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Simulation of Restraint Device Degradation of Long-Span Suspension Bridge Based on Finite Element Model 被引量:1
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作者 Qiaowei Ye Ying Peng +3 位作者 Zihang Wang Chao Deng Xiang Xu Yuan Ren 《Structural Durability & Health Monitoring》 2025年第4期851-868,共18页
The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restrain... The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance. 展开更多
关键词 Suspension bridge longitudinal displacement of girder end random vehicle load model deterioration of restraint devices
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Design and Optimization for the Occupant Restraint System of Vehicle Based on a Single Freedom Model 被引量:6
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作者 ZHANG Junyuan MA Yue +1 位作者 CHEN Chao ZHANG Yan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第3期492-497,共6页
Throughout the vehicle crash event, the interactions between vehicle, occupant, restraint system (VOR) are complicated and highly non-linear. CAE and physical tests are the most widely used in vehicle passive safety d... Throughout the vehicle crash event, the interactions between vehicle, occupant, restraint system (VOR) are complicated and highly non-linear. CAE and physical tests are the most widely used in vehicle passive safety development, but they can only be done with the detailed 3D model or physical samples. Often some design errors and imperfections are difficult to correct at that time, and a large amount of time will be needed. A restraint system concept design approach which based on single-degree-of-freedom occupant-vehicle model (SDOF) is proposed in this paper. The interactions between the restraint system parameters and the occupant responses in a crash are studied from the view of mechanics and energy. The discrete input and the iterative algorithm method are applied to the SDOF model to get the occupant responses quickly for arbitrary excitations (impact pulse) by MATLAB. By studying the relationships between the ridedown efficiency, the restraint stiffness, and the occupant response, the design principle of the restraint stiffness aiming to reduce occupant injury level during conceptual design is represented. Higher ridedown efficiency means more occupant energy absorbed by the vehicle, but the research result shows that higher ridedown efficiency does not mean lower occupant injury level. A proper restraint system design principle depends on two aspects. On one hand,the restraint system should lead to as high ridedown efficiency as possible, and at the same time, the restraint system should maximize use of the survival space to reduce the occupant deceleration level. As an example, an optimization of a passenger vehicle restraint system is designed by the concept design method above, and the final results are validated by MADYMO, which is the most widely used software in restraint system design, and the sled test. Consequently, a guideline and method for the occupant restraint system concept design is established in this paper. 展开更多
