Objective Previous studies on adakitic rocks with high Sr/Y and La/Yb ratios have established that such rocks may form in a variety of tectonic settings through different petrogenetic processes including： （1） parti...Objective Previous studies on adakitic rocks with high Sr/Y and La/Yb ratios have established that such rocks may form in a variety of tectonic settings through different petrogenetic processes including： （1） partial melting of subducted young （〈25 Ma）, hot and hydrated oceanic slab; （2） partial melting of thickened lower crust; （3） assimilation and fractional crystallization processes involving basaltic magma; （4） partial melting of delaminated lower crust; and （5） partial melting of hydrous garnet peridotite. The various origins for adakites provide important constraints on crustal growth and evolution throughout the Earth＇s history.展开更多
Elizabeth Fisher and Victor collaboratively for many years on Tybulewicz have worked the Down syndrome mouse model project. Elizabeth Fisher＇s background is in molecular genetics and mouse models, with an interest in...Elizabeth Fisher and Victor collaboratively for many years on Tybulewicz have worked the Down syndrome mouse model project. Elizabeth Fisher＇s background is in molecular genetics and mouse models, with an interest in anueploidy. Victor Tybulewicz is an immunologist whose primary interest is in signal transduction from the antigen receptors of B and T cells.展开更多
Based on the stratum settlement resulting from water drainage, this paper establishes the calculating method of stresses and displacements of shaft lining and stratum by using Fourier integration, obtains the calculat...Based on the stratum settlement resulting from water drainage, this paper establishes the calculating method of stresses and displacements of shaft lining and stratum by using Fourier integration, obtains the calculating formulas of tangiential load which shaft lining is subjected to, and provides theoretical basis for design of shaft lining.展开更多
PEG (Polyethylene glycol average molecular weight 300) is used as absorbent of NO2. The absorption efficiency is found to reach up to 97%. The absorbing product, PEG NO2, can be used to cleave benzyl ethers mildly a...PEG (Polyethylene glycol average molecular weight 300) is used as absorbent of NO2. The absorption efficiency is found to reach up to 97%. The absorbing product, PEG NO2, can be used to cleave benzyl ethers mildly and selectively to benzaldehyde and corresponding fatty alcohols, showing that PEG is a valuable oxidizing agent of benzyl ethers. As a carrier of NO2.PEG can be recovered and utilized repeatedly after the oxidation.展开更多
Objective To explore the relevant risk factors of tramatic arthritis resulting from the surgery of acetabular fractures. Methods From January 2000 to January 2009,88 patients aged from 20 to 60 years old with acetabul...Objective To explore the relevant risk factors of tramatic arthritis resulting from the surgery of acetabular fractures. Methods From January 2000 to January 2009,88 patients aged from 20 to 60 years old with acetabular fractures展开更多
To the Editor:Calcific discitis is a self-limiting cervical disc disease usually seen in children and uncommon in adults.[1]It can typically be cured by conservative treatment.[2]In this article,we reported a case of ...To the Editor:Calcific discitis is a self-limiting cervical disc disease usually seen in children and uncommon in adults.[1]It can typically be cured by conservative treatment.[2]In this article,we reported a case of paralysis caused by thoracolumbar calcific discitis,with acute herniation.展开更多
Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a referen...Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.展开更多
The original online version of this article was revised:Several errors occurred in the published version of the article.These have now been corrected as follows:Page 2,section"2.2 Laser Texturing Procedure of Sur...The original online version of this article was revised:Several errors occurred in the published version of the article.These have now been corrected as follows:Page 2,section"2.2 Laser Texturing Procedure of Surfaces",line 2:The device name was corrected from"YDFLP-E-50-M8"to"YDFLP-50-M8."Page 3,Section 2.4:The phrase"95%confidence interval"has been corrected to"95%confidence level."Page 3,Figure 1 caption:The phrase"fandg"has been corrected to"f and g."The order"C4 and C12"has been reversed to"C12 and C4,"in accordance with the display order in the figure.Page 4,Figure reference:The phrase"Figs.4c and d"has been corrected to"Figs.5b and c."Page 5,paragraph starting with"The ANOVA results are presented...":The phrase"95%confidence interval"has been corrected to"95%confidence level."展开更多
