Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental ...Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental trajectories of discrimination perception,vocational identity,and psychological resilience in this population.It further examined the longitudinal mediating role of vocational identity in the relationship between discrimination perception and psychological resilience.Methods:A total of 526 students from five vocational high schools in Guangdong,China,were assessed via convenience sampling at two time points:baseline(T1,September 2023)and six-month follow-up(T2,March 2024).Measures of discrimination perception,psychological resilience,and vocational identity were administered.Data were analyzed using a cross-lagged panel model to test for bidirectional relationships.Results:Over the six-month period,students showed significant decreases in discrimination perception and vocational identity,but a significant increase in psychological resilience.The cross-lagged model revealed significant bidirectional relationships:discrimination perception and psychological resilience negatively predicted each other over time(β=−0.124,p<0.01;β=−0.200,p<0.001),while psychological resilience and vocational identity positively predicted each other(β=0.084,p<0.05;β=0.076,p<0.05).The mediation analysis revealed a dual-pathway mechanism.T1 discrimination perception exerted both a significant direct negative effect on T2 psychological resilience(β=−0.332,p<0.001)and a significant indirect positive effect via T1 vocational identity(indirect effect=0.020,95%CI[0.001,0.046]).This confirms a partial mediating role,indicating that vocational identity functions as a compensatory mechanism,transforming the experience of discrimination perception into a potential source of psychological resilience.Conclusions:For vocational high school students,perception of discrimination directly undermines psychological resilience,but also indirectly fosters it through the positive development of vocational identity.These findings highlight vocational identity as a pivotal mechanism in the complex relationship between social adversity and mental resilience.展开更多
The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing ...The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing advanced teacher training programs aimed at cultivating student agency,a comprehensive set of skills necessary for children living in the future,as advocated by the Organisation for Economic Co-operation and Development(OECD)Education 2030 Project.To achieve this goal,I examined the curriculum and structure that are important for IB teacher training and the introduction of IBCTL.I attempted to achieve this goal by examining the curriculum being developed at a graduate school of teacher education attempting to implement IBCTL and the creation of a syllabus based on that curriculum through lesson planning.As a result,I examined the curriculum and structure as a perspective for introducing IBCTL into graduate school of teacher education in Japan,where advanced teacher training is required.I found that a core curriculum and structure that incorporates the core of the IBCTL into the core of graduate school of teacher education programs is important for implementing an IB education that is aligned with the advancement of teacher training and the development of student agency.展开更多
Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco...Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use^([1]).Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.展开更多
Inside the exhibition hall of the 2025 Osaka World Expo in Japan,crowds gathered before a cloisonne enamel painting titled The Pomegranate of Ethnic Unity.The pomegranate,outlined with gold filigree,appears full and r...Inside the exhibition hall of the 2025 Osaka World Expo in Japan,crowds gathered before a cloisonne enamel painting titled The Pomegranate of Ethnic Unity.The pomegranate,outlined with gold filigree,appears full and ripe;Tibetan auspicious motifs intertwine with Han-style cloud patterns,and the enamel glaze reflects brilliant colors under the lights.Created by teachers and students from Nyingchi Vocational and Technical School(hereafter“Nyingchi Vocational School”),this artwork not only drew admiration from countless visitors but also became a“silent envoy”of dialogue between Tibetan culture and the world.展开更多
目的:基于网络药理学和分子对接技术,探讨经验方归元膏的活性成分防治慢性疲劳综合征(CFS)的潜在机制。方法:从TCMSP数据库、BATMAN数据库筛选归元膏的化学成分和靶点,通过GeneCards、OMIM、DisGenet数据库检索收集CFS靶点,将归元膏作...目的:基于网络药理学和分子对接技术,探讨经验方归元膏的活性成分防治慢性疲劳综合征(CFS)的潜在机制。方法:从TCMSP数据库、BATMAN数据库筛选归元膏的化学成分和靶点,通过GeneCards、OMIM、DisGenet数据库检索收集CFS靶点,将归元膏作用靶点和疾病靶点取交集,使用Cytoscape Version 3.9.1制做药物和疾病靶点韦恩图,运用STRING数据库构建蛋白质与蛋白质相互作用的PPI网络作用图,并通过Cytoscape3.8.2软件中的插件CytoNCA筛选关键靶点,并将交集靶点导入David数据库,利用微生信程序进行基因本体(GO)和京都和基因组百科全书(KEGG)富集分析,并通过Cytoscape3.8.2构建归元膏药物–有效成分–靶点和归元膏药物–成分–靶点–通路网络,最后用AutoDock vinna软件进行分子对接验证。结果:检索出归元膏活性成分有111个,其中quercetin,isoflavanone,poriferasta-7,22E-dien-3beta-ol,hancinol,orchinol等为归元膏防治CFS的关键成分,CFS相关靶点507个,其中IL-6 (白细胞介素-6),TNF (肿瘤坏死因子),STAT3 (信号转导及转录激活因子3),JUN,BCL2 (B细胞淋巴瘤/白血病-2),HIF1A (缺氧诱导因子1α亚单位),AKT1 (AKT丝氨酸/苏氨酸激酶1),CASP3 (caspase-3),MMP9 (基质金属蛋白酶9),NFKB1 (核因子kappa B亚基1)为防治CFS的关键靶点,GO富集分析示生物学过程方面可能通过对凋亡过程的负调控、细胞增殖的正调控、蛋白质磷酸化的正调控、内皮细胞增殖的正调控等,分子功能主要包括酶结合、受体结合、蛋白酶结合等;细胞功能主要包含线粒体、蛋白质复合物、细胞内膜结合的细胞器等。