Absorption spectra of jet-cooled PH2 radicals were recorded in the wavelength range of 465- 555 nm using cavity ringdown spectroscopy. The PH2 radicals were produced in a supersonic jet by pulsed direct current discha...Absorption spectra of jet-cooled PH2 radicals were recorded in the wavelength range of 465- 555 nm using cavity ringdown spectroscopy. The PH2 radicals were produced in a supersonic jet by pulsed direct current discharge of a mixture of PHa and SF6 in argon. Seven vibronic bands with fine rotational structures have been observed and assigned as 0 0^, 2 0^n, and 2 1^n （n=1- 3） bands of the A^2A1- X~ 2B1 electronic transition. Rotational assignments and rotational term values for each band were re-identified, and the molecular parameters including rotational constants, centrifugal distortion constants, and spin-rotation interaction constants were also improved with reasonably high precision. In addition, large perturbations observed in each quantum number of total angular momentum of the a axis level of the excited vibronic states were briefly discussed.展开更多
Background:Lung cancer is one of the most common malignant tumors worldwide.Currently,effective screening methods for early lung cancer are still scarce.Breath analysis provides a promising method for the pre-screenin...Background:Lung cancer is one of the most common malignant tumors worldwide.Currently,effective screening methods for early lung cancer are still scarce.Breath analysis provides a promising method for the pre-screening or early screening of lung cancer.Isoprene is a potential and important breath biomarker of lung cancer.Material and Methods:To investigate the clinical value of isoprene for diagnosing lung cancer patients,a cavity ringdown spectroscopy(CRDS)based near-real time,sensitive analysis method of breath isoprene is developed in our lab.In this paper,92 breath samples from lung cancer patients,17 breath samples from patients with benign lesions,and 107 breath samples from healthy people were collected.Results:Research indicates that breath isoprene concentration is significantly higher in healthy individuals(221:3±122:2 ppbv)than in patients with lung cancer(112:0±36:6 ppbv)and benign lung lesions(127:9±41:2 ppbv).The result of Receiver Operating Characteristic(ROC)curve suggests that the concentration of isoprene is meaningful for the diagnosis of lung cancer(AUC=0:822,sensitivity=63:6%,specificity=90:2%,P<0:01).Conclusion:This study demonstrates that the CRDS breath isoprene analysis system can effectively analyze a large sample of human breath isoprene,and preliminarily confirms the use of breath isoprene as a biomarker for lung diseases.展开更多
We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimen...We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimental results. It has great potential for sensor applications.展开更多
Cavity ringdown spectroscopy(CRDS),relying on measuring the decay time of photons inside a high-finesse optical cavity,offers an important analytical tool for chemistry,physics,environmental science,and biology.Throug...Cavity ringdown spectroscopy(CRDS),relying on measuring the decay time of photons inside a high-finesse optical cavity,offers an important analytical tool for chemistry,physics,environmental science,and biology.Through the reflection of a slight amount of phase-coherent light back to the laser source,the resonant optical feedback approach effectively couples the laser beam into the optical cavity and achieves a high signal-to-noise ratio.However,the need for active phaselocking mechanisms complicates the spectroscopic system,limiting its primarily laboratory-based use.Here,we report how passive optical feedback can be implemented in a quantum cascade laser(QCL) based CRDS system to address this issue.Without using any phase-locking loops,we reflect a moderate amount of light(–18.2 dB) to a continuous-wave QCL simply using a fixed flat mirror,narrowing the QCL linewidth from 1.2 MHz to 170 kHz and significantly increasing the laser-cavity coupling efficiency.To validate the method's feasibility and effectiveness,we measured the absorption line(P(18e),2207.62 cm^(−1)) of N_(2)O in a Fabry–Perot cavity with a high finesse of ~52000 and an inter-mirror distance of 33 cm.This agile approach paves the way for revolutionizing existing analytical tools by offering compact and high-fidelity mid-infrared CRDS systems.展开更多
