Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-...Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-β), which causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, TGF-β, degree of lower urinary tract symptoms, and prostatic volume for the presence of ED in benign prostatic hyperplasia (BPH) patients.Methods: Our study performed an analytic observational retrospective cohort study using secondary data from four hospitals in Bali, Indonesia, including medical records and other administrative data. The sample was BPH patients with several history qualifications.Results: Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (p<0.0001). Despite these results, prostate volume is not significant with ED (p=0.947).Conclusion: TNF-α, TGF-β, and lower urinary tract symptoms severity can predict the occurrence of ED in BPH, while prostatic volume was not significant.展开更多
Background:In the 2022-2023 global outbreak,the United States and state of Texas recorded a total of 31,277 and 3,085 confirmed monkeypox(Mpox)cases respectively as of November 2023.This study aims to investigate the ...Background:In the 2022-2023 global outbreak,the United States and state of Texas recorded a total of 31,277 and 3,085 confirmed monkeypox(Mpox)cases respectively as of November 2023.This study aims to investigate the demographic characteristics and risk factors of Mpox outbreak in Houston and document the epidemiologic control measures implemented with their outcomes.Methods:Houston Health Department received reports of suspected Mpox cases via electronic case reports and laboratory reports from healthcare providers within Houston.These were then investigated and reclassified as either positive or negative using DNA polymerase chain reaction tests.All the reported cases received between May 2022 and January 2023 were included in this study using convenient sampling methods.Descriptive statistics using frequency distribution was used to analyze the sociodemographic,clinical features and travel history of the cases.A two-sided Chi-squared test was used to determine association between Mpox test results and risk factors with significant level set at P<0.05.Other infection control measures such as community engagement,health education,tracking and contact tracing,vaccination,referrals and laboratory sample logistics support were implemented by the health department.Results:Out of the total of 1,625 suspected persons investigated for Mpox,724(44.6%)tested positive.Among the 724 confirmed cases,male was 700(96.7%),females 20(2.8%),transgender male 1(0.1%),transgender female 3(0.4%).Age groups 30-39 years constituted 43.6%,18-29 years 27.4%,40-49 years 18.2%,50-59 years was 8%.Race distribution of positive cases was Whites 43.4%,African American 38.7%,Asian 1.4%.Risk factors with P<0.05 included male gender,age groups 30-39 years and 40-49 years,travel history to Mpox endemic areas,recent sexual contact with known or suspected Mpox cases,human immunodeficiency virus seropositivity.Identifying as gay and bisexual were also statistically significant risk factors for Mpox infection.Conclusion:The timely implementation of primary and secondary prevention measures targeted at the most at-risk populations was very effective at curtailing the spread of Mpox infection within the city of Houston.展开更多
目的探索急性中-重度后循环梗死(Posterior circulation ischemia,PCI)预后不良的危险因素并进行初步模型分析。方法纳入2019年7月至2021年1月咸宁市通山县中医医院收治的急性中-重度后循环脑梗死患者177例。以出院当天至出院后3个月进...目的探索急性中-重度后循环梗死(Posterior circulation ischemia,PCI)预后不良的危险因素并进行初步模型分析。方法纳入2019年7月至2021年1月咸宁市通山县中医医院收治的急性中-重度后循环脑梗死患者177例。以出院当天至出院后3个月进行随访,收集入院前一般临床资料、首发症状与体征、生化检查,美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分及治疗过程中的并发症等18个因素进行单因素分析,然后进行多元回归分析独立危险因素。结果分析显示年龄>60岁、有高血压、糖尿病、梗死灶为多灶、首诊NIHSS评分>9分、伴肢体瘫痪及肺部感染是影响急性中-重度后循环脑梗死患者预后不良的独立危险因素(P<0.05)。其中采用糖尿病、首诊NIHSS评分、肺部感染3个因素构建的最佳模型,其区分预后良好与预后不良的ROC曲线下面积为0.803,灵敏度77.1%,特异度76.5%。结论糖尿病的病史阳性、首诊NIHSS评分较高及住院期间肺部感染对急性中-重度PCI患者预后不良具有更加重要的参考价值。展开更多
文摘Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-β), which causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, TGF-β, degree of lower urinary tract symptoms, and prostatic volume for the presence of ED in benign prostatic hyperplasia (BPH) patients.Methods: Our study performed an analytic observational retrospective cohort study using secondary data from four hospitals in Bali, Indonesia, including medical records and other administrative data. The sample was BPH patients with several history qualifications.Results: Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (p<0.0001). Despite these results, prostate volume is not significant with ED (p=0.947).Conclusion: TNF-α, TGF-β, and lower urinary tract symptoms severity can predict the occurrence of ED in BPH, while prostatic volume was not significant.