KEGG富集分析一共得到186条信号通路,主要与PI3K-Akt通路、卡波西肉瘤相关疱疹病毒感染、丝裂原活化蛋白激酶信号通路等有关。分子对接结果表明归元膏中的核心作用靶点和主要活性成分具备稳定性的结合活性。结论:归元膏将quercetin、poriferasta-7,22E-dien-3beta-ol、orchinol、isoflavanone等关键活性成分与IL6、TNF、STAT3、JUN、BCL2、HIF1A、AKT1和CASP3等靶点结合,通过对PI3K/Akt、MAPK、NF-κB等多条信号通路的调控,调节了CFS患者的免疫反应、细胞凋亡、代谢紊乱等多个生物学过程。通过激活抗凋亡通路、抑制促炎因子的产生和调节能量代谢,验证了该方多靶点多线路的调控,发挥了多靶点、多通路的协同作用,显著改善了CFS的症状。Objective: Based on network pharmacology and molecular docking technology, this study explores the potential mechanisms of active ingredients in the empirical formula Guiyuan Ointment for the prevention and treatment of chronic fatigue syndrome (CFS). Methods: Chemical components and targets of Guiyuan Ointment were screened from the TCMSP database and BATMAN database. CFS targets were collected through GeneCards, OMIM, and DisGenet databases. The intersection of Guiyuan Ointment’s action targets and disease targets was taken. Cytoscape Version 3.9.1 was used to create a Venn diagram of drug and disease targets. The STRING database was employed to construct a protein-protein interaction (PPI) network diagram, and key targets were screened using the CytoNCA plugin in Cytoscape 3.8.2 software. The intersection targets were imported into the David database, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the microbioinformatics program. Cytoscape 3.8.2 was used to construct the Guiyuan Ointment drug-effective component-target and drug-component-target-pathway networks. Finally, molecular docking validation was conducted using AutoDock Vina software. Results: A total of 111 active components of Guiyuan Ointment were retrieved, among which quercetin, isoflavanone, poriferasta-7,22E-dien-3beta-ol, hancinol, and orchinol are key components for the prevention and treatment of CFS by Guiyuan Ointment. There are 507 CFS-related targets, with IL-6 (interleukin-6), TNF (tumor necrosis factor), STAT3 (signal transducer and activator of transcription 3), JUN, BCL2 (B-cell lymphoma/leukemia-2), HIF1A (hypoxia-inducible factor 1α subunit), AKT1 (AKT serine/threonine kinase 1), CASP3 (caspase-3), MMP9 (matrix metallopeptidase 9), and NFKB1 (nuclear factor kappa B subunit 1) being key targets for the prevention and treatment of CFS. GO enrichment analysis showed that in terms of biological processes, it may involve negative regulation of apoptosis, positive regulation of cell proliferation, positive regulation of protein phosphorylation, and positive regulation of endothelial cell proliferation, etc. The main molecular functions include enzyme binding, receptor binding, and protease binding, etc. The main cellular functions involve mitochondria, protein complexes, and cell organelles bound to the intracellular membrane, etc. KEGG enrichment analysis yielded a total of 186 signaling pathways, mainly related to the PI3K-Akt pathway, Kaposi’s sarcoma-associated herpesvirus infection, and mitogen-activated protein kinase signaling pathway, etc. The molecular docking results indicated that the core action targets and main active components in Guiyuan Ointment have stable binding activity. Conclusion: Guiyuan Ointment combines key active components such as quercetin, poriferasta-7,22E-dien-3beta-ol, orchinol, and isoflavanone with targets like IL6, TNF, STAT3, JUN, BCL2, HIF1A, AKT1, and CASP3. By regulating multiple signaling pathways such as PI3K/Akt, MAPK, and NF-κB, it modulates various biological processes in CFS patients, including immune response, cell apoptosis, and metabolic disorders. Through activating anti-apoptotic pathways, inhibiting the production of pro-inflammatory factors, and regulating energy metabolism, it verifies the multi-target and multi-pathway regulation of this formula, exerting synergistic effects on multiple targets and pathways, and significantly improving the symptoms of CFS.展开更多
Public English carries significant moral education responsibilities as a core general education course in vocational schools.By organically integrating English teaching content with moral education,it achieves the uni...Public English carries significant moral education responsibilities as a core general education course in vocational schools.By organically integrating English teaching content with moral education,it achieves the unity of knowledge imparting and value guidance.The course should fully leverage its educational function by strengthening humanistic care and psychological counseling,guiding students to develop self-awareness,understand their responsibilities,and establish correct worldviews,outlooks on life,and values,ultimately fostering well-rounded development.展开更多