关键词 vehicle crash occupant restraint system concept design single-degree-of-freedom occupant-vehicle model
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我国农村订单定向医学生免费培养项目执行制约因素与优化路径研究
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作者 李小丹 左延莉 +4 位作者 欧晏辰 王振邦 张鑫 赵越 陈丹 《中国全科医学》 北大核心 2026年第4期525-529,537,共6页
我国高度重视农村订单定向医学生培养项目实施效果,但该政策在实施过程中遇到多重挑战,也表明其仍需持续优化与完善。本文基于史密斯模型分析框架,全面、系统地探索农村订单定向医学生免费培养项目在执行过程中的制约因素,为完善农村订... 我国高度重视农村订单定向医学生培养项目实施效果,但该政策在实施过程中遇到多重挑战,也表明其仍需持续优化与完善。本文基于史密斯模型分析框架,全面、系统地探索农村订单定向医学生免费培养项目在执行过程中的制约因素,为完善农村订单定向医学生免费培养项目提供理论依据和决策参考。本文表明政策奖励机制不健全,政策内容宽泛,执行机构缺乏交流沟通、积极性不高,基层医疗卫生机构资源缺乏,定向生对政策一知半解、职业认同感不强及环境不稳定阻碍政策有效执行。农村订单定向医学生免费培养项目可解决基层人才短缺问题,应尽快完善农村订单定向医学生免费培养政策,为基层“留住人才”。 展开更多
关键词 教育 医学 订单定向医学生 政策执行 制约因素 优化路径 史密斯模型
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Physical restraint in mental health nursing: A concept analysis 被引量:9
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作者 Junrong Ye Chen Wang +6 位作者 Aixiang Xiao Zhichun Xia Lin Yu Jiankui Lin Yao Liao Yu Xu Yunlei Zhang 《International Journal of Nursing Sciences》 CSCD 2019年第3期343-348,共6页
Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related litera... Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related literature,this study aims to clarify the concept of physical restraint in mental health nursing.Method: Three databases (PubMed,PsyclNFO and CINAHL) were retrieved,and Walker and Avant's concept analysis method was used to analyze the concept of physical restraint in mental health nursing.Results: Physical restraint is a coercive approach that enables the administration of necessary treatment by safely reducing the patient's physical movement.It should be the last option used by qualified personnel.Antecedents of physical restraint are improper behavior (violence and disturbance) of patients,medical assessment prior to implementation and legislation governing clinical usage.Consequences of physical restraint are alleviation of conflict,physical injury,mental trauma and invisible impact on the institution.Discussion: This study defined the characteristics of physical restraint in mental health nursing.The proposed concept analysis provided theoretical foundation for future studies. 展开更多
关键词 Concept analysis Mental health services Physical restraint Qualitative study Walker and Avant's model
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Establishment and Validation for the Theoretical Model of the Vehicle Airbag 被引量:2
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作者 ZHANG Junyuan JIN Yang +1 位作者 XIE Lizhe CHEN Chao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第3期487-495,共9页
