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Kernel matrix learning with a general regularized risk functional criterion 被引量:3
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作者 Chengqun Wang Jiming Chen +1 位作者 Chonghai Hu Youxian Sun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第1期72-80,共9页
Kernel-based methods work by embedding the data into a feature space and then searching linear hypothesis among the embedding data points. The performance is mostly affected by which kernel is used. A promising way is... Kernel-based methods work by embedding the data into a feature space and then searching linear hypothesis among the embedding data points. The performance is mostly affected by which kernel is used. A promising way is to learn the kernel from the data automatically. A general regularized risk functional (RRF) criterion for kernel matrix learning is proposed. Compared with the RRF criterion, general RRF criterion takes into account the geometric distributions of the embedding data points. It is proven that the distance between different geometric distdbutions can be estimated by their centroid distance in the reproducing kernel Hilbert space. Using this criterion for kernel matrix learning leads to a convex quadratically constrained quadratic programming (QCQP) problem. For several commonly used loss functions, their mathematical formulations are given. Experiment results on a collection of benchmark data sets demonstrate the effectiveness of the proposed method. 展开更多
关键词 kernel method support vector machine kernel matrix learning HKRS geometric distribution regularized risk functional criterion.
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Robust survival model for the prediction of Li-ion battery lifetime reliability and risk functions
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作者 Rasheed Ibraheem Timothy I.Cannings +1 位作者 Torben Sell Gonçalo dos Reis 《Energy and AI》 2025年第1期152-163,共12页
Single-value prediction such as the End of Life and Remaining Useful Life is a common method of estimating the lifetime of Li-ion batteries.Information from such prediction is limited when the entire degradation patte... Single-value prediction such as the End of Life and Remaining Useful Life is a common method of estimating the lifetime of Li-ion batteries.Information from such prediction is limited when the entire degradation pattern is needed for practical applications such as dynamic adjustment of battery warranty,improved maintenance scheduling,and battery stock management.In this research,a predictive,semi-parametric survival model called the Cox Proportional Hazards is proposed for the prediction of cell degradation in the form of survival probability(battery reliability)and cumulative hazard(battery risk)functions.Once this model is trained,the two functions can be obtained directly for a new cell without having to predict several cogent points.The model is trained on the first 50 cycles of only the voltage profile from either the charge or discharge data regime,implying that our methodology is data region agnostic.The signature method with both desirable mathematical and machine learning properties was adopted as a feature extraction technique. 展开更多