I offer suggestions to increase the probability of success of an international research project.Collaborative studies often produce more innovative and transformative scientific results than work done by a single inve...I offer suggestions to increase the probability of success of an international research project.Collaborative studies often produce more innovative and transformative scientific results than work done by a single investigator or an isolated team.My advice is intended for early-career scientists.The product of the collaboration may be high-impact research publications,enhanced geophysical monitoring capabilities in a foreign country,or an advanced training course.Choosing the right international partner is the most important step.Keeping an open mind and being receptive to suggestions to modify the initial concept is critical.Other key steps include having a mutually agreed upon plan with achievable goals and well-defined expected outcomes.International cooperation is a richly rewarding experience that accelerates progress in the Earth Sciences.展开更多
Sleep is an indispensable part of life−its deficiency has significant implications for overall health and wellbeing[1].In today’s fast-paced society,sleep loss from either stressful or non-stressful origins has becom...Sleep is an indispensable part of life−its deficiency has significant implications for overall health and wellbeing[1].In today’s fast-paced society,sleep loss from either stressful or non-stressful origins has become prevalent.Specifically,active sleep deprivation(ASD),resulting from extended use of smartphones and other recreational activities,has risen as a global health issue.Clinical research has underscored a strong correlation between chronic pain and inadequate sleep[2].The relationship between pain and sleep is reciprocal:pain disturbs sleep,while poor sleep quality,in turn,reduces pain tolerance and exacerbates spontaneous pain sensations[3].While these interplays are well-documented in cases of passive sleep deprivation(PSD)associated with external pressures or illnesses,understanding how and which regions of the brain collaborate to recalibrate the intricate neural circuitry governing pain perception during ASD remains a crucial yet unresolved frontier.展开更多
BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
Journal of Future Foods(ISSN 2772-5669.Owner:Bejjing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on bchalf of KcAi Communications Co,Ltd.)is an intecrnational,pcer-reviewed open access journal bclongi...Journal of Future Foods(ISSN 2772-5669.Owner:Bejjing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on bchalf of KcAi Communications Co,Ltd.)is an intecrnational,pcer-reviewed open access journal bclonging to the disciplinc of food scicnce and technology.The aim of the journal is to report latcst rescarch results of high-tcch in food science.We welcome submissions that drive the ficld of food science towards whole food nutrition,intelligencc and high technology.展开更多
Retrieval analysis in total knee arthroplasty(TKA)has been little studied in the literature.A narrative review of the literature to understand the current importance of retrieval analysis in TKA has been conducted.On ...Retrieval analysis in total knee arthroplasty(TKA)has been little studied in the literature.A narrative review of the literature to understand the current importance of retrieval analysis in TKA has been conducted.On August 27,2024,a literature search was performed in PubMed using“TKA retrieval analysis”as keywords.A total of 160 articles were found,of which only 19 were analyzed because they were directly related to the subject of this article.Rotating-platform(mobile-bearing)TKA has no surface damage advantage over fixed-bearing TKA.TKAs with central locking mechanisms are more prone to debond from the cement mantle.No major wear of the polyethylene(PE)component in TKA using oxidized zirconium components occurs.Femoral components of cobalt-chromium roughen more than oxidized zirconium femoral components.The use of a polished tibial tray over an unpolished design is advised.At short-run assessment(15 months on average),antioxidant-stabilized highly crosslinked PE components are not clinically different in surface damage,density of crosslinking,or oxidation compared to standard remelted highly crosslinked PE components.A correlation between implant position and PE component surface damage has been reported.It shows the importance of optimizing component position to reduce PE component damage.Contemporary knee tumor megaendoprostheses show notable volumetric metal wear originated at the rotating hinge.Retrieval analysis in TKA renders relevant data on how different prosthetic designs described in the literature perform.Such information can help to improve future prosthetic designs to increase prosthetic survival.展开更多
Types of paper Research Article A complete report on original research.A clear structure is required,including introduction,material and methods,results and discussion,conclusions generally.
