to use both wood and a pressurized kerosene burner of a design that is widely used for cooking in rural areas of Bangladesh. The design was adapted to meet performance needs such as: heating rate, cooking efficiency, energy distribution, electric power generation, exhaust emissions and time taken to boil water using standardized water boiling tests. Performance was also compared with conventional (non-electrically generating) stoves that use a pressurized kerosene burn- er. The Score-Stove performance was then evaluated while increasing the pressure of the sealed working fluid (air in this case) from atmospheric to about 1.4 bar. The pressurization was found to almost double the power generation. An arrangement for utilizing cooling water waste heat was also devised in order to improve the thermal performance of the stove by 18%. Technical deficiencies are documented and recommendations for improvements and future research in order to obtain wider end-user acceptance are made. 展开更多
关键词 score-Stove Small-scale Power Thermo-Acoustics Clean COOKING STOVE KEROSENE BURNER PRESSURIZATION
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新型局部浸润麻醉应用于人工全膝关节置换的早期效果评估 被引量:2
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作者 王俊 张辉 +3 位作者 李正远 郝琳 陈圣洪 尹宗生 《中国组织工程研究》 CAS 北大核心 2025年第27期5839-5844,共6页
背景:全膝关节置换后患者会经历明显的疼痛,这对功能恢复存在负面影响,探索并寻求有效的镇痛手段具有重要的临床价值。目的:为探求全膝关节置换患者有效的围术期镇痛策略,首次提出了一种由吗啡、氟比洛芬酯和复方倍他米松配置而成的新... 背景:全膝关节置换后患者会经历明显的疼痛,这对功能恢复存在负面影响,探索并寻求有效的镇痛手段具有重要的临床价值。目的:为探求全膝关节置换患者有效的围术期镇痛策略,首次提出了一种由吗啡、氟比洛芬酯和复方倍他米松配置而成的新型局部浸润麻醉制剂,同时探讨该方案的有效性及安全性。方法:对2023年1月至2024年4月在安徽医科大学第一附属医院关节外科接受初次单侧全膝关节置换60例患者的临床资料进行回顾性分析,根据置换过程中是否使用局部浸润麻醉将患者分为对照组与研究组,每组30例。研究组在全膝关节置换过程中关节腔周围注射吗啡、氟比洛芬酯及复方倍他米松配置而成的局部浸润麻醉制剂,而对照组术中未使用任何镇痛药物作为空白对照。记录并比较两组患者在术后不同时间节点的疼痛目测类比评分、膝关节活动度、膝关节学会评分、术后膝关节肿胀程度及术后并发症的发生情况。结果与结论:①与对照组相比,研究组患者置换后6,12及24 h的疼痛目测类比评分更低,差异有显著性意义(Z=-2.367,-2.906,-4.199,P<0.05);但在术后48,72 h,两组患者的疼痛目测类比评分并无显著性差异(Z=-1.287,-1.478,P>0.05);②置换后第3天,研究组患者的膝关节活动度和膝关节学会评分均优于对照组,差异有显著性意义(t=-2.519,-8.027,P<0.05);③研究组患者术后的膝关节肿胀程度轻于对照组,差异有显著性意义(Z=-2.818,P<0.05);④在术后早期,两组患者的发热发生率相比无显著性差异(P>0.05),两组均未发生切口愈合不良及假体周围感染;⑤结果表明:在全膝关节置换过程中应用由吗啡、氟比洛芬酯及复方倍他米松组成的局部浸润麻醉制剂,可以明显减轻患者术后早期疼痛,并显示出较高的安全性,但仍需大样本的前瞻性研究提供数据支持。 展开更多
关键词 全膝关节置换 局部浸润麻醉 镇痛 复方倍他米松 疼痛目测类比评分 关节活动度
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熄风定颤丸分期治疗肝肾阴虚型帕金森病的多中心、分层随机、标准对照临床研究 被引量:1
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作者 张杰 马云枝 +5 位作者 沈晓明 许玉珉 孟毅 张培丽 贾奎 菅艳萍 《中华中医药杂志》 北大核心 2025年第2期939-944,共6页
目的:评价熄风定颤丸干预肝肾阴虚型帕金森病患者分期治疗方案的有效性和安全性。方法:采用多中心、分层随机、标准对照研究设计。早期对照组给予多巴丝肼片(美多芭),治疗组给予熄风定颤丸;中期对照组给予美多芭、吡呗地尔片,治疗组在... 目的:评价熄风定颤丸干预肝肾阴虚型帕金森病患者分期治疗方案的有效性和安全性。方法:采用多中心、分层随机、标准对照研究设计。早期对照组给予多巴丝肼片(美多芭),治疗组给予熄风定颤丸;中期对照组给予美多芭、吡呗地尔片,治疗组在此基础上给予熄风定颤丸。治疗周期均为12周。以帕金森病综合评定量表(UPDRS)评分、中医证候积分、健康调查简表(SF-36)评分、美多芭用量和安全性指标等的变化,评价治疗方案的有效性和安全性。结果:治疗后,与对照组比较,早、中期治疗组患者UPDRS总分、UPDRSⅠ评分、UPDRSⅣ评分、中医证候总积分显著降低,中期治疗组UPDRSⅡ评分显著降低、美多芭用量显著减少(P<0.05,P<0.01)。治疗期间,两组均未发现与研究药物有关的不良反应事件。结论:早期中药治疗、中期中西药联用,能够提高临床疗效,并能减少美多芭用量,延缓治疗并发症的发生,在改善患者症状尤其是非运动症状方面具有优势。 展开更多
