Background:Neurological disorders(NDs),including ischemic stroke(IS),Parkinson’s disease(PD),and Alzheimer’s disease(AD),are major contributors to global morbidity and mortality.Boswellia extract has demonstrated ne...Background:Neurological disorders(NDs),including ischemic stroke(IS),Parkinson’s disease(PD),and Alzheimer’s disease(AD),are major contributors to global morbidity and mortality.Boswellia extract has demonstrated neuroprotective properties,yet a comprehensive systematic review assessing its efficacy remains absent.This study aims to evaluate the efficacy of Boswellia extract in treating NDs,with a particular focus on its effects in AD and its potential for long-term neurorestoration,thereby supporting further investigation into Boswellia’s therapeutic role in ND management.Methods:A systematic literature search was performed in PubMed,Web of Science,ScienceDirect,and Google Scholar for English-language studies published up to March 2024.Eighteen studies met the inclusion criteria and were included in the meta-analysis.The study protocol was registered on PROSPERO(CRD42024524386).Eligible studies involved rodent models of IS,PD,or AD with post-operative interventions using Boswellia extract.Data extraction focused on mechanisms of action,dosages,treatment durations,and therapeutic outcomes.Studies were excluded if they involved non-ND models,combined treatments,or had incomplete data.Two researchers independently conducted literature screening and data extraction.Statistical analyses were conducted using Stata(version 17)and RevMan(version 5.4),employing fixed or random-effects models based on heterogeneity assessments.Result s:Boswellia extract significantly improved the mean effect size for NDs(ES=1.28,95%CI(1.05,1.51),P<0.001).Specifically,it reduced cerebral infarct volume in IS(SMD=−2.87,95%CI(−3.42,−2.32))and enhanced behavioral outcomes in AD(SMD=3.26,95%CI(2.07,5.14))and PD(SMD=5.37,95%CI(3.93,6.80)).Subgroup analyses revealed that Boswellia extract exhibited superior efficacy in AD when administered orally and via intra-cerebroventricular injection.Long-term treatment with Boswellia extract suggested potential neurorestorative effects.Additionally,Boswellia extract was more effective than its monomeric constituents,highlighting its promising role in ND treatment.Conclusion:Boswellia extract demonstrates significant neuroprotective effects across various NDs,particularly in AD and in promoting long-term neurorestoration.These findings support the need for further research into Boswellia’s potential as a therapeutic agent in the management of neurological disorders.展开更多
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’...Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.展开更多
Among hyperspectral imaging technologies, interferometric spectral imaging is widely used in remote sening due to advantages of large luminous flux and high resolution. However, with complicated mechanism, interferome...Among hyperspectral imaging technologies, interferometric spectral imaging is widely used in remote sening due to advantages of large luminous flux and high resolution. However, with complicated mechanism, interferometric imaging faces the impact of multi-stage degradation. Most exsiting interferometric spectrum reconstruction methods are based on tradition model-based framework with multiple steps, showing poor efficiency and restricted performance. Thus, we propose an interferometric spectrum reconstruction method based on degradation synthesis and deep learning.Firstly, based on imaging mechanism, we proposed an mathematical model of interferometric imaging to analyse the degradation components as noises and trends during imaging. The model consists of three stages, namely instrument degradation, sensing degradation, and signal-independent degradation process. Then, we designed calibration-based method to estimate parameters in the model, of which the results are used for synthesizing realistic dataset for learning-based algorithms.In addition, we proposed a dual-stage interferogram spectrum reconstruction framework, which supports pre-training and integration of denoising DNNs. Experiments exhibits the reliability of our degradation model and synthesized data, and the effectiveness of the proposed reconstruction method.展开更多
