In this article,we discuss a method to control the long-range interactions between bosons in a threedimensional Bose-Fermi mixture with the help of optical lattices on fermions.We find the range and the peaked momentu...In this article,we discuss a method to control the long-range interactions between bosons in a threedimensional Bose-Fermi mixture with the help of optical lattices on fermions.We find the range and the peaked momentum of the fermion-mediated interactions can be tuned by the optical lattice depth and the fermion density.If the fermion density is close to half-filling,roton excitations can be generated with weak Bose-Fermi interactions.Further,if the fermions are not exact at half-filling,multi-roton structure may emerge,implying competing density orders.Therefore,tuning the lattice depth and the fermion density in a Bose-Fermi mixture serves as an effective way to control the interaction range and resonant momentum between bosons.展开更多
A recent study by Farrelly,L.A.et al.published in Nature showed that the serotonylation of glutamine at the Q5 site in histone H3 promotes the recruitment of TFIID in collaboration with adjacent H3K4 trimethylation 1....A recent study by Farrelly,L.A.et al.published in Nature showed that the serotonylation of glutamine at the Q5 site in histone H3 promotes the recruitment of TFIID in collaboration with adjacent H3K4 trimethylation 1.Protein posttranslational modifications(PTMs)of histones are associated with diverse biological processes through dynamically modulating chromatin structure and the transcriptional activity of genes 2.Epigenetic regulations are an integral part of brain functions ranging from the development of the nervous system beyond basic neurological functions to higher-order cognitive processes 3.展开更多
目的:通过FAERS数据库系统挖掘导致急性肾损伤的药物,并对有价值的药物进行回顾性文献分析,分析其临床表现、治疗和转归等情况,为临床安全用药提供参考。方法:利用开放药物数据平台OpenVigil,检索2004年第1季度—2023年第3季度关于急性...目的:通过FAERS数据库系统挖掘导致急性肾损伤的药物,并对有价值的药物进行回顾性文献分析,分析其临床表现、治疗和转归等情况,为临床安全用药提供参考。方法:利用开放药物数据平台OpenVigil,检索2004年第1季度—2023年第3季度关于急性肾损伤药物报告,分析阳性信号,发现潜在风险药物;按“药物名称”及“肾损伤”检索PubMed、web of science、万方数据、中国知网和维普网收录的案例报道,对案例中患者年龄、性别、国籍、药物用法用量、用药时间分布、临床表现、治疗措施及转归情况等进行回顾性分析。结果:初步筛选获得53个阳性信号药物,前5位的药物中质子泵抑制剂(proton pump inhibitors,PPIs)有4种;对该类药物进行文献检索,5个PPIs药物有该类病例报道,共纳入案例报道65篇,病例152例;奥美拉唑病例最多(113例,74.3%);报告主要集中在2010—2019年(70例,46.1%);以美国报道最多(48例,31.6%);男女发病比例1∶1.5;发病年龄主要集中在60~80岁(96例,63.2%),平均年龄66.64岁,中位年龄70岁;用药剂量基本为常规剂量(84/85),发病时间2~6个月最高(67例,44.1%),6个月内累计数量为116例(76.3%);115例患者进行了肾活检,主要病理结果为急性间质性肾炎或表现出间质性肾炎(114例,75.0%);临床表现无明显特异性;基线肌酐与好转后肌酐水平差异P<0.01;主要治疗方式均为停药,60例患者进行了糖皮质激素治疗;12例患者二次用药或再激发阳性,其中5例需要额外的透析治疗。结论:PPIs导致的肾损伤是一个长期且广泛的情况,老年人群特别是老年女性患者存在更高的发病风险;在常规剂量下PPIs即可导致肾间质性损伤,建议在药物应用早期关注是否有前驱的临床症状,如发热、恶心、呕吐、皮疹等;对于已经发生PPIs肾损伤的患者,停药为最主要的治疗方式,可以考虑使用激素进行治疗,严重病例可以考虑短期血液透析治疗;虽然大部分患者转归良好,但肾功能仍低于发病前水平;对于发生过此类不良事件的患者应避免再次使用PPIs药物。展开更多
We investigate the effective interaction between two heavy impurities immersed in a quasi-twodimensional dipolar Bose-Einstein condensate via a variation approach.We show that the mediated interaction is highly tunabl...We investigate the effective interaction between two heavy impurities immersed in a quasi-twodimensional dipolar Bose-Einstein condensate via a variation approach.We show that the mediated interaction is highly tunable via the contact and the dipole-dipole interactions between the background gas atoms.Interestingly,the mediated interaction potential may become an oscillating function of inter-impurity distance when roton excitation emerges under sufficiently strong dipolar interaction.Our system therefore provides an efficient way for tuning the mediated interaction between impurities.展开更多
For the numerical simulation of the fractional quantum Hall(FQH) effects on a finite disk, the rotational symmetry is the only symmetry that is used in diagonalizing the Hamiltonian. In this work, we propose a method ...For the numerical simulation of the fractional quantum Hall(FQH) effects on a finite disk, the rotational symmetry is the only symmetry that is used in diagonalizing the Hamiltonian. In this work, we propose a method of using the weak translational symmetry for the center of mass of the many-body system. With this approach, the bulk properties, such as the energy gap and the magneto-roton excitation are consistent with those in the closed manifolds like the sphere and torus. As an application, we consider the FQH phase and its phase transition in the fast rotated dipolar fermions. We thus demonstrate the disk geometry having versatility in analyzing the bulk properties beside the usual edge physics.展开更多