关键词 Battery degradation Cox Proportional Hazards Path signature methodology Survival probability function Cumulative hazard function Survival analysis Reliability and risk functions
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The association between sexual function and prostate cancer risk in US veterans
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作者 Daniel F Zapata Lauren E Howard +5 位作者 Jennifer Frank Ross M Simon Cathrine Hoyo Delores J Grant Stephen J Freedland Adriana C Vidal 《Asian Journal of Andrology》 SCIE CAS CSCD 2017年第2期191-195,共5页
Sexual dysfunction and prostate cancer are common among older men. Few studies explored the association between these two illnesses. We examined whether sexual function is associated with prostate cancer risk among ol... Sexual dysfunction and prostate cancer are common among older men. Few studies explored the association between these two illnesses. We examined whether sexual function is associated with prostate cancer risk among older men. Among 448 men undergoing prostate biopsy at the Durham Veterans Affairs Hospital, sexual function was ascertained from the Expanded Prostate Cancer Index Composite sexual assessment. We tested the link between sexual function and prostate cancer risk adjusting for multiple demographic and clinical characteristics using logistic regression. Multinomial logistic regression was used to test the associations with risk of low-grade (Gleason 〈6) and high-grade (Gleason 〉7 or 〉4 + 3) disease versus no cancer. Of 448 men, 209 (47%) had a positive biopsy; these men were less likely to be white (43% vs 55%, P=0.013), had higher prostate-specific antigen (PSA) (6.0 vs 5.4 ng ml-1, P 〈 0.001), but with lower mean sexual function score (47 vs 54, P = 0.007). There was no difference in age, BMI, pack years smoked, history of heart disease and/or diabetes. After adjusting for baseline differences, sexual function was linked with a decreased risk of overall prostate cancer risk (OR. 0.91 per lO-point change in sexual function, P= 0.004) and high-grade disease whether defined as Gleason ≥7 (OR: 0.86, P= 0.001) or 〉4 + 3 (OR: 0.85, P= 0.009). Sexual function was unrelated to low-grade prostate cancer (OR: 0.94, P = 0.13). Thus, among men undergoing prostate biopsy, higher sexual function was associated with a decreased risk of overall and high-grade prostate cancer. Confirmatory studies are needed. 展开更多
关键词 erectile dysfunction PROSTATE prostate cancer risk sexual function
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Wind Power System Risk Assessment Based on Fuzzy Clustering and Copula Function Modeling
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作者 Mingshun Liu Lijin Zhao +3 位作者 Liang Huang Wenhao Han Changhong Deng Zhijun Long 《Energy and Power Engineering》 2017年第4期352-364,共13页
