BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular ...BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with non-STEMI.Types of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle rupture.The FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be effective.Ventricular septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair options.CASE SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary angiography.Prompt resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient recovery.CONCLUSION This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.展开更多
A great earthquake struck central Myanmar on March 28,2025,causing extensive and severe damage in Myanmar and neighboring countries such as Thailand.Observed waveforms indicated the possibility of supershear rupture a...A great earthquake struck central Myanmar on March 28,2025,causing extensive and severe damage in Myanmar and neighboring countries such as Thailand.Observed waveforms indicated the possibility of supershear rupture at the source of this event.To investigate this possibility,a joint source inversion using near-field and teleseismic waveforms was performed.The fault model used,with a total length of 580 km,comprises five segments with varying strike directions and dip angles.Within the first 10 s after initiation at the hypocenter,the rupture propagated southward at a high speed of 5–6 km/s.while rupture in the northern direction proceeded at a speed lower than the local S-wave velocity of 3.5 km/s.Subsequently,the rupture propagated bilaterally in both northern and southern directions at high speeds of 5–6 km/s.The largest asperity,with a maximum slip of 5–6 m,occurred in the shallow part of the fault model,approximately 240 km south of the hypocenter.Large slips of 2–3 m were also found near the southern end of the fault model.Slips on the fault plane were dominated by strike-slip components,though slips south of the largest asperity included significant dip-slip components.展开更多
Background:The incidence of spontaneously ruptured hepatocellular carcinoma(srHCC)has been shown to significantly elevate mortality rates.However,the precise mechanisms underlying srHCC remain poorly understood.Method...Background:The incidence of spontaneously ruptured hepatocellular carcinoma(srHCC)has been shown to significantly elevate mortality rates.However,the precise mechanisms underlying srHCC remain poorly understood.Methods:Analysis was conducted on the data of 198 hepatocellular carcinoma(HCC)patients to inves-tigate the factors contributing to srHCC.The clinical data of 33 transcriptome HCC patients were served for verification.An in-depth transcriptome analysis was conducted to investigate the distinctions between 26 cases of srHCC and 35 cases of non-ruptured hepatocellular carcinoma(nrHCC).Weighted Gene Co-expression Network Analysis(WGCNA)tool was utilized to develop a gene co-expression network.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathways enrichment,and protein-protein interaction(PPI)network were carried out.The corresponding samples for spontaneously rup-tured hepatocellular carcinoma tissue(srHCC-T)and ruptured hepatocellular carcinoma paracancerous tissue(srHCC-P)were selected for verification.Transcriptional data were validated through reverse tran-scription quantitative polymerase chain reaction(RT-qPCR).Immunofluorescence(IF),immunohistochem-istry(IHC)and Western blot were used to detect the protein expression.Results:Our results showed that white blood cell(WBC)and monocyte levels were significant inde-pendent risk factors for srHCC(P<0.05).There was a strong association between the srHCC-T and the expression of cell cycle-related genes BUB1B and macrophage function-related gene MACRO.Furthermore,chemokines and the PI3K/AKT signaling pathway play a crucial role in regulating the cell cycle process through a complex network of interactions,ultimately impacting the occurrence of srHCC.Conclusions:Our study confirms that chemokines and the PI3K/AKT signaling pathway mediate the occur-rence of HCC rupture by regulating the cell cycle.We provide a theoretical basis for the clinical treatment of srHCC.展开更多
The Hualien M 7.3 earthquake on April 3,2024,was a significant and strong earthquake in Taiwan,China in the past two decades.The rupture process of the main shock and strong aftershocks is of great significance to the...The Hualien M 7.3 earthquake on April 3,2024,was a significant and strong earthquake in Taiwan,China in the past two decades.The rupture process of the main shock and strong aftershocks is of great significance to the subsequent seismic activity and seismogenic tectonic research.Based on local strong-motion data,we used the IDS(Iterative Deconvolution and Stacking)method to obtain the rupture process of the mainshock and two strong aftershocks on the 23rd.The rupture of the mainshock was mainly unilateral,lasting 31 s,with a maximum slip of 2m,and the depth of the large slip zone is about 41–49 km.There is a clear difference between the rupture depth of the main shock and the two strong aftershocks.The depths of the large slip zones of the latter two are 3–9 km and 8–10 km,respectively.There is also a significant difference in the seismogenic fault between the mainshock and the aftershocks,and we believe that there are two seismogenic fault zones in the study area,the deep and the shallow fault zone.The slip of the deep faults activates the shallow faults.展开更多
BACKGROUND Boerhaave syndrome,or spontaneous esophageal rupture,is a rare and lifethreatening emergency,typically caused by a sudden increase in esophageal pressure due to violent coughing or vomiting.Early diagnosis ...BACKGROUND Boerhaave syndrome,or spontaneous esophageal rupture,is a rare and lifethreatening emergency,typically caused by a sudden increase in esophageal pressure due to violent coughing or vomiting.Early diagnosis is challenging as its symptoms often resemble those of other diseases.Understanding its pathological features and treatment strategies is therefore critical for clinical practice.CASE SUMMARY This report describes a case of spontaneous esophageal rupture triggered by violent coughing in a 55-year-old male with a history of smoking and hypertension.Following severe coughing,the patient developed chest pain,vomiting,and respiratory distress.Initial clinical evaluation was inconclusive,with a suspected diagnosis of cardiovascular or gastrointestinal conditions.After further examination,the diagnosis of spontaneous esophageal rupture was confirmed.Chest X-ray,computed tomography,and endoscopy revealed a rupture in the lower esophagus,along with mediastinal abscess and pleural effusion.Laboratory tests showed mild infection markers.The patient underwent surgical repair of the esophageal rupture(approximately 3 cm in length)with mediastinal drainage.Postoperatively,the patient’s temperature normalized within 3 days,respiratory function improved,and pleural effusion significantly decreased.After two weeks of treatment,the patient was discharged without complications and had a favorable prognosis.The study suggests that while violent coughing is a rare trigger,it can lead to severe damage,and imaging techniques play a crucial role in diagnosis.CONCLUSION Spontaneous esophageal rupture presents significant diagnostic and therapeutic challenges.Early recognition and timely intervention are crucial for improving prognosis.This case highlights the importance of imaging and surgical treatment,offering new insights for managing similar cases and providing valuable clinical guidance.展开更多
