Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical ...Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy.Hierarchical nanostructure construction involves coupling liganded nanoscale isotropic/anisotropic Au(comparable to few integrin molecules-scale)to the surface of microscale isotropic/anisotropic magnetic Fe3O4(comparable to integrin cluster-scale)and then elastically tethering them to a substrate.Systematic independent tailoring of nanoscale or microscale ligand isotropy versus anisotropy in four different hierarchical nanostructures with constant liganded surface area demonstrates similar levels of integrin molecule bridging and macrophage adhesion on the nanoscale ligand isotropy versus anisotropy.Conversely,the levels of integrin cluster bridging across hierarchical nanostructures and macrophage adhesion are significantly promoted by microscale ligand anisotropy compared with microscale ligand isotropy.Furthermore,microscale ligand anisotropy dominantly activates the host macrophage adhesion and pro-regenerative M2 polarization in vivo over the nanoscale ligand anisotropy,which can be cyclically reversed by substrate-proximate versus substrate-distant magnetic manipulation.This unprecedented scale-specific regulation of cells can be diversified by unlimited tuning of the scale,anisotropy,dimension,shape,and magnetism of hierarchical structures to decipher scale-specific dynamic cell-material interactions to advance immunoengineering strategies.展开更多
Reversible upconversion(UC)luminescence modulation by external stimuli(i.e.electric field,magnetic field,and light irradiation)is extremely attractive for applications in a broad range of fields,such as photoswitches,...Reversible upconversion(UC)luminescence modulation by external stimuli(i.e.electric field,magnetic field,and light irradiation)is extremely attractive for applications in a broad range of fields,such as photoswitches,high-density optical data storage devices,and optical sensing.In this work,one kind of novel phosphor,Er^(3+)-doped Bi_(4)Ti3O12(Bi_(4-x)Er_(x)Ti_(3)O1_(2))ceramics,prepared by a conventional solid-state reaction approach,is reported which exhibits both bright UC luminescence and a remarkable photochromic(PC)effect.The UC luminescence,PC effect,and the coupling between UC and PC performances were investigated in detail.It is found that the UC luminescence could be readily modulated by alternating visible light irradiation and a thermal stimulus,and a large reversible luminescence regulation has been achieved based on the PC reaction.Meanwhile,the modulation of UC luminescence was shown to tightly depend on the irradiation time and thermal treatment processes.In addition,the coloration and decoloration processes also exhibited good fatigue resistance.The mechanisms related to the UC emissions,PC processes,and luminescence modulation are also discussed.These results indicated that Bi_(4-x)Er_(x)Ti_(3)O1_(2) samples could be potentially utilized as a kind of optical data storage material.展开更多
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2023-00208427)supported by the Korea Basic Science Institute(National research Facilities and Equipment Center)grant fun-ded by the Korea government(MSIT)(No.RS-2024-00402412)+1 种基金supported by the Nano&Material Technology Develop-ment Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(RS-2024-00407093)supported by a Korea University Grant.
文摘Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy.Hierarchical nanostructure construction involves coupling liganded nanoscale isotropic/anisotropic Au(comparable to few integrin molecules-scale)to the surface of microscale isotropic/anisotropic magnetic Fe3O4(comparable to integrin cluster-scale)and then elastically tethering them to a substrate.Systematic independent tailoring of nanoscale or microscale ligand isotropy versus anisotropy in four different hierarchical nanostructures with constant liganded surface area demonstrates similar levels of integrin molecule bridging and macrophage adhesion on the nanoscale ligand isotropy versus anisotropy.Conversely,the levels of integrin cluster bridging across hierarchical nanostructures and macrophage adhesion are significantly promoted by microscale ligand anisotropy compared with microscale ligand isotropy.Furthermore,microscale ligand anisotropy dominantly activates the host macrophage adhesion and pro-regenerative M2 polarization in vivo over the nanoscale ligand anisotropy,which can be cyclically reversed by substrate-proximate versus substrate-distant magnetic manipulation.This unprecedented scale-specific regulation of cells can be diversified by unlimited tuning of the scale,anisotropy,dimension,shape,and magnetism of hierarchical structures to decipher scale-specific dynamic cell-material interactions to advance immunoengineering strategies.
基金supported by the National Natural Science Foundation of China(No.51772326,51802343 and 11804384)the Scientific Research Project of Tianjin Education Committee(2018KJ254)+1 种基金the Undergraduate Training Programs for Innovation and Entrepreneurship of Tianjin(No.201910059053)the Fundamental Research Funds for the Central Universities(No.201917).
文摘Reversible upconversion(UC)luminescence modulation by external stimuli(i.e.electric field,magnetic field,and light irradiation)is extremely attractive for applications in a broad range of fields,such as photoswitches,high-density optical data storage devices,and optical sensing.In this work,one kind of novel phosphor,Er^(3+)-doped Bi_(4)Ti3O12(Bi_(4-x)Er_(x)Ti_(3)O1_(2))ceramics,prepared by a conventional solid-state reaction approach,is reported which exhibits both bright UC luminescence and a remarkable photochromic(PC)effect.The UC luminescence,PC effect,and the coupling between UC and PC performances were investigated in detail.It is found that the UC luminescence could be readily modulated by alternating visible light irradiation and a thermal stimulus,and a large reversible luminescence regulation has been achieved based on the PC reaction.Meanwhile,the modulation of UC luminescence was shown to tightly depend on the irradiation time and thermal treatment processes.In addition,the coloration and decoloration processes also exhibited good fatigue resistance.The mechanisms related to the UC emissions,PC processes,and luminescence modulation are also discussed.These results indicated that Bi_(4-x)Er_(x)Ti_(3)O1_(2) samples could be potentially utilized as a kind of optical data storage material.