The measurement of the pairing gap is crucial for investigating the physical properties of superconductors or superfluids.We propose a strategy to measure the pairing gap through the dynamical excitations.With the ran...The measurement of the pairing gap is crucial for investigating the physical properties of superconductors or superfluids.We propose a strategy to measure the pairing gap through the dynamical excitations.With the random phase approximation(RPA),we study the dynamical excitations of a two-dimensional attractive Fermi-Hubbard model by calculating its dynamical structure factor.Two distinct collective modes emerge:a Goldstone phonon mode at transferred momentum q=[0,0]and a roton mode at q=[p,p].The roton mode exhibits a sharp molecular peak in the low-energy regime.Notably,the area under the roton molecular peak scales with the square of the pairing gap,which holds even in three-dimensional and spin-orbit coupled(SOC)optical lattices.This finding suggests an experimental approach to measure the pairing gap in lattice systems by analyzing the dynamical structure factor at q=[p,p].展开更多
Recently, the extraordinary structures and physiological activities of silatrane compounds have been paid much attention to and been studied with various physicoehemical methods by many authors. The concept of pentaco...Recently, the extraordinary structures and physiological activities of silatrane compounds have been paid much attention to and been studied with various physicoehemical methods by many authors. The concept of pentacoordinated silicon and tetracoordinated nitrogen in these compounds has been proposed. However, there is still much controversy about it.展开更多
基金Supported by National Natural Science Foundation of China under Grant Nos.11604225,11734010Beijing Natural Science Foundation(Z180013)Foundation of Beijing Education Committees under Grant No.KM201710028004
文摘In this article,we discuss a method to control the long-range interactions between bosons in a threedimensional Bose-Fermi mixture with the help of optical lattices on fermions.We find the range and the peaked momentum of the fermion-mediated interactions can be tuned by the optical lattice depth and the fermion density.If the fermion density is close to half-filling,roton excitations can be generated with weak Bose-Fermi interactions.Further,if the fermions are not exact at half-filling,multi-roton structure may emerge,implying competing density orders.Therefore,tuning the lattice depth and the fermion density in a Bose-Fermi mixture serves as an effective way to control the interaction range and resonant momentum between bosons.
基金support by the China Scholarship Council(CSC).This research has additionally been funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy via the Excellence Cluster“3D Matter Made to Order”(Grant No.EXC-2082/1-390761711)which has also been supported by the Carl Zeiss Foundation through the“Carl-Zeiss-Foundation-Focus@HEiKA”,by the State of Baden-Württemberg,and by the Karlsruhe Institute of Technology(KIT).We further acknowledge support by the Helmholtz program“Materials Systems Engineering”(MSE).Muamer Kadic is grateful for support by the EIPHI Graduate School(Grant No.ANR-17-EURE-0002)Changguo Wang is grateful for support by the National Natural Science Foundation of China(Grant No.12172102).
文摘A recent study by Farrelly,L.A.et al.published in Nature showed that the serotonylation of glutamine at the Q5 site in histone H3 promotes the recruitment of TFIID in collaboration with adjacent H3K4 trimethylation 1.Protein posttranslational modifications(PTMs)of histones are associated with diverse biological processes through dynamically modulating chromatin structure and the transcriptional activity of genes 2.Epigenetic regulations are an integral part of brain functions ranging from the development of the nervous system beyond basic neurological functions to higher-order cognitive processes 3.