The current design and optimization of the occupant restraint system(ORS) are based on numerous actual tests and mathematic simulations. These two methods are overly time-consuming and complex for the concept design... The current design and optimization of the occupant restraint system(ORS) are based on numerous actual tests and mathematic simulations. These two methods are overly time-consuming and complex for the concept design phase of the ORS, though they're quite effective and accurate. Therefore, a fast and directive method of the design and optimization is needed in the concept design phase of the ORS. Since the airbag system is a crucial part of the ORS, in this paper, a theoretical model for the vehicle airbag is established in order to clarify the interaction between occupants and airbags, and further a fast design and optimization method of airbags in the concept design phase is made based on the proposed theoretical model. First, the theoretical expression of the simplified mechanical relationship between the airbag's design parameters and the occupant response is developed based on classical mechanics, then the momentum theorem and the ideal gas state equation are adopted to illustrate the relationship between airbag's design parameters and occupant response. By using MATLAB software, the iterative algorithm method and discrete variables are applied to the solution of the proposed theoretical model with a random input in a certain scope. And validations by MADYMO software prove the validity and accuracy of this theoretical model in two principal design parameters, the inflated gas mass and vent diameter, within a regular range. This research contributes to a deeper comprehension of the relation between occupants and airbags, further a fast design and optimization method for airbags' principal parameters in the concept design phase, and provides the range of the airbag's initial design parameters for the subsequent CAE simulations and actual tests. 展开更多
关键词 occupant restraint systems AIRBAG theoretical model concept design
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Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Increased Toxin Uptake into the Brain in C57BL/6 Mice
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作者 Yasuhide Mitsumoto Atsushi Mori 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第5期849-853,共5页
As an environmental risk factor, psychological stress may trigger the onset or accelerate the progression of Parkinson's disease (PD). Here, we evaluated the effects of acute restraint stress on striatal dopaminerg... As an environmental risk factor, psychological stress may trigger the onset or accelerate the progression of Parkinson's disease (PD). Here, we evaluated the effects of acute restraint stress on striatal dopaminergic terminals and the brain metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahy- dropyridine (MPTP), which has been widely used for creating a mouse model of PD. Exposure to 2 h of restraint stress immediately after injection of a low dose of MPTP caused a severe loss of striatal dopaminergic terminals as indicated by decreases in the dopamine