The technology of expansion fracturing with liquid CO_(2)(EFLCO_(2))has attracted increasing attention due to reduced vibration and damage.The disposable fracturing tube has been developed and is gradually replacing t...The technology of expansion fracturing with liquid CO_(2)(EFLCO_(2))has attracted increasing attention due to reduced vibration and damage.The disposable fracturing tube has been developed and is gradually replacing the Cardox tube.However,there is a lack of impact pressure testing of disposable tubes under real working conditions,selection of gas explosion design parameters,and systematic analysis of blasting vibration.This limitation has constrained the widespread application of disposable fracturing tubes in engineering.A joint monitoring of the pressure-time curves in the disposable tubes and boreholes was conducted.The rock-breaking effect of varying hole spacing parameters in the EFLCO_(2)design was analyzed,and a systematic study was carried out on the vibration peak value,frequency,and energy characteristics.The results show that(1)the pressure distribution characteristics,stress peak value,and duration in the disposable tubes are different from those of Cardox tubes,which show multi-peak distribution,low-pressure peak value,and short duration.The correlation between the pressure in the disposable tube,filling pressure,and liquid CO_(2)weight is established,and a theoretical calculation method for the borehole wall pressure is proposed;(2)The hole spacing in rocks of different hardness is suggested;and(3)At the same scale distance,the peak particle velocity(PPV)caused by EFLCO_(2)(PPVCO_(2))is significantly smaller than that caused by blasting(PPVexplosive).The ratio of PPVexplosive to PPVCO_(2)is a power function related to scale distance,and a distance-related zonality exist in this relationship.The frequency composition of the vibration signal caused by EFLCO_(2)is relatively simple with a narrow frequency band.Its PPV and energy are mainly concentrated in the low-frequency band.This research contributes to the optimization of disposable fracturing tubes,gas explosion design,and vibration hazard control.展开更多
To address the challenges of rapid bit failure and high drilling costs associated with hard limestone in Sichuan Basin of China,we conducted rock-breaking experiments and simulations of shaped(cylindrical,ridge,and ch...To address the challenges of rapid bit failure and high drilling costs associated with hard limestone in Sichuan Basin of China,we conducted rock-breaking experiments and simulations of shaped(cylindrical,ridge,and chopper)cutters.Rock mechanics,drillability,and acoustic emission indentation tests revealed the drilling resistance characteristics of the limestone:average uniaxial compressive strength of 202.472 MPa,tensile strength of 7.092 MPa,and drillability of 7.866.We evaluated the performance differences between the shaped cutters before introducing an efficient and innovative finite-discrete-infinite element method(FDIEM)to establish an interaction model between the shaped cutters and limestone.The simulation results indicated the following:(1)The shaped cutters demonstrated superior rock-breaking performance compared to the traditional cylindrical cutter.(2)Compared with the cylindrical cutter,the ridge cutter yielded the lowest peak indentation force and mechanical specific energy,with reductions of 8.71%and 33.83%,respectively.This confirmed that the ridge cutter had the optimal tooth profile for the target formation.Its rock-breaking mechanism relied on the convex edges to induce localized high stress in the rock,which enabled efficient rock fragmentation via a plowing mode while mitigating frictional resistance from cuttings.(3)The novel chopper cutter with its secondary step surface exerted a buffering effect on the cuttings,thereby achieving high cutting stability.This study provides theoretical and technical support for the design of personalized drill bits and the acceleration of the rate of penetration(ROP)in deep hard rock formations.展开更多
Percussion drilling technology can be used to increase the rate of penetration in deep shale reservoirs,but the interaction mechanism among impact loads,drilling teeth and rock has not been sufficiently investigated.F...Percussion drilling technology can be used to increase the rate of penetration in deep shale reservoirs,but the interaction mechanism among impact loads,drilling teeth and rock has not been sufficiently investigated.For this reason,shales with different bedding angles are used to carry out impact compression and tensile experiments as well as the rock-breaking experiments by single axe-shaped tooth,the variation of dynamic strengths,rock failure characteristics,fractal dimensions,and tensile/compression ratios under different load-bedding angles(α)are investigated.Then,the three-dimensional scanning device is used to measure the penetration depth and rock-breaking volume under different load-bedding angles.The results show that with the increase of load-bedding angle(0°-90°),the compressive strength decreases and then increases,with the lowest strength atα=45°and the highest strength atα=0°;the tensile strength decreases and then increases,with the lowest strength nearα=30°and the highest strength atα=90°.With the growing impact rate,the effect of load-bedding angle on dynamic compressive strength decreases,and the effect on dynamic tensile strength becomes more significant.When the impact velocity is high(≥8.0 m/s),the tensile-compressive ratio first decreases and then increases,and both reach a minimum at a load-bedding angle of 30°and a maximum at 60°.With the increasing of the load-bedding angle,the depth of tooth penetration increases and then decreases,and the highest depth of tooth penetration and the highest energy absorption efficiency are achieved atα=45°;the width of the impact pit increases and then decreases,and the maximum width value is achieved atα=30°,with the smallest value of the specific work value of the rock-breaking.The results have significant reference value for improving the rock-breaking efficiency of percussion drilling in deep anisotropic formations.展开更多