Marine heatwaves(MHWs),which can exert devastating socioeconomic and ecological impacts,have attracted much public interest in recent years.In this study,we evaluate the sub-seasonal forecast skill of MHWs based on th...Marine heatwaves(MHWs),which can exert devastating socioeconomic and ecological impacts,have attracted much public interest in recent years.In this study,we evaluate the sub-seasonal forecast skill of MHWs based on the Nanjing University of Information Science&Technology Climate Forecast System version 1.1(NUIST CFS1.1)and analyze the related physical processes.Our results show that the model can accurately forecast the occurrence of MHWs on a global scale out to a lead time of 25 days.Notably,even at lead times of 51–55 days,the forecast skill in most tropical regions,as well as in the northeastern and southeastern Pacific,is superior to both random forecasts and persistence forecasts.Accurate predictions of sea level pressure,zonal currents,and mixed-layer depth are important for MHW forecasting.Furthermore,we also conduct forecast skill assessments for two well-documented MHW events.Due to its ability to correctly forecast the changes in heat flux anomalies at a lead time of 25 days,the model can accurately forecast the strong MHW event that occurred in the South China Sea in May–October 2020.However,the forecasting results were less than optimal for the strong MHW event that occurred along the Australian west coast in January–April 2011.Although the model accurately forecasts its occurrence,the forecast of its intensity is poor.Additionally,when the lead time exceeds 10 days,forecasts of the relevant physical processes of this MHW event are also inaccurate.展开更多
Hello,everyone.My English name is Molly.I am a girl.I am 7 years old.I'm a primary school student.I'm in Class 4,Grade 2 at Beijing Jianhua ExperimentalSchooll.
Tom is an American student.He is ten years old.But he does not live in the USA now.He lives with his father,mother and grandfather in a small city in China.Tom has a Chinese name,Tang Mu.He is in Grade Three at a prim...Tom is an American student.He is ten years old.But he does not live in the USA now.He lives with his father,mother and grandfather in a small city in China.Tom has a Chinese name,Tang Mu.He is in Grade Three at a primary school.He goes to school from Monday to Friday.Every morning,he gets up at 6:30.He brushes his teeth and washes his face.Then he has breakfast with his family.His parents often cook eggs and noodles.At 7:30,Tom goes to school.He walks to school with his best friend,Mike.Mike is a Chinese boy.His Chinese name is Ma Ke.Mike is his English name.Tom's house is to the left of Mike's.It is about 80 metres away from Mike's.展开更多
Parental educational anxiety has become a social symptom in China,and rural primary school students’mothers exhibit unique educational anxieties due to their special living environment.Based on interviews with 10 rur...Parental educational anxiety has become a social symptom in China,and rural primary school students’mothers exhibit unique educational anxieties due to their special living environment.Based on interviews with 10 rural primary school students’mothers,five typical educational anxiety experiences were selected for analysis,and themes such as rural life burden,children’s learning habits,mothers’educational expectations,mothers’educational methods,mothers’emotional state,deviation between reality and expectations,homework guidance ability,mothers’educational level,and attitudes towards children’s future development were refined.The root causes of educational anxiety among rural primary school students’mothers include the deviation between children’s actual performance and mothers’educational expectations,the sense of disparity under social comparison,physical and mental exhaustion caused by role overload,anxiety triggered by excessive economic burden,and a sense of powerlessness towards children’s educational outcomes.To alleviate the educational anxiety of rural primary school students’mothers,mothers should actively adjust themselves,fathers should actively participate in their children’s education,society should create a healthy atmosphere,and schools should strengthen family education guidance.展开更多
In the process of daily psychological counseling,it is found that more and more school-age children have a dislike for learning,and the rate is increasing year by year.They are unclear about the purpose of learning,lo...In the process of daily psychological counseling,it is found that more and more school-age children have a dislike for learning,and the rate is increasing year by year.They are unclear about the purpose of learning,lose interest in class,do not listen carefully,cannot complete homework independently,and even skip school.This case analyzes the mechanism of a 7-year-old primary school student's aversion to learning and analyzes and discusses this behavior.展开更多
Background: Clinical decision support tools provide suggestions to support healthcare providers and clinicians, as they attend to patients. Clinicians use these tools to rapidly consult the evidence at the point of ca...Background: Clinical decision support tools provide suggestions to support healthcare providers and clinicians, as they attend to patients. Clinicians use these tools to rapidly consult the evidence at the point of care, a practice which has been found to reduce the time patients spend in hospitals, promote the quality of care and improve healthcare outcomes. Such tools include Medscape, VisualDx, Clinical Key, DynaMed, BMJ Best Practice and UpToDate. However, use of such tools has not yet been fully embraced in low-resource settings such as Uganda. Objective: This