The aim of this study was to develop a novel pharmaceutical excipient:an anion exchange resin.Initially,polystyrenedivinylbenzene(PS-DVB)microspheres were synthesized via suspension polymerization.Subsequently,these m...The aim of this study was to develop a novel pharmaceutical excipient:an anion exchange resin.Initially,polystyrenedivinylbenzene(PS-DVB)microspheres were synthesized via suspension polymerization.Subsequently,these microspheres served as a substrate for chloromethylation using methanol,formaldehyde,and chlorosulfonic acid.By optimizing the reaction conditions,the chloromethylated microspheres were characterized using infrared spectroscopy,scanning electron microscopy,and the Mohr method.Under optimal reaction conditions,the resulting products exhibited uniformity and spherical morphology,with an average particle size of approximately 190μm.The PS-DVB microspheres effectively incorporated chloromethyl groups,as evidenced by a chlorine content of 14.67%.Scanning electron microscopy analysis indicated that the appearance of the microspheres remained largely unchanged post-reaction.Overall,the research findings demonstrated the successful preparation of the anion exchange resin.Characterization and quality assessment confirmed that the ion exchange resin met the required standards.展开更多
基金2023 Nantong Jianghai Talents Project,the Nantong Social Livelihood Science and Technology Plan for 2023the 2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research Institute.Additionally,support was provided by the Zhenjiang Science and Technology Project(Grant No.SH2020048)+2 种基金the China Postdoctoral Science Foundation(Grant No.2020M681532)the Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.2020Z209)the Natural Science Research Projects of Universities in Jiangsu Province(Grant No.20KJD350001).
文摘The aim of this study was to develop a novel pharmaceutical excipient:an anion exchange resin.Initially,polystyrenedivinylbenzene(PS-DVB)microspheres were synthesized via suspension polymerization.Subsequently,these microspheres served as a substrate for chloromethylation using methanol,formaldehyde,and chlorosulfonic acid.By optimizing the reaction conditions,the chloromethylated microspheres were characterized using infrared spectroscopy,scanning electron microscopy,and the Mohr method.Under optimal reaction conditions,the resulting products exhibited uniformity and spherical morphology,with an average particle size of approximately 190μm.The PS-DVB microspheres effectively incorporated chloromethyl groups,as evidenced by a chlorine content of 14.67%.Scanning electron microscopy analysis indicated that the appearance of the microspheres remained largely unchanged post-reaction.Overall,the research findings demonstrated the successful preparation of the anion exchange resin.Characterization and quality assessment confirmed that the ion exchange resin met the required standards.