High-energy plasma jet rock-breaking technology is regarded as a very promising new drilling approach for deep hard rock,attributed to its high energy density,high rock-breaking efficiency,absence of mechanical wear,a...High-energy plasma jet rock-breaking technology is regarded as a very promising new drilling approach for deep hard rock,attributed to its high energy density,high rock-breaking efficiency,absence of mechanical wear,and capability to drill high-hardness rocks.However,the thermal characteristics and rockbreaking mechanism of plasma jet remains unclear.This study thoroughly investigates the internal temperature distribution characteristics of granite and the thermal removal mechanism of plasma jet with combined experimental and numerical approaches.The spallation temperature of granite is calculated based on the Weibull statistical theory of tensile failure.A numerical model of the thermal melting process of granite is developed to obtain the erosion morphology and temperature distribution characteristics during the rock-breaking process.The results indicate that the spallation temperature induced by the plasma jet is approximately 557℃,and the experimentally obtained hole profile on the upper surface coincides with the isotherm corresponding to the spallation temperature from the simulation.The temperature gradients of granite in the radial and axial directions of plasma arc operation can reach up to 38.79 and 66.13℃/mm,respectively.And the heat-affected region expands with increasing current.The optimal removal efficiency can be achieved between 20 and 30 s under various plasma current conditions,with the maximum value of 1188 mm^(3)/s at a current of 300 A.The plasma jet rock-breaking process can be characterized into three stages:dominant spalling in the early rockbreaking stage,followed by the coexistence of hot melting and spalling in the middle stage,and dominant high-temperature melting removal in the later stage.The results of this study provide theoretical guidance for engineering application of high-energy plasma jet rock-breaking drilling.展开更多
Unsubmerged cavitating abrasive waterjet(UCAWJ)has been shown to artificially create a submerged environment that produces shear cavitation,which effectively enhances rock-breaking performance.The shear cavitation gen...Unsubmerged cavitating abrasive waterjet(UCAWJ)has been shown to artificially create a submerged environment that produces shear cavitation,which effectively enhances rock-breaking performance.The shear cavitation generation and collapse intensity depend on the pressure difference between the intermediate high-speed abrasive waterjet and the coaxial low-speed waterjet.However,the effect of the pressure of the coaxial low-speed waterjet is pending.For this purpose,the effect of low-speed waterjet pressure on rock-breaking performance at different standoff distances was experimentally investigated,and the effects of erosion time and ruby nozzle diameter on erosion performance were discussed.Finally,the micromorphology of the sandstone was observed at different locations.The results show that increased erosion time and ruby nozzle diameter can significantly improve the rock-breaking performance.At different standoff distances,the mass loss increases first and then decreases with the increase of low-speed waterjet pressure,the maximum mass loss is 10.4 g at a low-speed waterjet pressure of0.09 MPa.The surface morphology of cavitation erosion was measured using a 3D profiler,the increase in both erosion depth and surface roughness indicated a significant increase in the intensity of the shear cavitation collapse.At a low-speed waterjet pressure of 0.18 MPa,the cavitation erosion surface depth can reach 600μm with a roughness of 127μm.展开更多
Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms lig...Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms ligand bonds or hydrogen bonds with sulfur ions in lithium polysulfides(LiPSs),thus inhibiting the shuttle effect.Electrochemical analyses demonstrated that lithium‑sulfur(Li‑S)batteries employing the NH2‑SS interlayer exhibited discharge specific capacities of 1048 and 789 mAh·g^(-1) at 0.2C and 2C,respectively,and even at 4C,the initial discharge specific capacity remained at 590 mAh·g^(-1),outperforming the Li‑S battery with unmodified SS as the interlayer.展开更多
The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF...The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result.展开更多
Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticle...Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.展开更多
Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electro...Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,rem...The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,remove toxins,clear heat,and alleviate wind-heat syndromes.It also has hepatoprotective,anti-inflammatory,antiviral,antibacterial,anticancer,antioxidant,antiaging,and anti-obesity effects,as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy.It is used to treat scrofula,mastitis,wind-heat common cold,and other ailments.The review summarizes the chemical constituents and pharmacological effects of F.suspensa,aiming to provide a scientific foundation for its future development,research,and clinical utilization.展开更多
Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which...Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which has a Curie temperature of~290 K and an in-plane easy magnetization axis.Magnetotransport measurements show a positive magnetoresistance(MR)below 50 K,which becomes negative at higher temperatures.An intrinsic anomalous Hall conductivity of 114 S·cm^(-1)is observed in MgMn_(6)Sn_(6) single crystals,consistent with ab initio calculations.Moreover,theoretical predictions indicate that shifting the Fermi level(EF)upward by~70 meV could enhance the AHE to~528 S·cm^(-1).These results position MgMn_(6)Sn_(6) as a promising and tunable platform for exploring topological magnetism and related electronic phenomena.展开更多
[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based ...[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based on the demonstration construction project of the ecological ditch-constructed wetland system in the Hetao Irrigation District,an experimental study was conducted from July to September 2023 to investigate the interception and purification effects of ecological ditches,constructed wetlands,and the combined ecological ditch-constructed wetland system on farmland drainage pollutants.Key water quality parameters measured included total nitrogen(TN)concentration and total phosphorus(TP)concentration.[Results]Different treatment modes of ecological ditches and constructed wetlands have a certain removal effect on nitrogen and phosphorus pollutants in water bodies.The ecological ditches treated with Astragalus laxmannii,Melilotus officinalis,Medicago sativa,bio-ball substrate,and bio-sheet substrate showed reduction efficiencies for TN and TP of 21.09% and 23.84%,12.06% and 26.67%,20.08% and 34.15%,23.65% and 20.56%,and 19.92% and 25.83%,respectively.The emergent plant area showed reduction efficiencies of 24.28%for TN and 17.89%for TP,while the submerged plant area achieved a reduction efficiency of 10.21%for both TN and TP.Among the different treatment modes,the ecological ditch with M.sativa performed better in TP removal,whereas the bio-ball substrate treatment mode showed higher effectiveness in TN removal.In addition,the emergent plant area exhibited better TP removal performance,while the submerged plant area was more effective in TN removal.The combined system of ecological ditch and constructed wetland achieved removal rates of 37.55% for TN and 11.47% for TP.It effectively facilitates the step-by-step interception and adsorption purification of pollutants,thereby showing significant removal and purification effects on nitrogen and phosphorus contaminants.This contributes to mitigating agricultural non-point source pollution.[Conclusions]The combined ecological ditch-constructed wetland system serves dual functions of agricultural drainage and pollutant interception and purification.It reduces the pollution load of farmland drainage on receiving water bodies to some extent and mitigates agricultural non-point source pollution.Therefore,it is a relatively suitable technology for managing agricultural non-point source pollution in the Hetao Irrigation District.展开更多
The effect of adding hydroxycinnamic acids(caffeic acid,sinapic acid,p-coumaric acid and chlorogenic acid)in Cabernet Sauvignon dry red wine before and after fermentation was investigated,taking into account the color...The effect of adding hydroxycinnamic acids(caffeic acid,sinapic acid,p-coumaric acid and chlorogenic acid)in Cabernet Sauvignon dry red wine before and after fermentation was investigated,taking into account the color parameters,anthocyanin content,and overall polyphenol levels in the wine samples.The copigmentation effect of malvidin-3-Oglucoside and sinapic acid was further explored in model solution and through theoretical calculations.The results indicated that the addition of hydroxycinnamic acids significantly enhanced the wine's color with sinapic acid(before the fermentation)showing the most pronounced color protection effect.Compared to control samples,the addition of hydroxycinnamic acids resulted in a 36%increase in total phenolic content and a 28% increase in total anthocyanin content.Thermodynamic analysis revealed that the interaction between sinapic acid and malvidin-3-O-glucoside was spontaneous and exothermic.Theoretical studies identified hydrogen bonding(HB)and dispersion forces as the main primary stabilizing forces,with the carboxyl group of sinapic acid playing a critical role while the anthocyanin backbone also influenced the interaction.展开更多
Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects ho...Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects host glucose metabolism and drugbioavailability,increasingthe efficacy of T2DM therapy[2].In this context,probiotic-drug coadministration,an emerging adjunct approach for treating metabolic diseases,improves therapeutic outcomes and ameliorates side effects[3].展开更多
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu...Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.展开更多