关键词 帕金森病 中西药结合分期疗法 熄风定颤丸 帕金森病综合评定量表评分 生活质量
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Preliminary Report on Phenom<sup>®</sup>Femoral Component in Total Hip Replacement: The Correlation between Outcome Scores in a Cross-Seccional Study
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作者 Elmano de Araújo Loures Jose Ricardo Barroso Vitoi +3 位作者 Daniel Naya Loures Victor Henrique Coelho Adriano Fernando Mendes Junior Valeria Romero 《Open Journal of Orthopedics》 2021年第4期110-125,共16页
<strong>Background:</strong> The main purpose of the present study was to assess the short term performance of a cementless femoral stem in total hip replacement. <strong>Methods:</strong> Cros... <strong>Background:</strong> The main purpose of the present study was to assess the short term performance of a cementless femoral stem in total hip replacement. <strong>Methods:</strong> Cross-sectional observational study of a 48-patient cohort with Phenom? femoral stems implanted between June 1, 2014 and September 1, 2018, to determine clinical performance, stability, and radiographic osseointegration. Patients were followed-up from 13 to 76 months (mean: 44.5 months) and assessed using the Harris Hip Score-HHS, the Hip Disability and Osteoarthritis Outcome Score-HOOS and radiographs. <strong>Results:</strong> All stems were radiologically stable. Mean Harris Hip Score was 89.8 and the HOOS was 80.4. No statistical differences were observed among patients with different diagnoses. <strong>Conclusions:</strong> The short-term results revealed satisfactory clinical outcomes and radiological signs of implant stability in all cases. Using two functional scores was useful in detecting biases and a low to moderate agreement was found between the scores. 展开更多
关键词 OSSEOINTEGRATION Total Hip Replacement Hip Prosthesis Patient-Reported Outcome scales Functional scores
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Profitability Analysis of Small Scale Irrigation Technology Adoption to Farmers in Nasho Sector, Rwanda
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作者 Eliezel Habineza Jean Nepomuscene Nsengiyumva +1 位作者 Eric Ruzigamanzi Martin Vincent Nsanzumukiza 《Journal of Agricultural Chemistry and Environment》 2020年第2期73-84,共12页
