For catalytic materials,the characteristics of one-dimension and hollowness are the promotion factors for their full presentation of catalytic activity,and through a template-as sis ted method,both above superiorities...For catalytic materials,the characteristics of one-dimension and hollowness are the promotion factors for their full presentation of catalytic activity,and through a template-as sis ted method,both above superiorities can be fused simultaneously.Here,we proposed a novel strategy inspired by Pearson's principle with Cu_(2)O wires as templates,and prepared FeOOH hollow tubes,which covered by FeOOH scales.When applied as oxygen evolution reaction(OER)catalyst,the FeOOH scaly hollow tubes(FeOOH SHTs)showed outstanding catalytic activity with a low overpotential of 245 mV to drive a current density of10 mA·cm^(-2),excellent kinetics manifesting as a low Tafel slope of 46.9 mV·dec^(-1),and robust stability.This work provides a new synthesis strategy for an ideal OER catalyst,FeOOH,with high inherent activity and enhances the feasibility to broaden the design ideas of transition metalbased catalysts.展开更多
Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis,including erythema,scales,or scaly plaques on the skin.These symptoms significantly affect patients...Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis,including erythema,scales,or scaly plaques on the skin.These symptoms significantly affect patients'quality of life and cause severe physical and psychological distress.However,current treatment strategies have limited therapeutic effect and may lead to adverse side effects.In this study,we present the novel organic photosensitizer TBTDC[5-(((5-(7-(4-(diphenylamino)phenyl)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)methylene)amino)-3-methylthiophene-2,4-dicarbonitrile]nanoparticles(NPs)with aggregation-induced emission(AIE)characteristics to mediate photodynamic therapy(TBTDC NP-PDT)for psoriasis treatment.We demonstrate that TBTDC NPs effectively generate reactive oxygen species upon light irradiation and lead to significant apoptosis of psoriatic keratinocytes.Furthermore,TBTDC NPs exhibit high cellular uptake in diseased keratinocytes and induce endoplasmic reticulum stress(ERS)-mediated autophagy,which can also enhance apoptosis.Importantly,TBTDC NPs show no cytotoxicity toward keratinocytes.These unique properties of TBTDC NPs enable remarkable therapeutic effects against psoriasis-like skin lesions and related inflammation in vivo.Overall,our AIE-active TBTDC NP-PDT represents a promising strategy for treating psoriasis in clinical settings.展开更多
Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal ...Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal species spanning three skin covering types(hairless,scaly and spiny),we found some genes(e.g.,UVRAG,POLH,and XPC)involved in skin inflammation,skin innate immunity,and ultraviolet radiation damage repair were under selection in hairless ocean mammals(e.g.,whales and manatees).These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation.Moreover,the genomes from three spiny mammal species shared convergent genomic regions(EPHB2,EPHA4,and NIN)and unique positively selected genes(FZD6,INVS,and CDC42)involved in skin cell polarity,which might be related to the development of spines.In scaly mammals,the shared convergent genomic regions(e.g.,FREM2)were associated with the integrity of the skin epithelium and epidermal adhesion.This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.展开更多
基金financially supported by the National Key Research and Development Program of China(No.2018YFA0703700)the National Natural Science Foundation of China(Nos.12004031,12034002 and 51971025)+3 种基金Beijing Natural Science Foundation(No.2212034)Foshan Talents Special Foundation(No.BKBS202003)the Scientific and Technological Innovation Foundation of Foshan(No.BK22BE005)Foshan Science and Technology Innovation Project(No.2018IT100363)。
文摘For catalytic materials,the characteristics of one-dimension and hollowness are the promotion factors for their full presentation of catalytic activity,and through a template-as sis ted method,both above superiorities can be fused simultaneously.Here,we proposed a novel strategy inspired by Pearson's principle with Cu_(2)O wires as templates,and prepared FeOOH hollow tubes,which covered by FeOOH scales.When applied as oxygen evolution reaction(OER)catalyst,the FeOOH scaly hollow tubes(FeOOH SHTs)showed outstanding catalytic activity with a low overpotential of 245 mV to drive a current density of10 mA·cm^(-2),excellent kinetics manifesting as a low Tafel slope of 46.9 mV·dec^(-1),and robust stability.This work provides a new synthesis strategy for an ideal OER catalyst,FeOOH,with high inherent activity and enhances the feasibility to broaden the design ideas of transition metalbased catalysts.
基金supported by the Natural Science Funding of Guangdong Province(2022A1515012312 and 2021A1515010023)the National Natural Science Funding of China(82070083)Dongguan Social development technology projects Science and Technology Planning Project(20231800940792).
文摘Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis,including erythema,scales,or scaly plaques on the skin.These symptoms significantly affect patients'quality of life and cause severe physical and psychological distress.However,current treatment strategies have limited therapeutic effect and may lead to adverse side effects.In this study,we present the novel organic photosensitizer TBTDC[5-(((5-(7-(4-(diphenylamino)phenyl)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)methylene)amino)-3-methylthiophene-2,4-dicarbonitrile]nanoparticles(NPs)with aggregation-induced emission(AIE)characteristics to mediate photodynamic therapy(TBTDC NP-PDT)for psoriasis treatment.We demonstrate that TBTDC NPs effectively generate reactive oxygen species upon light irradiation and lead to significant apoptosis of psoriatic keratinocytes.Furthermore,TBTDC NPs exhibit high cellular uptake in diseased keratinocytes and induce endoplasmic reticulum stress(ERS)-mediated autophagy,which can also enhance apoptosis.Importantly,TBTDC NPs show no cytotoxicity toward keratinocytes.These unique properties of TBTDC NPs enable remarkable therapeutic effects against psoriasis-like skin lesions and related inflammation in vivo.Overall,our AIE-active TBTDC NP-PDT represents a promising strategy for treating psoriasis in clinical settings.
基金supported by the National Natural Science Fund for Outstanding Youth Fund(31222009,31272295,31570489,81622048 and 81473377)the Project of Quality Guarantee System of Chinese Herbal Medicines(201507002)+1 种基金Science Foundation for Distinguished Young Scholars of Jiangsu Province(BK20140049)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal species spanning three skin covering types(hairless,scaly and spiny),we found some genes(e.g.,UVRAG,POLH,and XPC)involved in skin inflammation,skin innate immunity,and ultraviolet radiation damage repair were under selection in hairless ocean mammals(e.g.,whales and manatees).These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation.Moreover,the genomes from three spiny mammal species shared convergent genomic regions(EPHB2,EPHA4,and NIN)and unique positively selected genes(FZD6,INVS,and CDC42)involved in skin cell polarity,which might be related to the development of spines.In scaly mammals,the shared convergent genomic regions(e.g.,FREM2)were associated with the integrity of the skin epithelium and epidermal adhesion.This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.
