[目的]分析针刺治疗原发性痛经(PD)随机对照试验(RCT)的结局指标使用现状,为日后开展针刺治疗PD的临床研究和构建核心指标集提供依据。[方法]检索中国知网(CNKI)、万方数据知识服务平台(Wangfang)、维普中文期刊数据库(VIP)、中国生物...[目的]分析针刺治疗原发性痛经(PD)随机对照试验(RCT)的结局指标使用现状,为日后开展针刺治疗PD的临床研究和构建核心指标集提供依据。[方法]检索中国知网(CNKI)、万方数据知识服务平台(Wangfang)、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、EMbase、Cochrane Library、Web of Science数据库中自2014年1月1日—2024年3月19日,关于针刺治疗PD的RCT,对其结局指标进行提取、分类和分析,形成针刺治疗PD的指标域。[结果]共纳入56项研究,共计49项结局指标,使用频次172次。按结局指标的频次排序,其所属的指标域依次为症状/体征(64.53%)、理化检查(18.60%)、远期预后(11.63%)、安全性事件(2.91%)、生活质量(2.33%)、满意度指标(1.16%)、中医病症(0.58%),纳入的研究均未报告经济学指标。[结论]结局指标使用现状存在偏倚风险较大,方法学质量待提升、主/次要结局指标区分不明、过度依赖主观结局指标,客观结局指标欠缺、忽视中医病症指标,未体现中医特色、忽视生活质量评价、经济学评估指标欠缺等问题,未来应加快构建针刺治疗PD的核心指标集,提高针刺治疗PD的RCT质量与公认度,最大限度地发挥单个RCT的价值。展开更多
现有偏倚风险评估工具主要针对传统两两比较Meta分析,难以全面评估网状Meta分析所特有的偏倚风险来源。为此,Lunny等研究者研发了针对网状Meta分析偏倚风险来源的评估工具(Risk of Bias in Network Meta-analysis,RoB NMA),专用于评估网...现有偏倚风险评估工具主要针对传统两两比较Meta分析,难以全面评估网状Meta分析所特有的偏倚风险来源。为此,Lunny等研究者研发了针对网状Meta分析偏倚风险来源的评估工具(Risk of Bias in Network Meta-analysis,RoB NMA),专用于评估网状Meta分析在干预选择与网络结构、效应修饰因素以及统计分析等层面可能带来的偏倚。本文旨在解读RoB NMA工具的制订背景、条目内容以及评价流程,为国内研究人员使用该工具提供参考。展开更多
OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently n...OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.展开更多
Plants and their interaction partners offer unparalleled views of evolutionary ecology.Nectar larceny,entailing nectar extraction without pollinating,is thought to be an example of a harmful,antagonistic behavior,but ...Plants and their interaction partners offer unparalleled views of evolutionary ecology.Nectar larceny,entailing nectar extraction without pollinating,is thought to be an example of a harmful,antagonistic behavior,but the precise consequences of floral larceny on plant reproductive success remain contentious.We conducted a comprehensive meta-analysis of 153 studies across 120 plant species,using 14 moderators to assess the effects of floral larceny on plant reproductive success and examine the key moderators.We found that floral larceny negatively impacts flower traits,pollinator visitation,pollen deposition,and fruit set,while having a neutral effect on critical female fitness indicators,such as seed set and seed quality,as well as on male fitness.By altering pollinator behavior,floral larceny may reduce geitonogamy,potentially enhancing genetic diversity.Additionally,factors such as pollinator type,plant mating system,and pollen limitation were identified as key moderators of these effects.Our analysis reveals an ultimately neutral effect of floral larceny on plant reproductive success,with potential benefits in certain contexts.These findings suggest that floral larceny plays a complex and multifaceted role within plant-pollinator interactions,facilitating the evolutionary stability and coexistence of floral larcenists and host plants.展开更多
文摘[目的]分析针刺治疗原发性痛经(PD)随机对照试验(RCT)的结局指标使用现状,为日后开展针刺治疗PD的临床研究和构建核心指标集提供依据。[方法]检索中国知网(CNKI)、万方数据知识服务平台(Wangfang)、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、EMbase、Cochrane Library、Web of Science数据库中自2014年1月1日—2024年3月19日,关于针刺治疗PD的RCT,对其结局指标进行提取、分类和分析,形成针刺治疗PD的指标域。[结果]共纳入56项研究,共计49项结局指标,使用频次172次。按结局指标的频次排序,其所属的指标域依次为症状/体征(64.53%)、理化检查(18.60%)、远期预后(11.63%)、安全性事件(2.91%)、生活质量(2.33%)、满意度指标(1.16%)、中医病症(0.58%),纳入的研究均未报告经济学指标。[结论]结局指标使用现状存在偏倚风险较大,方法学质量待提升、主/次要结局指标区分不明、过度依赖主观结局指标,客观结局指标欠缺、忽视中医病症指标,未体现中医特色、忽视生活质量评价、经济学评估指标欠缺等问题,未来应加快构建针刺治疗PD的核心指标集,提高针刺治疗PD的RCT质量与公认度,最大限度地发挥单个RCT的价值。
文摘现有偏倚风险评估工具主要针对传统两两比较Meta分析,难以全面评估网状Meta分析所特有的偏倚风险来源。为此,Lunny等研究者研发了针对网状Meta分析偏倚风险来源的评估工具(Risk of Bias in Network Meta-analysis,RoB NMA),专用于评估网状Meta分析在干预选择与网络结构、效应修饰因素以及统计分析等层面可能带来的偏倚。本文旨在解读RoB NMA工具的制订背景、条目内容以及评价流程,为国内研究人员使用该工具提供参考。
文摘OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.
基金support by the National Natural Science Foundation of China(32170241,32160054,and 32470241)supported by the Chinese Academy of Science's PIFI Fellowship Initiative(2024PVC0046).
文摘Plants and their interaction partners offer unparalleled views of evolutionary ecology.Nectar larceny,entailing nectar extraction without pollinating,is thought to be an example of a harmful,antagonistic behavior,but the precise consequences of floral larceny on plant reproductive success remain contentious.We conducted a comprehensive meta-analysis of 153 studies across 120 plant species,using 14 moderators to assess the effects of floral larceny on plant reproductive success and examine the key moderators.We found that floral larceny negatively impacts flower traits,pollinator visitation,pollen deposition,and fruit set,while having a neutral effect on critical female fitness indicators,such as seed set and seed quality,as well as on male fitness.By altering pollinator behavior,floral larceny may reduce geitonogamy,potentially enhancing genetic diversity.Additionally,factors such as pollinator type,plant mating system,and pollen limitation were identified as key moderators of these effects.Our analysis reveals an ultimately neutral effect of floral larceny on plant reproductive success,with potential benefits in certain contexts.These findings suggest that floral larceny plays a complex and multifaceted role within plant-pollinator interactions,facilitating the evolutionary stability and coexistence of floral larcenists and host plants.