BACKGROUND Transplantectomy has long been considered the preferred treatment for spontaneous renal graft rupture,prioritizing patient safety over kidney salvage.In the last decade,there has been an increasing number o...BACKGROUND Transplantectomy has long been considered the preferred treatment for spontaneous renal graft rupture,prioritizing patient safety over kidney salvage.In the last decade,there has been an increasing number of reports showing that,in selected scenarios,conservative management through graft repair represents a feasible option,challenging traditional approaches.CASE SUMMARY We describe the case of a 37-year-old sensitized XY patient who experienced early spontaneous graft rupture after receiving his second deceased donor kidney transplant.Following temporary hemodynamic stabilization and abdominal contrast enhanced computed tomography scan assessment,the recipient was brought back to theatre for surgical exploration.Possible causes of irreversible graft damage were immediately ruled out.The fractured upper pole of the transplanted kidney was repaired using a fibrin sealant,external compression,and a tailored polyglactin 910 mesh wrapped around the graft.The post-operative course was uneventful.After 20 months of follow up,the patient is doing very well,with excellent renal function and complete reabsorption of the mesh,as demonstrated by serial ultrasound evaluations of the graft.CONCLUSION Amid organ shortages and sensitized patients,graft nephrectomy is reserved for severe injuries;repair using sealants and mesh is effective.展开更多
This article revisits the concept of epistemological rupture by questioning the stark division between scientific and non-scientific thought. Drawing on the theory of representation, it contends that both forms of kno...This article revisits the concept of epistemological rupture by questioning the stark division between scientific and non-scientific thought. Drawing on the theory of representation, it contends that both forms of knowledge are socially constructed, moulded by communication, norms and group dynamics. Rather than labelling non-scientific thought as flawed or regressive, the discussion shows how decontextualization and recontextualization processes apply equally to everyday ‘natural' knowledge and formal science,exposing the social and historical contingencies shaping concepts. Consequently, rupture appears less a sudden break than a gradual threshold reached through dialectical transformations in cognition and society. Rather than conferring total superiority on science, ruptures highlight how certain discourses gain legitimacy while others become ‘non-knowledge'. The article concludes that science's dominance reflects broader power relationships and evolving modes of production and validation. By situating epistemological rupture within these processes, it illuminates how different knowledge forms coexist, evolve and sometimes conflict in stratified social fields—ultimately challenging a simplistic binary between scientific progress and supposedly primitive or natural thought. This viewpoint opens new possibilities for examining the shifting boundaries between rational explanations and the shared beliefs shaping collective reality and daily life.展开更多
On December 18,2023,an M_(s)6.2 earthquake jolted Jishishan County in the Linxia Hui Autonomous Prefecture in Northwest China's Gansu Province,causing substantial casualties and building collapses.The earthquake o...On December 18,2023,an M_(s)6.2 earthquake jolted Jishishan County in the Linxia Hui Autonomous Prefecture in Northwest China's Gansu Province,causing substantial casualties and building collapses.The earthquake occurred in the Qilian Block on the northeastern border of the Qinghai-Tibet Plateau,where faults are highly active and the geological structure is complex.In this study,we utilized methods such as relocation,focal mechanism solutions,and earthquake rupture processes to describe seismogenic faults.The results indicated that the majority of aftershocks occurred at a depth of 12 km.The centroid depth of the main shock and the depth of the maximum rupture point during the rupture process were also 12 km.Various geophysical methods exhibited a high degree of consistency in depth exploration.Aftershocks were distributed mainly to the west and north of the main shock and extended in the NNW direction,primarily through unilateral rupture.The main shock was a reverse thrust event with a small dextral strike-slip component.In this study,more regional data,such as previous GPS observations,field geological observations,and the distributions of the primary stress states in the region,were also incorporated.We inferred that the main shock was triggered by the main fault at the northern margin of the Lajishan Fault and that the movement of the main fault also activated some secondary faults.The compressive forces on both sides of the Lajishan Fault Zone led to the uplift of mountain areas,accompanied by some landslides,leading to this catastrophic earthquake event.In this article,the activity relationships among the 2022 M_(s)6.9 Menyuan earthquake,the 2019 M_(s)5.7 Xiahe earthquake,and the Jishishan earthquake under the action of regional stress are also discussed.This study provides additional evidence and new ideas for exploring the seismogenic process of the Lajishan Fault Zone and has implications for future in-depth research on underground activity in this region.展开更多
The effect of carbon content on the microstructures and stress rupture properties of a newly developed polycrystalline Ni-based superalloy with high Cr content has been studied.It was observed that both grain size and...The effect of carbon content on the microstructures and stress rupture properties of a newly developed polycrystalline Ni-based superalloy with high Cr content has been studied.It was observed that both grain size and the number of carbides increased with an increase in carbon content.After heat treatment,granular M_(23)C_(6)carbides were dispersed around MC carbides along grain boundaries and inside grains.The quantity of granular M_(23)C_(6)carbides increased while their sizes decreased.These findings can be verified with the results of thermodynamic calculation and differential scanning calorimetry analysis.The stress rupture times(975℃/225 MPa)increased from 13.3 to 25.5 h with the carbon content increased from 0.1 to 0.2 wt.%.The improvement can be attributed to two primary factors.Firstly,grain boundary is typically weak region during deformation process and the grain size increased as carbon content increased in the alloy.Secondly,carbides act as hindrances to impede dislocation movement,leading to dislocation entanglement.As carbon content rose,the quantity of carbides in interdendritic regions and grain boundaries increased,providing a certain degree of strengthening effect and resulting in a longer stress rupture time.展开更多
Mining-related seismicity poses significant challenges in underground coal mining due to its complex rupture mechanisms and associated hazards.To bridge gaps in understanding these intricate processes,this study emplo...Mining-related seismicity poses significant challenges in underground coal mining due to its complex rupture mechanisms and associated hazards.To bridge gaps in understanding these intricate processes,this study employed a multi-local seismic monitoring network,integrating both in-mine and local instruments at overlapping length scales.We specifically focused on a damaging local magnitude(ML)2.6 event and its aftershocks that occurred on 10 September 2022 in the vicinity of the 3308 working face of the Yangcheng coal mine in Shandong Province,China.Moment tensor(MT)inversion revealed a complex cascading rupture mechanism:an initial moment magnitude(M_(w))2.2 normal fault slip along the DF60 fault in an ESEeWNW direction,transitioning to a M_(w)3.0 event as the FD24 and DF60 faults unclamped.The scale-independent self-similarity and stress heterogeneity of mining-related seismicity were investigated through source parameter calculations,providing valuable insights into the driving mechanism of these seismic sequences.The in-mine network,constrained by its low dynamic changes,captured only the nucleation phase of the DF60 fault.Furthermore,standard decomposition of the MT solution from the seismic network proved inadequate for accurately identifying the complex nature of the rupture.To enhance safety and risk management in mining environments,we examined the implications of source reactivation within the cluster area post-stress-adjustment.This comprehensive multiscale analysis offers crucial insights into the complex rupture mechanisms and hazards associated with mining-related seismicity.The results underscore the importance of continuous multi-local network monitoring and advanced analytical techniques for improved disaster assessment and risk mitigation in mining operations.展开更多
Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain...Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain poorly understood.In this study,finite element method-based numerical simulations were conducted based on the rock slope at Dagangshan Hydropower Station in Sichuan province,China.Firstly,systematic analysis in both the time and frequency domains were performed to examine the seismic dynamic characteristics of the slope.Subsequently,the transfer function method and the multiple stepwise linear regression method were employed to clarify the underlying mechanism and determine critical factors influencing the slope instability during earthquakes.Time-domain analysis reveals that rock slope dynamic response exhibits notable elevation,surface,and local amplification effects.Specifically,the Peak Ground Acceleration(PGA)amplification coefficient(MPGA)is significantly higher at elevated locations,near the slope surface and in areas with protrusions.Moreover,the existence of fracture zones and anti-shear galleries minimally influences the dynamic responses but considerably affect the rupture.Specifically,fracture zones exacerbate rupture,while anti-shear galleries mitigate it.Frequency-domain analysis indicates that the dynamic responses of the slope are closely correlated with the degree of slope rupture.As earthquake magnitude increases,the rupture degree of the slope intensifies,and the dominant frequency of the response within the slope decreases,e.g.,its value shifts from 3.63 to 2.75 Hz at measurement point 9near the slope surface.The transfer function of rock slope,calculated under the excitation of wide flat spectrum white noise can reflect the interrelationships between the inherent properties and the rupture degree.Notably,the peak of the transfer function undergoes inversion as the degree of rupture increases.Furthermore,through multiple stepwise linear regression analysis,four key factors influencing the surface dynamic response of the slope were identified:rock strength,slope angle,elevation,and seismic dominant frequency.These findings provide valuable insights into the underlying mechanisms of rock slope dynamic responses triggered by earthquakes,offering essential guidance for understanding and mitigating seismic impacts on rock slopes.展开更多
BACKGROUND Gallstones are frequently observed in patients with cholecystitis,but the migration of free gallstones into the abdominal wall leading to chronic sinus formation is exceedingly rare.CASE SUMMARY We report a...BACKGROUND Gallstones are frequently observed in patients with cholecystitis,but the migration of free gallstones into the abdominal wall leading to chronic sinus formation is exceedingly rare.CASE SUMMARY We report a case of a 72-year-old woman who experienced recurring fever and abdominal pain following laparoscopic cholecystectomy for acute cholecystitis,during which gallbladder rupture was noted.Despite initial conservative management and temporary T-tube placement,the patient developed a chronic sinus in the abdominal wall 9.5 years later,characterized by an area of thickened soft tissue with ulceration and purulent discharge.Surgical exploration revealed the presence of a migrated gallstone at the base of the sinus tract,necessitating careful surgical removal and postoperative wound care.CONCLUSION This case highlights the potential long-term complications of retained free gallstones and the importance of thorough surgical retrieval.展开更多
Introduction: Arteriovenous malformation is a rare pathology, often discovered accidentally in children. Generally, it presents as an intra-parenchymal hematoma following rupture of the affected vessels. The risk of r...Introduction: Arteriovenous malformation is a rare pathology, often discovered accidentally in children. Generally, it presents as an intra-parenchymal hematoma following rupture of the affected vessels. The risk of rupture is linked to the volume of the malformation, its cortical location and venous drainage. In literature, few cases of rupture have been reported in cases of meningitis, but none are associated with a brain abscess. Objective: To report a case of an intraparenchymal hemorrhage due to rupture of an arteriovenous malformation with an associated brain abscess. Observation: The authors report the case of a 2-year-old child, admitted for impaired state of consciousness associated with a right hemiparesis and seizures in a febrile context. Clinical evaluation revealed a Blantyre score of 3, fever at 40˚C, divergent strabismus of the right eye, a right pyramidal syndrome and meningeal irritative syndrome. Cerebral CT scan revealed a left fronto-parietal intra-parenchymal hematoma and a right occipital ring-enhanced lesion, suggesting a brain abscess. An MRI suggested a probable rupture of an arteriovenous malformation resulting in the intra-parenchymal hematoma. Management consisted of craniotomy to evacuate the intra-parenchymal hematoma, antibiotic therapy with vancomycin and ceftriaxone at meningeal doses. Histopathological analysis of the intraoperative sample revealed an arteriovenous malformation. The postoperative course was marked by regression of hyperthermia, persistence of spasticity, irritability and clonic movement of the right lower limb. These were managed with baclofen, phenobarbital, and ergotherapy. We observed a regression of spasticity and improved motor skills in the right limbs. At 6 months follow-up, child could interact with his social environment despite aphasia, regression of spasticity and right hemiparesis. Conclusion: Rupture of arteriovenous malformations can be enhanced by neuro-meningeal infections and particularly brain abscesses. Cerebrovascular complications of these conditions mostly have unfavorable outcomes and neurological sequelae.展开更多
A self-developed crack-free advanced superalloy ZGH451 fabricated by direct energy deposition(DED)was applied to investigate the microstructure evolution,stress rupture behavior,and deformation mech-anisms at moderate...A self-developed crack-free advanced superalloy ZGH451 fabricated by direct energy deposition(DED)was applied to investigate the microstructure evolution,stress rupture behavior,and deformation mech-anisms at moderate-high temperatures and high-low stress conditions.The high Ta/Al ratio induces large misfit lattice stress and low stacking fault energy of alloy,resulting in approximate cubicγ′phases in dendrites and the formation of initial dislocation tangles.After the stress rupture test at 760℃/780 MPa,high content cubicγ′phases,small size of voids as well as preserved dislocation tangles are observed,showing stable structures with high-stress rupture resistance.High content and suitable size of cubicγ′phases,initial dislocation tangles,and L-C locks hinder the dislocation motion,which decreases the minimum strain rate and prolongs life significantly,forming four stress rupture stages.Hence,the defor-mation mechanism is determined by dislocation piled-up onγ/γ′interface,formation of stacking faults inγ′phases,and dislocations shearingγ′phases.However,the microstructure exhibits uneven struc-tures composed of large sizes of raftedγ′phases and voids at 980℃/260 MPa.The rafted structure and high temperature provide continuous channels and enough energy for dislocation motion,resulting in the increase of minimum strain rate,decline of life,and typic three stress rupture stages,even though there are obstacles to dislocation movement caused by dislocation networks.The deformation mecha-nism transforms to form dislocation networks onγ/γ′interface and dislocations shearingγ′phases.Be-sides,the decomposition of carbides on GBs also depends on temperature,which decomposes into harm-ful chain-like M23 C6 carbides at moderate temperatures and reinforced granular-shaped M6 C carbides at high temperatures.The applied stress always decreases mechanical properties due to its degradation of microstructure induced by elongating the precipitates and defects.展开更多