Lattice materials have demonstrated promising potential in engineering applications owing to their exceptional lightweight,high specific strength,and tunable mechanical properties.However,the traditional homogenizatio...Lattice materials have demonstrated promising potential in engineering applications owing to their exceptional lightweight,high specific strength,and tunable mechanical properties.However,the traditional homogenization methods based on the classical elasticity theory struggle to accurately describe the non-classical mechanical behaviors of lattice materials,especially when dealing with complex unit-cell geometries featured by non-symmetric configurations or non-single central node connections.In response to this limitation,this study establishes a generalized homogenization model based on the micropolar theory framework,employing Hill's boundary conditions to precisely predict the equivalent moduli of complex lattice materials.By introducing the independent rotational degree of freedom(DOF)characteristic of the micropolar theory,the proposed model successfully overcomes the limitation of conventional methods in accurately describing the asymmetric deformation and scale effects.We initially calculate the constitutive relations of two-dimensional(2D)cross-shaped multi-node chiral lattices and subsequently extend the method to three-dimensional(3D)lattices,successfully predicting the mechanical properties of both traditional and eccentric body-centered cubic(BCC)lattices.The theoretical model is validated through the finite element numerical verification which shows excellent consistency with the theoretical predictions.A further parametric study investigates the influence of geometric parameters,revealing the underlying size-effect mechanism.This paper provides a reliable theoretical tool for the design and property optimization of complex lattice materials.展开更多
This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinic...This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
Large magnetic entropy change(△S_(M))can realize a prominent heat transformation under the magnetic field and directly strengthen the efficacy of the magnetocaloric effect,which provides a pioneering environmentally ...Large magnetic entropy change(△S_(M))can realize a prominent heat transformation under the magnetic field and directly strengthen the efficacy of the magnetocaloric effect,which provides a pioneering environmentally friendly solidstate strategy to improve refrigeration capacities and efficiencies.The second-order magnetic transition(SOMT)materials have broader△S_(M) peaks without thermal hysteresis,making them highly attractive in magnetic refrigeration,especially in the room temperature range.Here,we report a significant enhancement of△S_(M) at room temperature in single-crystal Mn_(5)Ge_(3).In this SOMT system,we realize a 60%improvement of-△S_(M)^(max) from 3.5 J/kg·K to 5.6 J/kg·K at T=300 K.This considerable enhancement of△S_(M) is achieved by intentionally introducing strain energy through high-pressure constrained deformation.Both experimental results and Monte Carlo simulations demonstrate that the enhancement of△S_(M) originates from the microscopic strain and lattice deformation induced by strain energy after deformation.This strain energy will reconstruct the energy landscape of this ferromagnetic system and enhance magnetization,resulting in a giant intensity of magnetocaloric responses.Our findings provide an approach to increase magnetic entropy change and may give fresh ideas for exploring advanced magnetocaloric materials.展开更多
基金financially supported by the National Key R&D Program of China(Grant No.2020YFA0711802)the Wuhan Science and Technology Bureau of China(Grant No.2023020201010081)the National Nature Science Foundation of China(Grant No.U22A20239).
文摘The technology of expansion fracturing with liquid CO_(2)(EFLCO_(2))has attracted increasing attention due to reduced vibration and damage.The disposable fracturing tube has been developed and is gradually replacing the Cardox tube.However,there is a lack of impact pressure testing of disposable tubes under real working conditions,selection of gas explosion design parameters,and systematic analysis of blasting vibration.This limitation has constrained the widespread application of disposable fracturing tubes in engineering.A joint monitoring of the pressure-time curves in the disposable tubes and boreholes was conducted.The rock-breaking effect of varying hole spacing parameters in the EFLCO_(2)design was analyzed,and a systematic study was carried out on the vibration peak value,frequency,and energy characteristics.The results show that(1)the pressure distribution characteristics,stress peak value,and duration in the disposable tubes are different from those of Cardox tubes,which show multi-peak distribution,low-pressure peak value,and short duration.The correlation between the pressure in the disposable tube,filling pressure,and liquid CO_(2)weight is established,and a theoretical calculation method for the borehole wall pressure is proposed;(2)The hole spacing in rocks of different hardness is suggested;and(3)At the same scale distance,the peak particle velocity(PPV)caused by EFLCO_(2)(PPVCO_(2))is significantly smaller than that caused by blasting(PPVexplosive).The ratio of PPVexplosive to PPVCO_(2)is a power function related to scale distance,and a distance-related zonality exist in this relationship.The frequency composition of the vibration signal caused by EFLCO_(2)is relatively simple with a narrow frequency band.Its PPV and energy are mainly concentrated in the low-frequency band.This research contributes to the optimization of disposable fracturing tubes,gas explosion design,and vibration hazard control.