The study aims to assess the effect of small scale irrigation adoption to farmers in Nasho sector, Kirehe District in Rwanda. The average yield was 12,309.73 Kg/2.62 ha or 4698.73 Kg/ha for adopters with the mean diff... The study aims to assess the effect of small scale irrigation adoption to farmers in Nasho sector, Kirehe District in Rwanda. The average yield was 12,309.73 Kg/2.62 ha or 4698.73 Kg/ha for adopters with the mean difference between adopters and non adopters ranged from 2819.63 Kg to 4766.59 Kg per unit area of production. For food security status, the average mean quantity of maize consumed at home level was 615.54 Kg with the mean difference ranged from 377.29 Kg to 474.68 Kg. For market participation, the average treatment effect of the treated (ATT) of quantity of maize sold was 11,694.24 Kg while the mean difference ranged from 7165.98 Kg to 9015.60 Kg. The Average Treatment Effect of the Treated market price was 213 Frws/Kg while the mean difference ranged from 44.51 Frws/Kg to 48.3053 Frws/Kg. The Average Treatment Effect of the Treated of farmer’s revenues for the users was 938,772 Frws/ha, however, the mean difference between adopters and non adopters ranged from 1,732,942 Frws to 2,007,039 Frws. The Average Treatment Effect of the Treated of farmer’s net farm income was 1,066,393 Frws while mean difference between users and non users ranged from 803,967 Frws to 854,141 Frws. For profitability analysis, the cost benefit ratio (CBR) was taken into account. The total benefit per unit area was 2,434,509 Frws and total average mean cost of 1,382,313 Frws and CBR = 1.761 > 1. The findings of this study will help the policy makers for deeper sector planning and also, it will facilitate other stakeholders to invest in irrigation technology to improve the livelihoods of Rwandan farmers and other surroundings. 展开更多
关键词 PROFITABILITY Small scale ïrrigation PROPENSITY score Matching FARMERS Treatment Effect
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Arabic Version of the Modified Constant Murley Score
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作者 Raghad Mohammed Barri Arwa Mohammed Almasshan Sultan Saleh Aldosari 《Open Journal of Orthopedics》 2023年第6期254-265,共12页
Objectives: “Patient-reported outcome measures” has been used extensively, and it has shown the diseases’ impact on patient quality of life and has enabled the clinician to evaluate the clinical care efficacy. In t... Objectives: “Patient-reported outcome measures” has been used extensively, and it has shown the diseases’ impact on patient quality of life and has enabled the clinician to evaluate the clinical care efficacy. In the literature, there are more than 34 shoulder function assessment scoring instruments;the Modified Constant Murley Score (M-CMS) is one of the most popular scores. Although, the M-CMS had been translated and culturally adapted to Danish, Brazilian and Turkish versions, there is no Arabic version found in the literature. We aim to translate and culturally