Introduction: Uterine rupture is certainly one of the most serious, as it immediately jeopardises the vital prognosis of the mother and foetus. It is a common obstetric tragedy in our delivery rooms in countries with ...Introduction: Uterine rupture is certainly one of the most serious, as it immediately jeopardises the vital prognosis of the mother and foetus. It is a common obstetric tragedy in our delivery rooms in countries with limited resources, reflecting the poor quality of obstetric care and, consequently, an unmet obstetric need. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection over a four-year period from 1 January 2020 to 31 December 2023 at the University Hospital Centre (CHU) of Bouaké, in the Obstetrics and Gynaecology Department. The variables studied were epidemiological characteristics, therapeutic aspects and factors associated with maternal. Results: The prevalence of uterine rupture was 0.63%. The average age was 32, with patients aged 35 and over accounting for 33.68%, married 44.21% and 70% not in education. Patients with uterine rupture had been evacuated in 85.26% of cases. Uterine rupture was diagnosed in 97.89% of cases during labour. Maternal lethality due to rupture was 15.79%. The causes of maternal death were dominated by haemorrhagic shock (53.33%). Factors statistically associated with death were age ≥ 35 years (OR: 3.14), duration of labour ≥ 12 hours (OR: 5.8), multiparity (OR: 19.04), admission delay beyond 2 hours (OR: 4.36), haemoglobin level ≤ 7 g/dl (OR: 36.84), coma or obnubilation (OR: 71.82), haemorrhagic shock (OR: 243.94) and occurrence of post-operative complications (OR: 76.45). Conclusion: The frequency of uterine rupture remains significant in the department (0.63%), with maternal mortality still high (15.79%). The key to reducing uterine rupture and its consequences lies in timely referral and early, appropriate management.展开更多
BACKGROUND Fibro-adipogenic progenitors(FAPs)are a group of mesenchymal stem cells that cause fibro-fatty degeneration in skeletal muscle in various chronic disease mode-ls.FAPs also play a role in preventing muscle d...BACKGROUND Fibro-adipogenic progenitors(FAPs)are a group of mesenchymal stem cells that cause fibro-fatty degeneration in skeletal muscle in various chronic disease mode-ls.FAPs also play a role in preventing muscle degeneration at acute stages during disease progression.However,few studies have reported the changes in and function of FAPs in the acute phase after tendon rupture.AIM To clarify the changes in the number of FAPs and their impact on skeletal muscle soon after tendon rupture to facilitate future studies targeting FAPs to treat muscle degeneration.METHODS We utilized Pdgfra-H2B::eGFP mice to trace and quantify FAPs in a tibialis anterior tenotomy(TAT)model at 0 and 3 days,1 week,2 weeks,3 weeks,4 weeks,5 weeks,and 6 weeks post-injury,and the results were further validated using fluorescence-activated cell sorting analysis with C57BL/6 mice at the same post-injury timepoints.We subsequently used PdgfraCreERT::RosaDTA mice,and evaluated the severity of post-TAT skeletal muscle degeneration with or without FAP-depletion.RESULTS The number of FAPs peaked at 1 week post-TAT before gradually declining to a level comparable to that pre-TAT.The change in the number of FAPs was potentially temporally correlated with the progression of skeletal muscle degeneration after TAT.FAP-depletion led to more severe degeneration early after TAT,indicating that FAPs potentially alleviate muscle degeneration after tendon rupture in the early post-injury phase.CONCLUSION FAPs potentially alleviate the degeneration of skeletal muscle in the acute stage after tendon rupture.展开更多
Seismic fault rupture can extend to the surface,and the resulting surface deformation can cause severe damage to civil engineering structures crossing the fault zones.Coseismic Surface Rupture Prediction Models(CSRPMs...Seismic fault rupture can extend to the surface,and the resulting surface deformation can cause severe damage to civil engineering structures crossing the fault zones.Coseismic Surface Rupture Prediction Models(CSRPMs)play a crucial role in the structural design of fault-crossing engineering and in the hazard analysis of fault-intensive areas.In this study,a new global coseismic surface rupture database was constructed by compiling 171 earthquake events(Mw:5.5-7.9)that caused surface rupture.In contrast to the fault classification in traditional empirical relationships,this study categorizes earthquake events as strike-slip,dip-slip,and oblique-slip.CSRPMs utilizing Bayesian ridge regression(BRR)were developed to estimate parameters such as surface rupture length,average displacement,and maximum displacement.Based on Bayesian theory,BRR combines the benefits of both ridge regression and Bayesian linear regression.This approach effectively addresses the issue of overfitting while ensuring the strong model robustness.The reliability of the CSRPMs was validated by residual analysis and comparison with post-earthquake observations from the 2023 Türkiye earthquake doublet.The BRR-CSRPMs with new fault classification criteria are more suitable for the probabilistic hazard analysis of complex fault systems and dislocation design of fault-crossing engineering.展开更多
Case Letter Severe trauma has high morbidity and mortality rates,being the leading cause of death in young adults.Among all traumas,tra ffi c injuries are particularly lethal.^([1-2]) The injury severity score(ISS) ca...Case Letter Severe trauma has high morbidity and mortality rates,being the leading cause of death in young adults.Among all traumas,tra ffi c injuries are particularly lethal.^([1-2]) The injury severity score(ISS) can be used to assess trauma severity,with ISS of<9,9–15,16–24,and≥25 indicating minor,moderate,severe,and critical trauma,respectively.The ISS is correlated with mortality,morbidity,and hospitalization duration after injury.^([3-4]) Here,we report one patient who was admitted to our emergency intensive care unit(EICU) due to traumatic liver rupture and traumatic myocardial infarction complicated with inferior vena cava(IVC) thrombosis.展开更多
The size and shape effect(SSE)of components has become a critical issue for mechanical properties,application reliability,and processing.In this study,the creep rupture life(CRL)of components with different wall thick...The size and shape effect(SSE)of components has become a critical issue for mechanical properties,application reliability,and processing.In this study,the creep rupture life(CRL)of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated.The intrinsic mechanisms of the SSE were explored from the dendrite structure,volume fraction and size of theγ'phase,and element segregation,etc.It is shown that this casting exhibits a strong SSE of creep rupture life,characterized by a significant difference in the CRL values up to 60%with the variation of wall thickness and position in the casing.In terms of casting technology,the influence of SSE on CRL is actually determined by the cooling rate.The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing),volume fraction size of theγ'phase in the dendrite trunk,and elements segregation rate.This work may have implications for the design and application of engineering components with large sizes and complex structures.展开更多
Bronchial rupture from penetrating,perforating,or compressive cervical or thoracic injuries can lead to complete tracheal,mainstem bronchial,or lobar bronchial detachment.Although rare in children,bronchial rupture pr...Bronchial rupture from penetrating,perforating,or compressive cervical or thoracic injuries can lead to complete tracheal,mainstem bronchial,or lobar bronchial detachment.Although rare in children,bronchial rupture presents significant risks,including dyspnea,respiratory failure,and potentially fatal airway obstruction,and is often overlooked or diagnosed late in clinical settings.Prompt diagnosis and intervention are prognostically crucial.[1,2]Between January 2013 and December 2023,four children(two male and two female)with bronchial rupture were admitted to the Pediatric Surgical Intensive CareUnit(ICU)at Children’s Hospital,Zhejiang University School of Medicine.Here,we share our experience of patient management.展开更多
文摘BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with non-STEMI.Types of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle rupture.The FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be effective.Ventricular septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair options.CASE SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary angiography.Prompt resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient recovery.CONCLUSION This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.