According to the characteristics of the correlation of multiple wind farm output, this paper put forwards a modeling method based on fuzzy c-means clustering and the copula function, and correlation wind farms are ins... According to the characteristics of the correlation of multiple wind farm output, this paper put forwards a modeling method based on fuzzy c-means clustering and the copula function, and correlation wind farms are inserted into IEEE-RTS79 reliability system for risk assessment. By the probabilistic load flow calculated by Monte Carlo simulation method, the probability of the accident is derived, and bus voltage and branch power flow overload risk index are defined in this paper. The results show that this method can realize the modeling of the correlation of wind power output, and the risk index can identify the weakness of the system, which can provide reference for the operation and maintenance personnel. 展开更多
关键词 CORRELATION FUZZY CLUSTERING COPULA function risk Assessment
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Risk evaluation of natural disasters based on connection function 被引量:1
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作者 Zhengwei Pan Juliang Jin +1 位作者 Li Liu Xiaowei Liu 《Chinese Journal of Population,Resources and Environment》 2013年第2期118-124,共7页
There are many uncertain factors,such as stochastic,fuzzy and gray information in the risk analysis on natural hazard.The set pair analysis(SPA)deals effectively with the various uncertain factors contributing to eval... There are many uncertain factors,such as stochastic,fuzzy and gray information in the risk analysis on natural hazard.The set pair analysis(SPA)deals effectively with the various uncertain factors contributing to evaluation of the risk level of natural disasters.The evaluation indicators and standards of natural disasters risk are analyzed by identity-discrepancycontrary(IDC).The result,the connection numbers,still has uncertainty information.Thus,yielding the risk evaluation model of natural disasters based on connection function,which construct a set pair relation between the indicators of connection numbers and comprehensive evaluation standards,and describe uncertainty of the connection numbers by using connection function.The study showed that the proposed model takes into account only the uncertainty of risk evaluation indicator identification on natural disasters,also the uncertainty of result connection numbers.This approach gives full consideration to the uncertainty of systematic evaluation process along with the actual meaning of comprehensive evaluation functions.Therefore,this means it is able to reduce the uncertainty of final evaluation results and improve the accuracy and reasonability of evaluation results.This model is capable of reflecting actual situation of the risk evaluation on natural disaster affected by various uncertain factors and has a promotional value in the natural disaster risk assessment. 展开更多
关键词 set PAIR analysis CONNECTION function natural DISASTER risk level system COMPREHENSIVE evaluation
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Randomized Objective Function Linear Programming in Risk Management 被引量:1
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作者 Dennis Ridley Felipe Llaugel +1 位作者 Inger Daniels Abdullah Khan 《Journal of Applied Mathematics and Physics》 2021年第3期391-402,共12页
