Comprehensive Summary.Herein,we present the first examples of asymmetric reductive 1,4-dicarbofunctionalization of 1,3-dienes and 1,5-dicarbofunctionalization of vinylcyclopropanes,which proceed under the catalysis of...Comprehensive Summary.Herein,we present the first examples of asymmetric reductive 1,4-dicarbofunctionalization of 1,3-dienes and 1,5-dicarbofunctionalization of vinylcyclopropanes,which proceed under the catalysis of a chiral nickel/bis-imidazoline complex using alkyl halides and aryl iodides or alkenyl bromides as the electrophilic coupling partners.In these highly enantioselective transformations operating in a radical relay mechanism,the C(sp3)-and C(sp2)-type carbo-moieties are respectively installed on the terminal and internal position with a newly formed olefinic unit in high E-selectivity.展开更多
A convenient synthesis of intermediate 4,5-diamino-3-aryl-l-phenylpyrazoles 4a--4c was reported. The different cyclization reactions were carried out with chalcone, 2-mercaptoacetic acid and p-anisialdehyde, ethyl chl...A convenient synthesis of intermediate 4,5-diamino-3-aryl-l-phenylpyrazoles 4a--4c was reported. The different cyclization reactions were carried out with chalcone, 2-mercaptoacetic acid and p-anisialdehyde, ethyl chloroformate, glyoxal and thiourea to afford different N and S containing heterocycles. The reaction conditions were compared by conventional heating and microwave irradiation. The structures of the cyclization products were de- termined by analytical and spectroscopic data. All the synthesized compounds were screened for antibacterial activities in vitro.展开更多
基金supported by the National Natural Science Foundation of China(22271267,21772183,22471256).
文摘Comprehensive Summary.Herein,we present the first examples of asymmetric reductive 1,4-dicarbofunctionalization of 1,3-dienes and 1,5-dicarbofunctionalization of vinylcyclopropanes,which proceed under the catalysis of a chiral nickel/bis-imidazoline complex using alkyl halides and aryl iodides or alkenyl bromides as the electrophilic coupling partners.In these highly enantioselective transformations operating in a radical relay mechanism,the C(sp3)-and C(sp2)-type carbo-moieties are respectively installed on the terminal and internal position with a newly formed olefinic unit in high E-selectivity.
文摘A convenient synthesis of intermediate 4,5-diamino-3-aryl-l-phenylpyrazoles 4a--4c was reported. The different cyclization reactions were carried out with chalcone, 2-mercaptoacetic acid and p-anisialdehyde, ethyl chloroformate, glyoxal and thiourea to afford different N and S containing heterocycles. The reaction conditions were compared by conventional heating and microwave irradiation. The structures of the cyclization products were de- termined by analytical and spectroscopic data. All the synthesized compounds were screened for antibacterial activities in vitro.
