[ Objective ] The aim of the research was to reveal the mechanism of Yizhikang powder treatment on dairy cattle with retained placenta from the hemorheological perspective. [ Method] Dairy cattle with retained placent...[ Objective ] The aim of the research was to reveal the mechanism of Yizhikang powder treatment on dairy cattle with retained placenta from the hemorheological perspective. [ Method] Dairy cattle with retained placenta were treated with oral administration of Yizhikang powder. And their hemorheological indexes were measured and compared with the corresponding indicators of pre-administration group, healthy group, and control group （sick but untreated）.[ Result] There was large decrease amplitude in the indexes （whole blood viscosity, plasma viscosity, whole blood viscosity reduction viscosity, ESR, ESR equation K value, fibrinogen content, platelet aggregation rate, RBC deformability IF value） of treated dairy cattle with retained placenta. By t test, the indexes, except hematocrit, decreased significantly after treatment （P〈0.05） and reached the status of post partum healthy cows. The hemorheological indexes didn＇t change significantly in the control group before and after treatment. [ Conclusion] Yizhikang powder could significantly improve blood flow state and reduced the occurrence of qi stagnation and blood stasis in perinatal period.展开更多
Background： Failure to expel fetal membranes within 24 h of calving is a pathological condition defined as retained placenta（RP）. The objective of this investigation was to evaluate whether there are alterations in...Background： Failure to expel fetal membranes within 24 h of calving is a pathological condition defined as retained placenta（RP）. The objective of this investigation was to evaluate whether there are alterations in several selected serum variables related to innate immunity and carbohydrate and lipid metabolism that precede occurrence of RP in transition Holstein dairy cows.Methods： One hundred multiparous Holstein dairy cows were involved in the study. Blood samples were collected from the coccygeal vein during the-8 to ＋4 wks around parturition, once per week before the morning feeding.Six healthy control cows（CON） and 6 cows with RP were selected and serum samples at-8,-4, time of diagnosis of disease, and ＋4 wks relative to parturition were used for analyses. All samples were analyzed for lactate, nonesterified fatty acids（NEFA）, β-hydroxybutyrate（BHBA）, interleukin-1（IL-1）, interleukin-6（IL-6）, tumor necrosis factor（TNF）, haptoglobin（Hp）, and serum amyloid A（SAA）.Results： Cows with RP had greater concentrations of serum lactate, IL-1, IL-6, TNF, and SAA in comparison with CON cows. Intriguingly, elevated concentrations of all five variables were observed at-8 and-4 wks before the occurrence of RP compared to healthy cows. Cows with RP also had lower DMI and milk production vs CON animals; however milk composition was not affected by RP.Conclusions： Cows with RP showed an activated innate immunity 8 wks prior to diagnosis of disease. Overall results suggest that serum IL-1, IL- 6, and TNF, and lactate can be used as screening biomarkers to indicate cows that might have health issues during the transition period.展开更多
Retained placenta is a known cause of post-partum haemorrhage and maternal mortality. A recent systemic review has confirmed that the incidence of retained placenta had increased all over the world, which is more comm...Retained placenta is a known cause of post-partum haemorrhage and maternal mortality. A recent systemic review has confirmed that the incidence of retained placenta had increased all over the world, which is more common in developed countries. Failure of retroplacental myometrium contraction is the main cause of retained placenta. Maternal age greater than 35 years, grandmultipara, preterm labor, history of previous retained placenta, and caesarean section were the risk factors for retained placenta. Manual removal of the placenta has been the treatment of choice. Attempts had been made by clinician and researchers to find a safe, effective and reliable method to avoid the need for surgical intervention. The efficacy and safety of prostaglandin, nitroglycerin or acupuncture in the management of retained placenta are yet to be further evaluated. Nonetheless, till date only intraumbilical vein oxytocin has been studied extensively but with varied success. More randomized clinical trials are needed to address this issue. However, if immediate manual placenta removal service is unavailable, a trial of intra-umbilical vein oxytocin 100 IU at a totalvolume of at least 40 m L while preparing for transfer to a tertiary center or theatre may result in spontaneous expulsion of the placenta.展开更多
Background: Detachment of the placenta occurs in about 96% of patients within 30 minutes of completion of the second stage of labour, thus any further delay there after is usually considered as retained placenta. It i...Background: Detachment of the placenta occurs in about 96% of patients within 30 minutes of completion of the second stage of labour, thus any further delay there after is usually considered as retained placenta. It is associated with the risk of post-partum haemorrhage and anaemia. Objectives: To determine the incidence, risk factors, clinical presentation and complications of retained placenta at the study centre during the period under review. Methods: This was a retrospective case-control study in which records of women with retained placenta between January 2011 and December 2015 were retrieved and analysed for their age, parity, risk factors, clinical presentation and associated complications and compared with equal number of patients without retained placenta. Results: There were 11 cases of retained placenta recorded among the total number of 2068 deliveries during the study period, giving an incidence of 0.53% retained placenta in this study. Majority of cases (45.4%) were between age 30 and 39 years which was similar to the controls (54.5%). Most of the cases were unbooked (81%). Similarly, most women in both cases (82%) and controls (73%) were multiparae. All the 5 cases (45.5%) that had post-partum haemorrhage received blood transfusion. The overall incidence of post-partum anaemia was 54%. The average weights of the placentae were significantly smaller in the cases with placental retention (p = 0.010). Conclusion: Retained placenta is associated with significant risks of post-partum haemorrhage and blood transfusion. Non-booking for antenatal care is the commonest risk factor identified for retained placenta in this study.展开更多
基金Supported by Science and Technology Key Projects of Xinjiang Pro-duction and Construction Corps (2006GG22)~~
文摘[ Objective ] The aim of the research was to reveal the mechanism of Yizhikang powder treatment on dairy cattle with retained placenta from the hemorheological perspective. [ Method] Dairy cattle with retained placenta were treated with oral administration of Yizhikang powder. And their hemorheological indexes were measured and compared with the corresponding indicators of pre-administration group, healthy group, and control group （sick but untreated）.[ Result] There was large decrease amplitude in the indexes （whole blood viscosity, plasma viscosity, whole blood viscosity reduction viscosity, ESR, ESR equation K value, fibrinogen content, platelet aggregation rate, RBC deformability IF value） of treated dairy cattle with retained placenta. By t test, the indexes, except hematocrit, decreased significantly after treatment （P〈0.05） and reached the status of post partum healthy cows. The hemorheological indexes didn＇t change significantly in the control group before and after treatment. [ Conclusion] Yizhikang powder could significantly improve blood flow state and reduced the occurrence of qi stagnation and blood stasis in perinatal period.