Optical three-dimensional(3D)measurement is a critical tool in micro-nano manufacturing,the automotive industry,and medical technology due to its nondestructive nature,high precision,and sensitivity.However,passive li...Optical three-dimensional(3D)measurement is a critical tool in micro-nano manufacturing,the automotive industry,and medical technology due to its nondestructive nature,high precision,and sensitivity.However,passive light field system still requires a refractive primary lens to collect light of the scene,and structured light can not work well with the highly refractive object.Meta-optics,known for being lightweight,compact,and easily integrable,has enabled advancements in passive metalens-array light fields and active structured light techniques.Here,we propose and experimentally validate a novel 3D measurement metasystem.It features a transmitting metasurface generating chromatic line focuses as depth markers and a symmetrically arranged receiving metasurface collecting depth-dependent spectral responses.A lightweight,physically interpretable algorithm processes these data to yield high-precision depth information efficiently.Experiments on metallic and wafer materials demonstrate a depth accuracy of±20μm and lateral accuracy of±10μm.This single-layer optical metasystem,characterized by simplicity,micro-level accuracy,easy installation and scalability,shows potential for diverse applications,including process control,surface morphology analysis,and production measurement.展开更多
The structural dynamic response reconstruction technology can extract unmeasured information from limited measured data,significantly impacting vibration control,load identification,parameter identification,fault diag...The structural dynamic response reconstruction technology can extract unmeasured information from limited measured data,significantly impacting vibration control,load identification,parameter identification,fault diagnosis,and related fields.This paper proposes a dynamic response reconstruction method based on the Kalman filter,which simultaneously identifies external excitation and reconstructs dynamic responses at unmeasured positions.The weighted least squares method determines the load weighting matrix for excitation identification,while the minimum variance unbiased estimation determines the Kalman filter gain.The excitation prediction Kalman filter is constructed through time,excitation,and measurement updates.Subsequently,the response at the target point is reconstructed using the state vector,observation matrix,and excitation influence matrix obtained through the excitation prediction Kalman filter algorithm.An algorithm for reconstructing responses in continuous system using the excitation prediction Kalman filtering algorithm in modal space is derived.The proposed structural dynamic response reconstruction method evaluates the response reconstruction and the load identification performance under various load types and errors through simulation examples.Results demonstrate the accurate excitation identification under different load conditions and simultaneous reconstruction of target point responses,verifying the feasibility and reliability of the proposed method.展开更多
Background The middle ear pneumatic system(MEPS)supports pressure balance,essential for sound conduction.Its volume and surface area are key indicators of pneumatization and ventilation,yet their specific contribution...Background The middle ear pneumatic system(MEPS)supports pressure balance,essential for sound conduction.Its volume and surface area are key indicators of pneumatization and ventilation,yet their specific contributions to pressure regulation need further exploration.Objective To evaluate the accuracy and sensitivity of parameters characterizing the MEPS,including volume(V),surface area(S),and surface-area-to-volume ratio(S/V),in normal ears.Materials and Methods We collected CT images of the temporal bone from 63 normal ears for this study.The volume(V),surface area(S),and surface-area-to-volume ratio(S/V)of the MEPS were measured and calculated using three-dimensional reconstruction technology.Statistical methods were used to process the data and determine the 95%reference range for the S,V,and S/V of the MEPS in the normal ear.At the same time,we analyzed the impact of differences in gender and the left and right sides on the measurements.Results The 95%reference values for the S,V,and S/V of the MEPS in normal ears were 1057.10~18239.16 mm²,609.16~9854.11 mm^(3),and 1.39~2.52 mm^(-1) respectively.There were no significant differences in the measurements between genders and between the left and right sides.Conclusions and Significance This study has established the 95%reference values for the S,V,and S/V of the MEPS in normal ears,which were 1057.10-18239.16 mm²,609.16-9854.11 mm^(3),and 1.39-2.52 mm^(-1) respectively.We found that while there is a wide variation in the V values among normal ears,there is less variability in the S/V values.This structural characteristic suggests that changes in the S/V value may have a more significant impact on the balance of middle ear pressure,and it provides important reference data for the construction and functional reconstruction of three-dimensional models of the MEPS.These findings may aid in diagnosing middle ear disorders,such as otitis media with effusion,and guide interventions to restore pressure balance.展开更多
