Fluorescence tomography can obtain a sufficient dataset and optimal three-dimensional imageswhen projections are captured over 360◦ by CCD camera. Herein a non-stop dynamic samplingmode for fluorescence tomography is ...Fluorescence tomography can obtain a sufficient dataset and optimal three-dimensional imageswhen projections are captured over 360◦ by CCD camera. Herein a non-stop dynamic samplingmode for fluorescence tomography is proposed in an attempt to improve the optical measurementspeed of the traditional imaging system and stability of the object to be imaged. A series ofsimulations are carried out to evaluate the accuracy of dataset acquired from the dynamicsampling mode. Reconstruction with the corresponding data obtained in the dynamic-modeprocess is also performed with the phantom. The results demonstrate the feasibility of suchan imaging mode when the angular velocity is set to the appropriate value, thus laying thefoundation for real experiments to verify the superiority in performance of this new imagingmode over the traditional one.展开更多
The general strategy and method of constructing universal calibration model for levofioxacin injections by near-infrared spectroscopy have been investigated and discussed. Firstly, a constant-temperature homogeneous l...The general strategy and method of constructing universal calibration model for levofioxacin injections by near-infrared spectroscopy have been investigated and discussed. Firstly, a constant-temperature homogeneous liquid calibration model for levofloxacin hydrochloride injections with the same composition but different active principal ingredient （API） content was established as the basic unit for universal model. Then, samples of levofloxacin hydrochloride injections containing propylene glycol or levofloxacin lactate injections were added to develop a primary constant-temperature liquid universal model. Temperature- amended final universal model was established to apply to samples under different temperatures. The final model was built from 61 calibration samples and 77 validation samples. The value of the root mean square error of cross validation （RMSECV） and coefficient of determination （r2） of leave-one-out cross-validation （LOOCV） were 0.792 and 0.9993, respectively, the root mean square error of prediction （RMSEP） of test set validation （TSV） was 0.87, and the average relative deviation was 1.44%. According to the ICH guidelines, the universal calibration model was evaluated. Based on the experimental statistical results, the recommended number of calibration samples for a constant-temperature homogeneous liquid quantitative model was no less than 15.展开更多
文摘Fluorescence tomography can obtain a sufficient dataset and optimal three-dimensional imageswhen projections are captured over 360◦ by CCD camera. Herein a non-stop dynamic samplingmode for fluorescence tomography is proposed in an attempt to improve the optical measurementspeed of the traditional imaging system and stability of the object to be imaged. A series ofsimulations are carried out to evaluate the accuracy of dataset acquired from the dynamicsampling mode. Reconstruction with the corresponding data obtained in the dynamic-modeprocess is also performed with the phantom. The results demonstrate the feasibility of suchan imaging mode when the angular velocity is set to the appropriate value, thus laying thefoundation for real experiments to verify the superiority in performance of this new imagingmode over the traditional one.
基金National Science and Technology Major Project of the Ministry of Science and Technology of China(Grant No. 2010ZX09401-403)
文摘The general strategy and method of constructing universal calibration model for levofioxacin injections by near-infrared spectroscopy have been investigated and discussed. Firstly, a constant-temperature homogeneous liquid calibration model for levofloxacin hydrochloride injections with the same composition but different active principal ingredient （API） content was established as the basic unit for universal model. Then, samples of levofloxacin hydrochloride injections containing propylene glycol or levofloxacin lactate injections were added to develop a primary constant-temperature liquid universal model. Temperature- amended final universal model was established to apply to samples under different temperatures. The final model was built from 61 calibration samples and 77 validation samples. The value of the root mean square error of cross validation （RMSECV） and coefficient of determination （r2） of leave-one-out cross-validation （LOOCV） were 0.792 and 0.9993, respectively, the root mean square error of prediction （RMSEP） of test set validation （TSV） was 0.87, and the average relative deviation was 1.44%. According to the ICH guidelines, the universal calibration model was evaluated. Based on the experimental statistical results, the recommended number of calibration samples for a constant-temperature homogeneous liquid quantitative model was no less than 15.