transporter protein and dopamine levels compared with MPTP administration alone. Both striatal 1-methyl-4-phenylpyridinium ion (MPP+) and MPTP concentrations were significantly increased by the application of restraint stress. Striatal monoamine oxidase-B, which catalyzes the oxidation of MPTP to MPP+, was not changed by the restraint stress. Our results indicate that the enhanced striatal dopaminergic terminal loss in the stressed mice is associated with an increase in the transport of neurotoxin into the brain. 展开更多
关键词 MPTP MPP+ Mouse model restraint stress Dopaminergic neuron DEGENERATION Dopamine transporter Dopamine
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Numerical simulation and experimental verification of the restraint intensity of pipeline girth welding joint
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作者 Di Xinfie Liu Cuiying +1 位作者 Guo Xiaofiang Xue Zhenkui 《China Welding》 EI CAS 2016年第3期28-35,共8页
The restraint intensity (RI) of the pipeline girth welding joint was investigated using finite element method and experimental method to predict the cold cracking susceptibility of pipeline steel. The distribution o... The restraint intensity (RI) of the pipeline girth welding joint was investigated using finite element method and experimental method to predict the cold cracking susceptibility of pipeline steel. The distribution of RI along the girth weld was investigated to study the influence of welding position on the RL Subsequently, the effects of outer diameter (OD) and wall thickness of pipeline on the RI were studied with ABAQUS software. The results show that the RI is almost independent of welding position. The RI increased with the increasing wall thickness but decreased with the increasing OD. A prediction model of Rl was developed based on the effects of the OD and the wall thickness. It has been found that the predicted RIs were in good agreement with the experimental values. The maximum fractional error between the predicted RI and the experimental values was just about 10%. h was indicated that the errors were mainly caused by the heterogeneous of the weld bead. 展开更多
关键词 restraint intensity numerical simulation prediction model experimental verification
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Restraint Usage Characteristics and Other Factors Associated with Safety of Children Involved in Motor Vehicle Crashes
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作者 Sunanda Dissanayake Niranga Amarasingha 《Journal of Civil Engineering and Architecture》 2016年第1期81-95,共15页