Satellite communication plays an important role in 6G systems.However,satellite communication systems are more susceptible to intentional or unintentional interference signals than other communication systems because ...Satellite communication plays an important role in 6G systems.However,satellite communication systems are more susceptible to intentional or unintentional interference signals than other communication systems because of their working mechanism of transparent forwarding.For the purpose of eliminating the influence of interference,this paper develops an angle reciprocal interference suppression scheme based on the reconstruction of interferenceplus-noise covariance matrix(ARIS-RIN).Firstly,we utilize the reciprocity between the known beam central angle and the unknown signal arrival angle to estimate the angle of arrival(AOA)of desired signal due to the multi-beam coverage.Then,according to the priori known spatial spectrum distribution,the interferenceplus-noise covariance matrix(INCM)is reconstructed by integrating within the range except the direction of desired signal.In order to correct the estimation bias of the first two steps,the worst-case performance optimization technology is adopted in the process of solving the beamforming vector.Numerical simulation results show that the developed scheme:1)has a higher output signal-to-interference-plus-noise ratio(SINR)under arbitrary signal-to-noise ratio(SNR);2)still has good performance under small snapshots;3)is robuster and easier to be realized when comparing with minimum variance distortionless response(MVDR)and the traditional diagonal loading algorithms.展开更多
BACKGROUND Proximal gastrectomy(PG)with double tract reconstruction(DTR)has recently emerged as a function-preserving alternative to total gastrectomy(TG)with Rouxen-Y(RNY)reconstruction in patients with proximally lo...BACKGROUND Proximal gastrectomy(PG)with double tract reconstruction(DTR)has recently emerged as a function-preserving alternative to total gastrectomy(TG)with Rouxen-Y(RNY)reconstruction in patients with proximally located gastric cancer.AIM To evaluate the current evidence comparing PG-DTR with TG-RNY in terms of perioperative outcomes,long-term survival,complication rates,nutritional status and reflux esophagitis.METHODS A systematic literature search was conducted using PubMed,MEDLINE,Web of Science and the Cochrane Library for studies published between 2010 and January 2025.Search terms included gastric cancer,DTR and TG.Trials comparing PGDTR with TG-RNY or PG-esophagogastrostomy(EG)were included.Data on operative details,lymph node yield,complications(Clavien-Dindo≥III),nutritional markers and incidence of reflux were extracted.Nineteen trials met the inclusion criteria.The review followed the PRISMA guidelines.RESULTS PG-DTR was found to have comparable long-term oncological outcomes to TGRNY,despite a lower extent of lymph node dissection.Operative time and intraoperative blood loss were generally similar,with some studies favouring PGDTR.Rates of major postoperative complications were comparable between techniques.Notably,PG-DTR showed a significantly lower incidence of reflux esophagitis than PG-EG and was comparable or superior to TG-RNY in reflux control.Nutritionally,PG-DTR was associated with better post-operative weight maintenance and biochemical parameters such as haemoglobin,albumin and vitamin B12 levels compared to TG-RNY.No significant nutritional differences were observed between PG-DTR and PG-EG.PG-DTR appears to offer a balanced approach to the surgical treatment of proximal gastric cancer,combining oncological safety with functional and nutritional benefits.CONCLUSION Its superiority over TG-RNY in postoperative nutrition and reflux prevention,together with comparable complication rates and survival,supports its consideration as a preferred reconstruction method in selected patients.展开更多