基金Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant No.2024B15National Natural Science Fundation of China under Grant Nos.U2239252 and 52478567Natural Science Foundation of Heilongjiang Province under Grant No.JQ2023E002。
文摘A great earthquake struck central Myanmar on March 28,2025,causing extensive and severe damage in Myanmar and neighboring countries such as Thailand.Observed waveforms indicated the possibility of supershear rupture at the source of this event.To investigate this possibility,a joint source inversion using near-field and teleseismic waveforms was performed.The fault model used,with a total length of 580 km,comprises five segments with varying strike directions and dip angles.Within the first 10 s after initiation at the hypocenter,the rupture propagated southward at a high speed of 5–6 km/s.while rupture in the northern direction proceeded at a speed lower than the local S-wave velocity of 3.5 km/s.Subsequently,the rupture propagated bilaterally in both northern and southern directions at high speeds of 5–6 km/s.The largest asperity,with a maximum slip of 5–6 m,occurred in the shallow part of the fault model,approximately 240 km south of the hypocenter.Large slips of 2–3 m were also found near the southern end of the fault model.Slips on the fault plane were dominated by strike-slip components,though slips south of the largest asperity included significant dip-slip components.
基金supported by grants from the National Natu-ral Science Foundation of China(52072005 and 51872279).
文摘Background:The incidence of spontaneously ruptured hepatocellular carcinoma(srHCC)has been shown to significantly elevate mortality rates.However,the precise mechanisms underlying srHCC remain poorly understood.Methods:Analysis was conducted on the data of 198 hepatocellular carcinoma(HCC)patients to inves-tigate the factors contributing to srHCC.The clinical data of 33 transcriptome HCC patients were served for verification.An in-depth transcriptome analysis was conducted to investigate the distinctions between 26 cases of srHCC and 35 cases of non-ruptured hepatocellular carcinoma(nrHCC).Weighted Gene Co-expression Network Analysis(WGCNA)tool was utilized to develop a gene co-expression network.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathways enrichment,and protein-protein interaction(PPI)network were carried out.The corresponding samples for spontaneously rup-tured hepatocellular carcinoma tissue(srHCC-T)and ruptured hepatocellular carcinoma paracancerous tissue(srHCC-P)were selected for verification.Transcriptional data were validated through reverse tran-scription quantitative polymerase chain reaction(RT-qPCR).Immunofluorescence(IF),immunohistochem-istry(IHC)and Western blot were used to detect the protein expression.Results:Our results showed that white blood cell(WBC)and monocyte levels were significant inde-pendent risk factors for srHCC(P<0.05).There was a strong association between the srHCC-T and the expression of cell cycle-related genes BUB1B and macrophage function-related gene MACRO.Furthermore,chemokines and the PI3K/AKT signaling pathway play a crucial role in regulating the cell cycle process through a complex network of interactions,ultimately impacting the occurrence of srHCC.Conclusions:Our study confirms that chemokines and the PI3K/AKT signaling pathway mediate the occur-rence of HCC rupture by regulating the cell cycle.We provide a theoretical basis for the clinical treatment of srHCC.
基金sponsored by the Earthquake Spark Technology Project(XH23051B)。
文摘The Hualien M 7.3 earthquake on April 3,2024,was a significant and strong earthquake in Taiwan,China in the past two decades.The rupture process of the main shock and strong aftershocks is of great significance to the subsequent seismic activity and seismogenic tectonic research.Based on local strong-motion data,we used the IDS(Iterative Deconvolution and Stacking)method to obtain the rupture process of the mainshock and two strong aftershocks on the 23rd.The rupture of the mainshock was mainly unilateral,lasting 31 s,with a maximum slip of 2m,and the depth of the large slip zone is about 41–49 km.There is a clear difference between the rupture depth of the main shock and the two strong aftershocks.The depths of the large slip zones of the latter two are 3–9 km and 8–10 km,respectively.There is also a significant difference in the seismogenic fault between the mainshock and the aftershocks,and we believe that there are two seismogenic fault zones in the study area,the deep and the shallow fault zone.The slip of the deep faults activates the shallow faults.
基金Supported by Guangzhou Municipal Science and Technology Bureau,No.SL2024AD3JD0112.
文摘BACKGROUND Boerhaave syndrome,or spontaneous esophageal rupture,is a rare and lifethreatening emergency,typically caused by a sudden increase in esophageal pressure due to violent coughing or vomiting.Early diagnosis is challenging as its symptoms often resemble those of other diseases.Understanding its pathological features and treatment strategies is therefore critical for clinical practice.CASE SUMMARY This report describes a case of spontaneous esophageal rupture triggered by violent coughing in a 55-year-old male with a history of smoking and hypertension.Following severe coughing,the patient developed chest pain,vomiting,and respiratory distress.Initial clinical evaluation was inconclusive,with a suspected diagnosis of cardiovascular or gastrointestinal conditions.After further examination,the diagnosis of spontaneous esophageal rupture was confirmed.Chest X-ray,computed tomography,and endoscopy revealed a rupture in the lower esophagus,along with mediastinal abscess and pleural effusion.Laboratory tests showed mild infection markers.The patient underwent surgical repair of the esophageal rupture(approximately 3 cm in length)with mediastinal drainage.Postoperatively,the patient’s temperature normalized within 3 days,respiratory function improved,and pleural effusion significantly decreased.After two weeks of treatment,the patient was discharged without complications and had a favorable prognosis.The study suggests that while violent coughing is a rare trigger,it can lead to severe damage,and imaging techniques play a crucial role in diagnosis.CONCLUSION Spontaneous esophageal rupture presents significant diagnostic and therapeutic challenges.Early recognition and timely intervention are crucial for improving prognosis.This case highlights the importance of imaging and surgical treatment,offering new insights for managing similar cases and providing valuable clinical guidance.