adapt M-CMS into the Arabic language. Method: The M-CMS was translated using previously published guidelines. The translation and cultural adaptation were done in five stages, initial translation by two bilingual translators then a synthesis of the translations after that, back translation by two native English speakers. Then an expert committee meeting approved the pre-final Arabic version. Finally, a pilot test was conducted on 41 patients to ensure its validity. Results: The M-CMS was successfully translated from the original English version to the Arabic version;no difficulties in the translation process were faced. Conclusion: A validated Arabic version of the M-CMS was produced and ready to be used for functional assessment of different shoulder pathologies in Arabic-speaking countries. Future study is needed for translation and cultural adaptation of the English standardized test protocol to assure the reproducibility of the Arabic version of the M-CMS. 展开更多
关键词 Activity of Daily Living Constant score Patient Reported Outcome Measure Shoulder score TRANSLATION Visual Analog scale
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芍芪益甲方治疗肝郁脾虚型桥本甲状腺炎非甲减期的临床疗效及对血清炎症因子的影响
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作者 张志丹 卜健 +3 位作者 沈红权 汪红平 陈丽萍 王杰 《南京中医药大学学报》 北大核心 2025年第8期1087-1093,共7页
目的观察芍芪益甲方治疗肝郁脾虚型桥本甲状腺炎非甲减期的临床疗效及对血清炎症因子表达水平的影响。方法选取2024年6月至8月于上海市普陀区中心医院就诊的肝郁脾虚型桥本甲状腺炎非甲减期患者74例,采用随机数字表法分为观察组、对照组... 目的观察芍芪益甲方治疗肝郁脾虚型桥本甲状腺炎非甲减期的临床疗效及对血清炎症因子表达水平的影响。方法选取2024年6月至8月于上海市普陀区中心医院就诊的肝郁脾虚型桥本甲状腺炎非甲减期患者74例,采用随机数字表法分为观察组、对照组各37例(2组各脱落2例)。对照组予硒酵母片口服治疗,观察组予芍芪益甲方口服治疗,2组疗程均为12周。治疗前后评估2组患者中医证候积分、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和疲劳自评量表(Fatigue self-assessment scale,FSAS)评分;检测2组患者治疗前后血清甲状腺球蛋白抗体(Thyroglobulin antibody,TgAb)、甲状腺过氧化物酶抗体(Thyroidperoxidase antibody,TPOAb)以及白细胞介素(Interleukin,IL)-4、IL-10、IL-6、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、干扰素-γ(Interferon-γ,IFN-γ)水平变化。结果治疗后,观察组患者中医证候总积分及胃脘或胁肋胀痛、腹胀、食少纳呆、情绪抑郁或急躁易怒、善太息评分明显降低(P<0.05,P<0.01),观察组总积分优于对照组(P<0.01);治疗后,观察组血清TPOAb水平明显降低(P<0.05),对照组血清TPOAb水平无显著变化(P>0.05),观察组血清TgAb和TPOAb水平优于对照组(P<0.05);治疗后,观察组HAMA、HAMD评分明显减低(P<0.01),观察组HAMA、HAMD和FSAS评分均优于对照组(P<0.05);治疗后,观察组血清IL-4和IL-10水平均升高(P<0.05),IL-6、IFN-γ和TNF-α较治疗前降低(P<0.05),观察组血清IL-4、IL-6、IL-10水平与对照组存在显著差异(P<0.05)。结论芍芪益甲方能够改善肝郁脾虚型桥本甲状腺炎非甲减期患者的临床症状,同时改善焦虑、抑郁状态,可能与改善机体炎症反应有关。 展开更多
关键词 桥本甲状腺炎 肝郁脾虚证 芍芪益甲方 临床观察 甲状腺抗体 中医证候积分 情志量表 炎症因子
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早期预警评分量表在急性脑梗死静脉溶栓治疗中的应用效果
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作者 赵艳 尹俊锋 《临床研究》 2025年第7期165-168,共4页