Rectal cancer ranks as the third most prevalent malignancy globally,with an estimated 1.9 million incident cases reported in 2020.The management of low rectal cancer presents significant therapeutic challenges due to ...Rectal cancer ranks as the third most prevalent malignancy globally,with an estimated 1.9 million incident cases reported in 2020.The management of low rectal cancer presents significant therapeutic challenges due to its anatomical complexity,and substantially impacts patients'quality of life.While abdominoperineal resection(Miles procedure)ensures oncological radicality,the morbidity associated with permanent colostomy has driven innovations in sphincter-preserving surgical techniques.This review synthesizes current evidence on sphincter-preserving surgical approaches for low rectal cancer.The implementation of total mesorectal excision(TME)principles and enhanced understanding of circumferential resection margin have facilitated the evolution of diverse sphincter-preserving surgical modalities.These include local excision,low anterior resection(Dixon procedure),intersphincteric resection,pull-through procedures,transanal TME,and conventional sphincter-preserving operation.Minimally invasive approaches,particularly laparoscopic and robotic platforms,alongside natural orifice transluminal endoscopic surgery,have demonstrated improved surgical precision and enhanced postoperative recovery outcomes.Novel functional perineal reconstruction techniques offer promising alternatives for patients requiring posterior pelvic exenteration.Nevertheless,the high incidence of low anterior resection syndrome(LARS)and its chronic sequelae remain clinically notable.Evidence indicates that long-course neoadjuvant radiotherapy and TME constitute significant risk factors for LARS development.Contemporary sphincter-preserving surgery for low rectal cancer is advancing toward minimally invasive,personalized,and precision-based approaches.The increasing incidence of early-onset rectal cancer necessitates individualized treatment strategies that balance oncological efficacy with functional preservation.Future directions should focus on standardizing surgical indications,optimizing postoperative rehabilitation protocols,and enhancing treatment outcomes through multidisciplinary integration and technological innovation.展开更多
The carbon emissions and cost during the construction phase are significant contributors to the oilfield lifecycle.As oilfields enter the late stage,the adaptability of facilities decreases.To achieve sustainable deve...The carbon emissions and cost during the construction phase are significant contributors to the oilfield lifecycle.As oilfields enter the late stage,the adaptability of facilities decreases.To achieve sustainable development,oilfield reconstruction was usually conducted in discrete rather than continuous space.Motivated by economic and sustainability goals,a 3-phase heuristic model for oilfield reconstruction was developed to mine potential locations in continuous space.In phase 1,considering the process characteristics of the oil and gas gathering system,potential locations were mined in continuous space.In phase 2,incorporating comprehensive reconstruction measures,a reconstruction model was established in discrete space.In phase 3,the topology was further adjusted in continuous space.Subsequently,the model was transformed into a single-objective mixed integer linear programming model using the augmented ε-constraint method.Numerical experiments revealed that the small number of potential locations could effectively reduce the reconstruction cost,and the quality of potential locations mined in phase 1 surpassed those generated in random or grid form.Case studies showed that cost and carbon emissions for a new block were reduced by up to 10.45% and 7.21 %,respectively.These reductions were because the potential locations mined in 1P reduced the number of metering stations,and 3P adjusted the locations of metering stations in continuous space to shorten the pipeline length.For an old oilfield,the load and connection ratios of the old metering station increased to 89.7% and 94.9%,respectively,enhancing operation efficiency.Meanwhile,recycling facilitated the diversification of reconstruction measures and yielded a profit of 582,573 ¥,constituting 5.56% of the total cost.This study adopted comprehensive reconstruction measures and tapped into potential reductions in cost and carbon emissions for oilfield reconstruction,offering valuable insights for future oilfield design and construction.展开更多
Neural organoids and confocal microscopy have the potential to play an important role in microconnectome research to understand neural patterns.We present PLayer,a plug-and-play embedded neural system,which demonstrat...Neural organoids and confocal microscopy have the potential to play an important role in microconnectome research to understand neural patterns.We present PLayer,a plug-and-play embedded neural system,which demonstrates the utilization of sparse confocal microscopy layers to interpolate continuous axial resolution.With an embedded system focused on neural network pruning,image scaling,and post-processing,PLayer achieves high-performance metrics with an average structural similarity index of 0.9217 and a peak signal-to-noise ratio of 27.75 dB,all within 20 s.This represents a significant time saving of 85.71%with simplified image processing.By harnessing statistical map estimation in interpolation and incorporating the Vision Transformer–based Restorer,PLayer ensures 2D layer consistency while mitigating heavy computational dependence.As such,PLayer can reconstruct 3D neural organoid confocal data continuously under limited computational power for the wide acceptance of fundamental connectomics and pattern-related research with embedded devices.展开更多