The traditional linear programming model is deterministic. The way that uncertainty is handled is to compute the range of optimality. After the optimal solution is obtained, typically by the simplex method, one consid... The traditional linear programming model is deterministic. The way that uncertainty is handled is to compute the range of optimality. After the optimal solution is obtained, typically by the simplex method, one considers the effect of varying each objective function coefficient, one at a time. This yields the range of optimality within which the decision variables remain constant. This sensitivity analysis is useful for helping the analyst get a sense for the problem. However, it is unrealistic because objective function coefficients tend not to stand still. They are typically profit contributions from products sold and are subject to randomly varying selling prices. In this paper, a realistic linear program is created for simultaneously randomizing the coefficients from any probability distribution. Furthermore, we present a novel approach for designing a copula of random objective function coefficients according to a specified rank correlation. The corresponding distribution of objective function values is created. This distribution is examined directly for central tendency, spread, skewness and extreme values for the purpose of risk analysis. This enables risk analysis and business analytics, emerging topics in education and preparation for the knowledge economy. 展开更多
关键词 Linear Programming RANDOM Objective function Profit Distribution risk Monte Carlo Simulation
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ON THE EXPECTED DISCOUNTED PENALTY FUNCTION IN A MARKOV-DEPENDENT RISK MODEL WITH CONSTANT DIVIDEND BARRIER 被引量:7
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作者 刘娟 徐建成 胡亦钧 《Acta Mathematica Scientia》 SCIE CSCD 2010年第5期1481-1491,共11页
This article considers a Markov-dependent risk model with a constant dividend barrier. A system of integro-differential equations with boundary conditions satisfied by the expected discounted penalty function, with gi... This article considers a Markov-dependent risk model with a constant dividend barrier. A system of integro-differential equations with boundary conditions satisfied by the expected discounted penalty function, with given initial environment state, is derived and solved. Explicit formulas for the discounted penalty function are obtained when the initial surplus is zero or when all the claim amount distributions are from rational family. In two state model, numerical illustrations with exponential claim amounts are given. 展开更多
关键词 Markov-dependent risk model dividend barrier Cerber-Shiu function integro-differential equation Laplace transform
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NONPARAMETRIC ESTIMATION OF BIVARIATE SURVIVAL FUNCTION UNDER THE COMPETING RISKS CASE
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作者 陈平 《Journal of Southeast University(English Edition)》 EI CAS 1992年第2期100-108,共9页
Estimation of the bivariate survival function under the competing risks caseis considered.We give an explicit formula for the estimator from a decomposition of thebivariate survival function based on competing risks,w... Estimation of the bivariate survival function under the competing risks caseis considered.We give an explicit formula for the estimator from a decomposition of thebivariate survival function based on competing risks,which is almost sure consistent. 展开更多
