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Validation of marathon performance model based on physiological factors in world-class East African runners:a case series
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作者 Melanie Knopp Fergus Guppy +5 位作者 Michael Joyner Borja Muniz-Pardos Henning Wackerhage Martin Schönfelder Yannis Pitsiladis Daniel Ruiz 《Translational Exercise Biomedicine》 2025年第1期1-8,共8页
Objectives:The aim of this study was to compare the measured physiological factors that limit running performance with real marathon results from world-class distance runners,evaluating the compatibility between measu... Objectives:The aim of this study was to compare the measured physiological factors that limit running performance with real marathon results from world-class distance runners,evaluating the compatibility between measured data and predicted results based on the previously suggested model.Methods:Four world-class East African marathon runners(three male,one female)underwent physiological running assessments to predict marathon performance times using a model based on˙V O_(2)peak,percentage of˙V O_(2)peak at the second ventilatory threshold,and running economy.Predictions were then compared to participants’best marathon times.Results:The measured˙V O_(2)peak of the world-class runners was 75.1±2.7 mL/kg/min.The second ventilatory threshold occurred at 85±3%of the peak,with a running economy of 63.7±2.4 mL/kg/min at 19.6±0.9 km/h.The predicted marathon performance time was 2:06:51±0:03:17 h:min:s for the males and 2:17:36 h:min:s for the female.Comparing these predictions to their personal best times,the average difference was 00:55±00:51 min:s(range:00:20-02:08).Conclusions:This research provides laboratory data on world-class road running athletes,reinforcing the link between marathon performance and˙V O_(2)peak,the percentage of˙VO_(2)peak at the second ventilatory threshold,and running economy.The examined athletes had lower˙V O_(2)peak compared to predicted values,highlighting the importance of running economy and fractional utilization of˙V O_(2)peak in achieving such performances.Future studies should continue to advance the field by including additional bioenergetic parameters measured during race conditions and expanding the participant cohort of elite marathoners,encompassing both sexes. 展开更多
关键词 marathon performance predictive model peak aerobic capacity second ventilatory threshold running economy marathon running
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Examining the impact of urban environment on healthy vitality of outdoor running based on street view imagery and urban big data
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作者 GU Xinyue ZHU Lei LIU Xintao 《Journal of Geographical Sciences》 2025年第3期641-663,共23页
Urban environments offer a wealth of opportunities for residents to respite from their hectic life.Outdoor running or jogging becomes increasingly popular of an option.Impacts of urban environments on outdoor running,... Urban environments offer a wealth of opportunities for residents to respite from their hectic life.Outdoor running or jogging becomes increasingly popular of an option.Impacts of urban environments on outdoor running,despite some initial studies,remain underexplored.This study aims to establish an analytical framework that can holistically assess the urban environment on the healthy vitality of running.The proposed framework is applied to two modern Chinese cities,i.e.,Guangzhou and Shenzhen.We construct three interpretable random forest models to explore the non-linear relationship between environmental variables and running intensity(RI)through analyzing the runners'trajectories and integrating with multi-source urban big data(e.g.,street view imagery,remote sensing,and socio-economic data)across the built,natural,and social dimensions,The findings uncover that road density has the greatest impact on RI,and social variables(e.g.,population density and housing price)and natural variables(e.g.,slope and humidity)all make notable impact on outdoor running.Despite these findings,the impact of environmental variables likely change across different regions due to disparate regional construction and micro-environments,and those specific impacts as well as optimal thresholds also alter.Therefore,construction of healthy cities should take the whole urban environment into account and adapt to local conditions.This study provides a comprehensive evaluation on the influencing variables of healthy vitality and guides sustainable urban planning for creating running-friendly cities. 展开更多