基金supported by the National Natural Science Foundation of China,specifically through grants(No.8227431382304947)Key Research and Development Project of Shaanxi Province(2023GHZD43).Peer re v iew information。
文摘Background:Neurological disorders(NDs),including ischemic stroke(IS),Parkinson’s disease(PD),and Alzheimer’s disease(AD),are major contributors to global morbidity and mortality.Boswellia extract has demonstrated neuroprotective properties,yet a comprehensive systematic review assessing its efficacy remains absent.This study aims to evaluate the efficacy of Boswellia extract in treating NDs,with a particular focus on its effects in AD and its potential for long-term neurorestoration,thereby supporting further investigation into Boswellia’s therapeutic role in ND management.Methods:A systematic literature search was performed in PubMed,Web of Science,ScienceDirect,and Google Scholar for English-language studies published up to March 2024.Eighteen studies met the inclusion criteria and were included in the meta-analysis.The study protocol was registered on PROSPERO(CRD42024524386).Eligible studies involved rodent models of IS,PD,or AD with post-operative interventions using Boswellia extract.Data extraction focused on mechanisms of action,dosages,treatment durations,and therapeutic outcomes.Studies were excluded if they involved non-ND models,combined treatments,or had incomplete data.Two researchers independently conducted literature screening and data extraction.Statistical analyses were conducted using Stata(version 17)and RevMan(version 5.4),employing fixed or random-effects models based on heterogeneity assessments.Result s:Boswellia extract significantly improved the mean effect size for NDs(ES=1.28,95%CI(1.05,1.51),P<0.001).Specifically,it reduced cerebral infarct volume in IS(SMD=−2.87,95%CI(−3.42,−2.32))and enhanced behavioral outcomes in AD(SMD=3.26,95%CI(2.07,5.14))and PD(SMD=5.37,95%CI(3.93,6.80)).Subgroup analyses revealed that Boswellia extract exhibited superior efficacy in AD when administered orally and via intra-cerebroventricular injection.Long-term treatment with Boswellia extract suggested potential neurorestorative effects.Additionally,Boswellia extract was more effective than its monomeric constituents,highlighting its promising role in ND treatment.Conclusion:Boswellia extract demonstrates significant neuroprotective effects across various NDs,particularly in AD and in promoting long-term neurorestoration.These findings support the need for further research into Boswellia’s potential as a therapeutic agent in the management of neurological disorders.
基金supported by the National Key R&D Program of China,No.2021YFC2501200(to PC).
文摘Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.
文摘Among hyperspectral imaging technologies, interferometric spectral imaging is widely used in remote sening due to advantages of large luminous flux and high resolution. However, with complicated mechanism, interferometric imaging faces the impact of multi-stage degradation. Most exsiting interferometric spectrum reconstruction methods are based on tradition model-based framework with multiple steps, showing poor efficiency and restricted performance. Thus, we propose an interferometric spectrum reconstruction method based on degradation synthesis and deep learning.Firstly, based on imaging mechanism, we proposed an mathematical model of interferometric imaging to analyse the degradation components as noises and trends during imaging. The model consists of three stages, namely instrument degradation, sensing degradation, and signal-independent degradation process. Then, we designed calibration-based method to estimate parameters in the model, of which the results are used for synthesizing realistic dataset for learning-based algorithms.In addition, we proposed a dual-stage interferogram spectrum reconstruction framework, which supports pre-training and integration of denoising DNNs. Experiments exhibits the reliability of our degradation model and synthesized data, and the effectiveness of the proposed reconstruction method.
