In two-scale topology optimization,enhancing the connectivity between adjacent microstructures is crucial for achieving the collaborative optimization of micro-scale performance and macro-scale manufacturability.This ...In two-scale topology optimization,enhancing the connectivity between adjacent microstructures is crucial for achieving the collaborative optimization of micro-scale performance and macro-scale manufacturability.This paper proposes a two-scale concurrent topology optimization strategy aimed at improving the interface connection strength.This method employs a parametric approach to explicitly divide the micro-design domain into a“boundary connection region”and a“free design domain”at the initial stage of optimization.The boundary connection region is used to generate a connection layer that enhances the interface strength,while the free design domain is not constrained by this layer,thus fully exploiting the design potential of the material layout.During the optimization process,the solid isotropic material with penalization(SIMP)method is first used to optimize the material distribution in the free design domain,and filtering and projection techniques are employed to alleviate numerical instability and obtain a clear topological structure.Subsequently,the effective performance of the microstructure is calculated through homogenization and transferred to the macro-scale for global response analysis.Throughout the iterative process,the geometry of the connection layer remains unchanged,and only the free design domain is optimized,thereby achieving a balance between high performance and good manufacturability.The effectiveness of the proposed method is verified through numerical examples.展开更多
To achieve efficient connection and integrity in prefabricated frame structures,a novel beam-column connection between prefabricated steel-reinforced concrete(SRC)columns and cast-in-situ reinforced concrete(RC)beams ...To achieve efficient connection and integrity in prefabricated frame structures,a novel beam-column connection between prefabricated steel-reinforced concrete(SRC)columns and cast-in-situ reinforced concrete(RC)beams is proposed.Four connection specimens with varying thicknesses of connecting cover plates were designed and fabricated.Low-cycle reversed loading tests were conducted to obtain mechanical performance data,allowing for analysis of behavioral patterns,including load-displacement hysteresis curves,skeleton curves,load-carrying capacity,deformation performance,energy dissipation capacity,and stiffness degradation.Test results indicate that properly designed prefabricated connections exhibit mechanical properties comparable to those of cast-in-situ concrete connections.The hysteresis curves of the prefabricated connections are well-shaped,with nearly no reduction in load-carrying capacity and deformation performance,demonstrating excellent seismic behavior.The findings provide a theoretical basis and reference for the design of prefabricated concrete frame structures.展开更多
This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avo...This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties.展开更多
Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social con...Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social connection and mental health,focusing on the mediating role of quality of life(QoL)and the moderating effect of regional differences.Methods:We analyzed data from the 2019 Korean Community Health Survey,comprising 229,099 adults.Mental health was assessed through validated measures of depressive symptoms and psychological well-being.Social connection was measured using indicators of interpersonal ties and community participation,and QoL was assessed via self-reported health-related satisfaction across major life domains.Analytical procedures included mediation modeling and subgroup analyses by region,with significance levels set at p<0.05.Results:The results indicate that social connections are significantly associated with lower stress levels and reduced depressive symptoms,with QoL playing a critical mediating role.Notably,the indirect effect of social connection on mental health via QoL is stronger in rural areas compared to urban regions,highlighting the importance of social cohesion and community support in mental well-being.Among 203,567 adults,greater social participation was associated with lower subjective stress(total effect=−0.052,p<0.001)and fewer depressive symptoms(PHQ-9 total effect=−0.308,p<0.001).QoL significantly mediated these associations,with the strongest indirect pathways observed through usual activities(19.2%for stress;27.6%for depression)and mobility(24.4%for depression).Regional analysis showed stronger mediation in rural areas(up to 26.8%for stress and 32.6%for depression)than in urban areas(8–16%and 14.9–23%).Direct effects remained significant,indicating partial mediation.These findings highlight that social participation enhances mental health directly and indirectly through QoL,particularly in rural contexts.Conclusions:Social connection contributes to better mental health both directly and indirectly through improved QoL,with stronger effects observed in rural communities.These findings highlight the importance of fostering social cohesion and enhancing life quality as strategies for improving population mental health.Policy interventions should adopt context-sensitive approaches that account for regional differences in social resources and service availability.展开更多
Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet,this paper proposes a novel lightweight neural network model called ResghostNet.This model constr...Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet,this paper proposes a novel lightweight neural network model called ResghostNet.This model constructs the Resghost Module by combining residual connections and Adaptive-SE Blocks,which enhances the quality of generated feature maps through direct propagation of original input information and selection of important channels before cheap operations.Specifically,ResghostNet introduces residual connections on the basis of the Ghost Module to optimize the information flow,and designs a weight self-attention mechanism combined with SE blocks to enhance feature expression capabilities in cheap operations.Experimental results on the ImageNet dataset show that,compared to GhostNet,ResghostNet achieves higher accuracy while reducing the number of parameters by 52%.Although the computational complexity increases,by optimizing the usage strategy of GPU cachememory,themodel’s inference speed becomes faster.The ResghostNet is optimized in terms of classification accuracy and the number of model parameters,and shows great potential in edge computing devices.展开更多
The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor...The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor(QGT),another important concept in the field of quantum geometry.The DWZC is Hermitian with respect to the two integer indices,just like the original Hermitian WZC.Based on the symmetric logarithmic derivative operator,we propose a mixed-state quantum geometric tensor.Using the symmetric properties of the DWZC,we find that the real part of the QGT is connected to the real part of the DWZC and the square of eigenvalue differences of the density matrix,whereas the imaginary part can be given in terms of the imaginary part of the DWZC and the cube of the eigenvalue differences.For density matrices with full rank or no full rank,the QGT can be given in terms of real and imaginary parts of the DWZC.展开更多
Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined ex...Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined extensively.We used immunohistochemistry and immunofluorescence staining to analyze the forebrain tissue slices of Alzheimer’s disease patients.Widespread axonal amyloidosis with distinctive axonal enlargement was observed in patients with Alzheimer’s disease.On average,amyloid-β-positive axon diameters in Alzheimer’s disease brains were 1.72 times those of control brain axons.Furthermore,axonal amyloidosis was associated with microtubule-associated protein 2 reduction,tau phosphorylation,lysosome destabilization,and several blood-related markers,such as apolipoprotein E,alpha-hemoglobin,glycosylated hemoglobin type A1C,and hemin.Lysosome destabilization in Alzheimer’s disease was also clearly identified in the neuronal soma,where it was associated with the co-expression of amyloid-β,Cathepsin D,alpha-hemoglobin,actin alpha 2,and collagen type IV.This suggests that exogenous hemorrhagic protein intake influences neural lysosome stability.Additionally,the data showed that amyloid-β-containing lysosomes were 2.23 times larger than control lysosomes.Furthermore,under rare conditions,axonal breakages were observed,which likely resulted in Wallerian degeneration.In summary,axonal enlargement associated with amyloidosis,micro-bleeding,and lysosome destabilization is a major defect in patients with Alzheimer’s disease.This finding suggests that,in addition to the well-documented neural soma and synaptic damage,axonal damage is a key component of neuronal defects in Alzheimer’s disease.展开更多
Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent ...Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions.展开更多
For the ultra HVDC(UHVDC)with the hierarchical connection mode at the inverter side,considering the change of the Thevenin equivalent parameters(TEP)of post-fault AC grid,a coordinated control strategy to the subseque...For the ultra HVDC(UHVDC)with the hierarchical connection mode at the inverter side,considering the change of the Thevenin equivalent parameters(TEP)of post-fault AC grid,a coordinated control strategy to the subsequent commutation failure(SCF)at both layers is newly proposed.The originality of this work is manifested in three aspects.1)The mechanism of the SCF at the fault layer is newly found by deriving the analytical expression of the extinction angle with the TEP,and that at the non-fault layer is newly found by the voltage-time area theory with the DC current coupling.2)An estimation model for the TEPs of two AC grids at the inverter side is proposed with the post-fault quantities.To address the random noise and inaccurate measurement data,an adaptive robust least squares method based on the median principle is proposed to solve the TEP model.3)A coordinated control strategy with the estimated TEP is proposed to compensate for the extinction angle at the fault layer and limit the DC current at the non-fault layer,thus suppressing the SCF.The simulation results verify the suppression effect of the proposed control on the SCF under different fault conditions.展开更多
Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSL...Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSLA has established a technical standards system for wireless short-range communication covering full-stack standards such as the end-to-end protocol system.展开更多
基金supported by the Science and Technology Research Project of Henan Province(242102241055)the Industry-University-Research Collaborative Innovation Base on Automobile Lightweight of“Science and Technology Innovation in Central Plains”(2024KCZY315)the Opening Fund of State Key Laboratory of Structural Analysis,Optimization and CAE Software for Industrial Equipment(GZ2024A03-ZZU).