paper intends to collate data on the use and uptake of one such tool, UpToDate, which was provided at no cost to five medical schools in Uganda. Methods: Free access to UpToDate was granted through the IP addresses of five medical schools in Uganda in collaboration with Better Evidence at The Global Health Delivery Project at Harvard and Brigham and Women’s Hospital and Wolters Kluwer Health. Following the donation, medical librarians in the respective institutions conducted training sessions and created awareness of the tool. Usage data was aggregated, based on logins and content views, presented and analyzed using Excel tables and graphs. Results: The data shows similar trends in increased usage over the period of August 2022 to August 2023 across the five medical schools. The most common topics viewed, mode of access (using either the computer or the mobile app), total usage by institution, ratio of uses to eligible users by institution and ratio of uses to students by institution are shared. Conclusion: The study revealed that the tool was used by various user categories across the institutions with similar steady improved usage over the year. These results can inform the librarians as they encourage their respective institutions to continue using the tool to support uptake of point-of-care tools in clinical practice.展开更多
From the Lhasa River valley to the pastures of the northern plateau,the lights of boarding schools now stretch like a quiet,glowing ribbon across the high-altitude night sky.Sixty years ago,this ribbon did not exist;t...From the Lhasa River valley to the pastures of the northern plateau,the lights of boarding schools now stretch like a quiet,glowing ribbon across the high-altitude night sky.Sixty years ago,this ribbon did not exist;today,it has become one of the most heartwarming footnotes to Xizang's modernization.As the Xizang Autonomous Region marks its 60th founding anniversary,we retrace the development of boarding education and witness how the sense of community for the Chinese nation has taken root-in dormitories and classrooms alike-while also observing the transformation from"access to schooling"to"access to quality education"under the framework of regional ethnic autonomy.展开更多
Hello,everyone.My name is Guo Yunhan,and I am twelve years old.I study at Xinshidai Primary Schoolof Xinxiang County.Now I am in Class Fourr,Grade Six.I love my school very much.There are tall buildings and a big play...Hello,everyone.My name is Guo Yunhan,and I am twelve years old.I study at Xinshidai Primary Schoolof Xinxiang County.Now I am in Class Fourr,Grade Six.I love my school very much.There are tall buildings and a big playground in my school.The playground is wide and bright.We often do sports there,such as ping-pong,basketball,football,and badminton.Sometimes we run races,and sometimes we play games together.It is always full of laughter.展开更多
Objective:This study aimed to evaluate the effectiveness of an integrative educational intervention-combining hospital-based schooling programs,child-centered communication,and therapeutic play-on clinical,psychosocia...Objective:This study aimed to evaluate the effectiveness of an integrative educational intervention-combining hospital-based schooling programs,child-centered communication,and therapeutic play-on clinical,psychosocial,and educational outcomes among school-aged children with cancer.Materials and Methods:A quasi-experimental pre-and post-test control group design was conducted at the pediatric oncology unit of Rumah Sakit Islam Jemursari,Surabaya,Indonesia.Fifty-two hospitalized children aged 6-18 years were randomly assigned to an intervention group(n=26)or a control group(n=26).The intervention lasted 1 month and integrated hospital-based lessons aligned with the national curriculum,therapeutic play,and developmentally appropriate communication by trained staff.Outcomes included pain intensity(Wong-Baker FACES Scale),treatment adherence,quality of life(Pediatric Cancer Quality of Life-32[PCQL-32]),anxiety(Revised Children’s Manifest Anxiety Scale),and literacy-numeracy performance.Data were analyzed using paired t-tests,ANCOVA,and Cohen’s d,with significance set at P<0.05.Results:Compared with controls,the intervention group showed significant improvements in pain reduction(P<0.001),treatment adherence(P<0.001),and quality of life across all PCQL-32 domains(P<0.001).Anxiety levels decreased significantly(P<0.001),and academic performance in literacy and numeracy improved markedly(P<0.001).Conclusion:The integrative educational intervention effectively enhanced clinical recovery,psychosocial well-being,and academic continuity among hospitalized children with cancer,emphasizing the need to integrate hospital-based education and play-based communication into pediatric oncology care.展开更多
基金supported by the Guangdong Provincial Philosophy and Social Science“14th Five-Year Plan”Discipline Co-Construction Project(Grant No.GD22XJY14)the 2022 Guangdong Provincial Higher Education Teaching Reform Project(Grant No.Yue Jiao Gao[2023]4)Guangdong Polytechnic Normal University’s Project for Enhancing the Research Capacity of Doctoral Application Institution(Grant No.22GPNUZDJS48).