Involvement in road traffic crashes as vehicle occupants is a leading cause of death and serious injury among children. The objective of this study was to investigate crash severity factors and child safety restraint ... Involvement in road traffic crashes as vehicle occupants is a leading cause of death and serious injury among children. The objective of this study was to investigate crash severity factors and child safety restraint use characteristics in order to identify effective countermeasures to increase children's highway safety. Characteristics and percentages of restraint use among child passengers aged 4-13 years were examined using highway crash data from Kansas. The association between restraint use, injury severity and characteristics of children involved in crashes were investigated using OR (odds ratios) and a logistic regression model, which was used to identify risk factors. Results showed that children, who were unrestrained, were seated in the front seat, traveling with drunk drivers and on rural roads, and traveling during nighttime was more vulnerable to severe injury in the case of motor vehicle crashes. The most frequent contributing causes related to crashes involving children included driver's inattention while driving, failure to yield right-of-way, driving too fast, wet roads and animals in the road. Based on identified critical factors, general countermeasure ideas to improve children's traffic safety were suggested, including age-appropriate and size-appropriate seat belt restraints and having children seated in the rear seat. Parents and children must gain better education regarding these safety measures in order to increase child safety on the road. 展开更多
关键词 Child safety child restraint use severity model logistic regression model crash data analysis.
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不同端部约束下GFRP管混凝土长柱轴压性能影响
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作者 金清平 武博 易建明 《中国塑料》 北大核心 2025年第10期69-75,共7页
为研究不同端部约束对玻璃纤维增强聚合物(GFRP)管混凝土长柱轴压性能的影响,进行了两端固结、一端固结一端铰结和两端铰结约束的单调轴压试验,主要分析了端部约束对试件的破坏形态,荷载应变曲线、极限承载力和侧向位移的影响。结果表明... 为研究不同端部约束对玻璃纤维增强聚合物(GFRP)管混凝土长柱轴压性能的影响,进行了两端固结、一端固结一端铰结和两端铰结约束的单调轴压试验,主要分析了端部约束对试件的破坏形态,荷载应变曲线、极限承载力和侧向位移的影响。结果表明,两端固结的破坏模式为端部材料发生脆性破坏,两种铰接则为弯曲失稳;两端固结具有最高的极限承载力和延性,两种铰结较两端固结极限承载力分别下降23.9%和25.5%,轴向极限应变分别下降53.4%和65.8%;现有稳定系数法极限承载力计算模型总体与试验吻合较好;两端铰结侧向位移增长最为显著,采用理想压杆挠度曲线模型对试验数据拟合效果良好,极限荷载下,两端铰结侧向位移峰值分别高于两端固结和一固一铰41.4%和35.8%。 展开更多
关键词 玻璃纤维增强聚合物管混凝土长柱 端部约束 轴压性能 极限承载力模型 侧向位移
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昼夜节律对慢性束缚应激小鼠焦虑、抑郁及认知行为的影响 被引量:1
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作者 强萌 姜宁 +5 位作者 黄红 张亦文 陈芳 李召辉 刘新民 吕光华 《中国比较医学杂志》 北大核心 2025年第2期45-57,共13页
目的探讨白天和夜晚两个不同束缚时段的慢性束缚应激28 d对雌雄ICR小鼠情绪及认知样行为的影响,为慢性束缚应激模型中实验动物性别和束缚时段的选择提供依据。方法将72只雌雄各半的ICR小鼠分为6组:雄性空白组、雄性白天束缚组、雄性夜... 目的探讨白天和夜晚两个不同束缚时段的慢性束缚应激28 d对雌雄ICR小鼠情绪及认知样行为的影响,为慢性束缚应激模型中实验动物性别和束缚时段的选择提供依据。方法将72只雌雄各半的ICR小鼠分为6组:雄性空白组、雄性白天束缚组、雄性夜间束缚组、雌性空白组、雌性白天束缚组、雌性夜间束缚组。除空白组外,其余各组每天束缚10 h,连续束缚28 d建立慢性束缚应激模型。通过旷场实验、Y迷宫实验、新奇抑制摄食实验、高架十字迷宫实验、悬尾实验、强迫游泳实验和避暗实验等方法,观察不同时段的束缚对雌雄ICR小鼠情绪和认知行为的影响。结果将雌雄小鼠分组统计时,在悬尾实验中,雄性白天束缚组的不动时间与雄性空白组相比呈显著性增加(P<0.05)。在强迫游泳实验中,雄性白天束缚组和夜间束缚组的不动时间与雄性空白组相比均显著性增加(P<0.05)。在新奇抑制摄食实验中,与雌性空白组相比,雌性白天束缚组的摄食潜伏期无明显差异,夜间束缚组显著性延长(P<0.05),且夜间与白天束缚组相比呈显著性延长(P<0.05);在夜间束缚时雌性的摄食潜伏期与雄性相比呈显著性延长(P<0.05)。旷场实验中,雌性空白组与雄性空白组相比,中央区时间、中央区/边缘区时间呈显著性降低(P<0.05);雌性白天束缚组的中央区时间、中央区/边缘区时间与雌性空白组相比呈显著性降低(P<0.05)。在高架十字迷宫实验和Y迷宫实验中,各组均无明显差异。避暗实验中,雄性白天束缚组的入暗潜伏期与雄性空白组相比无明显差异,夜间束缚组的入暗潜伏期与空白组相比显著性缩短(P<0.05)。将雌雄小鼠合并统计时,在悬尾实验中,白天雌雄束缚组的不动时间呈显著性增加(P<0.05);在强迫游泳实验中,白天和夜间雌雄束缚组的不动时间呈显著性增加(P<0.01,P<0.05);在旷场实验中,白天雌雄束缚组的中央区时间、中央区/边缘区时间呈显著性缩短(P<0.05,P<0.01),夜间雌雄束缚组的中央区时间、中央区/边缘区时间、白天和夜间雌雄束缚组的平均速度和总路程无明显差异。结论白天时段慢性束缚应激28 d后雄性小鼠表现出抑郁情绪;慢性束缚应激28 d后雌性小鼠易致焦虑情绪;夜间时段慢性束缚应激28 d后雄性小鼠出现学习记忆损伤。 展开更多