BACKGROUND Esophageal cancer is a significant global health concern,characterized by high mortality rates and diverse histological types,primarily adenocarcinoma and squamous cell carcinoma.AIM To analyze trends in es...BACKGROUND Esophageal cancer is a significant global health concern,characterized by high mortality rates and diverse histological types,primarily adenocarcinoma and squamous cell carcinoma.AIM To analyze trends in esophageal cancer using Surveillance,Epidemiology,and End Results(SEER)data,focusing on patient characteristics,stage at diagnosis,treatment modalities,and survival outcomes,to provide insights that may guide clinical practice and public health initiatives.METHODS Age-adjusted incidence and mortality rates for esophageal cancer,2004-2021,were obtained from SEER rate sessions using SEER*Stat version 8.4.4.Average percent changes(APC)over time in age-adjusted incidence and mortality rates relative to gender,race/ethnicity,and stage at diagnosis were assessed using Joinpoint’s loglinear regression.Finally,Poisson regression was used to ascertain incidence and mortality rate ratios to ascertain associations between age,gender,race/ethnicity,and staging with incidence and mortality rates.All analyses were further stratified by gender to assess interactions between gender and the other demographic and clinical characteristics.RESULTS Overall,the data reveals significant trends in both the incidence and mortality rates of esophageal cancer,with notable variations across gender,race,and stage at diagnosis.Age-adjusted incidence and mortality rates were higher in males compared to females(incidence:4.1 per 100000 vs 0.9 per 100000,mortality:3.4 per 100000 vs 0.7 per 100000),P<0.001.Furthermore,the APC among males decreased more significantly over time[APC(95%CI):-1.14(-1.52 to-0.78);P<0.001].Both non-Hispanic(NH)Blacks and NH Whites showed significant decreases in cancer incidence,with NH Blacks observing a 3.27%decline and NH Whites a 0.51%decline.Patients with distant staging had a 5%APC increase in mortality rates over time(P=0.003).Additionally,mortality rates increased with age,and all minority groups showed declines in incidence and mortality compared to NH Whites.Cancer diagnosed at a distant stage had a mortality rate 4.16 times higher than in situ cases.CONCLUSION The analysis reveals clear disparities in both the incidence and mortality of esophageal cancer,with males,particularly NH Whites,experiencing significantly higher rates than females.Despite a general decline in incidence rates over time,the upward trend in mortality for certain subgroups warrants further investigation into potential contributing factors such as healthcare access,treatment efficacy,and underlying socio-economic disparities.展开更多
This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo(ABC)sense.Unlike traditional ...This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo(ABC)sense.Unlike traditional epidemiological models that rely on classical or Caputo fractional derivatives,the proposed model incorporates nonlocal memory effects,hereditary properties,and complex transmission dynamics through fractalfractional calculus.The Atangana-Baleanu operator,with its non-singular Mittag-Leffler kernel,ensures a more realistic representation of disease progression compared to classical integer-order models and singular kernel-based fractional models.The study establishes the existence and uniqueness of the proposed system and conducts a comprehensive stability analysis,including local and global stability.Furthermore,numerical simulations illustrate the effectiveness of the ABC operator in capturing long-memory effects and nonlocal interactions in disease transmission.The results provide valuable insights into public health interventions,particularly in optimizing vaccination strategies,treatment approaches,and mitigation measures.By extending epidemiological modeling through fractal-fractional derivatives,this study offers an advanced framework for analyzing infectious disease dynamics with enhanced accuracy and predictive capabilities.展开更多
Article Categories⋅Research article is a complete academic investigation that covers a significant advance in a specialty.It usually includes a structured abstract under 300 words,an introduction,sections with heading...Article Categories⋅Research article is a complete academic investigation that covers a significant advance in a specialty.It usually includes a structured abstract under 300 words,an introduction,sections with headings of Materials and Methods,Results,and Discussion,and References.Meta-analyses are published as original articles as well.The full text is about 3500 words and the figures and tables need to be kept under 7 items.展开更多
BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are rare malignancies frequently associated with liver metastases(LM).The benefit of primary tumor resection(PTR)in patients with unresectable LM remains controversial...BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are rare malignancies frequently associated with liver metastases(LM).The benefit of primary tumor resection(PTR)in patients with unresectable LM remains controversial.This study evaluates the impact of PTR on overall survival(OS)and tumor grading by integrating evidence from a systematic review,meta-analysis,and Surveillance,Epidemiology,and End Results(SEER)database analysis.AIM To evaluate the survival benefits of PTR in patients with PNETs and LM.METHODS This study was conducted in accordance with the PRISMA guidelines.A systematic literature search and meta-analysis were performed using five databases:PubMed,Web of Science,EMBASE,Cochrane Library,and CNKI,with records included up to February 2025.A total of 16 studies(n=8761;including 1 prospective and 15 retrospective studies)were included.A random-effects model was applied to pool hazard ratios for OS and odds ratios for tumor grading,with heterogeneity assessed by the I2 statistic.Risk of bias was evaluated using the ROBINS-I tool.In addition,an independent analysis based on the SEER database(n=791)was conducted using Kaplan-Meier survival curves and log-rank tests.RESULTS Meta-analysis results revealed that PTR significantly improved OS in patients showed that neither study design(prospective vs.retrospective)nor sample size(<400 vs≥400)significantly influenced the survival benefit.In terms of tumor grading,no statistically significant difference was observed between the surgical and non-surgical groups(odds ratio=1.60,95%confidence interval:0.70-3.63,P=0.26).Independent analysis of the SEER database(n=791)further confirmed the survival advantage of PTR across different tumor differentiation levels,with significant differences in OS between surgical and non-surgical groups(P<0.05).CONCLUSION PTR significantly improves OS in PNET patients with LM.However,its effect on tumor grading remains unclear,warranting further prospective studies to refine surgical strategies for this population.展开更多
基金financially supported by the National Nature Science Foundation of China(grant No. 41202037)
文摘Objective Previous studies on adakitic rocks with high Sr/Y and La/Yb ratios have established that such rocks may form in a variety of tectonic settings through different petrogenetic processes including： （1） partial melting of subducted young （〈25 Ma）, hot and hydrated oceanic slab; （2） partial melting of thickened lower crust; （3） assimilation and fractional crystallization processes involving basaltic magma; （4） partial melting of delaminated lower crust; and （5） partial melting of hydrous garnet peridotite. The various origins for adakites provide important constraints on crustal growth and evolution throughout the Earth＇s history.
基金the Brain Research Trust,the Wellcome Trust,the UK Medical Research Council and the AnEUploidy grant from Framework Programme 6 from the European Union Commission for funding
文摘Elizabeth Fisher and Victor collaboratively for many years on Tybulewicz have worked the Down syndrome mouse model project. Elizabeth Fisher＇s background is in molecular genetics and mouse models, with an interest in anueploidy. Victor Tybulewicz is an immunologist whose primary interest is in signal transduction from the antigen receptors of B and T cells.
文摘Based on the stratum settlement resulting from water drainage, this paper establishes the calculating method of stresses and displacements of shaft lining and stratum by using Fourier integration, obtains the calculating formulas of tangiential load which shaft lining is subjected to, and provides theoretical basis for design of shaft lining.
文摘PEG (Polyethylene glycol average molecular weight 300) is used as absorbent of NO2. The absorption efficiency is found to reach up to 97%. The absorbing product, PEG NO2, can be used to cleave benzyl ethers mildly and selectively to benzaldehyde and corresponding fatty alcohols, showing that PEG is a valuable oxidizing agent of benzyl ethers. As a carrier of NO2.PEG can be recovered and utilized repeatedly after the oxidation.
文摘Objective To explore the relevant risk factors of tramatic arthritis resulting from the surgery of acetabular fractures. Methods From January 2000 to January 2009,88 patients aged from 20 to 60 years old with acetabular fractures
文摘To the Editor:Calcific discitis is a self-limiting cervical disc disease usually seen in children and uncommon in adults.[1]It can typically be cured by conservative treatment.[2]In this article,we reported a case of paralysis caused by thoracolumbar calcific discitis,with acute herniation.
文摘Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.
文摘The original online version of this article was revised:Several errors occurred in the published version of the article.These have now been corrected as follows:Page 2,section"2.2 Laser Texturing Procedure of Surfaces",line 2:The device name was corrected from"YDFLP-E-50-M8"to"YDFLP-50-M8."Page 3,Section 2.4:The phrase"95%confidence interval"has been corrected to"95%confidence level."Page 3,Figure 1 caption:The phrase"fandg"has been corrected to"f and g."The order"C4 and C12"has been reversed to"C12 and C4,"in accordance with the display order in the figure.Page 4,Figure reference:The phrase"Figs.4c and d"has been corrected to"Figs.5b and c."Page 5,paragraph starting with"The ANOVA results are presented...":The phrase"95%confidence interval"has been corrected to"95%confidence level."