文摘Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental trajectories of discrimination perception,vocational identity,and psychological resilience in this population.It further examined the longitudinal mediating role of vocational identity in the relationship between discrimination perception and psychological resilience.Methods:A total of 526 students from five vocational high schools in Guangdong,China,were assessed via convenience sampling at two time points:baseline(T1,September 2023)and six-month follow-up(T2,March 2024).Measures of discrimination perception,psychological resilience,and vocational identity were administered.Data were analyzed using a cross-lagged panel model to test for bidirectional relationships.Results:Over the six-month period,students showed significant decreases in discrimination perception and vocational identity,but a significant increase in psychological resilience.The cross-lagged model revealed significant bidirectional relationships:discrimination perception and psychological resilience negatively predicted each other over time(β=−0.124,p<0.01;β=−0.200,p<0.001),while psychological resilience and vocational identity positively predicted each other(β=0.084,p<0.05;β=0.076,p<0.05).The mediation analysis revealed a dual-pathway mechanism.T1 discrimination perception exerted both a significant direct negative effect on T2 psychological resilience(β=−0.332,p<0.001)and a significant indirect positive effect via T1 vocational identity(indirect effect=0.020,95%CI[0.001,0.046]).This confirms a partial mediating role,indicating that vocational identity functions as a compensatory mechanism,transforming the experience of discrimination perception into a potential source of psychological resilience.Conclusions:For vocational high school students,perception of discrimination directly undermines psychological resilience,but also indirectly fosters it through the positive development of vocational identity.These findings highlight vocational identity as a pivotal mechanism in the complex relationship between social adversity and mental resilience.
文摘The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing advanced teacher training programs aimed at cultivating student agency,a comprehensive set of skills necessary for children living in the future,as advocated by the Organisation for Economic Co-operation and Development(OECD)Education 2030 Project.To achieve this goal,I examined the curriculum and structure that are important for IB teacher training and the introduction of IBCTL.I attempted to achieve this goal by examining the curriculum being developed at a graduate school of teacher education attempting to implement IBCTL and the creation of a syllabus based on that curriculum through lesson planning.As a result,I examined the curriculum and structure as a perspective for introducing IBCTL into graduate school of teacher education in Japan,where advanced teacher training is required.I found that a core curriculum and structure that incorporates the core of the IBCTL into the core of graduate school of teacher education programs is important for implementing an IB education that is aligned with the advancement of teacher training and the development of student agency.
基金supported by the World Health Organization Global Youth Tobacco Survey(WPDHP1206671)the Global Health Capacity Building and Tobacco Control Project:Tobacco Epidemic Monitoring and Comprehensive Tobacco Control Intervention。
文摘Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use^([1]).Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.
文摘Inside the exhibition hall of the 2025 Osaka World Expo in Japan,crowds gathered before a cloisonne enamel painting titled The Pomegranate of Ethnic Unity.The pomegranate,outlined with gold filigree,appears full and ripe;Tibetan auspicious motifs intertwine with Han-style cloud patterns,and the enamel glaze reflects brilliant colors under the lights.Created by teachers and students from Nyingchi Vocational and Technical School(hereafter“Nyingchi Vocational School”),this artwork not only drew admiration from countless visitors but also became a“silent envoy”of dialogue between Tibetan culture and the world.