关键词 street view imagery urban pavements healthy cities urban vitality running-friendly cities running intensity
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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise 被引量:2
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作者 Do-Hun Lee Dan Cao +4 位作者 Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu 《Neural Regeneration Research》 SCIE CAS 2025年第3期836-844,共9页
Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery ... Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury. 展开更多
关键词 behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise
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Development of a Shoelace Tensile Testing System and Investigation into the Effects of Different Running Speeds on Shoelace Tensile Variation
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作者 Shutao Wei Xinyu Guo +4 位作者 Shaocong Zhao Biao Yan Lingjun Li Jiahao Pan Li Li 《Journal of Bionic Engineering》 2025年第1期214-225,共12页
This study investigated the validity and sensitivity of a custom-made shoelace tensile testing system.The aim was to analyze the distribution pattern of shoelace tension in different positions and under different tigh... This study investigated the validity and sensitivity of a custom-made shoelace tensile testing system.The aim was to analyze the distribution pattern of shoelace tension in different positions and under different tightness levels during running.Mechanical tests were conducted using 16 weights,and various statistical analyses,including linear regression,Bland-Altman plots,coefficient of variation,and intraclass correlation coefficient,were performed to assess the system’s validity.Fifteen male amateur runners participated in the study,and three conditions(loose,comfortable,and tight)were measured during an upright stance.The system utilized VICON motion systems,a Kistler force plate,and a Photoelectric gate speed measurement system.Results showed a linear relationship between voltage and load at the three sensors(R2≥0.9997).Bland-Altman plots demonstrated 95%prediction intervals within±1.96SD from zero for all sensors.The average coefficient of variation for each sensor was less than 0.38%.Intraclass correlation coefficient values were larger than 0.999(p<0.0001)for each sensor.The peak tension of the front shoelace was greater than that of the front and middle when the shoelace was loose and tight.The rear shoelace had the highest tension force.The study also found that shoelace tension varied throughout the gait cycle during running.Overall,this research provides a novel and validated method for measuring shoelace tensile stress,which has implications for developing automatic shoelace fastening systems. 展开更多
关键词 Force sensor Shoelace Tensile stress Upright stance running shoes
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Electromechanical coupling vibration characteristics of high-speed train transmission system considering gear eccentricity and running resistance
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作者 Yeping Yuan Junguo Wang 《Acta Mechanica Sinica》 2025年第5期219-241,共23页
The gear transmission system directly affects the operational performance of high-speed trains(HST).However,current research on gear transmission systems of HST often overlooks the effects of gear eccentricity and run... The gear transmission system directly affects the operational performance of high-speed trains(HST).However,current research on gear transmission systems of HST often overlooks the effects of gear eccentricity and running resistance,and the dynamic models of gear transmission system are not sufficiently comprehensive.This paper aims to establish an electromechanical coupling dynamic model of HST traction transmission system and study its electromechanical coupling vibration characteristics,in which the internal excitation factors such as gear eccentricity,time-varying meshing stiffness,backlash,meshing error,and external excitation factors such as electromagnetic torque and running resistance are stressed.The research results indicate that gear eccentricity and running resistance have a significant impact on the stability of the system,and gear eccentricity leads to intensified system vibration and decreased anti-interference ability.In addition,the characteristic frequency of gear eccentricity can be extracted from mechanical signals and current signals as a preliminary basis for eccentricity detection,and electrical signals can also be used to monitor changes in train running resistance in real time.The results of this study provide some useful insights into designing dynamic performance parameters for HST transmission systems and monitoring train operational states. 展开更多