目的 观察早期预警评分量表在急性脑梗死(ACI)静脉溶栓治疗中的应用效果。方法 将2018年12月至2023年12月郑州市第一人民医院收治的65例行静脉溶栓治疗的ACI患者采用随机数表法分为两组。干预组33例采用常规护理结合早期预警评分量表,... 目的 观察早期预警评分量表在急性脑梗死(ACI)静脉溶栓治疗中的应用效果。方法 将2018年12月至2023年12月郑州市第一人民医院收治的65例行静脉溶栓治疗的ACI患者采用随机数表法分为两组。干预组33例采用常规护理结合早期预警评分量表,对照组32例采用常规护理。两组均干预至出院判定疗效。对比两组神经功能缺损程度、认知障碍程度、吞咽障碍程度、日常生活活动能力及不良反应。结果 干预后,两组美国国立卫生研究院卒中量表(NIHSS)、吞咽功能评价量表(SSA)评分下降,且干预组低于对照组,差异有统计学意义(P<0.05);简易精神状态检查表(MMSE)评分、Barthel指数(BI)评分升高,且干预组高于对照组,差异有统计学意义(P<0.05)。干预组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 早期预警评分量表应用于ACI静脉溶栓治疗可改善患者神经功能及认知障碍,促进吞咽功能恢复,提高日常生活活动能力,降低不良反应发生率。 展开更多
关键词 急性脑梗死 静脉溶栓 早期预警评分量表 神经功能
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Nutech functional score: A novel scoring system to assess spinal cord injury patients
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作者 Geeta Shroff Jitendra Kumar Barthakur 《World Journal of Methodology》 2017年第2期68-72,共5页
AIM To develop a new scoring system, nutech functional scores(NFS) for assessing the patients with spinal cord injury(SCI).METHODS The conventional scale, American Spinal Injury Association's(ASIA) impairment scal... AIM To develop a new scoring system, nutech functional scores(NFS) for assessing the patients with spinal cord injury(SCI).METHODS The conventional scale, American Spinal Injury Association's(ASIA) impairment scale is a measure which precisely describes the severity of the SCI.However, it has various limitations which lead to incomplete assessment of SCI patients.We have developed a 63 point scoring system, i.e., NFS for patients suffering with SCI.A list of symptoms either common or rare that were found to be associated with SCI was recorded for each patient.On the basis of these lists, we have developed NFS.RESULTS These lists served as a base to prepare NFS, a 63 point positional(each symptom is sub-graded and get points based on position) and directional(moves in direction BAD → GOOD) scoring system.For non-progressive diseases, 1, 2, 3, 4, 5 denote worst, bad, moderate, good and best(normal), respectively.NFS for SCI has been divided into different groups based on the affected part of the body being assessed, i.e., motor assessment(shoulders, elbow, wrist, fingers-grasp, fingers-release, hip, knee, ankle and toe), sensory assessment, autonomic assessment, bed sore assessment and general assessment.As probability based studies required a range of(-1, 1) or at least the range of(0, 1) to be useful for real world analysis, the grades were converted to respective numeric values.CONCLUSION NFS can be considered as a unique tool to assess the improvement in patients with SCI as it overcomes the limitations of ASIA impairment scale. 展开更多
关键词 Spinal cord injury American Spinal Injury Association’s Impairment scale Nutech functional score Comparison of assessment Positional scoring system
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鼻中隔改良缝合技术在鼻中隔偏曲矫正术中的应用价值研究