文摘目的:基于网络药理学和分子对接技术,探讨经验方归元膏的活性成分防治慢性疲劳综合征(CFS)的潜在机制。方法:从TCMSP数据库、BATMAN数据库筛选归元膏的化学成分和靶点,通过GeneCards、OMIM、DisGenet数据库检索收集CFS靶点,将归元膏作用靶点和疾病靶点取交集,使用Cytoscape Version 3.9.1制做药物和疾病靶点韦恩图,运用STRING数据库构建蛋白质与蛋白质相互作用的PPI网络作用图,并通过Cytoscape3.8.2软件中的插件CytoNCA筛选关键靶点,并将交集靶点导入David数据库,利用微生信程序进行基因本体(GO)和京都和基因组百科全书(KEGG)富集分析,并通过Cytoscape3.8.2构建归元膏药物–有效成分–靶点和归元膏药物–成分–靶点–通路网络,最后用AutoDock vinna软件进行分子对接验证。结果:检索出归元膏活性成分有111个,其中quercetin,isoflavanone,poriferasta-7,22E-dien-3beta-ol,hancinol,orchinol等为归元膏防治CFS的关键成分,CFS相关靶点507个,其中IL-6 (白细胞介素-6),TNF (肿瘤坏死因子),STAT3 (信号转导及转录激活因子3),JUN,BCL2 (B细胞淋巴瘤/白血病-2),HIF1A (缺氧诱导因子1α亚单位),AKT1 (AKT丝氨酸/苏氨酸激酶1),CASP3 (caspase-3),MMP9 (基质金属蛋白酶9),NFKB1 (核因子kappa B亚基1)为防治CFS的关键靶点,GO富集分析示生物学过程方面可能通过对凋亡过程的负调控、细胞增殖的正调控、蛋白质磷酸化的正调控、内皮细胞增殖的正调控等,分子功能主要包括酶结合、受体结合、蛋白酶结合等;细胞功能主要包含线粒体、蛋白质复合物、细胞内膜结合的细胞器等。KEGG富集分析一共得到186条信号通路,主要与PI3K-Akt通路、卡波西肉瘤相关疱疹病毒感染、丝裂原活化蛋白激酶信号通路等有关。分子对接结果表明归元膏中的核心作用靶点和主要活性成分具备稳定性的结合活性。结论:归元膏将quercetin、poriferasta-7,22E-dien-3beta-ol、orchinol、isoflavanone等关键活性成分与IL6、TNF、STAT3、JUN、BCL2、HIF1A、AKT1和CASP3等靶点结合,通过对PI3K/Akt、MAPK、NF-κB等多条信号通路的调控,调节了CFS患者的免疫反应、细胞凋亡、代谢紊乱等多个生物学过程。通过激活抗凋亡通路、抑制促炎因子的产生和调节能量代谢,验证了该方多靶点多线路的调控,发挥了多靶点、多通路的协同作用,显著改善了CFS的症状。Objective: Based on network pharmacology and molecular docking technology, this study explores the potential mechanisms of active ingredients in the empirical formula Guiyuan Ointment for the prevention and treatment of chronic fatigue syndrome (CFS). Methods: Chemical components and targets of Guiyuan Ointment were screened from the TCMSP database and BATMAN database. CFS targets were collected through GeneCards, OMIM, and DisGenet databases. The intersection of Guiyuan Ointment’s action targets and disease targets was taken. Cytoscape Version 3.9.1 was used to create a Venn diagram of drug and disease targets. The STRING database was employed to construct a protein-protein interaction (PPI) network diagram, and key targets were screened using the CytoNCA plugin in Cytoscape 3.8.2 software. The intersection targets were imported into the David database, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the microbioinformatics program. Cytoscape 3.8.2 was used to construct the Guiyuan Ointment drug-effective component-target and drug-component-target-pathway networks. Finally, molecular docking validation was conducted using AutoDock Vina software. Results: A total of 111 active components of Guiyuan Ointment were retrieved, among which quercetin, isoflavanone, poriferasta-7,22E-dien-3beta-ol, hancinol, and orchinol are key components for the prevention and treatment of CFS by Guiyuan Ointment. There are 507 CFS-related targets, with IL-6 (interleukin-6), TNF (tumor necrosis factor), STAT3 (signal transducer and activator of transcription 3), JUN, BCL2 (B-cell lymphoma/leukemia-2), HIF1A (hypoxia-inducible factor 1α subunit), AKT1 (AKT serine/threonine kinase 1), CASP3 (caspase-3), MMP9 (matrix metallopeptidase 9), and NFKB1 (nuclear factor kappa B subunit 1) being key targets for the prevention and treatment of CFS. GO enrichment analysis showed that in terms of biological processes, it may involve negative regulation of apoptosis, positive regulation of cell proliferation, positive regulation of protein phosphorylation, and positive regulation of endothelial cell proliferation, etc. The main molecular functions include enzyme binding, receptor binding, and protease binding, etc. The main cellular functions involve mitochondria, protein complexes, and cell organelles bound to the intracellular membrane, etc. KEGG enrichment analysis yielded a total of 186 signaling pathways, mainly related to the PI3K-Akt pathway, Kaposi’s sarcoma-associated herpesvirus infection, and mitogen-activated protein kinase signaling pathway, etc. The molecular docking results indicated that the core action targets and main active components in Guiyuan Ointment have stable binding activity. Conclusion: Guiyuan Ointment combines key active components such as quercetin, poriferasta-7,22E-dien-3beta-ol, orchinol, and isoflavanone with targets like IL6, TNF, STAT3, JUN, BCL2, HIF1A, AKT1, and CASP3. By regulating multiple signaling pathways such as PI3K/Akt, MAPK, and NF-κB, it modulates various biological processes in CFS patients, including immune response, cell apoptosis, and metabolic disorders. Through activating anti-apoptotic pathways, inhibiting the production of pro-inflammatory factors, and regulating energy metabolism, it verifies the multi-target and multi-pathway regulation of this formula, exerting synergistic effects on multiple targets and pathways, and significantly improving the symptoms of CFS.