关键词 NON-PARAMETRIC statistics/competing riskS BIVARIATE survival function NONPARAMETRIC estimation ALMOST sure CONSISTENT
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Rainfall-runoff risk characteristics of urban function zones in Beijing using the SCS-CN model 被引量:2
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作者 姚磊 卫伟 +2 位作者 于洋 肖峻 陈利顶 《Journal of Geographical Sciences》 SCIE CSCD 2018年第5期656-668,共13页
Urbanization significantly increases the risk of urban flooding. Therefore, quantitative study of urban rainfall-runoff processes can provide a scientific basis for urban planning and management. In this paper, the bu... Urbanization significantly increases the risk of urban flooding. Therefore, quantitative study of urban rainfall-runoff processes can provide a scientific basis for urban planning and management. In this paper, the built-up region within the Fifth Ring Road of Beijing was selected as the study area. The details of land cover and urban function zones(UFZs) were identified using GIS and RS methods. On this basis, the SCS-CN model was adopted to analyze the rainfall-runoff risk characteristics of the study area. The results showed that:(1) UFZs within different levels of runoff risk varied under different rainfall conditions. The area ratio of the UFZs with high runoff risk increased from 18.90%(for rainfall return period of 1 a) to 54.74%(for period of 100 a). Specifically, urban commercial areas tended to have the highest runoff risk, while urban greening spaces had the lowest.(2) The spatial characteristics of the runoff risks showed an obvious circular distribution. Spatial cluster areas with high runoff risk were mainly concentrated in the center of the study area, while those with low runoff risk were mainly distributed between the fourth and fifth ring roads. The results indicated that the spatial clustering characteristic of urban runoff risk and runoff heterogeneity among different UFZs should be fully considered during urban rainwater management. 展开更多
关键词 SCS-CN model urban function zone spatial cluster runoff risk
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Association of Fibrin Monomer Polymerization Function, Cerebrovascular Risk Factors and Ischemic Cerebrovascular Disease in Old People
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作者 洪梅 魏文宁 +2 位作者 李红戈 杨锐 杨焰 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2003年第2期131-133,共3页
In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control compa... In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk. 展开更多
关键词 old people fibrin monomer polymerization function cerebrovascular disease risk factor
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父母低头行为与流动儿童辍学风险:一个有调节的中介模型
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作者 李洁 吴慧莲 刘芳 《中国临床心理学杂志》 北大核心 2026年第1期196-201,117,共7页
目的:探究家庭功能、学校依恋在父母低头行为对流动儿童辍学风险影响中的作用,以及父亲、母亲低头行为对流动儿童辍学风险的影响差异。方法:采用父母低头行为量表、家庭功能评定量表、流动儿童辍学风险问卷、学校依恋问卷对1280名初中... 目的:探究家庭功能、学校依恋在父母低头行为对流动儿童辍学风险影响中的作用,以及父亲、母亲低头行为对流动儿童辍学风险的影响差异。方法:采用父母低头行为量表、家庭功能评定量表、流动儿童辍学风险问卷、学校依恋问卷对1280名初中阶段流动儿童进行调查。结果:(1)父母低头行为显著正向预测流动儿童辍学风险,母亲低头行为显著少于父亲,但对辍学风险预测更强;(2)家庭功能在父母低头行为与流动儿童辍学风险间起中介作用;(3)学校依恋调节中介模型后半路径,即高水平学校依恋能缓冲家庭功能对流动儿童辍学风险的影响。结论:父母低头行为通过影响家庭功能进而影响流动儿童辍学风险,且母亲影响更大;学校依恋可作为保护性因子缓冲该风险。 展开更多