文摘BACKGROUND Transplantectomy has long been considered the preferred treatment for spontaneous renal graft rupture,prioritizing patient safety over kidney salvage.In the last decade,there has been an increasing number of reports showing that,in selected scenarios,conservative management through graft repair represents a feasible option,challenging traditional approaches.CASE SUMMARY We describe the case of a 37-year-old sensitized XY patient who experienced early spontaneous graft rupture after receiving his second deceased donor kidney transplant.Following temporary hemodynamic stabilization and abdominal contrast enhanced computed tomography scan assessment,the recipient was brought back to theatre for surgical exploration.Possible causes of irreversible graft damage were immediately ruled out.The fractured upper pole of the transplanted kidney was repaired using a fibrin sealant,external compression,and a tailored polyglactin 910 mesh wrapped around the graft.The post-operative course was uneventful.After 20 months of follow up,the patient is doing very well,with excellent renal function and complete reabsorption of the mesh,as demonstrated by serial ultrasound evaluations of the graft.CONCLUSION Amid organ shortages and sensitized patients,graft nephrectomy is reserved for severe injuries;repair using sealants and mesh is effective.
文摘This article revisits the concept of epistemological rupture by questioning the stark division between scientific and non-scientific thought. Drawing on the theory of representation, it contends that both forms of knowledge are socially constructed, moulded by communication, norms and group dynamics. Rather than labelling non-scientific thought as flawed or regressive, the discussion shows how decontextualization and recontextualization processes apply equally to everyday ‘natural' knowledge and formal science,exposing the social and historical contingencies shaping concepts. Consequently, rupture appears less a sudden break than a gradual threshold reached through dialectical transformations in cognition and society. Rather than conferring total superiority on science, ruptures highlight how certain discourses gain legitimacy while others become ‘non-knowledge'. The article concludes that science's dominance reflects broader power relationships and evolving modes of production and validation. By situating epistemological rupture within these processes, it illuminates how different knowledge forms coexist, evolve and sometimes conflict in stratified social fields—ultimately challenging a simplistic binary between scientific progress and supposedly primitive or natural thought. This viewpoint opens new possibilities for examining the shifting boundaries between rational explanations and the shared beliefs shaping collective reality and daily life.
基金funded by the National Natural Science Foundation of China(Grant No.42304072)。
文摘On December 18,2023,an M_(s)6.2 earthquake jolted Jishishan County in the Linxia Hui Autonomous Prefecture in Northwest China's Gansu Province,causing substantial casualties and building collapses.The earthquake occurred in the Qilian Block on the northeastern border of the Qinghai-Tibet Plateau,where faults are highly active and the geological structure is complex.In this study,we utilized methods such as relocation,focal mechanism solutions,and earthquake rupture processes to describe seismogenic faults.The results indicated that the majority of aftershocks occurred at a depth of 12 km.The centroid depth of the main shock and the depth of the maximum rupture point during the rupture process were also 12 km.Various geophysical methods exhibited a high degree of consistency in depth exploration.Aftershocks were distributed mainly to the west and north of the main shock and extended in the NNW direction,primarily through unilateral rupture.The main shock was a reverse thrust event with a small dextral strike-slip component.In this study,more regional data,such as previous GPS observations,field geological observations,and the distributions of the primary stress states in the region,were also incorporated.We inferred that the main shock was triggered by the main fault at the northern margin of the Lajishan Fault and that the movement of the main fault also activated some secondary faults.The compressive forces on both sides of the Lajishan Fault Zone led to the uplift of mountain areas,accompanied by some landslides,leading to this catastrophic earthquake event.In this article,the activity relationships among the 2022 M_(s)6.9 Menyuan earthquake,the 2019 M_(s)5.7 Xiahe earthquake,and the Jishishan earthquake under the action of regional stress are also discussed.This study provides additional evidence and new ideas for exploring the seismogenic process of the Lajishan Fault Zone and has implications for future in-depth research on underground activity in this region.
基金supported by the National Natural Science Foundation of China(No.52303394)the National Key Research and Development Program of China(No.2022YFB3705000)+1 种基金the Natural Science Foundation of Liaoning Province(No.2023-BS-015)the Science Center for Gas Turbine Project(No.P2022-C-IV-002-001).
文摘The effect of carbon content on the microstructures and stress rupture properties of a newly developed polycrystalline Ni-based superalloy with high Cr content has been studied.It was observed that both grain size and the number of carbides increased with an increase in carbon content.After heat treatment,granular M_(23)C_(6)carbides were dispersed around MC carbides along grain boundaries and inside grains.The quantity of granular M_(23)C_(6)carbides increased while their sizes decreased.These findings can be verified with the results of thermodynamic calculation and differential scanning calorimetry analysis.The stress rupture times(975℃/225 MPa)increased from 13.3 to 25.5 h with the carbon content increased from 0.1 to 0.2 wt.%.The improvement can be attributed to two primary factors.Firstly,grain boundary is typically weak region during deformation process and the grain size increased as carbon content increased in the alloy.Secondly,carbides act as hindrances to impede dislocation movement,leading to dislocation entanglement.As carbon content rose,the quantity of carbides in interdendritic regions and grain boundaries increased,providing a certain degree of strengthening effect and resulting in a longer stress rupture time.
基金funded by the National Natural Science Foundation of China(Grant No.51574225)Shandong Energy Group(Grant No.SNKJ2022BJ03-R28)for Caiping Lu+1 种基金the Research Team on MonitoringActivity Mechanisms of Unnatural Earthquakes of Shandong Earthquake Agency(Grant No.TD202301)for Chengyu Liu.
文摘Mining-related seismicity poses significant challenges in underground coal mining due to its complex rupture mechanisms and associated hazards.To bridge gaps in understanding these intricate processes,this study employed a multi-local seismic monitoring network,integrating both in-mine and local instruments at overlapping length scales.We specifically focused on a damaging local magnitude(ML)2.6 event and its aftershocks that occurred on 10 September 2022 in the vicinity of the 3308 working face of the Yangcheng coal mine in Shandong Province,China.Moment tensor(MT)inversion revealed a complex cascading rupture mechanism:an initial moment magnitude(M_(w))2.2 normal fault slip along the DF60 fault in an ESEeWNW direction,transitioning to a M_(w)3.0 event as the FD24 and DF60 faults unclamped.The scale-independent self-similarity and stress heterogeneity of mining-related seismicity were investigated through source parameter calculations,providing valuable insights into the driving mechanism of these seismic sequences.The in-mine network,constrained by its low dynamic changes,captured only the nucleation phase of the DF60 fault.Furthermore,standard decomposition of the MT solution from the seismic network proved inadequate for accurately identifying the complex nature of the rupture.To enhance safety and risk management in mining environments,we examined the implications of source reactivation within the cluster area post-stress-adjustment.This comprehensive multiscale analysis offers crucial insights into the complex rupture mechanisms and hazards associated with mining-related seismicity.The results underscore the importance of continuous multi-local network monitoring and advanced analytical techniques for improved disaster assessment and risk mitigation in mining operations.