基金2024 Jilin Province Vocational and Adult Education Teaching Reform Research Project,“Ideological and Political Education in Public English Curriculum of Vocational Schools:Construction and Practice”(Project No.:2024ZCY352)。
文摘Public English carries significant moral education responsibilities as a core general education course in vocational schools.By organically integrating English teaching content with moral education,it achieves the unity of knowledge imparting and value guidance.The course should fully leverage its educational function by strengthening humanistic care and psychological counseling,guiding students to develop self-awareness,understand their responsibilities,and establish correct worldviews,outlooks on life,and values,ultimately fostering well-rounded development.
基金supported by National Natural Science Foundation of China(Grant Nos.42030605 and 42088101)National Key R&D Program of China(Grant No.2020YFA0608004)High Performance Computing of Nanjing University of Information Science&Technology for their support of this work。
文摘Marine heatwaves(MHWs),which can exert devastating socioeconomic and ecological impacts,have attracted much public interest in recent years.In this study,we evaluate the sub-seasonal forecast skill of MHWs based on the Nanjing University of Information Science&Technology Climate Forecast System version 1.1(NUIST CFS1.1)and analyze the related physical processes.Our results show that the model can accurately forecast the occurrence of MHWs on a global scale out to a lead time of 25 days.Notably,even at lead times of 51–55 days,the forecast skill in most tropical regions,as well as in the northeastern and southeastern Pacific,is superior to both random forecasts and persistence forecasts.Accurate predictions of sea level pressure,zonal currents,and mixed-layer depth are important for MHW forecasting.Furthermore,we also conduct forecast skill assessments for two well-documented MHW events.Due to its ability to correctly forecast the changes in heat flux anomalies at a lead time of 25 days,the model can accurately forecast the strong MHW event that occurred in the South China Sea in May–October 2020.However,the forecasting results were less than optimal for the strong MHW event that occurred along the Australian west coast in January–April 2011.Although the model accurately forecasts its occurrence,the forecast of its intensity is poor.Additionally,when the lead time exceeds 10 days,forecasts of the relevant physical processes of this MHW event are also inaccurate.
文摘Hello,everyone.My English name is Molly.I am a girl.I am 7 years old.I'm a primary school student.I'm in Class 4,Grade 2 at Beijing Jianhua ExperimentalSchooll.
文摘Tom is an American student.He is ten years old.But he does not live in the USA now.He lives with his father,mother and grandfather in a small city in China.Tom has a Chinese name,Tang Mu.He is in Grade Three at a primary school.He goes to school from Monday to Friday.Every morning,he gets up at 6:30.He brushes his teeth and washes his face.Then he has breakfast with his family.His parents often cook eggs and noodles.At 7:30,Tom goes to school.He walks to school with his best friend,Mike.Mike is a Chinese boy.His Chinese name is Ma Ke.Mike is his English name.Tom's house is to the left of Mike's.It is about 80 metres away from Mike's.
基金Hunan Provincial Social Science Foundation“A Phenomenological Study on the Educational Life Experiences of Rural Young Teachers”(20YBA017)。
文摘Parental educational anxiety has become a social symptom in China,and rural primary school students’mothers exhibit unique educational anxieties due to their special living environment.Based on interviews with 10 rural primary school students’mothers,five typical educational anxiety experiences were selected for analysis,and themes such as rural life burden,children’s learning habits,mothers’educational expectations,mothers’educational methods,mothers’emotional state,deviation between reality and expectations,homework guidance ability,mothers’educational level,and attitudes towards children’s future development were refined.The root causes of educational anxiety among rural primary school students’mothers include the deviation between children’s actual performance and mothers’educational expectations,the sense of disparity under social comparison,physical and mental exhaustion caused by role overload,anxiety triggered by excessive economic burden,and a sense of powerlessness towards children’s educational outcomes.To alleviate the educational anxiety of rural primary school students’mothers,mothers should actively adjust themselves,fathers should actively participate in their children’s education,society should create a healthy atmosphere,and schools should strengthen family education guidance.