文摘目的:通过FAERS数据库系统挖掘导致急性肾损伤的药物,并对有价值的药物进行回顾性文献分析,分析其临床表现、治疗和转归等情况,为临床安全用药提供参考。方法:利用开放药物数据平台OpenVigil,检索2004年第1季度—2023年第3季度关于急性肾损伤药物报告,分析阳性信号,发现潜在风险药物;按“药物名称”及“肾损伤”检索PubMed、web of science、万方数据、中国知网和维普网收录的案例报道,对案例中患者年龄、性别、国籍、药物用法用量、用药时间分布、临床表现、治疗措施及转归情况等进行回顾性分析。结果:初步筛选获得53个阳性信号药物,前5位的药物中质子泵抑制剂(proton pump inhibitors,PPIs)有4种;对该类药物进行文献检索,5个PPIs药物有该类病例报道,共纳入案例报道65篇,病例152例;奥美拉唑病例最多(113例,74.3%);报告主要集中在2010—2019年(70例,46.1%);以美国报道最多(48例,31.6%);男女发病比例1∶1.5;发病年龄主要集中在60~80岁(96例,63.2%),平均年龄66.64岁,中位年龄70岁;用药剂量基本为常规剂量(84/85),发病时间2~6个月最高(67例,44.1%),6个月内累计数量为116例(76.3%);115例患者进行了肾活检,主要病理结果为急性间质性肾炎或表现出间质性肾炎(114例,75.0%);临床表现无明显特异性;基线肌酐与好转后肌酐水平差异P<0.01;主要治疗方式均为停药,60例患者进行了糖皮质激素治疗;12例患者二次用药或再激发阳性,其中5例需要额外的透析治疗。结论:PPIs导致的肾损伤是一个长期且广泛的情况,老年人群特别是老年女性患者存在更高的发病风险;在常规剂量下PPIs即可导致肾间质性损伤,建议在药物应用早期关注是否有前驱的临床症状,如发热、恶心、呕吐、皮疹等;对于已经发生PPIs肾损伤的患者,停药为最主要的治疗方式,可以考虑使用激素进行治疗,严重病例可以考虑短期血液透析治疗;虽然大部分患者转归良好,但肾功能仍低于发病前水平;对于发生过此类不良事件的患者应避免再次使用PPIs药物。
基金the NSFC(Grants No.11674334,No.11974363,and No.11947302)the Strategic Priority Research Program of CAS(Grant No.XDB28000000)the Thousand-Youth-Talent Program of China。
文摘We investigate the effective interaction between two heavy impurities immersed in a quasi-twodimensional dipolar Bose-Einstein condensate via a variation approach.We show that the mediated interaction is highly tunable via the contact and the dipole-dipole interactions between the background gas atoms.Interestingly,the mediated interaction potential may become an oscillating function of inter-impurity distance when roton excitation emerges under sufficiently strong dipolar interaction.Our system therefore provides an efficient way for tuning the mediated interaction between impurities.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11674041,91630205,11474144,and 11847301)Chongqing Research Program of Basic Research and Frontier Technology(Grant No.cstc2017jcyjAX0084)FRF for the Central Universities(Grant No.2019CDJDWL0005)
文摘For the numerical simulation of the fractional quantum Hall(FQH) effects on a finite disk, the rotational symmetry is the only symmetry that is used in diagonalizing the Hamiltonian. In this work, we propose a method of using the weak translational symmetry for the center of mass of the many-body system. With this approach, the bulk properties, such as the energy gap and the magneto-roton excitation are consistent with those in the closed manifolds like the sphere and torus. As an application, we consider the FQH phase and its phase transition in the fast rotated dipolar fermions. We thus demonstrate the disk geometry having versatility in analyzing the bulk properties beside the usual edge physics.
基金supported by the National Natural Science Foundation of China[Grant Nos.U23A2073(P.Z.)and 11547034(H.Z.)].
文摘The measurement of the pairing gap is crucial for investigating the physical properties of superconductors or superfluids.We propose a strategy to measure the pairing gap through the dynamical excitations.With the random phase approximation(RPA),we study the dynamical excitations of a two-dimensional attractive Fermi-Hubbard model by calculating its dynamical structure factor.Two distinct collective modes emerge:a Goldstone phonon mode at transferred momentum q=[0,0]and a roton mode at q=[p,p].The roton mode exhibits a sharp molecular peak in the low-energy regime.Notably,the area under the roton molecular peak scales with the square of the pairing gap,which holds even in three-dimensional and spin-orbit coupled(SOC)optical lattices.This finding suggests an experimental approach to measure the pairing gap in lattice systems by analyzing the dynamical structure factor at q=[p,p].
文摘Recently, the extraordinary structures and physiological activities of silatrane compounds have been paid much attention to and been studied with various physicoehemical methods by many authors. The concept of pentacoordinated silicon and tetracoordinated nitrogen in these compounds has been proposed. However, there is still much controversy about it.