关键词 流动儿童 父母低头行为 辍学风险 家庭功能 学校依恋
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基于复杂网络的船舶营运安全风险功能共振模型
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作者 胡甚平 王圣君 +1 位作者 席秀婷 陈炎 《安全与环境学报》 北大核心 2026年第3期823-833,共11页
为确立船舶营运过程中的风险涌现特征,需要考虑复杂系统组成因子的不确定结构问题。以复杂性系统为视角,提出了一种复杂网络不确定结构的风险功能共振分析模型。首先,利用Apriori算法对船舶系统组分进行风险分析,计算组成因子间的非线... 为确立船舶营运过程中的风险涌现特征,需要考虑复杂系统组成因子的不确定结构问题。以复杂性系统为视角,提出了一种复杂网络不确定结构的风险功能共振分析模型。首先,利用Apriori算法对船舶系统组分进行风险分析,计算组成因子间的非线性交互效用,生成交互强度矩阵,从而确立船舶营运安全风险的功能共振分析模型(Functional Resonance Analysis Model,FRAM)。随后,采用图卷积网络(Graph Convolutional Network,GCN)构建系统组分网络,识别关键节点,并对因子交互关系网络结构进行重塑。最后,引入深度优先搜索(Depth First Search,DFS)算法,识别关键风险路径,计算出船舶系统组分因子的影响度。结合港口国监督(Port State Control,PSC)缺陷数据,运用前述模型对船舶营运风险进行仿真应用。应用结果表明,船舶的不安全状态受到内外部组成因子的属性影响,并存在关键共振路径关系,其中消防系统、船舶结构状态等是影响船舶不安全状态的核心节点。构建的风险功能共振分析模型能够基于不同的数据输入,自适应生成相应的风险路径依赖。基于复杂网络结构的风险功能共振模型有助于分析不确定结构复杂系统的风险涌现。 展开更多
关键词 安全系统学 复杂网络 船舶营运风险 功能共振分析模型 图卷积网络
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儿童传染性单核细胞增多症与肝功能异常的相关性及长期预后分析
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作者 王沁芳 冯晅 秦海荣 《中国现代医学杂志》 2026年第2期72-77,共6页
目的探讨儿童传染性单核细胞增多症(IM)合并肝功能异常的危险因素及长期预后,并分析其潜在机制。方法回顾性分析2021年1月—2023年12月山西省儿童医院收治的80例IM住院患儿的临床资料。依据肝功能状态分为肝功能异常组(32例)和肝功能正... 目的探讨儿童传染性单核细胞增多症(IM)合并肝功能异常的危险因素及长期预后,并分析其潜在机制。方法回顾性分析2021年1月—2023年12月山西省儿童医院收治的80例IM住院患儿的临床资料。依据肝功能状态分为肝功能异常组(32例)和肝功能正常组(48例)。比较两组的一般临床特征及实验室指标,采用多因素一般Logistic回归模型分析IM合并肝功能异常的影响因素。随访12个月,评估患儿的肝功能恢复情况、复发率及并发症发生情况。结果肝功能异常组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶、总胆红素和直接胆红素水平均高于肝功能正常组(P<0.05)。两组患儿发热天数、肝脏肿大、皮疹、异形淋巴细胞比值、中性粒细胞与淋巴细胞比值(NLR)和CD4^(+)/CD8^(+)比值比较,差异均有统计学意义(P<0.05)。两组患儿性别构成、年龄、咽峡炎、淋巴结肿大、脾脏肿大、白细胞计数、血红蛋白、EB病毒DNA载量、EB病毒衣壳抗原抗体阳性和CD3^(+)比较,差异均无统计学意义(P>0.05)。多因素一般Logistic回归分析结果显示:发热天数长[O^R=4.775(95%CI:1.550,14.709)]、肝脏肿大[O^R=5.438(95%CI:1.529,19.338)]、皮疹[O^R=5.370(95%CI:1.725,16.712)]、异形淋巴细胞比例大[O^R=6.234(95%CI:1.673,23.226)]、NLR水平低[O^R=0.315(95%CI:0.107,0.928)]、CD4^(+)/CD8^(+)水平低[O^R=0.384(95%CI:0.153,0.967)]均是IM患儿发生肝功能异常的危险因素(P<0.05)。肝功能异常组中87.50%(28/32)的患儿在3个月内肝酶及胆红素水平恢复正常;9.38%(3/32)的患儿在6个月内恢复;仅1例(3.13%)患儿在6个月后ALT仍轻度升高,但至12个月随访时已基本恢复正常。两组患儿均复发2例,均未出现典型慢性IM或慢性肝炎病例。结论IM患儿易合并肝功能异常,其发生与发热持续时间长、肝脏肿大、皮疹、异形淋巴细胞比例升高、NLR降低及CD4^(+)/CD8^(+)比值下降关系密切。尽管部分患儿肝功能恢复较慢,但长期预后总体良好,未见严重慢性肝损伤。 展开更多
关键词 传染性单核细胞增多症 肝功能异常 危险因素 免疫调节 长期预后
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老年股骨转子间骨折患者PFNA术后髋关节功能不良风险等级预测模型的构建和评价
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作者 武志刚 张海东 刘海洋 《临床误诊误治》 2026年第1期44-52,共9页
目的构建老年股骨转子间骨折患者股骨近端防旋髓内钉(PFNA)术后髋关节功能不良的风险等级预测模型,并评价其效能。方法选取2021年1月至2023年6月收治的208例老年股骨转子间骨折患者为研究对象,通过一般资料调查表、医院电子病历系统、Ha... 目的构建老年股骨转子间骨折患者股骨近端防旋髓内钉(PFNA)术后髋关节功能不良的风险等级预测模型,并评价其效能。方法选取2021年1月至2023年6月收治的208例老年股骨转子间骨折患者为研究对象,通过一般资料调查表、医院电子病历系统、Harris髋关节功能评分系统、恐动症Tampa量表进行问卷调查。采用单因素、多因素Logistic回归分析老年股骨转子间骨折患者PFNA术后髋关节功能不良的影响因素,将Logistic回归分析中有意义变量纳入列线图模型,采用受试者工作特征(ROC)曲线验证其效能,根据个体携带的危险因素,运用列线图模型计算患者PFNA术后髋关节功能不良的风险总得分及其风险概率,并根据风险总得分进行危险等级划分。结果最终完成206例老年股骨转子间骨折患者的随访及资料收集,Harris髋关节功能评分(86.12±7.32)分,髋关节功能预后良好率为75.24%(155/206),预后不良率为24.76%(51/206)。单因素、多因素Logistic回归分析显示,超重/肥胖、不稳定性骨折、手术时机≥7 d、Clavien-Dindo分级、恐动症、营养不良、骨质疏松症、血清Ⅰ型胶原氨基端前肽、血清骨织素均为老年股骨转子间骨折患者PFNA术后髋关节功能不良的独立危险因素,而功能锻炼依从性、血清25羟维生素D3是其保护因素(P<0.01)。基于上述影响因素构建列线图模型预测PFNA术后髋关节功能不良的曲线下面积为0.861(95%CI:0.793,0.928)。依据列线图模型计算髋关节功能不良风险总得分、预测风险概率,依据总得分分为低风险(≤160分)、中风险(>160~200分)、高风险(>200分)3个等级,对应概率分别为≤10%、>10%~50%、>50%。结论超重/肥胖、营养不良、骨质疏松症等是老年股骨转子间骨折患者PFNA术后髋关节功能不良的影响因素,以此为基础构建的列线图模型具有良好临床预测效用,可指导临床建立风险预警模式。 展开更多
