Objective:To assess the pharmaceutical quality of different brands of metronidazole manufactured,available and prescribed by the doctors of Peshawar,Pakistan.Methods:Different film-coated metronidazole products manufa...Objective:To assess the pharmaceutical quality of different brands of metronidazole manufactured,available and prescribed by the doctors of Peshawar,Pakistan.Methods:Different film-coated metronidazole products manufactured by multinational and national pharmaceutical industries and prescribed by the doctors were collected from Peshawar,Khyber Pakhtunkhwa,Pakistan.Their hysico-chemical properties were assessed,which included friability,hardness,disintegration,dissolution and weight variation tests according to the the United States Pharmacopoeia(USP)standards.Results:All the brands showed a average weight of 5.74 g for 13 tablets(products A-M).Product J had the highest weight and products D and E failed the hardness,friability and disintegration time according to USP standards.Products M,K and G,L failed disintegration test and dissolution test,respectively.Weight variation of all the products proved statistically that they were in accordance with the standards of USP.Conclusions:The study suggested that products A,F,H and J passed all the tests according to the USP standards while the rest of them did not fulfill the standards specification.展开更多
文摘Objective:To assess the pharmaceutical quality of different brands of metronidazole manufactured,available and prescribed by the doctors of Peshawar,Pakistan.Methods:Different film-coated metronidazole products manufactured by multinational and national pharmaceutical industries and prescribed by the doctors were collected from Peshawar,Khyber Pakhtunkhwa,Pakistan.Their hysico-chemical properties were assessed,which included friability,hardness,disintegration,dissolution and weight variation tests according to the the United States Pharmacopoeia(USP)standards.Results:All the brands showed a average weight of 5.74 g for 13 tablets(products A-M).Product J had the highest weight and products D and E failed the hardness,friability and disintegration time according to USP standards.Products M,K and G,L failed disintegration test and dissolution test,respectively.Weight variation of all the products proved statistically that they were in accordance with the standards of USP.Conclusions:The study suggested that products A,F,H and J passed all the tests according to the USP standards while the rest of them did not fulfill the standards specification.