For the exploration of gas hydrate resources by measuring the dissolved methane concentration in seawater, a continuous-wave cavity ringdown spectroscopy (CW-CRDS) experimental setup was constructed for trace methane ...For the exploration of gas hydrate resources by measuring the dissolved methane concentration in seawater, a continuous-wave cavity ringdown spectroscopy (CW-CRDS) experimental setup was constructed for trace methane detection. A current-modulation method, rather than a cavity-modulation method using an optical switch and a piezoelectric transducer, was employed to realize the cavity excitation and shutoff. Such a current-modulation method enabled the improvement of the experimental setup construction and stability, and the system size and stability are critical for a sensor to be deployed underwater. Ringdown data acquisition and processing were performed, followed by an evaluation of the experimental setup stability and sensitivity. The obtained results demonstrate that great errors are introduced when a large fitting window is selected if the analog-to-digital converter has an insufficient resolution. The ringdown spectrum of methane corresponding to the 2 nu(3) band R(4) branch was captured, and the methane concentration in lab air was determined to be 2.06 ppm. Further experiments for evaluating the quantitative ability of this CW-CRDS experimental setup are underway from which a high-sensitivity methane sensor that can be combined with a degassing system is expected.展开更多
Fiber loop ringdown (FLRD) has demonstrated to be capable of sensing various quantities, such as chemical species, pressure, refractive index, strain, temperature, etc.;and it has high potential for the development of...Fiber loop ringdown (FLRD) has demonstrated to be capable of sensing various quantities, such as chemical species, pressure, refractive index, strain, temperature, etc.;and it has high potential for the development of a sensor network. In the present work, we describe design and development of three different types of FLRD sensors for water, cracks, and temperature sensing in concrete structures. All of the three aforementioned sensors were indigenously developed very recently in our laboratory and their capabilities of detecting the respective quantities were demonstrated. Later, all of the sensors were installed in a test grout cube for real-time monitoring. This work presents the results obtained in the laboratory-based experiments as well as the results from the real-time monitoring process in the test cube.展开更多
针对传统腔衰荡光谱技术浓度获取率低,提出基于双重锁定的连续波腔衰荡吸收光谱技术.通过波长调制一次谐波信号将激光器的频率锁定到C_2H_2吸收线上,同时使用PDH锁频技术将衰荡腔锁定到激光器上,从而避免了测量过程中激光器的频率漂移...针对传统腔衰荡光谱技术浓度获取率低,提出基于双重锁定的连续波腔衰荡吸收光谱技术.通过波长调制一次谐波信号将激光器的频率锁定到C_2H_2吸收线上,同时使用PDH锁频技术将衰荡腔锁定到激光器上,从而避免了测量过程中激光器的频率漂移和腔长的抖动,使测量结果更加精确;并且,由于双重锁定,单次衰荡事件的发生率,也就是浓度信息的获取率只受衰荡时间以及重新锁定时间限制,在本试验系统中采集速率可以达到30 k Hz,可以实现对气体浓度的快速测量.为了提高信噪比,采用Kalman滤波技术,对浓度信息进行实时处理,有效抑制了噪声,根据阿伦方差分析,探测灵敏度可以达到4×10^(-9)cm^(-1)(2 s平均).展开更多
基金This work was supported by the National Natural Science Foundation of China （No.20673107）, the National Key Basic Research Special Foundation of China （No.2007CB815203）, and the Chinese Academy of Sciences （No.KJCX2-SW-H08）.
文摘Absorption spectra of jet-cooled PH2 radicals were recorded in the wavelength range of 465- 555 nm using cavity ringdown spectroscopy. The PH2 radicals were produced in a supersonic jet by pulsed direct current discharge of a mixture of PHa and SF6 in argon. Seven vibronic bands with fine rotational structures have been observed and assigned as 0 0^, 2 0^n, and 2 1^n （n=1- 3） bands of the A^2A1- X~ 2B1 electronic transition. Rotational assignments and rotational term values for each band were re-identified, and the molecular parameters including rotational constants, centrifugal distortion constants, and spin-rotation interaction constants were also improved with reasonably high precision. In addition, large perturbations observed in each quantum number of total angular momentum of the a axis level of the excited vibronic states were briefly discussed.
基金support provided by The Chinese Academy of Medical Sciences Initiative for Innovative Medicine(2018-I2M-AI-012).
文摘Background:Lung cancer is one of the most common malignant tumors worldwide.Currently,effective screening methods for early lung cancer are still scarce.Breath analysis provides a promising method for the pre-screening or early screening of lung cancer.Isoprene is a potential and important breath biomarker of lung cancer.Material and Methods:To investigate the clinical value of isoprene for diagnosing lung cancer patients,a cavity ringdown spectroscopy(CRDS)based near-real time,sensitive analysis method of breath isoprene is developed in our lab.In this paper,92 breath samples from lung cancer patients,17 breath samples from patients with benign lesions,and 107 breath samples from healthy people were collected.Results:Research indicates that breath isoprene concentration is significantly higher in healthy individuals(221:3±122:2 ppbv)than in patients with lung cancer(112:0±36:6 ppbv)and benign lung lesions(127:9±41:2 ppbv).The result of Receiver Operating Characteristic(ROC)curve suggests that the concentration of isoprene is meaningful for the diagnosis of lung cancer(AUC=0:822,sensitivity=63:6%,specificity=90:2%,P<0:01).Conclusion:This study demonstrates that the CRDS breath isoprene analysis system can effectively analyze a large sample of human breath isoprene,and preliminarily confirms the use of breath isoprene as a biomarker for lung diseases.