文摘In two-scale topology optimization,enhancing the connectivity between adjacent microstructures is crucial for achieving the collaborative optimization of micro-scale performance and macro-scale manufacturability.This paper proposes a two-scale concurrent topology optimization strategy aimed at improving the interface connection strength.This method employs a parametric approach to explicitly divide the micro-design domain into a“boundary connection region”and a“free design domain”at the initial stage of optimization.The boundary connection region is used to generate a connection layer that enhances the interface strength,while the free design domain is not constrained by this layer,thus fully exploiting the design potential of the material layout.During the optimization process,the solid isotropic material with penalization(SIMP)method is first used to optimize the material distribution in the free design domain,and filtering and projection techniques are employed to alleviate numerical instability and obtain a clear topological structure.Subsequently,the effective performance of the microstructure is calculated through homogenization and transferred to the macro-scale for global response analysis.Throughout the iterative process,the geometry of the connection layer remains unchanged,and only the free design domain is optimized,thereby achieving a balance between high performance and good manufacturability.The effectiveness of the proposed method is verified through numerical examples.
基金supported by High-level Talents Program of Hainan Basic and Applied Basic Research Program of China(520RC543)Crosswise Tasks of Enterprise Entrusted(JG-ZH-A-202411-003).
文摘To achieve efficient connection and integrity in prefabricated frame structures,a novel beam-column connection between prefabricated steel-reinforced concrete(SRC)columns and cast-in-situ reinforced concrete(RC)beams is proposed.Four connection specimens with varying thicknesses of connecting cover plates were designed and fabricated.Low-cycle reversed loading tests were conducted to obtain mechanical performance data,allowing for analysis of behavioral patterns,including load-displacement hysteresis curves,skeleton curves,load-carrying capacity,deformation performance,energy dissipation capacity,and stiffness degradation.Test results indicate that properly designed prefabricated connections exhibit mechanical properties comparable to those of cast-in-situ concrete connections.The hysteresis curves of the prefabricated connections are well-shaped,with nearly no reduction in load-carrying capacity and deformation performance,demonstrating excellent seismic behavior.The findings provide a theoretical basis and reference for the design of prefabricated concrete frame structures.
基金Natural Science Foundation of China under Grant No.52178449,the Beijing Natural Science Foundation under Grant No.8234060the Innovation Center of Beijing Association for Science and Technology。
文摘This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties.
基金supported by the“Regional Innovation System&Education(RISE)”through the Seoul RISE Center,funded by the Ministry of Education(MOE)and the Seoul Metropolitan Government.(2025-RISE-01-005-07).
文摘Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social connection and mental health,focusing on the mediating role of quality of life(QoL)and the moderating effect of regional differences.Methods:We analyzed data from the 2019 Korean Community Health Survey,comprising 229,099 adults.Mental health was assessed through validated measures of depressive symptoms and psychological well-being.Social connection was measured using indicators of interpersonal ties and community participation,and QoL was assessed via self-reported health-related satisfaction across major life domains.Analytical procedures included mediation modeling and subgroup analyses by region,with significance levels set at p<0.05.Results:The results indicate that social connections are significantly associated with lower stress levels and reduced depressive symptoms,with QoL playing a critical mediating role.Notably,the indirect effect of social connection on mental health via QoL is stronger in rural areas compared to urban regions,highlighting the importance of social cohesion and community support in mental well-being.Among 203,567 adults,greater social participation was associated with lower subjective stress(total effect=−0.052,p<0.001)and fewer depressive symptoms(PHQ-9 total effect=−0.308,p<0.001).QoL significantly mediated these associations,with the strongest indirect pathways observed through usual activities(19.2%for stress;27.6%for depression)and mobility(24.4%for depression).Regional analysis showed stronger mediation in rural areas(up to 26.8%for stress and 32.6%for depression)than in urban areas(8–16%and 14.9–23%).Direct effects remained significant,indicating partial mediation.These findings highlight that social participation enhances mental health directly and indirectly through QoL,particularly in rural contexts.Conclusions:Social connection contributes to better mental health both directly and indirectly through improved QoL,with stronger effects observed in rural communities.These findings highlight the importance of fostering social cohesion and enhancing life quality as strategies for improving population mental health.Policy interventions should adopt context-sensitive approaches that account for regional differences in social resources and service availability.
基金funded by Science and Technology Innovation Project grant No.ZZKY20222304.