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作者 仇继兵 曹影 +2 位作者 宋红毛 李秀婷 秦锋 《中国现代药物应用》 2025年第3期52-55,共4页
目的评价鼻中隔改良缝合技术在鼻中隔偏曲矫正术中的应用价值。方法选取86例行鼻中隔偏曲矫正术的患者,随机分为缝合组和对照组,每组43例。缝合组予以鼻中隔改良缝合,对照组予以膨胀海绵填塞鼻腔。比较两组术后疼痛情况[视觉模拟评分法(... 目的评价鼻中隔改良缝合技术在鼻中隔偏曲矫正术中的应用价值。方法选取86例行鼻中隔偏曲矫正术的患者,随机分为缝合组和对照组,每组43例。缝合组予以鼻中隔改良缝合,对照组予以膨胀海绵填塞鼻腔。比较两组术后疼痛情况[视觉模拟评分法(VAS)评分],症状评分,鼻窦CT评分及鼻内镜评分,并发症发生情况。结果术后24 h,缝合组VAS评分为(2.07±0.72)分,对照组为(9.56±0.89)分,缝合组明显低于对照组,差异具有统计学意义(P<0.05)。术后48 h,对照组抽出鼻腔填塞膨胀海绵后VAS评分为(7.16±0.69)分,缝合组为(2.31±0.72)分,缝合组明显低于对照组,差异具有统计学意义(P<0.05)。缝合组鼻部疼痛、头痛、溢泪、耳闷、吞咽困难、睡眠困难评分分别为(2.86±0.57)、(1.19±0.49)、(3.11±0.94)、(1.13±0.62)、(1.97±0.96)、(2.59±1.17)分,均低于对照组的(5.72±0.63)、(4.28±1.17)、(7.15±1.98)、(4.07±0.89)、(4.01±1.17)、(4.82±1.31)分,差异具有统计学意义(P<0.05)。术后,缝合组鼻窦CT评分(2.09±0.74)分及鼻内镜评分(2.01±0.51)分均低于对照组的(3.59±1.02)、(2.91±0.93)分,差异有统计学意义(P<0.05)。术后随访6个月,对照组并发症发生率为18.60%,缝合组并发症发生率为4.65%,缝合组显著低于对照组,差异有统计学意义(P<0.05)。结论鼻中隔偏曲矫正术中应用鼻中隔改良缝合技术能明显改善患者术后的不适感,减少并发症的发生,值得临床推广应用。 展开更多
关键词 鼻中隔偏曲矫正术 改良缝合技术 视觉模拟评分法 并发症发生率
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尼卡地平联合颅内血肿微创清除术治疗高血压脑出血的疗效
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作者 曹海波 王晓军 +6 位作者 卞杰勇 于涛 周林强 石磊 任峰 蒋才奇 顾雨佳 《中国药物应用与监测》 2025年第8期1350-1355,共6页
目的探讨颅内血肿微创清除术后给予尼卡地平治疗高血压脑出血的临床疗效。方法采取随机数字表法将2020年5月至2024年5月收治于苏州市相城人民医院的高血压脑出血患者(80例)分为对照组(n=40)与观察组(n=40)。对照组和观察组患者均接受颅... 目的探讨颅内血肿微创清除术后给予尼卡地平治疗高血压脑出血的临床疗效。方法采取随机数字表法将2020年5月至2024年5月收治于苏州市相城人民医院的高血压脑出血患者(80例)分为对照组(n=40)与观察组(n=40)。对照组和观察组患者均接受颅内血肿微创清除术,术后对照组患者采用硝苯地平缓释片治疗,观察组患者接受尼卡地平注射液治疗,疗程均为2周。比较对照组和观察组患者治疗后的疗效,治疗前后血流动力学参数(搏动指数、阻力指数、血流平均速度)、应激指标(血清皮质醇、丙二醛、超氧化物歧化酶)、脑神经功能因子(神经元特异性烯醇化酶、脑源性神经营养因子、神经肽Y)水平,治疗前及治疗后1周、2周的中国卒中量表评分及不良反应发生情况。结果观察组患者的治疗总有效率为90.00%(36/40),高于对照组的72.50%(29/40),差异有统计学意义(χ^(2)=4.021,P=0.045)。治疗后观察组患者的搏动指数及血流平均速度[分别为(1.49±0.42)、(72.48±6.54)cm/s]均高于对照组[分别为(1.31±0.34)、(67.84±5.93)cm/s];观察组患者的阻力指数(1.14±0.47)低于对照组(1.38±0.49),差异有统计学意义(t=2.107、3.324、2.236,P=0.038、0.001、0.028)。治疗后观察组患者的皮质醇、丙二醛水平[分别为(14.26±2.87)μg/dL、(4.21±0.89)nmol/mL]均低于对照组[分别为(16.52±3.02)μg/dL、(5.65±1.02)nmol/mL],超氧化物歧化酶水平[(161.54±13.54)U/mL]高于对照组[(142.45±12.87)U/mL],差异有统计学意义(t=3.431、6.728、6.463,P<0.05)。治疗后观察组患者的神经元特异性烯醇化酶、神经肽Y水平[分别为(14.56±2.13)ng/mL、(125.85±12.31)pg/mL]均低于对照组[分别为(16.45±2.87)ng/mL、(136.72±14.84)pg/mL],脑源性神经营养因子水平[(2540.68±421.63)pg/mL]高于对照组[(2270.31±372.51)pg/mL],差异有统计学意义(t=3.345、3.566、4.287,P<0.05)。对照组和观察组患者中国卒中量表评分的组间效应、时间效应和交互效应比较,差异均有统计学意义(F_(组间)=11.630,P_(组间)=0.001;F_(时间)=87.840,P_(时间)<0.001;F_(交互)=5.068,P_(交互)=0.007)。治疗后1周、2周观察组患者的中国卒中量表评分[分别为(16.14±5.18)分、(11.32±5.91)分]均低于对照组[分别为(21.23±5.07)分、(15.23±5.12)分],差异有统计学意义(t=4.441、3.163,均P<0.05)。观察组和对照组患者的不良反应发生率分别为15.00%(6/40)、17.50%(7/40),差异无统计学意义(χ^(2)=0.092,P>0.05)。结论尼卡地平联合颅内血肿微创清除术治疗高血压脑出血的效果明显,可有效调节血流动力学及应激水平,促进脑神经功能恢复,且安全性较好。 展开更多
关键词 尼卡地平 颅内血肿微创清除术 高血压脑出血 脑神经功能因子 应激水平 中国卒中量表评分
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