基金financial supports from the National Key R&D Program of China (2021YFA1401200)Beijing Outstanding Young Scientist Program (BJJWZYJH01201910007022)+1 种基金National Natural Science Foundation of China (No. U21A20140, No. 92050117, No. 62105024) programBeijing Natural Science Foundation (JQ24028)
文摘Optical three-dimensional(3D)measurement is a critical tool in micro-nano manufacturing,the automotive industry,and medical technology due to its nondestructive nature,high precision,and sensitivity.However,passive light field system still requires a refractive primary lens to collect light of the scene,and structured light can not work well with the highly refractive object.Meta-optics,known for being lightweight,compact,and easily integrable,has enabled advancements in passive metalens-array light fields and active structured light techniques.Here,we propose and experimentally validate a novel 3D measurement metasystem.It features a transmitting metasurface generating chromatic line focuses as depth markers and a symmetrically arranged receiving metasurface collecting depth-dependent spectral responses.A lightweight,physically interpretable algorithm processes these data to yield high-precision depth information efficiently.Experiments on metallic and wafer materials demonstrate a depth accuracy of±20μm and lateral accuracy of±10μm.This single-layer optical metasystem,characterized by simplicity,micro-level accuracy,easy installation and scalability,shows potential for diverse applications,including process control,surface morphology analysis,and production measurement.
基金supported by the National Natural Science Foundation of China(Nos.12372066,U23B6009,52171261)the Aeronautical Science Fund(No.20240013052002)the Qing Lan Project。
文摘The structural dynamic response reconstruction technology can extract unmeasured information from limited measured data,significantly impacting vibration control,load identification,parameter identification,fault diagnosis,and related fields.This paper proposes a dynamic response reconstruction method based on the Kalman filter,which simultaneously identifies external excitation and reconstructs dynamic responses at unmeasured positions.The weighted least squares method determines the load weighting matrix for excitation identification,while the minimum variance unbiased estimation determines the Kalman filter gain.The excitation prediction Kalman filter is constructed through time,excitation,and measurement updates.Subsequently,the response at the target point is reconstructed using the state vector,observation matrix,and excitation influence matrix obtained through the excitation prediction Kalman filter algorithm.An algorithm for reconstructing responses in continuous system using the excitation prediction Kalman filtering algorithm in modal space is derived.The proposed structural dynamic response reconstruction method evaluates the response reconstruction and the load identification performance under various load types and errors through simulation examples.Results demonstrate the accurate excitation identification under different load conditions and simultaneous reconstruction of target point responses,verifying the feasibility and reliability of the proposed method.
基金supported by the[National Natural Science Foundation of China]under Grant[number 12172082][Catch up with and surpass technology projects]under Grant[number 2022LCJSGC24]。
文摘Background The middle ear pneumatic system(MEPS)supports pressure balance,essential for sound conduction.Its volume and surface area are key indicators of pneumatization and ventilation,yet their specific contributions to pressure regulation need further exploration.Objective To evaluate the accuracy and sensitivity of parameters characterizing the MEPS,including volume(V),surface area(S),and surface-area-to-volume ratio(S/V),in normal ears.Materials and Methods We collected CT images of the temporal bone from 63 normal ears for this study.The volume(V),surface area(S),and surface-area-to-volume ratio(S/V)of the MEPS were measured and calculated using three-dimensional reconstruction technology.Statistical methods were used to process the data and determine the 95%reference range for the S,V,and S/V of the MEPS in the normal ear.At the same time,we analyzed the impact of differences in gender and the left and right sides on the measurements.Results The 95%reference values for the S,V,and S/V of the MEPS in normal ears were 1057.10~18239.16 mm²,609.16~9854.11 mm^(3),and 1.39~2.52 mm^(-1) respectively.There were no significant differences in the measurements between genders and between the left and right sides.Conclusions and Significance This study has established the 95%reference values for the S,V,and S/V of the MEPS in normal ears,which were 1057.10-18239.16 mm²,609.16-9854.11 mm^(3),and 1.39-2.52 mm^(-1) respectively.We found that while there is a wide variation in the V values among normal ears,there is less variability in the S/V values.This structural characteristic suggests that changes in the S/V value may have a more significant impact on the balance of middle ear pressure,and it provides important reference data for the construction and functional reconstruction of three-dimensional models of the MEPS.These findings may aid in diagnosing middle ear disorders,such as otitis media with effusion,and guide interventions to restore pressure balance.
基金supported by the National Natural Science Foundation of China under Grants No.61671367 and 62471381the Research Foundation of Science and Technology on Communication Networks Laboratory,and the National Key Laboratory of Wireless Communications Foundation under Grant No.IFN202401.