基金supported by U.S.Centers for Disease Control and Prevention Public Health Crisis Response Funding titled CDC-RFA-TP22-2201:Public Health Crisis Response Cooperative Agreement.
文摘Background:In the 2022-2023 global outbreak,the United States and state of Texas recorded a total of 31,277 and 3,085 confirmed monkeypox(Mpox)cases respectively as of November 2023.This study aims to investigate the demographic characteristics and risk factors of Mpox outbreak in Houston and document the epidemiologic control measures implemented with their outcomes.Methods:Houston Health Department received reports of suspected Mpox cases via electronic case reports and laboratory reports from healthcare providers within Houston.These were then investigated and reclassified as either positive or negative using DNA polymerase chain reaction tests.All the reported cases received between May 2022 and January 2023 were included in this study using convenient sampling methods.Descriptive statistics using frequency distribution was used to analyze the sociodemographic,clinical features and travel history of the cases.A two-sided Chi-squared test was used to determine association between Mpox test results and risk factors with significant level set at P<0.05.Other infection control measures such as community engagement,health education,tracking and contact tracing,vaccination,referrals and laboratory sample logistics support were implemented by the health department.Results:Out of the total of 1,625 suspected persons investigated for Mpox,724(44.6%)tested positive.Among the 724 confirmed cases,male was 700(96.7%),females 20(2.8%),transgender male 1(0.1%),transgender female 3(0.4%).Age groups 30-39 years constituted 43.6%,18-29 years 27.4%,40-49 years 18.2%,50-59 years was 8%.Race distribution of positive cases was Whites 43.4%,African American 38.7%,Asian 1.4%.Risk factors with P<0.05 included male gender,age groups 30-39 years and 40-49 years,travel history to Mpox endemic areas,recent sexual contact with known or suspected Mpox cases,human immunodeficiency virus seropositivity.Identifying as gay and bisexual were also statistically significant risk factors for Mpox infection.Conclusion:The timely implementation of primary and secondary prevention measures targeted at the most at-risk populations was very effective at curtailing the spread of Mpox infection within the city of Houston.
文摘目的探索急性中-重度后循环梗死(Posterior circulation ischemia,PCI)预后不良的危险因素并进行初步模型分析。方法纳入2019年7月至2021年1月咸宁市通山县中医医院收治的急性中-重度后循环脑梗死患者177例。以出院当天至出院后3个月进行随访,收集入院前一般临床资料、首发症状与体征、生化检查,美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分及治疗过程中的并发症等18个因素进行单因素分析,然后进行多元回归分析独立危险因素。结果分析显示年龄>60岁、有高血压、糖尿病、梗死灶为多灶、首诊NIHSS评分>9分、伴肢体瘫痪及肺部感染是影响急性中-重度后循环脑梗死患者预后不良的独立危险因素(P<0.05)。其中采用糖尿病、首诊NIHSS评分、肺部感染3个因素构建的最佳模型,其区分预后良好与预后不良的ROC曲线下面积为0.803,灵敏度77.1%,特异度76.5%。结论糖尿病的病史阳性、首诊NIHSS评分较高及住院期间肺部感染对急性中-重度PCI患者预后不良具有更加重要的参考价值。