文摘We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimental results. It has great potential for sensor applications.
基金National Natural Science Foundation of China(NSFC)(52122003,62305279),ChinaInnovation and Technology Fund(GHP/129/20SZ)from the Innovation and Technology Commission,Hong Kong SAR,China+1 种基金Collaborative Research Fund(C4002-22Y)General Research Fund(14208221)from the University Grants Committee,Hong Kong SAR,China.
文摘Cavity ringdown spectroscopy(CRDS),relying on measuring the decay time of photons inside a high-finesse optical cavity,offers an important analytical tool for chemistry,physics,environmental science,and biology.Through the reflection of a slight amount of phase-coherent light back to the laser source,the resonant optical feedback approach effectively couples the laser beam into the optical cavity and achieves a high signal-to-noise ratio.However,the need for active phaselocking mechanisms complicates the spectroscopic system,limiting its primarily laboratory-based use.Here,we report how passive optical feedback can be implemented in a quantum cascade laser(QCL) based CRDS system to address this issue.Without using any phase-locking loops,we reflect a moderate amount of light(–18.2 dB) to a continuous-wave QCL simply using a fixed flat mirror,narrowing the QCL linewidth from 1.2 MHz to 170 kHz and significantly increasing the laser-cavity coupling efficiency.To validate the method's feasibility and effectiveness,we measured the absorption line(P(18e),2207.62 cm^(−1)) of N_(2)O in a Fabry–Perot cavity with a high finesse of ~52000 and an inter-mirror distance of 33 cm.This agile approach paves the way for revolutionizing existing analytical tools by offering compact and high-fidelity mid-infrared CRDS systems.
文摘For the exploration of gas hydrate resources by measuring the dissolved methane concentration in seawater, a continuous-wave cavity ringdown spectroscopy (CW-CRDS) experimental setup was constructed for trace methane detection. A current-modulation method, rather than a cavity-modulation method using an optical switch and a piezoelectric transducer, was employed to realize the cavity excitation and shutoff. Such a current-modulation method enabled the improvement of the experimental setup construction and stability, and the system size and stability are critical for a sensor to be deployed underwater. Ringdown data acquisition and processing were performed, followed by an evaluation of the experimental setup stability and sensitivity. The obtained results demonstrate that great errors are introduced when a large fitting window is selected if the analog-to-digital converter has an insufficient resolution. The ringdown spectrum of methane corresponding to the 2 nu(3) band R(4) branch was captured, and the methane concentration in lab air was determined to be 2.06 ppm. Further experiments for evaluating the quantitative ability of this CW-CRDS experimental setup are underway from which a high-sensitivity methane sensor that can be combined with a degassing system is expected.
文摘Fiber loop ringdown (FLRD) has demonstrated to be capable of sensing various quantities, such as chemical species, pressure, refractive index, strain, temperature, etc.;and it has high potential for the development of a sensor network. In the present work, we describe design and development of three different types of FLRD sensors for water, cracks, and temperature sensing in concrete structures. All of the three aforementioned sensors were indigenously developed very recently in our laboratory and their capabilities of detecting the respective quantities were demonstrated. Later, all of the sensors were installed in a test grout cube for real-time monitoring. This work presents the results obtained in the laboratory-based experiments as well as the results from the real-time monitoring process in the test cube.
文摘针对传统腔衰荡光谱技术浓度获取率低,提出基于双重锁定的连续波腔衰荡吸收光谱技术.通过波长调制一次谐波信号将激光器的频率锁定到C_2H_2吸收线上,同时使用PDH锁频技术将衰荡腔锁定到激光器上,从而避免了测量过程中激光器的频率漂移和腔长的抖动,使测量结果更加精确;并且,由于双重锁定,单次衰荡事件的发生率,也就是浓度信息的获取率只受衰荡时间以及重新锁定时间限制,在本试验系统中采集速率可以达到30 k Hz,可以实现对气体浓度的快速测量.为了提高信噪比,采用Kalman滤波技术,对浓度信息进行实时处理,有效抑制了噪声,根据阿伦方差分析,探测灵敏度可以达到4×10^(-9)cm^(-1)(2 s平均).
