BACKGROUND Anhedonia,a hallmark symptom of major depressive disorder(MDD),is often resistant to common antidepressants.Preliminary evidence indicates that Pedio-coccus acidilactici(P.acidilactici)CCFM6432 may offer po...BACKGROUND Anhedonia,a hallmark symptom of major depressive disorder(MDD),is often resistant to common antidepressants.Preliminary evidence indicates that Pedio-coccus acidilactici(P.acidilactici)CCFM6432 may offer potential benefits in ame-liorating this symptomatology in patients with MDD.AIM To further assess the efficacy of P.acidilactici CCFM6432 in alleviating anhedonia in patients with MDD,using a combination of objective and subjective assessment tools.METHODS Adult patients with MDD exhibiting anhedonic symptoms were enrolled and randomly assigned to two treatment groups:One receiving standard antide-pressant therapy plus P.acidilactici CCFM6432,and the other receiving standard antidepressant treatment along with a placebo,for 30 days.Assessments were conducted at baseline and post-intervention using the Hamilton Depression Rating Scale(HAMD),Temporal Experience of Pleasure Scale(TEPS),and synchronous electroencephalography(EEG)during a"Doors Guessing Task."Changes in both clinical outcomes and EEG biomarkers,specifically the stimulus-preceding negativity(SPN)and feedback-related nega-tivity amplitudes,were analyzed.RESULTS Of the 92 screened participants,71 were enrolled and 55 completed the study(CCFM6432 group:n=27;Placebo group:n=28).No baseline differences were noted between the groups in terms of demographics,clinical assessments,or EEG metrics.A mixed-design analysis of variance revealed that the CCFM6432 group showed significantly greater improvements in both HAMD and TEPS scores compared to the Placebo group.Moreover,the CCFM6432 group demonstrated a significant increase in SPN amplitudes,which were inversely correlated with the improvements observed in HAMD scores.No such changes were observed in the Placebo group.CONCLUSION Adjunctive administration of P.acidilactici CCFM6432 not only augments the therapeutic efficacy of antide-pressants but also significantly ameliorates the symptoms of anhedonia in MDD.展开更多
In this paper,we provide a new theoretical framework of pyramid Markov processes to solve some open and fundamental problems of blockchain selfish mining under a rigorous mathematical setting.We first describe a more ...In this paper,we provide a new theoretical framework of pyramid Markov processes to solve some open and fundamental problems of blockchain selfish mining under a rigorous mathematical setting.We first describe a more general model of blockchain selfish mining with both a two-block leading competitive criterion and a new economic incentive mechanism.Then we establish a pyramid Markov process and show that it is irreducible and positive recurrent,and its stationary probability vector is matrix-geometric with an explicitly representable rate matrix.Also,we use the stationary probability vector to study the influence of orphan blocks on the waste of computing resource.Next,we set up a pyramid Markov reward process to investigate the long-run average mining profits of the honest and dishonest mining pools,respectively.As a by-product,we build one-dimensional Markov reward processes and provide some new interesting interpretation on the Markov chain and the revenue analysis reported in the seminal work by Eyal and Sirer(2014).Note that the pyramid Markov(reward)processes can open up a new avenue in the study of blockchain selfish mining.Thus we hope that the methodology and results developed in this paper shed light on the blockchain selfish mining such that a series of promising research can be developed potentially.展开更多
This paper studies the strong n(n =—1,0)-discount and finite horizon criteria for continuoustime Markov decision processes in Polish spaces.The corresponding transition rates are allowed to be unbounded,and the rewar...This paper studies the strong n(n =—1,0)-discount and finite horizon criteria for continuoustime Markov decision processes in Polish spaces.The corresponding transition rates are allowed to be unbounded,and the reward rates may have neither upper nor lower bounds.Under mild conditions,the authors prove the existence of strong n(n =—1,0)-discount optimal stationary policies by developing two equivalence relations:One is between the standard expected average reward and strong—1-discount optimality,and the other is between the bias and strong 0-discount optimality.The authors also prove the existence of an optimal policy for a finite horizon control problem by developing an interesting characterization of a canonical triplet.展开更多
基金Supported by the Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee,No.BJ2023086Wuxi Taihu Talent Project,No.WXTTP 2021.