文摘Satellite communication plays an important role in 6G systems.However,satellite communication systems are more susceptible to intentional or unintentional interference signals than other communication systems because of their working mechanism of transparent forwarding.For the purpose of eliminating the influence of interference,this paper develops an angle reciprocal interference suppression scheme based on the reconstruction of interferenceplus-noise covariance matrix(ARIS-RIN).Firstly,we utilize the reciprocity between the known beam central angle and the unknown signal arrival angle to estimate the angle of arrival(AOA)of desired signal due to the multi-beam coverage.Then,according to the priori known spatial spectrum distribution,the interferenceplus-noise covariance matrix(INCM)is reconstructed by integrating within the range except the direction of desired signal.In order to correct the estimation bias of the first two steps,the worst-case performance optimization technology is adopted in the process of solving the beamforming vector.Numerical simulation results show that the developed scheme:1)has a higher output signal-to-interference-plus-noise ratio(SINR)under arbitrary signal-to-noise ratio(SNR);2)still has good performance under small snapshots;3)is robuster and easier to be realized when comparing with minimum variance distortionless response(MVDR)and the traditional diagonal loading algorithms.
文摘BACKGROUND Proximal gastrectomy(PG)with double tract reconstruction(DTR)has recently emerged as a function-preserving alternative to total gastrectomy(TG)with Rouxen-Y(RNY)reconstruction in patients with proximally located gastric cancer.AIM To evaluate the current evidence comparing PG-DTR with TG-RNY in terms of perioperative outcomes,long-term survival,complication rates,nutritional status and reflux esophagitis.METHODS A systematic literature search was conducted using PubMed,MEDLINE,Web of Science and the Cochrane Library for studies published between 2010 and January 2025.Search terms included gastric cancer,DTR and TG.Trials comparing PGDTR with TG-RNY or PG-esophagogastrostomy(EG)were included.Data on operative details,lymph node yield,complications(Clavien-Dindo≥III),nutritional markers and incidence of reflux were extracted.Nineteen trials met the inclusion criteria.The review followed the PRISMA guidelines.RESULTS PG-DTR was found to have comparable long-term oncological outcomes to TGRNY,despite a lower extent of lymph node dissection.Operative time and intraoperative blood loss were generally similar,with some studies favouring PGDTR.Rates of major postoperative complications were comparable between techniques.Notably,PG-DTR showed a significantly lower incidence of reflux esophagitis than PG-EG and was comparable or superior to TG-RNY in reflux control.Nutritionally,PG-DTR was associated with better post-operative weight maintenance and biochemical parameters such as haemoglobin,albumin and vitamin B12 levels compared to TG-RNY.No significant nutritional differences were observed between PG-DTR and PG-EG.PG-DTR appears to offer a balanced approach to the surgical treatment of proximal gastric cancer,combining oncological safety with functional and nutritional benefits.CONCLUSION Its superiority over TG-RNY in postoperative nutrition and reflux prevention,together with comparable complication rates and survival,supports its consideration as a preferred reconstruction method in selected patients.
文摘Rectal cancer ranks as the third most prevalent malignancy globally,with an estimated 1.9 million incident cases reported in 2020.The management of low rectal cancer presents significant therapeutic challenges due to its anatomical complexity,and substantially impacts patients'quality of life.While abdominoperineal resection(Miles procedure)ensures oncological radicality,the morbidity associated with permanent colostomy has driven innovations in sphincter-preserving surgical techniques.This review synthesizes current evidence on sphincter-preserving surgical approaches for low rectal cancer.The implementation of total mesorectal excision(TME)principles and enhanced understanding of circumferential resection margin have facilitated the evolution of diverse sphincter-preserving surgical modalities.These include local excision,low anterior resection(Dixon procedure),intersphincteric resection,pull-through procedures,transanal TME,and conventional sphincter-preserving operation.Minimally invasive approaches,particularly laparoscopic and robotic platforms,alongside natural orifice transluminal endoscopic surgery,have demonstrated improved surgical precision and enhanced postoperative recovery outcomes.Novel functional perineal reconstruction techniques offer promising alternatives for patients requiring posterior pelvic exenteration.Nevertheless,the high incidence of low anterior resection syndrome(LARS)and its chronic sequelae remain clinically notable.Evidence indicates that long-course neoadjuvant radiotherapy and TME constitute significant risk factors for LARS development.Contemporary sphincter-preserving surgery for low rectal cancer is advancing toward minimally invasive,personalized,and precision-based approaches.The increasing incidence of early-onset rectal cancer necessitates individualized treatment strategies that balance oncological efficacy with functional preservation.Future directions should focus on standardizing surgical indications,optimizing postoperative rehabilitation protocols,and enhancing treatment outcomes through multidisciplinary integration and technological innovation.