文摘I offer suggestions to increase the probability of success of an international research project.Collaborative studies often produce more innovative and transformative scientific results than work done by a single investigator or an isolated team.My advice is intended for early-career scientists.The product of the collaboration may be high-impact research publications,enhanced geophysical monitoring capabilities in a foreign country,or an advanced training course.Choosing the right international partner is the most important step.Keeping an open mind and being receptive to suggestions to modify the initial concept is critical.Other key steps include having a mutually agreed upon plan with achievable goals and well-defined expected outcomes.International cooperation is a richly rewarding experience that accelerates progress in the Earth Sciences.
基金supported by the National Natural Science Foundation of China(U21A20418).
文摘Sleep is an indispensable part of life−its deficiency has significant implications for overall health and wellbeing[1].In today’s fast-paced society,sleep loss from either stressful or non-stressful origins has become prevalent.Specifically,active sleep deprivation(ASD),resulting from extended use of smartphones and other recreational activities,has risen as a global health issue.Clinical research has underscored a strong correlation between chronic pain and inadequate sleep[2].The relationship between pain and sleep is reciprocal:pain disturbs sleep,while poor sleep quality,in turn,reduces pain tolerance and exacerbates spontaneous pain sensations[3].While these interplays are well-documented in cases of passive sleep deprivation(PSD)associated with external pressures or illnesses,understanding how and which regions of the brain collaborate to recalibrate the intricate neural circuitry governing pain perception during ASD remains a crucial yet unresolved frontier.
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
文摘Journal of Future Foods(ISSN 2772-5669.Owner:Bejjing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on bchalf of KcAi Communications Co,Ltd.)is an intecrnational,pcer-reviewed open access journal bclonging to the disciplinc of food scicnce and technology.The aim of the journal is to report latcst rescarch results of high-tcch in food science.We welcome submissions that drive the ficld of food science towards whole food nutrition,intelligencc and high technology.
文摘Retrieval analysis in total knee arthroplasty(TKA)has been little studied in the literature.A narrative review of the literature to understand the current importance of retrieval analysis in TKA has been conducted.On August 27,2024,a literature search was performed in PubMed using“TKA retrieval analysis”as keywords.A total of 160 articles were found,of which only 19 were analyzed because they were directly related to the subject of this article.Rotating-platform(mobile-bearing)TKA has no surface damage advantage over fixed-bearing TKA.TKAs with central locking mechanisms are more prone to debond from the cement mantle.No major wear of the polyethylene(PE)component in TKA using oxidized zirconium components occurs.Femoral components of cobalt-chromium roughen more than oxidized zirconium femoral components.The use of a polished tibial tray over an unpolished design is advised.At short-run assessment(15 months on average),antioxidant-stabilized highly crosslinked PE components are not clinically different in surface damage,density of crosslinking,or oxidation compared to standard remelted highly crosslinked PE components.A correlation between implant position and PE component surface damage has been reported.It shows the importance of optimizing component position to reduce PE component damage.Contemporary knee tumor megaendoprostheses show notable volumetric metal wear originated at the rotating hinge.Retrieval analysis in TKA renders relevant data on how different prosthetic designs described in the literature perform.Such information can help to improve future prosthetic designs to increase prosthetic survival.
文摘Types of paper Research Article A complete report on original research.A clear structure is required,including introduction,material and methods,results and discussion,conclusions generally.
文摘BACKGROUND Esophageal cancer is a significant global health concern,characterized by high mortality rates and diverse histological types,primarily adenocarcinoma and squamous cell carcinoma.AIM To analyze trends in esophageal cancer using Surveillance,Epidemiology,and End Results(SEER)data,focusing on patient characteristics,stage at diagnosis,treatment modalities,and survival outcomes,to provide insights that may guide clinical practice and public health initiatives.METHODS Age-adjusted incidence and mortality rates for esophageal cancer,2004-2021,were obtained from SEER rate sessions using SEER*Stat version 8.4.4.Average percent changes(APC)over time in age-adjusted incidence and mortality rates relative to gender,race/ethnicity,and stage at diagnosis were assessed using Joinpoint’s loglinear regression.Finally,Poisson regression was used to ascertain incidence and mortality rate ratios to ascertain associations between age,gender,race/ethnicity,and staging with incidence and mortality rates.All analyses were further stratified by gender to assess interactions between gender and the other demographic and clinical characteristics.RESULTS Overall,the data reveals significant trends in both the incidence and mortality rates of esophageal cancer,with notable variations across gender,race,and stage at diagnosis.Age-adjusted incidence and mortality rates were higher in males compared to females(incidence:4.1 per 100000 vs 0.9 per 100000,mortality:3.4 per 100000 vs 0.7 per 100000),P<0.001.Furthermore,the APC among males decreased more significantly over time[APC(95%CI):-1.14(-1.52 to-0.78);P<0.001].Both non-Hispanic(NH)Blacks and NH Whites showed significant decreases in cancer incidence,with NH Blacks observing a 3.27%decline and NH Whites a 0.51%decline.Patients with distant staging had a 5%APC increase in mortality rates over time(P=0.003).Additionally,mortality rates increased with age,and all minority groups showed declines in incidence and mortality compared to NH Whites.Cancer diagnosed at a distant stage had a mortality rate 4.16 times higher than in situ cases.CONCLUSION The analysis reveals clear disparities in both the incidence and mortality of esophageal cancer,with males,particularly NH Whites,experiencing significantly higher rates than females.Despite a general decline in incidence rates over time,the upward trend in mortality for certain subgroups warrants further investigation into potential contributing factors such as healthcare access,treatment efficacy,and underlying socio-economic disparities.