关键词 股骨转子间骨折 老年 股骨近端防旋髓内钉 髋关节功能 危险因素 预测模型 列线图
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改良宫颈冷刀锥切术联合抗人乳头瘤病毒生物蛋白敷料对HSIL伴高危型HPV感染患者疗效及免疫功能的影响
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作者 赵丹 张宇敏 +1 位作者 王东海 刘秋颖 《临床和实验医学杂志》 2026年第1期67-71,共5页
目的探究改良宫颈冷刀锥切术联合抗人乳头瘤病毒(HPV)生物蛋白敷料对高级别鳞状上皮内病变(HSIL)伴高危型HPV感染患者疗效及免疫功能的影响。方法前瞻性选择2022年1月至2024年3月保定市第二中心医院接诊的102例HSIL伴高危型HPV感染的患... 目的探究改良宫颈冷刀锥切术联合抗人乳头瘤病毒(HPV)生物蛋白敷料对高级别鳞状上皮内病变(HSIL)伴高危型HPV感染患者疗效及免疫功能的影响。方法前瞻性选择2022年1月至2024年3月保定市第二中心医院接诊的102例HSIL伴高危型HPV感染的患者,按照随机数字表法将其分为对照组和联合治疗组,每组各51例。对照组给予改良宫颈冷刀锥切术,联合治疗组在对照组基础上给予抗HPV生物蛋白敷料治疗。比较两组患者治疗6、9个月后的疗效,治疗前、治疗6个月后的Survivin、Ki-67水平、HPV病毒载量和免疫功能,治疗6、9个月后的阴道分泌物异常情况。结果治疗6、9个月后,联合治疗组治疗总有效率分别为62.75%、84.31%,均高于对照组(41.18%、66.67%),差异均有统计学意义(P<0.05)。治疗6个月后,两组患者的Survivin、Ki-67、HPV病毒载量均较治疗前降低,且联合治疗组的Survivin、Ki-67、HPV病毒载量分别为(49.65±5.43)%、(47.82±5.24)%、21.70±2.57,均明显低于对照组[(52.53±6.48)%、(53.69±5.68)%、28.11±3.21],差异均有统计学意义(P<0.05)。治疗6个月后,两组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前升高,且联合治疗组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)分别为(67.09±7.38)%、(36.22±4.39)%、1.58±0.26,均明显高于对照组[(64.13±7.51)%、(34.15±4.19)%、1.29±0.21],差异均有统计学意义(P<0.05)。治疗6、9个月后,联合治疗组阴道分泌物异常发生率分别为35.29%、13.73%,均显著低于对照组(58.82%、31.37%),差异均有统计学意义(P<0.05)。结论改良宫颈冷刀锥切术联合抗HPV生物蛋白敷料治疗HSIL伴高危型HPV感染患者,有助于提高治疗效果,降低Survivin、Ki-67和HPV病毒载量水平,增强免疫功能,改善阴道分泌物异常。 展开更多
关键词 改良宫颈冷刀锥切术 抗人乳头瘤病毒生物蛋白敷料 HSIL伴高危型HPV感染 免疫功能
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认知-Otago运动双重康复训练对老年非痴呆型血管性认知障碍患者认知与步行能力及跌倒风险的影响
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作者 李远 占美荣 《中国实用神经疾病杂志》 2026年第1期74-78,共5页
目的探讨认知-Otago运动双重康复训练对老年非痴呆型血管性认知障碍(VCIND)患者认知功能、步行能力及跌倒风险的影响。方法选取郑州大学第二附属医院2022-01—2023-12收治的128例老年VCIND患者,采用随机数字表法分为认知训练组和双重训... 目的探讨认知-Otago运动双重康复训练对老年非痴呆型血管性认知障碍(VCIND)患者认知功能、步行能力及跌倒风险的影响。方法选取郑州大学第二附属医院2022-01—2023-12收治的128例老年VCIND患者,采用随机数字表法分为认知训练组和双重训练组,各64例。认知训练组在对症支持治疗基础上进行认知功能康复训练,双重训练组进行认知-Otago运动双重康复训练。干预3个月后,比较2组患者认知功能[蒙特利尔认知功能评估量表(MoCA)评分、简易智力状态检测量表(MMSE)评分]、步行能力[Holden功能性步行分级(FAC)、步频和步速]、平衡能力[Berg平衡量表(BBS)评分]、跌倒风险[修订版跌倒功效量表(MFES)评分]、日常生活能力[Barthel指数(BI)]。结果干预后,双重训练组MoCA评分、MMSE评分均高于认知训练组,FAC分级优于认知训练组,步频、步速均大于认知训练组(P<0.05)。干预后,双重训练组BBS评分、MFES评分、BI评分均高于认知训练组(P<0.05)。结论认知-Otago运动双重康复训练可有效改善VCIND患者的认知功能,提升平衡能力和步行能力,强化日常生活能力,降低跌倒发生风险,有助于控制VCIND病情进展。 展开更多
关键词 非痴呆型血管性认知障碍 认知功能训练 Otago运动 认知功能 步行能力 跌倒风险
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基于纵向数据联合模型的中国中老年人午睡时长与认知功能减退的关联研究
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作者 白汪洋 叶小飞 +3 位作者 王宗玉 潘喆敏 郭晓晶 贺佳 《海军军医大学学报》 北大核心 2026年第2期231-237,共7页
目的利用纵向数据联合模型探索中国中老年人午睡时长和认知功能减退之间的关联。方法基于递归特征消除的方法对中国健康与养老追踪调查(CHARLS)数据进行自变量筛选。采用多因素Cox比例风险回归模型分析基线午睡时长对认知功能结局的影响... 目的利用纵向数据联合模型探索中国中老年人午睡时长和认知功能减退之间的关联。方法基于递归特征消除的方法对中国健康与养老追踪调查(CHARLS)数据进行自变量筛选。采用多因素Cox比例风险回归模型分析基线午睡时长对认知功能结局的影响;同时构建纵向数据和时间-事件数据联合模型,以分析午睡时长与认知功能减退的关联。结果纳入10314名受访者,共计40579次随访记录,中位随访时间为10(8,10)年,共有2975人(28.8%)发生了认知功能减退。基于递归特征消除方法筛选出的4个关键自变量分别是衰弱指数、年龄、受教育程度和社会参与程度。多因素Cox比例风险回归模型分析结果显示,基线午睡时长对认知功能减退的影响不显著(P=0.453)。联合模型分析结果显示,午睡时长的纵向变化与认知功能减退存在关联(HR=1.112,95%CI1.099~1.126)。结论基于联合模型发现午睡时长与认知功能减退存在关联,较长的午睡时间与认知功能减退风险增加相关,长时间午睡是认知功能减退的危险因素。纵向数据联合模型可为健康问题相关危险因素的关联性分析探索提供方法学支持。 展开更多
