RITA(reactivation of p53 and induction of tumor cell apoptosis)是经筛选得到的小分子化合物,它主要通过抑制鼠双微体2(murine double minute 2,MDM2)和p53的结合激活p53功能。RITA通过调控细胞内参与细胞增殖、凋亡、衰老和代谢等...RITA(reactivation of p53 and induction of tumor cell apoptosis)是经筛选得到的小分子化合物,它主要通过抑制鼠双微体2(murine double minute 2,MDM2)和p53的结合激活p53功能。RITA通过调控细胞内参与细胞增殖、凋亡、衰老和代谢等过程的信号通路,抑制肿瘤的发生和发展,提高耐药细胞对化疗药物的敏感性。本文主要从靶向MDM2和p53结合位点的抑癌小分子概况、RITA的结构与作用机制以及RITA的功能研究进展三个方面进行论述,为进一步推进抑癌小分子化合物RITA在抗肿瘤中发挥作用的研究提供理论参考。展开更多
Fish (Rita rita) were exposed to an anionic detergent, dodecylbenzene sodium sulfonate, at a concentration of 6.9mg/liter (96-hr LC_(50) of the detergent).A series of histochemical techniques, used in this study for t...Fish (Rita rita) were exposed to an anionic detergent, dodecylbenzene sodium sulfonate, at a concentration of 6.9mg/liter (96-hr LC_(50) of the detergent).A series of histochemical techniques, used in this study for the demonstration of various protein constituents, indicated a gradual decrease in the intensity of staining reactions of the cytoplasmic material, suggesting a loss of protein moieties from the club cells and the epithelial cells of the opercular epidermis as a result of detergent exposure. 1990 Academic Press.Inc.展开更多
Rita rita exposed to a concentration of 6.9 mg per liter(96-h LC_(50)of an anionic detergent, dodecylbenzene sodium sulfonate)exhibited a gradual decrease in the lipid moieties of the epi- thelial cells,club cells,and...Rita rita exposed to a concentration of 6.9 mg per liter(96-h LC_(50)of an anionic detergent, dodecylbenzene sodium sulfonate)exhibited a gradual decrease in the lipid moieties of the epi- thelial cells,club cells,and goblet mucous cells lining the gill arch and gill filament epithelium. However,in time,no reaction of any of the lipid moieties could be observed,indicating the absence of the same,using various histochemical techniques.The results are discussed in light of the mechanistic understanding of detergent action.1989 Academic Press,Inc.展开更多
The relationship between literature and society has been a subject of continuous exploration since the inception of literature itself.On the one hand,from Plato’s theory of mimesis onward,literature has consistently ...The relationship between literature and society has been a subject of continuous exploration since the inception of literature itself.On the one hand,from Plato’s theory of mimesis onward,literature has consistently been viewed as a representation of social reality,positioning literature as subordinate to society.On the other hand,with the rise of structuralism and the New Criticism,certain schools of thought have focused exclusively on literature itself,deliberately overlooking the complex connections between literature and society.The growing tension between these two perspectives has increasingly placed contemporary literary studies in a polarized state,leading to a crisis in the legitimacy of literary scholarship.In response to this,Rita Felski’s exploration of the uses of literature embodies a new literary sociology that offers a way out of the current impasse in literary studies.展开更多
文摘RITA(reactivation of p53 and induction of tumor cell apoptosis)是经筛选得到的小分子化合物,它主要通过抑制鼠双微体2(murine double minute 2,MDM2)和p53的结合激活p53功能。RITA通过调控细胞内参与细胞增殖、凋亡、衰老和代谢等过程的信号通路,抑制肿瘤的发生和发展,提高耐药细胞对化疗药物的敏感性。本文主要从靶向MDM2和p53结合位点的抑癌小分子概况、RITA的结构与作用机制以及RITA的功能研究进展三个方面进行论述,为进一步推进抑癌小分子化合物RITA在抗肿瘤中发挥作用的研究提供理论参考。
文摘Fish (Rita rita) were exposed to an anionic detergent, dodecylbenzene sodium sulfonate, at a concentration of 6.9mg/liter (96-hr LC_(50) of the detergent).A series of histochemical techniques, used in this study for the demonstration of various protein constituents, indicated a gradual decrease in the intensity of staining reactions of the cytoplasmic material, suggesting a loss of protein moieties from the club cells and the epithelial cells of the opercular epidermis as a result of detergent exposure. 1990 Academic Press.Inc.
文摘Rita rita exposed to a concentration of 6.9 mg per liter(96-h LC_(50)of an anionic detergent, dodecylbenzene sodium sulfonate)exhibited a gradual decrease in the lipid moieties of the epi- thelial cells,club cells,and goblet mucous cells lining the gill arch and gill filament epithelium. However,in time,no reaction of any of the lipid moieties could be observed,indicating the absence of the same,using various histochemical techniques.The results are discussed in light of the mechanistic understanding of detergent action.1989 Academic Press,Inc.
文摘The relationship between literature and society has been a subject of continuous exploration since the inception of literature itself.On the one hand,from Plato’s theory of mimesis onward,literature has consistently been viewed as a representation of social reality,positioning literature as subordinate to society.On the other hand,with the rise of structuralism and the New Criticism,certain schools of thought have focused exclusively on literature itself,deliberately overlooking the complex connections between literature and society.The growing tension between these two perspectives has increasingly placed contemporary literary studies in a polarized state,leading to a crisis in the legitimacy of literary scholarship.In response to this,Rita Felski’s exploration of the uses of literature embodies a new literary sociology that offers a way out of the current impasse in literary studies.