基金the National Science and Technology Major Project(Grant No.2025ZD1008300)the Major Scientific Research Instrument Development Project of the National Natural Science Foundation of China(Grant No.52327803).
文摘To address the challenges of rapid bit failure and high drilling costs associated with hard limestone in Sichuan Basin of China,we conducted rock-breaking experiments and simulations of shaped(cylindrical,ridge,and chopper)cutters.Rock mechanics,drillability,and acoustic emission indentation tests revealed the drilling resistance characteristics of the limestone:average uniaxial compressive strength of 202.472 MPa,tensile strength of 7.092 MPa,and drillability of 7.866.We evaluated the performance differences between the shaped cutters before introducing an efficient and innovative finite-discrete-infinite element method(FDIEM)to establish an interaction model between the shaped cutters and limestone.The simulation results indicated the following:(1)The shaped cutters demonstrated superior rock-breaking performance compared to the traditional cylindrical cutter.(2)Compared with the cylindrical cutter,the ridge cutter yielded the lowest peak indentation force and mechanical specific energy,with reductions of 8.71%and 33.83%,respectively.This confirmed that the ridge cutter had the optimal tooth profile for the target formation.Its rock-breaking mechanism relied on the convex edges to induce localized high stress in the rock,which enabled efficient rock fragmentation via a plowing mode while mitigating frictional resistance from cuttings.(3)The novel chopper cutter with its secondary step surface exerted a buffering effect on the cuttings,thereby achieving high cutting stability.This study provides theoretical and technical support for the design of personalized drill bits and the acceleration of the rate of penetration(ROP)in deep hard rock formations.
基金supported by the National Natural Science Foundation of China(52374001,52104001).
文摘Percussion drilling technology can be used to increase the rate of penetration in deep shale reservoirs,but the interaction mechanism among impact loads,drilling teeth and rock has not been sufficiently investigated.For this reason,shales with different bedding angles are used to carry out impact compression and tensile experiments as well as the rock-breaking experiments by single axe-shaped tooth,the variation of dynamic strengths,rock failure characteristics,fractal dimensions,and tensile/compression ratios under different load-bedding angles(α)are investigated.Then,the three-dimensional scanning device is used to measure the penetration depth and rock-breaking volume under different load-bedding angles.The results show that with the increase of load-bedding angle(0°-90°),the compressive strength decreases and then increases,with the lowest strength atα=45°and the highest strength atα=0°;the tensile strength decreases and then increases,with the lowest strength nearα=30°and the highest strength atα=90°.With the growing impact rate,the effect of load-bedding angle on dynamic compressive strength decreases,and the effect on dynamic tensile strength becomes more significant.When the impact velocity is high(≥8.0 m/s),the tensile-compressive ratio first decreases and then increases,and both reach a minimum at a load-bedding angle of 30°and a maximum at 60°.With the increasing of the load-bedding angle,the depth of tooth penetration increases and then decreases,and the highest depth of tooth penetration and the highest energy absorption efficiency are achieved atα=45°;the width of the impact pit increases and then decreases,and the maximum width value is achieved atα=30°,with the smallest value of the specific work value of the rock-breaking.The results have significant reference value for improving the rock-breaking efficiency of percussion drilling in deep anisotropic formations.