关键词 慢性束缚应激模型 抑郁症 焦虑症 认知障碍
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基于“微生物群-肠-脑轴”探讨复方抗焦虑胶囊对慢性束缚应激大鼠的抗焦虑作用及机制 被引量:3
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作者 范文昕 姜婷月 +6 位作者 王宇 张鸽 芦艺凡 刘朦朦 李佳园 马仁芝 石晋丽 《中国实验方剂学杂志》 北大核心 2025年第4期95-107,共13页
目的:观察复方抗焦虑胶囊对慢性束缚应激(CRS)模型大鼠焦虑样行为的干预作用,探究复方抗焦虑胶囊通过“微生物群-肠-脑轴”发挥抗焦虑的作用机制。方法:采用CRS建立大鼠焦虑模型,将大鼠分为正常组、模型组、阳性药组(地西泮,1 mg·k... 目的:观察复方抗焦虑胶囊对慢性束缚应激(CRS)模型大鼠焦虑样行为的干预作用,探究复方抗焦虑胶囊通过“微生物群-肠-脑轴”发挥抗焦虑的作用机制。方法:采用CRS建立大鼠焦虑模型,将大鼠分为正常组、模型组、阳性药组(地西泮,1 mg·kg^(-1))及复方抗焦虑胶囊低、中、高剂量组(0.75、1.5、3 g·kg^(-1))。给药14 d后进行高架十字迷宫实验(EPM)、旷场实验(OFT)、明暗箱实验(LDB)和埋珠实验(MBT)。采用苏木素-伊红(HE)染色观察大鼠海马及结肠病理变化,尼氏(Nissl)染色观察海马神经元损伤情况;16S rRNA测序技术检测各组大鼠肠道菌群多样性变化;实时荧光定量聚合酶链式反应(Real-time PCR)检测大鼠结肠中功能蛋白闭锁小带蛋白-1(ZO-1)及闭合蛋白(Occludin)mRNA的表达;酶联免疫吸附测定法(ELISA)检测大鼠结肠、血清及海马体中炎症因子肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-1β的含量;蛋白免疫印迹法(Western blot)检测大鼠结肠组织ZO-1、Occludin、核转录因子-κB p65(NF-κB p65)及大鼠海马组织NF-κB p65和脑源性神经营养因子(BDNF)蛋白表达。结果:与正常组比较,模型组大鼠进入高架十字迷宫时间及次数比例,进入旷场中央区域的时间及次数,进入明箱时间及穿越明暗箱次数及未被掩埋珠子的个数明显降低(P<0.05,P<0.01);与模型组比较,复方抗焦虑胶囊给药组能在不同程度上改善CRS模型大鼠的焦虑状态,其中高剂量组效果最优,能明显增加大鼠在高架十字迷宫中进入开臂的时间及次数比例(P<0.05),提升大鼠在旷场中进入中央区域的次数(P<0.05),显著增加其进入明箱时间、穿越明暗箱次数和未被掩埋珠子的个数(P<0.01),并能缓解大鼠海马神经元及结肠病理损伤。16S rRNA结果表明,模型组厚壁菌门、Deferribacterota、罗姆布茨菌属(Romboutsia)、Phascolarctobacterium占比升高,拟杆菌门(Bavcteroidota)、乳杆菌属(Lactobacillus)相对丰度降低;给药组肠道菌群中Bavcteroidota、拟杆菌属(Bacteroides)、norank f norank o Clostridia UCG-014、及布劳特氏菌属(Blautia)相对丰度增加,厚壁菌门、Deferribacterota相对丰度降低。Real-time PCR、ELISA及Western blot实验结果表明,与正常组比较,模型组结肠ZO-1、Occludin及其mRNA表达水平显著降低(P<0.01);结肠、血清及海马体中TNF-α、IL-6、IL-β含量显著升高(P<0.01),结肠及海马NF-κB p65蛋白表达显著上升(P<0.01),海马BDNF水平明显降低(P<0.05)。与模型组比较,复方抗焦虑胶囊高剂量组可显著增加结肠ZO-1、Occludin mRNA(P<0.01)的表达;降低CRS致焦虑大鼠结肠、血清及海马体中TNF-α、IL-6、IL-β含量(P<0.01);增加结肠组织中ZO-1(P<0.01),Occludin蛋白表达(P<0.05),降低结肠及海马组织NF-κB p65蛋白表达(P<0.05),并增加海马BDNF蛋白表达。结论:复方抗焦虑胶囊能明显改善CRS大鼠的焦虑样行为,其作用机制可能与调节肠道菌群紊乱、上调结肠紧密连接蛋白表达、修复肠黏膜机械屏障、下调NF-κB/BDNF信号通路,从而降低外周及中枢炎症反应有关。该研究证明复方抗焦虑胶囊通过“微生物-肠-脑轴”发挥抗焦虑作用的理论,可为其进一步的研究提供新思路。 展开更多
关键词 复方抗焦虑胶囊 焦虑症 慢性束缚应激模型 肠道菌群 肠道屏障 炎症
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番泻叶灌胃联合慢性束缚应激构建腹泻型肠易激综合征小鼠模型的研究
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作者 李艳秋 何悦 +5 位作者 侯雨君 罗芳丽 鄢香芸 何昭璇 李瑛 周思远 《中国实验动物学报》 北大核心 2025年第7期958-967,共10页