文摘BACKGROUND Anhedonia,a hallmark symptom of major depressive disorder(MDD),is often resistant to common antidepressants.Preliminary evidence indicates that Pedio-coccus acidilactici(P.acidilactici)CCFM6432 may offer potential benefits in ame-liorating this symptomatology in patients with MDD.AIM To further assess the efficacy of P.acidilactici CCFM6432 in alleviating anhedonia in patients with MDD,using a combination of objective and subjective assessment tools.METHODS Adult patients with MDD exhibiting anhedonic symptoms were enrolled and randomly assigned to two treatment groups:One receiving standard antide-pressant therapy plus P.acidilactici CCFM6432,and the other receiving standard antidepressant treatment along with a placebo,for 30 days.Assessments were conducted at baseline and post-intervention using the Hamilton Depression Rating Scale(HAMD),Temporal Experience of Pleasure Scale(TEPS),and synchronous electroencephalography(EEG)during a"Doors Guessing Task."Changes in both clinical outcomes and EEG biomarkers,specifically the stimulus-preceding negativity(SPN)and feedback-related nega-tivity amplitudes,were analyzed.RESULTS Of the 92 screened participants,71 were enrolled and 55 completed the study(CCFM6432 group:n=27;Placebo group:n=28).No baseline differences were noted between the groups in terms of demographics,clinical assessments,or EEG metrics.A mixed-design analysis of variance revealed that the CCFM6432 group showed significantly greater improvements in both HAMD and TEPS scores compared to the Placebo group.Moreover,the CCFM6432 group demonstrated a significant increase in SPN amplitudes,which were inversely correlated with the improvements observed in HAMD scores.No such changes were observed in the Placebo group.CONCLUSION Adjunctive administration of P.acidilactici CCFM6432 not only augments the therapeutic efficacy of antide-pressants but also significantly ameliorates the symptoms of anhedonia in MDD.
基金This work is supported by the National Key R&D Program of China under Grant No.2020AAA0103801Quanlin Li is supported by the National Natural Science Foundation of China under Grant Nos.71671158 and 71932002+1 种基金the Beijing Social Science Foundation Research Base Project under Grant No.19JDGLA004Xiaole Wu is supported by the National Natural Science Foundation of China under Grant No.72025102.
文摘In this paper,we provide a new theoretical framework of pyramid Markov processes to solve some open and fundamental problems of blockchain selfish mining under a rigorous mathematical setting.We first describe a more general model of blockchain selfish mining with both a two-block leading competitive criterion and a new economic incentive mechanism.Then we establish a pyramid Markov process and show that it is irreducible and positive recurrent,and its stationary probability vector is matrix-geometric with an explicitly representable rate matrix.Also,we use the stationary probability vector to study the influence of orphan blocks on the waste of computing resource.Next,we set up a pyramid Markov reward process to investigate the long-run average mining profits of the honest and dishonest mining pools,respectively.As a by-product,we build one-dimensional Markov reward processes and provide some new interesting interpretation on the Markov chain and the revenue analysis reported in the seminal work by Eyal and Sirer(2014).Note that the pyramid Markov(reward)processes can open up a new avenue in the study of blockchain selfish mining.Thus we hope that the methodology and results developed in this paper shed light on the blockchain selfish mining such that a series of promising research can be developed potentially.
基金supported by the National Natural Science Foundation of China under Grant Nos.61374080 and 61374067the Natural Science Foundation of Zhejiang Province under Grant No.LY12F03010+1 种基金the Natural Science Foundation of Ningbo under Grant No.2012A610032Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘This paper studies the strong n(n =—1,0)-discount and finite horizon criteria for continuoustime Markov decision processes in Polish spaces.The corresponding transition rates are allowed to be unbounded,and the reward rates may have neither upper nor lower bounds.Under mild conditions,the authors prove the existence of strong n(n =—1,0)-discount optimal stationary policies by developing two equivalence relations:One is between the standard expected average reward and strong—1-discount optimality,and the other is between the bias and strong 0-discount optimality.The authors also prove the existence of an optimal policy for a finite horizon control problem by developing an interesting characterization of a canonical triplet.
