We herein present an efficient denitrative iodination method of(hetero)nitroarenes mediated by commercially available and cost-effective hydroiodic acid(HI).During the reaction process,HI plays its dual roles as both ...We herein present an efficient denitrative iodination method of(hetero)nitroarenes mediated by commercially available and cost-effective hydroiodic acid(HI).During the reaction process,HI plays its dual roles as both the sustainable reductant of nitro group and iodine source in the iodination step,which successfully integrates three steps into a one-pot procedure and significantly simplifies the reaction system.This approach enables a smooth metal-free conversion of nitroarenes to corresponding aryl iodides via one-pot process,exhibits a broad substrate scope and good reaction efficiency,and was conveniently applied in the concise synthesis of pharmaceuticals.展开更多
基金the National Key Research and Development Project(No.2023YFF1205103)the National Natural Science Foundation of China(No.22371007)the Peking University Medicine plus X Pilot Program-Key Technologies R&D Project(No.2024YXXLHGG001)for financial support。
文摘We herein present an efficient denitrative iodination method of(hetero)nitroarenes mediated by commercially available and cost-effective hydroiodic acid(HI).During the reaction process,HI plays its dual roles as both the sustainable reductant of nitro group and iodine source in the iodination step,which successfully integrates three steps into a one-pot procedure and significantly simplifies the reaction system.This approach enables a smooth metal-free conversion of nitroarenes to corresponding aryl iodides via one-pot process,exhibits a broad substrate scope and good reaction efficiency,and was conveniently applied in the concise synthesis of pharmaceuticals.