基金supported by the Excellent Youth Science Fund Project(Overseas)of Shandong Province(No.2024HWYQ-045)the Taishan Scholars Project of Shandong Province(No.tsqn202211085)+3 种基金the National Natural Science Foundation of China(No.5240051775)the Equipment Pre-Research Collaborative Foundation for Innovation Team from Ministry of Education of the People's Republic of China(No.8091B042209)the Postdoctoral Fellowship Program of CPSF(No.GZC20242009)the Shandong Postdoctoral Innovation Project(No.SDCX-ZG-202400192)。
文摘High-energy plasma jet rock-breaking technology is regarded as a very promising new drilling approach for deep hard rock,attributed to its high energy density,high rock-breaking efficiency,absence of mechanical wear,and capability to drill high-hardness rocks.However,the thermal characteristics and rockbreaking mechanism of plasma jet remains unclear.This study thoroughly investigates the internal temperature distribution characteristics of granite and the thermal removal mechanism of plasma jet with combined experimental and numerical approaches.The spallation temperature of granite is calculated based on the Weibull statistical theory of tensile failure.A numerical model of the thermal melting process of granite is developed to obtain the erosion morphology and temperature distribution characteristics during the rock-breaking process.The results indicate that the spallation temperature induced by the plasma jet is approximately 557℃,and the experimentally obtained hole profile on the upper surface coincides with the isotherm corresponding to the spallation temperature from the simulation.The temperature gradients of granite in the radial and axial directions of plasma arc operation can reach up to 38.79 and 66.13℃/mm,respectively.And the heat-affected region expands with increasing current.The optimal removal efficiency can be achieved between 20 and 30 s under various plasma current conditions,with the maximum value of 1188 mm^(3)/s at a current of 300 A.The plasma jet rock-breaking process can be characterized into three stages:dominant spalling in the early rockbreaking stage,followed by the coexistence of hot melting and spalling in the middle stage,and dominant high-temperature melting removal in the later stage.The results of this study provide theoretical guidance for engineering application of high-energy plasma jet rock-breaking drilling.
基金financially supported by the National Natural Science Foundation of China (Nos.52175245 and 52274093)the Natural Science Foundation of Hubei Province (No.2021CFB462)the Knowledge Innovation Special Project of Wuhan (whkxjsj007)。
文摘Unsubmerged cavitating abrasive waterjet(UCAWJ)has been shown to artificially create a submerged environment that produces shear cavitation,which effectively enhances rock-breaking performance.The shear cavitation generation and collapse intensity depend on the pressure difference between the intermediate high-speed abrasive waterjet and the coaxial low-speed waterjet.However,the effect of the pressure of the coaxial low-speed waterjet is pending.For this purpose,the effect of low-speed waterjet pressure on rock-breaking performance at different standoff distances was experimentally investigated,and the effects of erosion time and ruby nozzle diameter on erosion performance were discussed.Finally,the micromorphology of the sandstone was observed at different locations.The results show that increased erosion time and ruby nozzle diameter can significantly improve the rock-breaking performance.At different standoff distances,the mass loss increases first and then decreases with the increase of low-speed waterjet pressure,the maximum mass loss is 10.4 g at a low-speed waterjet pressure of0.09 MPa.The surface morphology of cavitation erosion was measured using a 3D profiler,the increase in both erosion depth and surface roughness indicated a significant increase in the intensity of the shear cavitation collapse.At a low-speed waterjet pressure of 0.18 MPa,the cavitation erosion surface depth can reach 600μm with a roughness of 127μm.
文摘Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms ligand bonds or hydrogen bonds with sulfur ions in lithium polysulfides(LiPSs),thus inhibiting the shuttle effect.Electrochemical analyses demonstrated that lithium‑sulfur(Li‑S)batteries employing the NH2‑SS interlayer exhibited discharge specific capacities of 1048 and 789 mAh·g^(-1) at 0.2C and 2C,respectively,and even at 4C,the initial discharge specific capacity remained at 590 mAh·g^(-1),outperforming the Li‑S battery with unmodified SS as the interlayer.
基金National Natural Science Foundation of China(11875039)Shanxi Scholarship Council of China(2023-033)+2 种基金Fundamental Research Program of Shanxi Province(202303021221071)China Baowu Low Carbon Metallurgical Innovation Foundation(2022)2023 Anhui Major Industrial Innovation Plan Project。
文摘The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result.
文摘Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.
基金supported by the National Natural Science Foundation of China(No.62464010)Spring City Plan-Special Program for Young Talents(K202005007)+2 种基金Yunnan Talents Support Plan for Young Talents(XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects(202101BA070001-138)Frontier Research Team of Kunming University 2023.