关键词 午睡 认知功能 危险因素 纵向数据 中老年人
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肝硬化合并门静脉血栓形成患者的抗凝治疗研究进展
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作者 龚伟 李芸 《中国药房》 北大核心 2026年第4期533-539,共7页
门静脉血栓(PVT)作为肝硬化常见且严重的并发症,其抗凝治疗因患者凝血功能异常与出血风险并存而颇具挑战。本文综合近年来肝硬化合并PVT抗凝治疗的研究成果及国内外指南与共识,围绕肝硬化合并PVT的高发原因、临床表现与诊断、抗凝治疗决... 门静脉血栓(PVT)作为肝硬化常见且严重的并发症,其抗凝治疗因患者凝血功能异常与出血风险并存而颇具挑战。本文综合近年来肝硬化合并PVT抗凝治疗的研究成果及国内外指南与共识,围绕肝硬化合并PVT的高发原因、临床表现与诊断、抗凝治疗决策(包括指征确定、时机选择、疗程选择)、药物合理使用4个方面展开综述。结果表明,肝硬化患者中PVT高发是多因素共同作用的结果。目前普遍认为,门静脉血流瘀滞、机体高凝状态以及血管内皮损伤是PVT形成的三大危险因素。肝硬化合并PVT的临床表现丰富,其诊断需结合临床背景、影像学检查以及实验室检查进行综合判断,其中影像学检查是核心诊断依据。抗凝治疗能够显著提高PVT的血栓再通率,降低血栓进展风险,且不会增加门静脉高压相关的出血风险。在治疗时机上,确诊后6个月内,尤其是2周内启动抗凝治疗可显著提高血栓再通率。对于肝硬化合并PVT的抗凝治疗,临床上常用的药物主要包括肝素类药物、维生素K拮抗剂(VKA)及直接口服抗凝剂(DOACs)。其中,低分子肝素作为一线药物的证据十分充分;DOACs在代偿期肝硬化合并PVT患者中显示出良好的疗效与安全性,不过其在失代偿期肝硬化合并PVT患者中的应用仍需格外谨慎。建议疗程通常不少于6个月。对于存在肠系膜静脉受累、等待肝移植或遗传性血栓形成倾向的肝硬化合并PVT患者,应考虑进行长期抗凝治疗。 展开更多
关键词 肝硬化 门静脉血栓 抗凝治疗 凝血功能异常 出血风险
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东南沿海热带气旋风雨时空演变及危险性分析
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作者 翁铭锴 胡金红 肖桂荣 《福州大学学报(自然科学版)》 北大核心 2026年第1期83-90,共8页
针对热带气旋风雨复合致灾研究不足,结合去趋势预白化检验及经验正交函数,分析1979—2018年间东南沿海热带气旋过程最大风速和过程累积降水风雨致灾因子的时空演变过程;解决致灾因子非同步性的伪相关干扰,开展风雨复合的多因子联合分析... 针对热带气旋风雨复合致灾研究不足,结合去趋势预白化检验及经验正交函数,分析1979—2018年间东南沿海热带气旋过程最大风速和过程累积降水风雨致灾因子的时空演变过程;解决致灾因子非同步性的伪相关干扰,开展风雨复合的多因子联合分析,评估东南沿海热带气旋风雨联合危险性.研究表明:过去40 a东南沿海热带气旋过程中最大风速和累积降水整体偏强,通过经验累积分布函数(EOF)计算第一主成分进一步揭示了南部“风增雨减”、北部“雨增风缓”的南北反相位特征.风雨联合概率计算结果显示,危险性排序为“风或雨>风灾>雨灾>风雨同时”,风灾具有更强广域代表性,暴雨则主要增加少数极端风雨并发事件的联合风险. 展开更多
关键词 热带气旋 时空演变 COPULA函数 联合危险概率
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Study on risk measurement about ammunition-rocket system
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作者 GuXiaohui ZhaoYoushou 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2005年第1期228-232,共5页
Modern ammunition-rocket system is a complicated multidisciplinary system. During its development, undetermined factors will bring many risks. This paper elaborates the importance of risk analysis approach to ammuniti... Modern ammunition-rocket system is a complicated multidisciplinary system. During its development, undetermined factors will bring many risks. This paper elaborates the importance of risk analysis approach to ammunition-rocket system development and analyses various methods of risk analysis and estimation. Combined with practical situation of weapon system development, the risk measurement function with characteristics of risk preference is given provided that the risk preference characteristic of behavior maker is risk neutral of fixed constant. The development risk analysis based on risk measurement function enables effective risk decision to be made on the basis of quantified risk. Taking anti-helicopter intelligent mine warhead as an example, the paper verifies the efficiency of the method and shows that it has a scientific and practical value. 展开更多
关键词 risk analysis risk function ammunition-rocket system.
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