关键词 Gear eccentricity Electromechanical coupling running resistance System stability Vibration characteristics
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The effects of running shoe longitudinal bending stiffness and midsole energy return on oxygen consumption and ankle mechanics and energetics:A systematic review and meta-analysis
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作者 Cameron H.N.Stephen Luke A.Kelly +1 位作者 Robert W.Schuster Laura E.Diamond 《Journal of Sport and Health Science》 2025年第6期149-157,共9页
Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,C... Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,CINAHL,and Web of Science were systematically searched for this meta-analysis.Crossover studies comparing the effects of running shoe LBS and/or midsole energy return on at least 1 of the following outcomes:running economy,ankle plantarflexion moment,work,power,or angular velocity were included.Results Of the 2453 studies screened,48 were included(n=878).Results indicated that advanced footwear technologies(AFTs)significantly reduced oxygen consumption(standardized mean difference=–0.44,95%confidence interval:–0.60 to–0.28),p<0.001)as well as peak ankle moments and positive/negative ankle work and power.However,neither LBS nor midsole energy return alone significantly affected oxygen consumption,ankle moments,positive and negative work,or positive power.The effects of AFTs were moderated by the training status and speed of the runner.The quality of evidence for all outcomes were low or very low for all outcomes except the effect of LBS on negative ankle work.Conclusion AFT may improve running economy by minimizing ankle moments,work,and power.The absence of significant independent effects of LBS and midsole energy return suggests that the benefits of AFTs arise from the interaction of these properties.Further research is necessary to understand the mechanisms for improved running performance in AFTs. 展开更多
关键词 Advanced footwear technology running economy Ankle biomechanics
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Average Run Length in TEWMA Control Charts:Analytical Solutions for AR(p)Processes and Real Data Applications
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作者 Sirawit Makaew Yupaporn Areepong Saowanit Sukparungsee 《Computer Modeling in Engineering & Sciences》 2025年第5期1617-1634,共18页
This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is ... This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is an autoregressive model of order p,representing a time series with dependencies on its p previous values.Additionally,the study evaluates the accuracy of both explicit and numerical integral equation(NIE)solutions for AR(p)using the TEWMA control chart,focusing on the absolute percentage relative error.The results indicate that the explicit and approximate solutions are in close agreement.Furthermore,the study investigates the performance of exponentially weighted moving average(EWMA)and TEWMA control charts in detecting changes in the process,using the relative mean index(RMI)as a measure.The findings demonstrate that the TEWMA control chart outperforms the EWMA control chart in detecting process changes,especially when the value ofλis sufficiently large.In addition,an analysis using historical data from the SET index between January 2024 and May 2024 and historical data of global annual plastic production,the results of both data sets also emphasize the superior performance of the TEWMA control chart. 展开更多
关键词 EWMA control chart TEWMA control charts average run length shift detection explicit formula Fredholm integral equation Banach’s fixed-point theorem AR(p)process
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基于RUN-XGBoost算法的土石坝渗流预测模型 被引量:8
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作者 马春辉 侯媛媛 +2 位作者 杨杰 袁帅 徐笑颜 《水利水电科技进展》 CSCD 北大核心 2024年第2期72-78,共7页