文摘Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
文摘The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,remove toxins,clear heat,and alleviate wind-heat syndromes.It also has hepatoprotective,anti-inflammatory,antiviral,antibacterial,anticancer,antioxidant,antiaging,and anti-obesity effects,as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy.It is used to treat scrofula,mastitis,wind-heat common cold,and other ailments.The review summarizes the chemical constituents and pharmacological effects of F.suspensa,aiming to provide a scientific foundation for its future development,research,and clinical utilization.
基金Project supported by the National Natural Science Foundation of China(Grant No.12204347)National Key Research and Development Program of China(Grant No.2022YFA1402600)the Fund from Beijing National Laboratory for Condensed Matter Physics(Grant No.2023BNLCMPKF011)。
文摘Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which has a Curie temperature of~290 K and an in-plane easy magnetization axis.Magnetotransport measurements show a positive magnetoresistance(MR)below 50 K,which becomes negative at higher temperatures.An intrinsic anomalous Hall conductivity of 114 S·cm^(-1)is observed in MgMn_(6)Sn_(6) single crystals,consistent with ab initio calculations.Moreover,theoretical predictions indicate that shifting the Fermi level(EF)upward by~70 meV could enhance the AHE to~528 S·cm^(-1).These results position MgMn_(6)Sn_(6) as a promising and tunable platform for exploring topological magnetism and related electronic phenomena.
基金Supported by Special Fund Project for the Transformation of Scientific and Technological Achievements in Inner Mongolia Autonomous Region(2021CG0013)Bayannur City Science and Technology Plan Project(K202014)+1 种基金Inner Mongolia Autonomous Region Science and Technology Plan Project(2022YFHH0088)Research Special Project of the Education Department of Inner Mongolia Autonomous Region(STAQZX202320).
文摘[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based on the demonstration construction project of the ecological ditch-constructed wetland system in the Hetao Irrigation District,an experimental study was conducted from July to September 2023 to investigate the interception and purification effects of ecological ditches,constructed wetlands,and the combined ecological ditch-constructed wetland system on farmland drainage pollutants.Key water quality parameters measured included total nitrogen(TN)concentration and total phosphorus(TP)concentration.[Results]Different treatment modes of ecological ditches and constructed wetlands have a certain removal effect on nitrogen and phosphorus pollutants in water bodies.The ecological ditches treated with Astragalus laxmannii,Melilotus officinalis,Medicago sativa,bio-ball substrate,and bio-sheet substrate showed reduction efficiencies for TN and TP of 21.09% and 23.84%,12.06% and 26.67%,20.08% and 34.15%,23.65% and 20.56%,and 19.92% and 25.83%,respectively.The emergent plant area showed reduction efficiencies of 24.28%for TN and 17.89%for TP,while the submerged plant area achieved a reduction efficiency of 10.21%for both TN and TP.Among the different treatment modes,the ecological ditch with M.sativa performed better in TP removal,whereas the bio-ball substrate treatment mode showed higher effectiveness in TN removal.In addition,the emergent plant area exhibited better TP removal performance,while the submerged plant area was more effective in TN removal.The combined system of ecological ditch and constructed wetland achieved removal rates of 37.55% for TN and 11.47% for TP.It effectively facilitates the step-by-step interception and adsorption purification of pollutants,thereby showing significant removal and purification effects on nitrogen and phosphorus contaminants.This contributes to mitigating agricultural non-point source pollution.[Conclusions]The combined ecological ditch-constructed wetland system serves dual functions of agricultural drainage and pollutant interception and purification.It reduces the pollution load of farmland drainage on receiving water bodies to some extent and mitigates agricultural non-point source pollution.Therefore,it is a relatively suitable technology for managing agricultural non-point source pollution in the Hetao Irrigation District.
基金supported by the Key R&D Program of Shaanxi Province,China(2024NC-YBXM-146)the Xi’an Agricultural Technology Research and Development Project,China(24NYGG0048)+1 种基金the Key R&D Program of Xianyang,China(L2024-ZDYF-ZDYF-NY-0028)the National Foreign Expert Project of China(G2023172002L)。
文摘The effect of adding hydroxycinnamic acids(caffeic acid,sinapic acid,p-coumaric acid and chlorogenic acid)in Cabernet Sauvignon dry red wine before and after fermentation was investigated,taking into account the color parameters,anthocyanin content,and overall polyphenol levels in the wine samples.The copigmentation effect of malvidin-3-Oglucoside and sinapic acid was further explored in model solution and through theoretical calculations.The results indicated that the addition of hydroxycinnamic acids significantly enhanced the wine's color with sinapic acid(before the fermentation)showing the most pronounced color protection effect.Compared to control samples,the addition of hydroxycinnamic acids resulted in a 36%increase in total phenolic content and a 28% increase in total anthocyanin content.Thermodynamic analysis revealed that the interaction between sinapic acid and malvidin-3-O-glucoside was spontaneous and exothermic.Theoretical studies identified hydrogen bonding(HB)and dispersion forces as the main primary stabilizing forces,with the carboxyl group of sinapic acid playing a critical role while the anthocyanin backbone also influenced the interaction.