基金supported by the National Natural Science Foundation of China (Grant No.52174065)the National Natural Science Foundation of China (Grant No.52304071)+1 种基金China University of Petroleum,Beijing (Grant No.ZX20220040)MOE Key Laboratory of Petroleum Engineering (China University of Petroleum,No.2462024PTJS002)。
文摘The carbon emissions and cost during the construction phase are significant contributors to the oilfield lifecycle.As oilfields enter the late stage,the adaptability of facilities decreases.To achieve sustainable development,oilfield reconstruction was usually conducted in discrete rather than continuous space.Motivated by economic and sustainability goals,a 3-phase heuristic model for oilfield reconstruction was developed to mine potential locations in continuous space.In phase 1,considering the process characteristics of the oil and gas gathering system,potential locations were mined in continuous space.In phase 2,incorporating comprehensive reconstruction measures,a reconstruction model was established in discrete space.In phase 3,the topology was further adjusted in continuous space.Subsequently,the model was transformed into a single-objective mixed integer linear programming model using the augmented ε-constraint method.Numerical experiments revealed that the small number of potential locations could effectively reduce the reconstruction cost,and the quality of potential locations mined in phase 1 surpassed those generated in random or grid form.Case studies showed that cost and carbon emissions for a new block were reduced by up to 10.45% and 7.21 %,respectively.These reductions were because the potential locations mined in 1P reduced the number of metering stations,and 3P adjusted the locations of metering stations in continuous space to shorten the pipeline length.For an old oilfield,the load and connection ratios of the old metering station increased to 89.7% and 94.9%,respectively,enhancing operation efficiency.Meanwhile,recycling facilitated the diversification of reconstruction measures and yielded a profit of 582,573 ¥,constituting 5.56% of the total cost.This study adopted comprehensive reconstruction measures and tapped into potential reductions in cost and carbon emissions for oilfield reconstruction,offering valuable insights for future oilfield design and construction.
基金supported by the National Key R&D Program of China(Grant No.2021YFA1001000)the National Natural Science Foundation of China(Grant Nos.82111530212,U23A20282,and 61971255)+2 种基金the Natural Science Founda-tion of Guangdong Province(Grant No.2021B1515020092)the Shenzhen Bay Laboratory Fund(Grant No.SZBL2020090501014)the Shenzhen Science,Technology and Innovation Commission(Grant Nos.KJZD20231023094659002,JCYJ20220530142809022,and WDZC20220811170401001).
文摘Neural organoids and confocal microscopy have the potential to play an important role in microconnectome research to understand neural patterns.We present PLayer,a plug-and-play embedded neural system,which demonstrates the utilization of sparse confocal microscopy layers to interpolate continuous axial resolution.With an embedded system focused on neural network pruning,image scaling,and post-processing,PLayer achieves high-performance metrics with an average structural similarity index of 0.9217 and a peak signal-to-noise ratio of 27.75 dB,all within 20 s.This represents a significant time saving of 85.71%with simplified image processing.By harnessing statistical map estimation in interpolation and incorporating the Vision Transformer–based Restorer,PLayer ensures 2D layer consistency while mitigating heavy computational dependence.As such,PLayer can reconstruct 3D neural organoid confocal data continuously under limited computational power for the wide acceptance of fundamental connectomics and pattern-related research with embedded devices.