针对传统土石坝渗流预测模型存在局部最优、抗干扰性差和预测精度低等问题,通过RUN算法优化XGBoost算法得到RUN-XGBoost算法,构建了RUN-XGBoost模型以获得更优的土石坝渗流预测结果。该模型在种群初始化时采用RUN算法对XGBoost算法的3... 针对传统土石坝渗流预测模型存在局部最优、抗干扰性差和预测精度低等问题,通过RUN算法优化XGBoost算法得到RUN-XGBoost算法,构建了RUN-XGBoost模型以获得更优的土石坝渗流预测结果。该模型在种群初始化时采用RUN算法对XGBoost算法的3个主要参数进行改进,使预测结果有较高的有效性;通过自动寻找最优参数增进算法的整体收敛速度和预测精度,同时引入随机解,使算法能够排除局部最小值并继续搜索,从而获得全局最优结果。工程实例验证结果表明,RUN-XGBoost模型具有简洁、高效、预测精度高、鲁棒性强等优点。 展开更多
关键词 土石坝 渗流监测 run-XGBoost算法 预测模型
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基于复杂适应系统理论“跑”与“run”带宾构式搭配特征的历时演变 被引量:2
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作者 邓云华 邓凯方 《语言研究》 CSSCI 北大核心 2024年第4期36-45,共10页
“跑”与“run”带宾构式初始义都与腿脚移动行为相关,其宾语类型、构式义等整体上都呈现递增趋势,二者均有中性韵和消极韵表达形式,以中性韵为主。“跑”和“run”带宾构式义都基于基本义“快速奔跑”而衍生,但由于词源、社会习俗、文... “跑”与“run”带宾构式初始义都与腿脚移动行为相关,其宾语类型、构式义等整体上都呈现递增趋势,二者均有中性韵和消极韵表达形式,以中性韵为主。“跑”和“run”带宾构式义都基于基本义“快速奔跑”而衍生,但由于词源、社会习俗、文化环境等因素,“run”带宾构式的衍生义更加丰富。此外,“跑”与“run”带宾构式义演变的认知机制是隐喻,作为一个复杂语言系统,其语义的涌现源自构成系统的众多要素,是语言使用主体内部环境与外部客观环境交互作用的结果。 展开更多
关键词 “跑”与“run 构式搭配强度 对应分析 历时演变 复杂适应系统理论
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考虑蓄电池Run-time等效模型的船舶直流应急电网短路电流计算 被引量:4
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作者 王朝红 曹穆 +1 位作者 许嘉沄 雷加智 《武汉大学学报(工学版)》 CAS CSCD 北大核心 2024年第3期348-355,共8页
为计算直流应急电网不同故障类型下的短路电流,便于直流应急电网开关器件的型号以及相应的保护措施的选择,提出了一种考虑蓄电池Run-time等效模型的船舶直流应急电网短路电流计算方法。与传统蓄电池的Thevenin等效模型和PNGV(the partne... 为计算直流应急电网不同故障类型下的短路电流,便于直流应急电网开关器件的型号以及相应的保护措施的选择,提出了一种考虑蓄电池Run-time等效模型的船舶直流应急电网短路电流计算方法。与传统蓄电池的Thevenin等效模型和PNGV(the partnership for a new generation of vehicles)等效模型相比,所提方法考虑了蓄电池容量衰减、温度、循环次数、存储时长、电流倍率、自身产热等多因素的影响,对蓄电池的故障等值电路进行了精确模拟。最后,利用实际的直流应急电网短路电流仿真和实验验证了所提方法的准确性,与Thevenin等效模型和PNGV等效模型相比,不同故障下蓄电池Run-time等效模型短路电流的计算误差更小。 展开更多
关键词 直流应急电网 run-time等效模型 短路电流 故障等值 故障类型
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Modified DS np Chart Using Generalized Multiple Dependent State Sampling under Time Truncated Life Test
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作者 Wimonmas Bamrungsetthapong Pramote Charongrattanasakul 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2471-2495,共25页
This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of t... This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of the product based on the time truncated life test employing theWeibull distribution.The control chart developed supports the examination of the mean lifespan variation for a particular product in the process of manufacturing.Three control limit levels are used:the warning control limit,inner control limit,and outer control limit.Together,they enhance the capability for variation detection.A genetic algorithm can be used for optimization during the in-control process,whereby the optimal parameters can be established for the proposed control chart.The control chart performance is assessed using the average run length,while the influence of the model parameters upon the control chart solution is assessed via sensitivity analysis based on an orthogonal experimental design withmultiple linear regression.A comparative study was conducted based on the out-of-control average run length,in which the developed control chart offered greater sensitivity in the detection of process shifts while making use of smaller samples on average than is the case for existing control charts.Finally,to exhibit the utility of the developed control chart,this paper presents its application using simulated data with parameters drawn from the real set of data. 展开更多
关键词 Modified DS np chart generalizedmultiple dependent state sampling time truncated life test Weibull distribution average run length average sample size
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Acute effect of foot strike patterns on in vivo tibiotalar and subtalar joint kinematics during barefoot running 被引量:2
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作者 Dongqiang Ye Lu Li +4 位作者 Shen Zhang Songlin Xiao Xiaole Sun Shaobai Wang Weijie Fu 《Journal of Sport and Health Science》 SCIE CSCD 2024年第1期108-117,共10页
Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related injuries.The maj ority of studies to date show that different foot strike patte... Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related injuries.The maj ority of studies to date show that different foot strike patterns influence these specific foot and ankle kinematics.However,technical deficiencies in traditional motion capture approaches limit knowledge of in vivo joint kinematics with respect to rearfoot and forefoot strike patterns(RFS and FFS,respectively).This study uses a high-speed dual fluoroscopic imaging system(DFIS)to determine the effects of different foot strike patterns on 3D in vivo tibiotalar and subtalar joints kinematics.Methods:Fifteen healthy male recreational runners underwent foot computed tomography scanning for the construction of 3-dimensional models.A high-speed DFIS(100 Hz)was used to collect 6 degrees of freedom kinematics for participants’tibiotalar and subtalar joints when they adopted RFS and FFS in barefoot condition.Results:Compared with RFS,FFS exhibited greater internal rotation at 0%-20%of the stance phase in the tibiotalar joint.The peak internal rotation angle of the tibiotalar joint under FFS was greater than under RFS(p<0.001,Cohen’s d=0.92).RFS showed more dorsiflexion at 0%-20%of the stance phase in the tibiotalar joint than FFS.RFS also presented a larger anterior translation(p<0.001,Cohen’s d=1.28)in the subtalar joint at i nitial contact than FFS.Conclusion:Running with acute barefoot FFS increases the internal rotation of the tibiotalar joint in the early stance.The use of high-speed DFIS to quantify the movement of the tibiotalar and subtalar joint was critical to revealing the effects of RF S and FFS during running. 展开更多
关键词 Foot strike patterns High-speed dual fluoroscopic imaging system In vivo kinematics running
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宫颈癌患者HPV感染情况对癌组织Runx3、NOB1、NK-1R表达水平的影响及其检测价值分析 被引量:2
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作者 梁菊华 曲书平 刘春君 《中国病原生物学杂志》 CSCD 北大核心 2024年第11期1312-1316,共5页
目的宫颈癌患者人乳头瘤病毒(HPV)感染情况对癌组织Run相关转录因子3(Runx3)、NIN1/RPN12结合蛋白1同源物(NOB1)、神经激肽-1受体(NK-1R)表达水平的影响及其检测价值分析。方法选取本院在2019年2月~2024年2月进行住院治疗的109例宫颈癌... 目的宫颈癌患者人乳头瘤病毒(HPV)感染情况对癌组织Run相关转录因子3(Runx3)、NIN1/RPN12结合蛋白1同源物(NOB1)、神经激肽-1受体(NK-1R)表达水平的影响及其检测价值分析。方法选取本院在2019年2月~2024年2月进行住院治疗的109例宫颈癌HPV感染患者作为研究组,依据HPV感染检查结果,将其分为高危型组(n=62)、低危型组(n=47)。同期选取在本院就诊的100例宫颈癌无HPV感染患者作为对照组。采用qRT-PCR法分别检测癌组织中Runx3、NOB1、NK-1R表达水平;多因素Logistic回归分析影响宫颈癌患者HPV感染情况的相关因素;运用ROC曲线分析癌组织Runx3、NOB1、NK-1R对宫颈癌患者高危型HPV感染的诊断价值。结果与对照组比较,研究组NOB1、NK-1R表达水平显著升高,Runx3表达水平显著下降(P<0.05);高危型组发生淋巴结转移占比、低分化程度占比、NOB1、NK-1R表达水平显著高于低危型组,而Runx3表达水平低于低危型组(P<0.05);淋巴结转移、分化程度、Runx3、NOB1、NK-1R为宫颈癌患者高危型HPV感染的影响因素(P<0.05);Runx3、NOB1、NK-1R联合诊断宫颈癌患者高危型HPV感染的曲线下面积(AUC)为0.946,优于各自单独诊断(Z_(三者联合-Runx3)=2.113、Z_(三者联合-NOB1)=2.634、Z三者联合-NK-1R=2.538,P=0.035、0.008、0.011),其敏感度及特异度分别为95.16%、89.36%。结论宫颈癌HPV感染患者及其高危型患者NOB1、NK-1R表达水平显著升高,Runx3表达水平显著降低,三者联合对宫颈癌患者高危型HPV感染有更高的诊断价值。 展开更多
关键词 宫颈癌 run相关转录因子3 NIN1/RPN12结合蛋白1同源物 神经激肽-1受体 人乳头瘤病毒感染 检测价值
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SmartMicro Grid Energy System Management Based on Optimum Running Cost for Rural Communities in Rwanda 被引量:2
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作者 Fabien Mukundufite Jean Marie Vianney Bikorimana Alexander Kyaruzi Lugatona 《Energy Engineering》 EI 2024年第7期1805-1821,共17页
The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in re... The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in remote areas.So far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural areas.SHSs have continuous constraints to meet electricity demands and cannot run income-generating activities.The current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case study.The renewable energy resources available in Remera are the key sources of electricity in that village.The generation capacity is estimated based on the load profile.The microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum cost.By analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public utility.The microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to customers.By considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda. 展开更多
关键词 Load demand load profile optimum running cost power demand satisfaction smart meters and smart micro grid
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Voluntary wheel running ameliorated the deleterious effects of high-fat diet on glucose metabolism,gut microbiota and microbial-associated metabolites 被引量:1
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作者 Ling Zhang Wenyu Zou +4 位作者 Yongyan Hu Honghua Wu Ying Gao Junqing Zhang Jia Zheng 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1672-1684,共13页
Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus.However,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running o... Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus.However,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully elaborated.C57BL/6 male mice were randomly assigned to 4 groups according to diets(fed with normal chow diet or high-fat diet)and running paradigm(housed in static cage or with voluntary running wheel).An integrative 16S rDNA sequencing and metabolites profiling was synchronously performed to characterize the effects of voluntary wheel running on gut microbiota and metabolites.It showed that voluntary wheel running prevented the detrimental effects of high-fat feeding on glucose metabolism 16S rDNA sequencing showed remarkable changes in Rikenella and Marvinbryantia genera.Metabolic profiling indicated multiple altered metabolites,which were enriched in secondary bile acid biosynthesis signaling.In conclusion,our study indicated that voluntary wheel running significantly improved glucose metabolism and counteracted the deleterious effects of high-fat feeding on body weight and glucose intolerance.We further found that voluntary wheel running could integratively program gut microbiota composition and fecal metabolites changes,and may regulate muricholic acid metabolism and secondary bile acid biosynthesis in high-fat fed mice. 展开更多
关键词 High-fat diet Voluntary wheel running Gut microbiota Metabolomics Glucose metabolism
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Influence of pier height on the safety of trains running on high-speed railway bridges during earthquakes 被引量:1
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作者 NIE Yu-tao GUO Wei +8 位作者 JIANG Li-zhong YU Zhi-wu ZENG Chen WANG Yang HE Xu-en REN Shao-xun HUANG Ren-qiang LIANG Guang-yue LI Chang-qing 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第6期2102-2115,共14页
Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system.In this paper... Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system.In this paper,a experiment of a train running on a high-speed railway bridge is performed based on a dynamic experiment system,and the corresponding numerical model is established.The reliability of the numerical model is verified by experiments.Then,the experiment and numerical data are analyzed to reveal the pier height effects on the running safety of trains on bridges.The results show that when the pier height changes,the frequency of the bridge below the 30 m pier height changes greater;the increase of pier height causes the transverse fundamental frequency of the bridge close to that of the train,and the shaking angle and lateral displacement of the train are the largest for bridge with 50 m pier,which increases the risk of derailment;with the pier height increases from 8 m to 50 m,the derailment coefficient obtained by numerical simulations increases by 75% on average,and the spectral intensity obtained by experiments increases by 120% on average,two indicators exhibit logarithmic variation. 展开更多
关键词 pier height high-speed railway bridge running safety numerical model
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A novel refined dynamic model of high-speed maglev train-bridge coupled system for random vibration and running safety assessment 被引量:1
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作者 MAO Jian-feng LI Dao-hang +3 位作者 YU Zhi-wu CAI Wen-feng GUO Wei ZHANG Guang-wen 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2532-2544,共13页
Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can b... Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can be well characterized based on various stochastic excitations.A three-dimensional refined spatial random vibration analysis model of high-speed maglev train-bridge coupled system is established in this paper,in which multi-source uncertainty excitation can be considered simultaneously,and the probability density evolution method(PDEM)is adopted to reveal the system-specific uncertainty dynamic characteristic.The motion equation of the maglev vehicle model is composed of multi-rigid bodies with a total 210-degrees of freedom for each vehicle,and a refined electromagnetic force-air gap model is used to account for the interaction and coupling effect between the moving train and track beam bridges,which are directly established by using finite element method.The model is proven to be applicable by comparing with Monte Carlo simulation.By applying the proposed stochastic framework to the high maglev line,the random dynamic responses of maglev vehicles running on the bridges are studied for running safety and stability assessment.Moreover,the effects of track irregularity wavelength range under different amplitude and running speeds on the coupled system are investigated.The results show that the augmentation of train speed will move backward the sensitive wavelength interval,and track irregularity amplitude influences the response remarkably in the sensitive interval. 展开更多