文摘Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet,this paper proposes a novel lightweight neural network model called ResghostNet.This model constructs the Resghost Module by combining residual connections and Adaptive-SE Blocks,which enhances the quality of generated feature maps through direct propagation of original input information and selection of important channels before cheap operations.Specifically,ResghostNet introduces residual connections on the basis of the Ghost Module to optimize the information flow,and designs a weight self-attention mechanism combined with SE blocks to enhance feature expression capabilities in cheap operations.Experimental results on the ImageNet dataset show that,compared to GhostNet,ResghostNet achieves higher accuracy while reducing the number of parameters by 52%.Although the computational complexity increases,by optimizing the usage strategy of GPU cachememory,themodel’s inference speed becomes faster.The ResghostNet is optimized in terms of classification accuracy and the number of model parameters,and shows great potential in edge computing devices.
基金Project supported by Quantum Science and Technology–National Science and Technology Major Project(Grant No.2024ZD0301000)the National Natural Science Foundation of China(Grant No.12305031)+1 种基金the Hangzhou Joint Fund of the Natural Science Foundation of Zhejiang Province,China(Grant No.LHZSD24A050001)the Science Foundation of Zhejiang Sci-Tech University(Grant Nos.23062088Y and 23062153-Y)。
文摘The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor(QGT),another important concept in the field of quantum geometry.The DWZC is Hermitian with respect to the two integer indices,just like the original Hermitian WZC.Based on the symmetric logarithmic derivative operator,we propose a mixed-state quantum geometric tensor.Using the symmetric properties of the DWZC,we find that the real part of the QGT is connected to the real part of the DWZC and the square of eigenvalue differences of the density matrix,whereas the imaginary part can be given in terms of the imaginary part of the DWZC and the cube of the eigenvalue differences.For density matrices with full rank or no full rank,the QGT can be given in terms of real and imaginary parts of the DWZC.
基金supported by the National Natural Science Foundation of China,No.81472235(to HF)the Shanghai Jiao Tong University Medical and Engineering Project,Nos.YG2021QN53(to HF),YG2017MS71(to HF)+1 种基金the International Cooperation Project of the National Natural Science Foundation of China,No.82020108017(to DC)the Innovation Group Project of the National Natural Science Foundation of China,No.81921002(to DC).
文摘Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined extensively.We used immunohistochemistry and immunofluorescence staining to analyze the forebrain tissue slices of Alzheimer’s disease patients.Widespread axonal amyloidosis with distinctive axonal enlargement was observed in patients with Alzheimer’s disease.On average,amyloid-β-positive axon diameters in Alzheimer’s disease brains were 1.72 times those of control brain axons.Furthermore,axonal amyloidosis was associated with microtubule-associated protein 2 reduction,tau phosphorylation,lysosome destabilization,and several blood-related markers,such as apolipoprotein E,alpha-hemoglobin,glycosylated hemoglobin type A1C,and hemin.Lysosome destabilization in Alzheimer’s disease was also clearly identified in the neuronal soma,where it was associated with the co-expression of amyloid-β,Cathepsin D,alpha-hemoglobin,actin alpha 2,and collagen type IV.This suggests that exogenous hemorrhagic protein intake influences neural lysosome stability.Additionally,the data showed that amyloid-β-containing lysosomes were 2.23 times larger than control lysosomes.Furthermore,under rare conditions,axonal breakages were observed,which likely resulted in Wallerian degeneration.In summary,axonal enlargement associated with amyloidosis,micro-bleeding,and lysosome destabilization is a major defect in patients with Alzheimer’s disease.This finding suggests that,in addition to the well-documented neural soma and synaptic damage,axonal damage is a key component of neuronal defects in Alzheimer’s disease.
文摘Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions.
基金supported in part by the National Natural Science Foundation of China under Grant 51877061.
文摘For the ultra HVDC(UHVDC)with the hierarchical connection mode at the inverter side,considering the change of the Thevenin equivalent parameters(TEP)of post-fault AC grid,a coordinated control strategy to the subsequent commutation failure(SCF)at both layers is newly proposed.The originality of this work is manifested in three aspects.1)The mechanism of the SCF at the fault layer is newly found by deriving the analytical expression of the extinction angle with the TEP,and that at the non-fault layer is newly found by the voltage-time area theory with the DC current coupling.2)An estimation model for the TEPs of two AC grids at the inverter side is proposed with the post-fault quantities.To address the random noise and inaccurate measurement data,an adaptive robust least squares method based on the median principle is proposed to solve the TEP model.3)A coordinated control strategy with the estimated TEP is proposed to compensate for the extinction angle at the fault layer and limit the DC current at the non-fault layer,thus suppressing the SCF.The simulation results verify the suppression effect of the proposed control on the SCF under different fault conditions.
文摘Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSLA has established a technical standards system for wireless short-range communication covering full-stack standards such as the end-to-end protocol system.