基金supported by the National Natural Science Foundation of China(Grant Nos.52274075,42122052,52379098)。
文摘Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain poorly understood.In this study,finite element method-based numerical simulations were conducted based on the rock slope at Dagangshan Hydropower Station in Sichuan province,China.Firstly,systematic analysis in both the time and frequency domains were performed to examine the seismic dynamic characteristics of the slope.Subsequently,the transfer function method and the multiple stepwise linear regression method were employed to clarify the underlying mechanism and determine critical factors influencing the slope instability during earthquakes.Time-domain analysis reveals that rock slope dynamic response exhibits notable elevation,surface,and local amplification effects.Specifically,the Peak Ground Acceleration(PGA)amplification coefficient(MPGA)is significantly higher at elevated locations,near the slope surface and in areas with protrusions.Moreover,the existence of fracture zones and anti-shear galleries minimally influences the dynamic responses but considerably affect the rupture.Specifically,fracture zones exacerbate rupture,while anti-shear galleries mitigate it.Frequency-domain analysis indicates that the dynamic responses of the slope are closely correlated with the degree of slope rupture.As earthquake magnitude increases,the rupture degree of the slope intensifies,and the dominant frequency of the response within the slope decreases,e.g.,its value shifts from 3.63 to 2.75 Hz at measurement point 9near the slope surface.The transfer function of rock slope,calculated under the excitation of wide flat spectrum white noise can reflect the interrelationships between the inherent properties and the rupture degree.Notably,the peak of the transfer function undergoes inversion as the degree of rupture increases.Furthermore,through multiple stepwise linear regression analysis,four key factors influencing the surface dynamic response of the slope were identified:rock strength,slope angle,elevation,and seismic dominant frequency.These findings provide valuable insights into the underlying mechanisms of rock slope dynamic responses triggered by earthquakes,offering essential guidance for understanding and mitigating seismic impacts on rock slopes.
文摘BACKGROUND Gallstones are frequently observed in patients with cholecystitis,but the migration of free gallstones into the abdominal wall leading to chronic sinus formation is exceedingly rare.CASE SUMMARY We report a case of a 72-year-old woman who experienced recurring fever and abdominal pain following laparoscopic cholecystectomy for acute cholecystitis,during which gallbladder rupture was noted.Despite initial conservative management and temporary T-tube placement,the patient developed a chronic sinus in the abdominal wall 9.5 years later,characterized by an area of thickened soft tissue with ulceration and purulent discharge.Surgical exploration revealed the presence of a migrated gallstone at the base of the sinus tract,necessitating careful surgical removal and postoperative wound care.CONCLUSION This case highlights the potential long-term complications of retained free gallstones and the importance of thorough surgical retrieval.
文摘Introduction: Arteriovenous malformation is a rare pathology, often discovered accidentally in children. Generally, it presents as an intra-parenchymal hematoma following rupture of the affected vessels. The risk of rupture is linked to the volume of the malformation, its cortical location and venous drainage. In literature, few cases of rupture have been reported in cases of meningitis, but none are associated with a brain abscess. Objective: To report a case of an intraparenchymal hemorrhage due to rupture of an arteriovenous malformation with an associated brain abscess. Observation: The authors report the case of a 2-year-old child, admitted for impaired state of consciousness associated with a right hemiparesis and seizures in a febrile context. Clinical evaluation revealed a Blantyre score of 3, fever at 40˚C, divergent strabismus of the right eye, a right pyramidal syndrome and meningeal irritative syndrome. Cerebral CT scan revealed a left fronto-parietal intra-parenchymal hematoma and a right occipital ring-enhanced lesion, suggesting a brain abscess. An MRI suggested a probable rupture of an arteriovenous malformation resulting in the intra-parenchymal hematoma. Management consisted of craniotomy to evacuate the intra-parenchymal hematoma, antibiotic therapy with vancomycin and ceftriaxone at meningeal doses. Histopathological analysis of the intraoperative sample revealed an arteriovenous malformation. The postoperative course was marked by regression of hyperthermia, persistence of spasticity, irritability and clonic movement of the right lower limb. These were managed with baclofen, phenobarbital, and ergotherapy. We observed a regression of spasticity and improved motor skills in the right limbs. At 6 months follow-up, child could interact with his social environment despite aphasia, regression of spasticity and right hemiparesis. Conclusion: Rupture of arteriovenous malformations can be enhanced by neuro-meningeal infections and particularly brain abscesses. Cerebrovascular complications of these conditions mostly have unfavorable outcomes and neurological sequelae.
基金financially supported by the Technology Area Fund of the Basic Strengthening Program(No.2021-JCJQ-JJ-0092)the Science Center for Gas Turbine Project(Project No.P2022-C-Ⅳ-002-001)+2 种基金the Defense Industrial Technology Development Program(No.JCKY2020130C024)the National Key R&D Program of China(Grant No.2021YFB3702503)the National Science and Tech-nology Major Project(No.Y2019-VII-0011-0151).
文摘A self-developed crack-free advanced superalloy ZGH451 fabricated by direct energy deposition(DED)was applied to investigate the microstructure evolution,stress rupture behavior,and deformation mech-anisms at moderate-high temperatures and high-low stress conditions.The high Ta/Al ratio induces large misfit lattice stress and low stacking fault energy of alloy,resulting in approximate cubicγ′phases in dendrites and the formation of initial dislocation tangles.After the stress rupture test at 760℃/780 MPa,high content cubicγ′phases,small size of voids as well as preserved dislocation tangles are observed,showing stable structures with high-stress rupture resistance.High content and suitable size of cubicγ′phases,initial dislocation tangles,and L-C locks hinder the dislocation motion,which decreases the minimum strain rate and prolongs life significantly,forming four stress rupture stages.Hence,the defor-mation mechanism is determined by dislocation piled-up onγ/γ′interface,formation of stacking faults inγ′phases,and dislocations shearingγ′phases.However,the microstructure exhibits uneven struc-tures composed of large sizes of raftedγ′phases and voids at 980℃/260 MPa.The rafted structure and high temperature provide continuous channels and enough energy for dislocation motion,resulting in the increase of minimum strain rate,decline of life,and typic three stress rupture stages,even though there are obstacles to dislocation movement caused by dislocation networks.The deformation mecha-nism transforms to form dislocation networks onγ/γ′interface and dislocations shearingγ′phases.Be-sides,the decomposition of carbides on GBs also depends on temperature,which decomposes into harm-ful chain-like M23 C6 carbides at moderate temperatures and reinforced granular-shaped M6 C carbides at high temperatures.The applied stress always decreases mechanical properties due to its degradation of microstructure induced by elongating the precipitates and defects.