基金Financial support for this project was provided by Genome Alberta(Calgary,Alberta,Canada)and National Science and Engineering Council of Canada(NSERC)to Dr.Ametaj as Principal Investigator
文摘Background： Failure to expel fetal membranes within 24 h of calving is a pathological condition defined as retained placenta（RP）. The objective of this investigation was to evaluate whether there are alterations in several selected serum variables related to innate immunity and carbohydrate and lipid metabolism that precede occurrence of RP in transition Holstein dairy cows.Methods： One hundred multiparous Holstein dairy cows were involved in the study. Blood samples were collected from the coccygeal vein during the-8 to ＋4 wks around parturition, once per week before the morning feeding.Six healthy control cows（CON） and 6 cows with RP were selected and serum samples at-8,-4, time of diagnosis of disease, and ＋4 wks relative to parturition were used for analyses. All samples were analyzed for lactate, nonesterified fatty acids（NEFA）, β-hydroxybutyrate（BHBA）, interleukin-1（IL-1）, interleukin-6（IL-6）, tumor necrosis factor（TNF）, haptoglobin（Hp）, and serum amyloid A（SAA）.Results： Cows with RP had greater concentrations of serum lactate, IL-1, IL-6, TNF, and SAA in comparison with CON cows. Intriguingly, elevated concentrations of all five variables were observed at-8 and-4 wks before the occurrence of RP compared to healthy cows. Cows with RP also had lower DMI and milk production vs CON animals; however milk composition was not affected by RP.Conclusions： Cows with RP showed an activated innate immunity 8 wks prior to diagnosis of disease. Overall results suggest that serum IL-1, IL- 6, and TNF, and lactate can be used as screening biomarkers to indicate cows that might have health issues during the transition period.
文摘Retained placenta is a known cause of post-partum haemorrhage and maternal mortality. A recent systemic review has confirmed that the incidence of retained placenta had increased all over the world, which is more common in developed countries. Failure of retroplacental myometrium contraction is the main cause of retained placenta. Maternal age greater than 35 years, grandmultipara, preterm labor, history of previous retained placenta, and caesarean section were the risk factors for retained placenta. Manual removal of the placenta has been the treatment of choice. Attempts had been made by clinician and researchers to find a safe, effective and reliable method to avoid the need for surgical intervention. The efficacy and safety of prostaglandin, nitroglycerin or acupuncture in the management of retained placenta are yet to be further evaluated. Nonetheless, till date only intraumbilical vein oxytocin has been studied extensively but with varied success. More randomized clinical trials are needed to address this issue. However, if immediate manual placenta removal service is unavailable, a trial of intra-umbilical vein oxytocin 100 IU at a totalvolume of at least 40 m L while preparing for transfer to a tertiary center or theatre may result in spontaneous expulsion of the placenta.
文摘Background: Detachment of the placenta occurs in about 96% of patients within 30 minutes of completion of the second stage of labour, thus any further delay there after is usually considered as retained placenta. It is associated with the risk of post-partum haemorrhage and anaemia. Objectives: To determine the incidence, risk factors, clinical presentation and complications of retained placenta at the study centre during the period under review. Methods: This was a retrospective case-control study in which records of women with retained placenta between January 2011 and December 2015 were retrieved and analysed for their age, parity, risk factors, clinical presentation and associated complications and compared with equal number of patients without retained placenta. Results: There were 11 cases of retained placenta recorded among the total number of 2068 deliveries during the study period, giving an incidence of 0.53% retained placenta in this study. Majority of cases (45.4%) were between age 30 and 39 years which was similar to the controls (54.5%). Most of the cases were unbooked (81%). Similarly, most women in both cases (82%) and controls (73%) were multiparae. All the 5 cases (45.5%) that had post-partum haemorrhage received blood transfusion. The overall incidence of post-partum anaemia was 54%. The average weights of the placentae were significantly smaller in the cases with placental retention (p = 0.010). Conclusion: Retained placenta is associated with significant risks of post-partum haemorrhage and blood transfusion. Non-booking for antenatal care is the commonest risk factor identified for retained placenta in this study.
