Allergic conjunctivitis is a common ocular surface condition.Although corticosteroids are potent antiinflammatory agents for its management,their use is often restricted by potential side effects.Conventional eye drop...Allergic conjunctivitis is a common ocular surface condition.Although corticosteroids are potent antiinflammatory agents for its management,their use is often restricted by potential side effects.Conventional eye drops face challenges such as short retention time and poor corneal permeability,resulting in low drug bioavailability.To overcome these limitations,we developed a preservative-free synthetic high-density lipoprotein(sHDL)nanodisc eye drop containing dexamethasone palmitate.This novel formulation enhances drug stability and extends retention time on the ocular surface.In a mouse model of ovalbumin(OVA)-induced allergic conjunctivitis,the nanodisc eye drop significantly alleviated symptoms while reducing corticosteroid concentration,demonstrating excellent safety and biocompatibility.This innovative approach shows great promise for the treatment of allergic conjunctivitis and may lay the groundwork for new therapeutic strategies in anterior ocular disease management.展开更多
基金financially supported by General Scientific Research Project for Higher Education Institutions of Liaoning Provincial Department of Education(Grant No.:LJKMZ20221171)Liaoning Provincial Science and Technology Planning Joint Program(Grant No.:2024-MSLH-580).
文摘Allergic conjunctivitis is a common ocular surface condition.Although corticosteroids are potent antiinflammatory agents for its management,their use is often restricted by potential side effects.Conventional eye drops face challenges such as short retention time and poor corneal permeability,resulting in low drug bioavailability.To overcome these limitations,we developed a preservative-free synthetic high-density lipoprotein(sHDL)nanodisc eye drop containing dexamethasone palmitate.This novel formulation enhances drug stability and extends retention time on the ocular surface.In a mouse model of ovalbumin(OVA)-induced allergic conjunctivitis,the nanodisc eye drop significantly alleviated symptoms while reducing corticosteroid concentration,demonstrating excellent safety and biocompatibility.This innovative approach shows great promise for the treatment of allergic conjunctivitis and may lay the groundwork for new therapeutic strategies in anterior ocular disease management.