目的对比不同质量浓度的番泻叶灌胃联合慢性束缚应激法构建的腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)小鼠模型差异性,以确定适宜的番泻叶灌胃质量浓度。方法根据相关研究中构建IBS-D小鼠模型使用的... 目的对比不同质量浓度的番泻叶灌胃联合慢性束缚应激法构建的腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)小鼠模型差异性,以确定适宜的番泻叶灌胃质量浓度。方法根据相关研究中构建IBS-D小鼠模型使用的番泻叶灌胃质量浓度,制定质量浓度梯度,并开展实验。雌性C57BL/6小鼠随机分成空白组(N组)、低剂量组(0.25 g/mL番泻叶,L组)、中剂量组(0.50 g/mL番泻叶,M组)和高剂量组(1.0 g/mL番泻叶,H组),每组10只。连续造模14 d后,观察并记录各组小鼠排便情况、腹泻指数、内脏敏感性及结肠组织形态学变化,比较不同番泻叶质量浓度构建的模型差异。结果与N组小鼠(42.90±11.90)%相比,L组(80.30±5.77)%、M组(80.50±3.44)%、H组(81.90±2.68)%小鼠的6 h粪便含水率显著增加(P<0.01);与N组小鼠(0.00±0.00)相比,L组(0.57±0.16)、M组(0.62±0.23)、H组(0.60±0.23)小鼠的腹泻指数也均显著增加(P<0.01)。与N组小鼠(0.65(0.60,0.65))相比,M组(0.32(0.24,0.39))和H组(0.34(0.27,0.47))小鼠的内脏痛阈值显著降低,内脏敏感性增高(P<0.01)。此外,M组小鼠首粒蓝便时间(98.15(93.41,100.44))min较N组小鼠(186.81(109.28,192.05))min显著缩短(P<0.01)且M组小鼠的6 h粪便总粒数(22.4±3.73)也较N组小鼠(17.90±4.48)相比明显增加(P<0.05)。结论与0.25和1.0 g/mL相比,0.50 g/mL的番泻叶灌胃联合慢性束缚应激能更好的构建IBS-D小鼠模型。 展开更多
关键词 腹泻型肠易激综合征 小鼠模型 番泻叶灌胃 慢性束缚应激
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小偏置碰撞工况下假人与人体模型的碰撞响应对比
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作者 任立海 陈建卓 +3 位作者 范体强 杨佩龙 万鑫铭 刘煜 《湖南大学学报(自然科学版)》 北大核心 2025年第10期75-86,共12页
为探究混合Ⅲ(HybridⅢ)假人与人体乘员约束测试装置(test device for human occupant restraint,THOR)在小偏置碰撞试验中的生物逼真度差异,对比分析了HybridⅢ假人、THOR和人体安全模型(total human model for safety,THUMS)3种乘员... 为探究混合Ⅲ(HybridⅢ)假人与人体乘员约束测试装置(test device for human occupant restraint,THOR)在小偏置碰撞试验中的生物逼真度差异,对比分析了HybridⅢ假人、THOR和人体安全模型(total human model for safety,THUMS)3种乘员模型在不同小偏置碰撞模式下的碰撞响应情况.采用有限元数值模拟方法,以吸能与侧滑两种典型小偏置碰撞模式的整车模型在碰撞过程中的脉冲曲线作为边界条件;结合包含完整内饰结构的某中型轿车驾驶舱模型和HybridⅢ假人、THOR以及THUMS,构建驾驶员侧约束系统仿真模型,分析小偏置碰撞过程中乘员模型的运动学响应与损伤风险差异.与HybridⅢ假人相比,THOR躯干的整体运动趋势与THUMS近似.在损伤方面,THOR头部、脑部和下肢部位的损伤风险与THUMS更接近.THOR胸部整体压缩量要高于HybridⅢ假人和THUMS 10 mm左右;颈部损伤风险大体介于HybridⅢ假人和THUMS中间,更接近THUMS.结果表明,THOR在小偏置碰撞过程中表现出的运动趋势与预测损伤风险的能力与THUMS更接近,与HybridⅢ假人相比,在小偏置碰撞过程中展现出了更高的生物逼真度. 展开更多
关键词 HybridⅢ假人 人体乘员约束测试装置 人体安全模型 生物逼真度 损伤风险 碰撞测试
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基于“五行学说”探讨心力衰竭治疗的季节规律
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作者 李荣山 郭淑婷 +3 位作者 杨松儒 张挺 吕嵘 陈会花 《上海中医药杂志》 2025年第12期61-69,共9页
目的基于“五行学说”探讨冬夏两季同龄心力衰竭小鼠心脏结构和功能差异以及温阳利水代表方苓桂术甘汤治疗效果差异,为“五行学说”提供科学依据。方法C57BL/6J小鼠夏季批次26只,冬季批次22只,分别按季节随机分为夏季/冬季假手术组、夏... 目的基于“五行学说”探讨冬夏两季同龄心力衰竭小鼠心脏结构和功能差异以及温阳利水代表方苓桂术甘汤治疗效果差异,为“五行学说”提供科学依据。方法C57BL/6J小鼠夏季批次26只,冬季批次22只,分别按季节随机分为夏季/冬季假手术组、夏季/冬季模型组、夏季/冬季中药组。采用微渗透泵以40 mg·kg^(-1)·d^(-1)剂量持续给予异丙肾上腺素(ISO)14 d制备慢性心力衰竭(CHF)小鼠模型。其中夏季/冬季中药组小鼠灌胃苓桂术甘汤(2.4 g·kg^(-1)),夏季/冬季假手术组、夏季/冬季模型组小鼠给予等量的0.9%氯化钠溶液灌胃,共干预4周。采用小动物心脏超声观察小鼠心脏结构和功能改变;采用心质量/体质量(HW/BW)和心质量/胫骨长(HW/TL)变化幅度衡量心肌肥大情况,肺质量/体质量(LW/BW)和肺质量/胫骨长(LW/TL)的变化幅度衡量心力衰竭情况;采用苏木精-伊红(HE)染色、天狼猩红和马松(Masson)染色观察心肌组织结构改变。结果①冬季模型组小鼠HW/BW、HW/TL、LW/BW、LW/TL变化幅度与夏季模型组相比无显著差异(P>0.05);苓桂术甘汤治疗后变化幅度无显著差异(P>0.05)。②冬季模型组小鼠心脏的收缩期左室后壁厚度(LVPWs)变化幅度显著大于夏季模型组小鼠(P<0.05),冬季模型组小鼠心脏的收缩期左心室内径(LVIDs)变化幅度显著大于夏季模型组(P<0.05);苓桂术甘汤治疗后冬季中药组小鼠收缩期室间隔厚度(IVSs)和LVPWs变化幅度显著大于夏季中药组(P<0.05)。③冬季模型组小鼠的心脏功能左心室射血分数(EF)和左心室缩短分数(FS)变化幅度显著大于夏季模型组(P<0.05);苓桂术甘汤治疗后冬季中药组小鼠EF和FS提高均显著大于夏季中药组(P<0.05)。④HE染色显示,冬季模型组小鼠心肌细胞紊乱更加严重、肥大更加明显,苓桂术甘汤干预后冬季中药组心肌结构恢复更加明显;Masson和天狼猩红染色显示纤维化情况在冬、夏季节无显著差异。结论基于五行乘侮理论,冬季CHF模型小鼠心脏功能更差,即耐夏不耐冬;辨证论治采用温阳利水代表方苓桂术甘汤在冬季的治疗更加对证,因此疗效更佳。 展开更多
关键词 心力衰竭 苓桂术甘汤 五行学说 乘侮理论 季节 小鼠模型 中药研究
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正面碰撞自动紧急制动系统作用下六岁儿童乘员姿态对损伤风险的影响 被引量:1
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作者 王鹏 潘迪 +2 位作者 叶美婷 叶凡 韩勇 《中国机械工程》 北大核心 2025年第3期483-492,共10页