基金supported by the National Natural Science Foundation of China(32525049).
文摘Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects host glucose metabolism and drugbioavailability,increasingthe efficacy of T2DM therapy[2].In this context,probiotic-drug coadministration,an emerging adjunct approach for treating metabolic diseases,improves therapeutic outcomes and ameliorates side effects[3].
基金supported by the National Natural Science Foundation of China(Nos.82003977,82274134 and 82274139)the National Key Research and Development Plan(No.2017YFC1702200)+1 种基金the Key Research and Development Program of Zhejiang Province(No.2020C04020)the Science and Technology Program of Zhejiang Province(No.2025C02183).
文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.
基金Project supported by the National Natural Science Foundation of China(No.12472077)the supports from Shanghai Gaofeng Project for University Academic Program Development,Fundamental Research Funds for the Central Universities(No.22120240353).
文摘Lattice materials have demonstrated promising potential in engineering applications owing to their exceptional lightweight,high specific strength,and tunable mechanical properties.However,the traditional homogenization methods based on the classical elasticity theory struggle to accurately describe the non-classical mechanical behaviors of lattice materials,especially when dealing with complex unit-cell geometries featured by non-symmetric configurations or non-single central node connections.In response to this limitation,this study establishes a generalized homogenization model based on the micropolar theory framework,employing Hill's boundary conditions to precisely predict the equivalent moduli of complex lattice materials.By introducing the independent rotational degree of freedom(DOF)characteristic of the micropolar theory,the proposed model successfully overcomes the limitation of conventional methods in accurately describing the asymmetric deformation and scale effects.We initially calculate the constitutive relations of two-dimensional(2D)cross-shaped multi-node chiral lattices and subsequently extend the method to three-dimensional(3D)lattices,successfully predicting the mechanical properties of both traditional and eccentric body-centered cubic(BCC)lattices.The theoretical model is validated through the finite element numerical verification which shows excellent consistency with the theoretical predictions.A further parametric study investigates the influence of geometric parameters,revealing the underlying size-effect mechanism.This paper provides a reliable theoretical tool for the design and property optimization of complex lattice materials.
基金Supported by National Natural Science Foundation of China(82374346)Double Hundred Outstanding Young and Middle-aged Medical and Health Talents of Wuxi City(BJ2023071)Scientific Research Project of Wuxi Municipal Health Commission(Q202358).
文摘This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
文摘AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
基金Project supported by the National Key Research and Decelopment Program of China(Grant No.2021YFB3500302)the National Natural Science Foundation of China(Grant Nos.U22A20116 and 52371200)the Innovation Capability Improvement Project of Hebei Province,China(Grant No.22567605H)。
文摘Large magnetic entropy change(△S_(M))can realize a prominent heat transformation under the magnetic field and directly strengthen the efficacy of the magnetocaloric effect,which provides a pioneering environmentally friendly solidstate strategy to improve refrigeration capacities and efficiencies.The second-order magnetic transition(SOMT)materials have broader△S_(M) peaks without thermal hysteresis,making them highly attractive in magnetic refrigeration,especially in the room temperature range.Here,we report a significant enhancement of△S_(M) at room temperature in single-crystal Mn_(5)Ge_(3).In this SOMT system,we realize a 60%improvement of-△S_(M)^(max) from 3.5 J/kg·K to 5.6 J/kg·K at T=300 K.This considerable enhancement of△S_(M) is achieved by intentionally introducing strain energy through high-pressure constrained deformation.Both experimental results and Monte Carlo simulations demonstrate that the enhancement of△S_(M) originates from the microscopic strain and lattice deformation induced by strain energy after deformation.This strain energy will reconstruct the energy landscape of this ferromagnetic system and enhance magnetization,resulting in a giant intensity of magnetocaloric responses.Our findings provide an approach to increase magnetic entropy change and may give fresh ideas for exploring advanced magnetocaloric materials.