关键词 maglev train-bridge interaction electromagnetic force-air gap model stochastic dynamic analysis running safety assessment probability density evolution method
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Running safety assessment method of trains under seismic conditions based on the derailment risk domain
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作者 Zhihui Zhu Gaoyang Zhou +2 位作者 Weiqi Zheng Wei Gong Yongjiu Tang 《Railway Engineering Science》 EI 2024年第4期499-517,共19页
The accurate assessment of running safety during earthquakes is of significant importance for ensuring the safety of railway lines.Currently,assessment methods based on a single index suffer from issues such as misjud... The accurate assessment of running safety during earthquakes is of significant importance for ensuring the safety of railway lines.Currently,assessment methods based on a single index suffer from issues such as misjudgment of operational safety and difficulty in evaluating operational margin,making them unsuitable for assessing train safety during earthquakes.Therefore,in order to propose an effective evaluation method for the running safety of trains during earthquakes,this study employs three indexes,namely lateral displacement of the wheel–rail contact point,wheel unloading rate,and wheel lift,to describe the lateral and vertical contact states between the wheel and rail.The corresponding evolution characteristics of the wheel–rail contact states are determined,and the derailment forms under different frequency components of seismic motion are identified through dynamic numerical simulations of the train–track coupled system under sine excitation.The variations in the wheel–rail contact states during the transition from a safe state to the critical state of derailment are analyzed,thereby constructing the evolutionary path of train derailment and seismic derailment risk domain.Lastly,the wheel–rail contact and derailment states under seismic conditions are analyzed,thus verifying the effectiveness of the evaluation method for assessing running safety under earthquakes proposed in this study.The results indicate that the assessment method based on the derailment risk domain accurately and comprehensively reflects the wheel–rail contact states under seismic conditions.It successfully determines the forms of train derailment,the risk levels of derailment,and the evolutionary paths of derailment risk. 展开更多
关键词 Earthquake High-speed train running safety Wheel–rail contact Derailment risk domain
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RUN和FYVE结构域蛋白1在胰腺癌中的表达特征及功能作用
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作者 钱志鑫 李俊强 +1 位作者 宋扬 苏海川 《空军军医大学学报》 CAS 2024年第7期769-774,共6页
目的探究RUN和FYVE结构域蛋白1(RUFY1)在胰腺癌中的表达特征及功能作用。方法通过分析癌症基因组图谱、临床蛋白质组肿瘤分析协作组、基因表达综合数据库等,探究RUFY1在胰腺癌中mRNA、蛋白的表达水平以及与胰腺癌患者预后关系。采用免... 目的探究RUN和FYVE结构域蛋白1(RUFY1)在胰腺癌中的表达特征及功能作用。方法通过分析癌症基因组图谱、临床蛋白质组肿瘤分析协作组、基因表达综合数据库等,探究RUFY1在胰腺癌中mRNA、蛋白的表达水平以及与胰腺癌患者预后关系。采用免疫组织化学染色比对胰腺癌患者肿瘤组织与正常胰腺组织中RUFY1蛋白表达水平。在胰腺癌细胞系中敲低RUFY1,并通过肿瘤成球、CCK-8、克隆形成实验验证RUFY1在胰腺癌细胞系中发挥的功能与作用。联合CTRP和PRISM等数据库探究RUFY1与部分抗肿瘤药物敏感性的关系。结果通过分析公共数据库发现,与正常胰腺组织相比,胰腺癌肿瘤组织中RUFY1 mRNA和蛋白表达水平显著升高(P<0.05,P<0.01);RUFY1的高表达与胰腺癌患者的预后呈显著负相关(P<0.05)。免疫组织化学染色结果表明,相较于癌旁组织,RUFY1蛋白表达水平在胰腺癌肿瘤组织中升高。肿瘤成球、CCK-8、克隆形成实验结果显示RUFY1敲低会显著抑制胰腺癌细胞系的增殖功能(P<0.01)。由CTRP和PRISM数据库分析得出,低RUFY1表达的患者对PD318088(P<0.01)、RITA(P<0.01)、selumetinib(P<0.05)、AZD8931(P<0.01)等药物更加敏感。结论RUFY1 mRNA及蛋白水平在胰腺癌肿瘤组织中升高,RUFY1的高表达与胰腺癌患者的预后呈负相关,敲低RUFY1可抑制胰腺癌细胞系的增殖能力,RUFY1有望成为用来预测临床用药治疗敏感性的靶点。 展开更多
关键词 run和FYVE结构域蛋白1 胰腺癌 药物敏感性 增殖能力
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Safety of the express freight train running over a long-span bridge
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作者 Jingcheng Wen Yihao Qin +1 位作者 Ye Bai Xiaoqing Dong 《Railway Sciences》 2024年第4期469-479,共11页
Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of win... Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains. 展开更多
关键词 Express freight train Long-span bridge CROSSWIND Wind tunnel test running safety Paper type Research paper
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