基金funded by the Research,Development,and Innovation Authority(RDIA)-Kingdom of Saudi Arabia-with grant number 12803-baha-2023-BU-R-3-1-EI.
文摘This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo(ABC)sense.Unlike traditional epidemiological models that rely on classical or Caputo fractional derivatives,the proposed model incorporates nonlocal memory effects,hereditary properties,and complex transmission dynamics through fractalfractional calculus.The Atangana-Baleanu operator,with its non-singular Mittag-Leffler kernel,ensures a more realistic representation of disease progression compared to classical integer-order models and singular kernel-based fractional models.The study establishes the existence and uniqueness of the proposed system and conducts a comprehensive stability analysis,including local and global stability.Furthermore,numerical simulations illustrate the effectiveness of the ABC operator in capturing long-memory effects and nonlocal interactions in disease transmission.The results provide valuable insights into public health interventions,particularly in optimizing vaccination strategies,treatment approaches,and mitigation measures.By extending epidemiological modeling through fractal-fractional derivatives,this study offers an advanced framework for analyzing infectious disease dynamics with enhanced accuracy and predictive capabilities.
文摘Article Categories⋅Research article is a complete academic investigation that covers a significant advance in a specialty.It usually includes a structured abstract under 300 words,an introduction,sections with headings of Materials and Methods,Results,and Discussion,and References.Meta-analyses are published as original articles as well.The full text is about 3500 words and the figures and tables need to be kept under 7 items.
文摘BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are rare malignancies frequently associated with liver metastases(LM).The benefit of primary tumor resection(PTR)in patients with unresectable LM remains controversial.This study evaluates the impact of PTR on overall survival(OS)and tumor grading by integrating evidence from a systematic review,meta-analysis,and Surveillance,Epidemiology,and End Results(SEER)database analysis.AIM To evaluate the survival benefits of PTR in patients with PNETs and LM.METHODS This study was conducted in accordance with the PRISMA guidelines.A systematic literature search and meta-analysis were performed using five databases:PubMed,Web of Science,EMBASE,Cochrane Library,and CNKI,with records included up to February 2025.A total of 16 studies(n=8761;including 1 prospective and 15 retrospective studies)were included.A random-effects model was applied to pool hazard ratios for OS and odds ratios for tumor grading,with heterogeneity assessed by the I2 statistic.Risk of bias was evaluated using the ROBINS-I tool.In addition,an independent analysis based on the SEER database(n=791)was conducted using Kaplan-Meier survival curves and log-rank tests.RESULTS Meta-analysis results revealed that PTR significantly improved OS in patients showed that neither study design(prospective vs.retrospective)nor sample size(<400 vs≥400)significantly influenced the survival benefit.In terms of tumor grading,no statistically significant difference was observed between the surgical and non-surgical groups(odds ratio=1.60,95%confidence interval:0.70-3.63,P=0.26).Independent analysis of the SEER database(n=791)further confirmed the survival advantage of PTR across different tumor differentiation levels,with significant differences in OS between surgical and non-surgical groups(P<0.05).CONCLUSION PTR significantly improves OS in PNET patients with LM.However,its effect on tumor grading remains unclear,warranting further prospective studies to refine surgical strategies for this population.
