Ultrasound imaging-guided spinal puncture is highly desirable for the treat-ment of degenerative diseases of the spine,cerebrospinal fluid sampling,and spinal anesthesia administration due to its real-time and portabl...Ultrasound imaging-guided spinal puncture is highly desirable for the treat-ment of degenerative diseases of the spine,cerebrospinal fluid sampling,and spinal anesthesia administration due to its real-time and portable na-ture.However,conventional ultrasound imaging guidance methods image the target area from outside the body and obtain only two-dimensional(2D)images,making it very difficult to identify the puncture needle and under-stand the situation behind the vertebrae during the puncture process.Here,we present a new method for placing a 2D ultrasound array trans-ducer into the needle tip.The array has a stepped shape that fits well with the puncture needle,and real-time three-dimensional(3D)volumetric images can be obtained in the body in front of the needle as guidance dur-ing the puncture procedure.Our innovative transducer design and fabrica-tion method enable the integration of a 10-MHz,256-element 2D array transducer in the needle tip,leading to superior imaging resolution.The re-sults of in vitro and in vivo pig experiments demonstrate that the needle po-sition can be clearly identified and guided during the puncture process.This technology can improve the guidance accuracy and greatly reduce un-expected risks during puncture procedures,which has great potential in spinal punctures in clinical settings.展开更多
基金supported by National Key R&D Program of China(2023YFC2416400)Shenzhen Medical Research Fund(B2302053)+6 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0930000)National Natural Science Foundation of China Grants of China(12274430,82327805,12304516,12174267,and 12204504)Shenzhen Foundation Grant(GJHZ20220913142810021,KCXFZ20230731093959009,JSGGZD20220822095602005,and ZDSYS201802061806314)CAS research projects(KFJ-PTXM-012)Natural Science Foundation of Guangdong Province(2024B1212010010,2022A1515011343,and 2020B1212060051)Youth Innovation Promotion Association CAS 2018391the ethical guidelines of the Shenzhen Advanced Animal Study Service Center,China(AMS D2305011P).
文摘Ultrasound imaging-guided spinal puncture is highly desirable for the treat-ment of degenerative diseases of the spine,cerebrospinal fluid sampling,and spinal anesthesia administration due to its real-time and portable na-ture.However,conventional ultrasound imaging guidance methods image the target area from outside the body and obtain only two-dimensional(2D)images,making it very difficult to identify the puncture needle and under-stand the situation behind the vertebrae during the puncture process.Here,we present a new method for placing a 2D ultrasound array trans-ducer into the needle tip.The array has a stepped shape that fits well with the puncture needle,and real-time three-dimensional(3D)volumetric images can be obtained in the body in front of the needle as guidance dur-ing the puncture procedure.Our innovative transducer design and fabrica-tion method enable the integration of a 10-MHz,256-element 2D array transducer in the needle tip,leading to superior imaging resolution.The re-sults of in vitro and in vivo pig experiments demonstrate that the needle po-sition can be clearly identified and guided during the puncture process.This technology can improve the guidance accuracy and greatly reduce un-expected risks during puncture procedures,which has great potential in spinal punctures in clinical settings.