文摘In the process of daily psychological counseling,it is found that more and more school-age children have a dislike for learning,and the rate is increasing year by year.They are unclear about the purpose of learning,lose interest in class,do not listen carefully,cannot complete homework independently,and even skip school.This case analyzes the mechanism of a 7-year-old primary school student's aversion to learning and analyzes and discusses this behavior.
文摘Background: Clinical decision support tools provide suggestions to support healthcare providers and clinicians, as they attend to patients. Clinicians use these tools to rapidly consult the evidence at the point of care, a practice which has been found to reduce the time patients spend in hospitals, promote the quality of care and improve healthcare outcomes. Such tools include Medscape, VisualDx, Clinical Key, DynaMed, BMJ Best Practice and UpToDate. However, use of such tools has not yet been fully embraced in low-resource settings such as Uganda. Objective: This paper intends to collate data on the use and uptake of one such tool, UpToDate, which was provided at no cost to five medical schools in Uganda. Methods: Free access to UpToDate was granted through the IP addresses of five medical schools in Uganda in collaboration with Better Evidence at The Global Health Delivery Project at Harvard and Brigham and Women’s Hospital and Wolters Kluwer Health. Following the donation, medical librarians in the respective institutions conducted training sessions and created awareness of the tool. Usage data was aggregated, based on logins and content views, presented and analyzed using Excel tables and graphs. Results: The data shows similar trends in increased usage over the period of August 2022 to August 2023 across the five medical schools. The most common topics viewed, mode of access (using either the computer or the mobile app), total usage by institution, ratio of uses to eligible users by institution and ratio of uses to students by institution are shared. Conclusion: The study revealed that the tool was used by various user categories across the institutions with similar steady improved usage over the year. These results can inform the librarians as they encourage their respective institutions to continue using the tool to support uptake of point-of-care tools in clinical practice.
文摘From the Lhasa River valley to the pastures of the northern plateau,the lights of boarding schools now stretch like a quiet,glowing ribbon across the high-altitude night sky.Sixty years ago,this ribbon did not exist;today,it has become one of the most heartwarming footnotes to Xizang's modernization.As the Xizang Autonomous Region marks its 60th founding anniversary,we retrace the development of boarding education and witness how the sense of community for the Chinese nation has taken root-in dormitories and classrooms alike-while also observing the transformation from"access to schooling"to"access to quality education"under the framework of regional ethnic autonomy.
文摘Hello,everyone.My name is Guo Yunhan,and I am twelve years old.I study at Xinshidai Primary Schoolof Xinxiang County.Now I am in Class Fourr,Grade Six.I love my school very much.There are tall buildings and a big playground in my school.The playground is wide and bright.We often do sports there,such as ping-pong,basketball,football,and badminton.Sometimes we run races,and sometimes we play games together.It is always full of laughter.
文摘Objective:This study aimed to evaluate the effectiveness of an integrative educational intervention-combining hospital-based schooling programs,child-centered communication,and therapeutic play-on clinical,psychosocial,and educational outcomes among school-aged children with cancer.Materials and Methods:A quasi-experimental pre-and post-test control group design was conducted at the pediatric oncology unit of Rumah Sakit Islam Jemursari,Surabaya,Indonesia.Fifty-two hospitalized children aged 6-18 years were randomly assigned to an intervention group(n=26)or a control group(n=26).The intervention lasted 1 month and integrated hospital-based lessons aligned with the national curriculum,therapeutic play,and developmentally appropriate communication by trained staff.Outcomes included pain intensity(Wong-Baker FACES Scale),treatment adherence,quality of life(Pediatric Cancer Quality of Life-32[PCQL-32]),anxiety(Revised Children’s Manifest Anxiety Scale),and literacy-numeracy performance.Data were analyzed using paired t-tests,ANCOVA,and Cohen’s d,with significance set at P<0.05.Results:Compared with controls,the intervention group showed significant improvements in pain reduction(P<0.001),treatment adherence(P<0.001),and quality of life across all PCQL-32 domains(P<0.001).Anxiety levels decreased significantly(P<0.001),and academic performance in literacy and numeracy improved markedly(P<0.001).Conclusion:The integrative educational intervention effectively enhanced clinical recovery,psychosocial well-being,and academic continuity among hospitalized children with cancer,emphasizing the need to integrate hospital-based education and play-based communication into pediatric oncology care.