文摘Introduction: Uterine rupture is certainly one of the most serious, as it immediately jeopardises the vital prognosis of the mother and foetus. It is a common obstetric tragedy in our delivery rooms in countries with limited resources, reflecting the poor quality of obstetric care and, consequently, an unmet obstetric need. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection over a four-year period from 1 January 2020 to 31 December 2023 at the University Hospital Centre (CHU) of Bouaké, in the Obstetrics and Gynaecology Department. The variables studied were epidemiological characteristics, therapeutic aspects and factors associated with maternal. Results: The prevalence of uterine rupture was 0.63%. The average age was 32, with patients aged 35 and over accounting for 33.68%, married 44.21% and 70% not in education. Patients with uterine rupture had been evacuated in 85.26% of cases. Uterine rupture was diagnosed in 97.89% of cases during labour. Maternal lethality due to rupture was 15.79%. The causes of maternal death were dominated by haemorrhagic shock (53.33%). Factors statistically associated with death were age ≥ 35 years (OR: 3.14), duration of labour ≥ 12 hours (OR: 5.8), multiparity (OR: 19.04), admission delay beyond 2 hours (OR: 4.36), haemoglobin level ≤ 7 g/dl (OR: 36.84), coma or obnubilation (OR: 71.82), haemorrhagic shock (OR: 243.94) and occurrence of post-operative complications (OR: 76.45). Conclusion: The frequency of uterine rupture remains significant in the department (0.63%), with maternal mortality still high (15.79%). The key to reducing uterine rupture and its consequences lies in timely referral and early, appropriate management.
基金Supported by National Natural Science Foundation of China,No.82172509.
文摘BACKGROUND Fibro-adipogenic progenitors(FAPs)are a group of mesenchymal stem cells that cause fibro-fatty degeneration in skeletal muscle in various chronic disease mode-ls.FAPs also play a role in preventing muscle degeneration at acute stages during disease progression.However,few studies have reported the changes in and function of FAPs in the acute phase after tendon rupture.AIM To clarify the changes in the number of FAPs and their impact on skeletal muscle soon after tendon rupture to facilitate future studies targeting FAPs to treat muscle degeneration.METHODS We utilized Pdgfra-H2B::eGFP mice to trace and quantify FAPs in a tibialis anterior tenotomy(TAT)model at 0 and 3 days,1 week,2 weeks,3 weeks,4 weeks,5 weeks,and 6 weeks post-injury,and the results were further validated using fluorescence-activated cell sorting analysis with C57BL/6 mice at the same post-injury timepoints.We subsequently used PdgfraCreERT::RosaDTA mice,and evaluated the severity of post-TAT skeletal muscle degeneration with or without FAP-depletion.RESULTS The number of FAPs peaked at 1 week post-TAT before gradually declining to a level comparable to that pre-TAT.The change in the number of FAPs was potentially temporally correlated with the progression of skeletal muscle degeneration after TAT.FAP-depletion led to more severe degeneration early after TAT,indicating that FAPs potentially alleviate muscle degeneration after tendon rupture in the early post-injury phase.CONCLUSION FAPs potentially alleviate the degeneration of skeletal muscle in the acute stage after tendon rupture.
基金Foundation of China under Grant Nos. U2139207 and 52378517the Natural Science Foundation of Hubei Province under Grant No. 2023AFB934
文摘Seismic fault rupture can extend to the surface,and the resulting surface deformation can cause severe damage to civil engineering structures crossing the fault zones.Coseismic Surface Rupture Prediction Models(CSRPMs)play a crucial role in the structural design of fault-crossing engineering and in the hazard analysis of fault-intensive areas.In this study,a new global coseismic surface rupture database was constructed by compiling 171 earthquake events(Mw:5.5-7.9)that caused surface rupture.In contrast to the fault classification in traditional empirical relationships,this study categorizes earthquake events as strike-slip,dip-slip,and oblique-slip.CSRPMs utilizing Bayesian ridge regression(BRR)were developed to estimate parameters such as surface rupture length,average displacement,and maximum displacement.Based on Bayesian theory,BRR combines the benefits of both ridge regression and Bayesian linear regression.This approach effectively addresses the issue of overfitting while ensuring the strong model robustness.The reliability of the CSRPMs was validated by residual analysis and comparison with post-earthquake observations from the 2023 Türkiye earthquake doublet.The BRR-CSRPMs with new fault classification criteria are more suitable for the probabilistic hazard analysis of complex fault systems and dislocation design of fault-crossing engineering.
文摘Case Letter Severe trauma has high morbidity and mortality rates,being the leading cause of death in young adults.Among all traumas,tra ffi c injuries are particularly lethal.^([1-2]) The injury severity score(ISS) can be used to assess trauma severity,with ISS of<9,9–15,16–24,and≥25 indicating minor,moderate,severe,and critical trauma,respectively.The ISS is correlated with mortality,morbidity,and hospitalization duration after injury.^([3-4]) Here,we report one patient who was admitted to our emergency intensive care unit(EICU) due to traumatic liver rupture and traumatic myocardial infarction complicated with inferior vena cava(IVC) thrombosis.
基金financially supported by the National Science and Technology Major Project of China (No.J2019-VI-0004-0117)a Laboratory Fund Project (6142903220101)。
文摘The size and shape effect(SSE)of components has become a critical issue for mechanical properties,application reliability,and processing.In this study,the creep rupture life(CRL)of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated.The intrinsic mechanisms of the SSE were explored from the dendrite structure,volume fraction and size of theγ'phase,and element segregation,etc.It is shown that this casting exhibits a strong SSE of creep rupture life,characterized by a significant difference in the CRL values up to 60%with the variation of wall thickness and position in the casing.In terms of casting technology,the influence of SSE on CRL is actually determined by the cooling rate.The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing),volume fraction size of theγ'phase in the dendrite trunk,and elements segregation rate.This work may have implications for the design and application of engineering components with large sizes and complex structures.
文摘Bronchial rupture from penetrating,perforating,or compressive cervical or thoracic injuries can lead to complete tracheal,mainstem bronchial,or lobar bronchial detachment.Although rare in children,bronchial rupture presents significant risks,including dyspnea,respiratory failure,and potentially fatal airway obstruction,and is often overlooked or diagnosed late in clinical settings.Prompt diagnosis and intervention are prognostically crucial.[1,2]Between January 2013 and December 2023,four children(two male and two female)with bronchial rupture were admitted to the Pediatric Surgical Intensive CareUnit(ICU)at Children’s Hospital,Zhejiang University School of Medicine.Here,we share our experience of patient management.