为厘清汽车正面碰撞事故中不同坐姿儿童乘员在有无自动紧急制动系统(AEB)介入时头部及胸腹部损伤差异,结合城市快速路汽车的行驶速度(90km/h)与NHTSA-NCAP测试条件,建立了整车100%重叠率刚性壁障正面碰撞仿真模型。选取了某款带靠背的... 为厘清汽车正面碰撞事故中不同坐姿儿童乘员在有无自动紧急制动系统(AEB)介入时头部及胸腹部损伤差异,结合城市快速路汽车的行驶速度(90km/h)与NHTSA-NCAP测试条件,建立了整车100%重叠率刚性壁障正面碰撞仿真模型。选取了某款带靠背的增高垫儿童约束系统(CRS)。采用THUMS 6YO人体有限元模型模拟了参考坐姿(RF)、前倾坐姿(HF-OP)和下潜坐姿(PSB),对比分析了有无AEB作用下儿童乘员在各坐姿下的运动学响应及头部和胸腹部损伤风险。结果表明:有AEB作用下,RF坐姿的儿童乘员HIC_(15)减小了43.6%,胸部3 ms合成加速度降低了24.6%;PSB坐姿的儿童头部3 ms合成加速度降低了19.2%,胸部压缩量减小了18.1%;HF-OP坐姿的儿童头部加速度峰值和胸部加速度峰值分别降低了28%和25%。可见各坐姿下AEB的介入均可显著降低儿童乘员的头部和胸部损伤风险。 展开更多
关键词 正面碰撞 儿童约束系统 自动紧急制动 THUMS 6YO人体有限元模型 坐姿
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基于五脏生克制化辨证模式论治双心疾病
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作者 王润英 邓芳隽 +4 位作者 梁嘉钰 赵玉珂 郭海珍 李晓凤 杜武勋 《山东中医杂志》 2025年第7期744-748,共5页
双心医学认为心血管疾病以及心理障碍两种疾病多互为因果,相互影响,二者共病率高,临床常见冠心病、慢性心力衰竭等心血管疾病患者合并抑郁、焦虑状态。文章基于五脏生克制化辨证模式总结双心疾病的共同病机在于五脏气化失司,导致气郁、... 双心医学认为心血管疾病以及心理障碍两种疾病多互为因果,相互影响,二者共病率高,临床常见冠心病、慢性心力衰竭等心血管疾病患者合并抑郁、焦虑状态。文章基于五脏生克制化辨证模式总结双心疾病的共同病机在于五脏气化失司,导致气郁、痰饮、热邪、瘀血等病理产物积聚,进而引发胸中气机不利。据此创立胸痞方,旨在斡旋中土气机、通达左右金木之气、开宣胸中郁结之气,可使诸脏并调,达双心俱健之效。附验案1则。 展开更多
关键词 五脏生克制化辨证模式 双心疾病 脏腑气化 心血管疾病 心理障碍
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密闭环境危害因素所致睡眠障碍小鼠模型的构建
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作者 张晨阳 边祥雨 +4 位作者 朱云峰 姚站馨 郭宝石 邓致荣 郭长江 《世界睡眠医学杂志》 2025年第7期1445-1448,共4页
目的:探究模拟密闭环境条件下小鼠睡眠障碍模型的建立方法。方法:将40只雄性昆明小鼠随机分为对照组(CON组)、束缚组(R组)、光照变化组(L组)以及光照变化+束缚组(LR组)。每周测量各组小鼠体质量;干预处理30 d后,采用戊巴比妥钠腹腔注射... 目的:探究模拟密闭环境条件下小鼠睡眠障碍模型的建立方法。方法:将40只雄性昆明小鼠随机分为对照组(CON组)、束缚组(R组)、光照变化组(L组)以及光照变化+束缚组(LR组)。每周测量各组小鼠体质量;干预处理30 d后,采用戊巴比妥钠腹腔注射进行睡眠试验,记录睡眠潜伏期及睡眠时间;实验结束取血清及下丘脑组织。通过ELISA测定小鼠血清激素食欲素(OXA)、皮质酮(CORT)、促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)以及下丘脑组织中γ-氨基丁酸(GABA)、多巴胺(DA)、5-羟色胺(5-HT)等指标,探究不同条件下小鼠睡眠障碍模型的建立效果。结果:实验结束时R组和LR组体质量与CON组相比显著降低,差异有统计学意义(P<0.05);LR组小鼠睡眠潜伏期显著延长,差异有统计学意义(P<0.05),睡眠时间显著缩短,差异有统计学意义(P<0.01);在下丘脑神经递质含量测定中,与CON组相比,LR组GABA、5-HT含量显著降低,差异有统计学意义(P<0.05),DA含量显著升高,差异有统计学意义(P<0.05);在血清激素含量测定中,与CON组相比,LR组OXA、CORT、ACTH含量显著升高,差异有统计学意义(P<0.05,P<0.05)。结论:密闭环境中光照变化复合束缚可显著改变下丘脑和血清中神经递质及激素含量,影响小鼠睡眠过程,从而形成睡眠障碍。 展开更多
关键词 小鼠 密闭环境 光照 束缚 睡眠障碍模型 下丘脑神经递质 血清激素 ELISA
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全域土地综合整治资金平衡路径与机制优化研究
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作者 杨培源 《乡村科技》 2025年第19期42-46,共5页
根据我国全域土地综合整治的实际情况,全面梳理现阶段土地综合整治存在的问题。研究发现,全域土地综合整治工作的推进,不仅会受自然资源条件的限制,而且在资金平衡路径上存在问题。这些问题主要体现在资金缺口频繁出现、投融资体制尚未... 根据我国全域土地综合整治的实际情况,全面梳理现阶段土地综合整治存在的问题。研究发现,全域土地综合整治工作的推进,不仅会受自然资源条件的限制,而且在资金平衡路径上存在问题。这些问题主要体现在资金缺口频繁出现、投融资体制尚未完善、利益分配机制存在结构性漏洞等方面。为解决这一系列问题,该研究总结了广东省、浙江省、湖北省、湖南省等地的成功经验,在此基础上提出了一系列关于全域土地综合整治资金平衡优化路径:一是构建“国企平台+社会资本”投融资模式,提高全域土地综合整治的资金供给与保障能力;二是改革土地整治指标交易体系,保障土地整治资金实现有效回流;三是完善多方参与的土地整治收益分配机制,增强治理内生动力。在未来,还需要从政策扶持、制度保障、技术支撑等方面不断努力,因地制宜创造出符合不同地域特征且系统协调的整治模式,进而为守住耕地保护红线提供支撑。 展开更多
关键词 全域土地综合整治 资金平衡 投融资模式 利益分配机制 激励约束机制
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考虑碳排放时空演变特征的火力发电时序协调优化模型
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作者 罗德海 颜绍霖 +3 位作者 韩学波 罗代强 黄烈明 徐松超 《微型电脑应用》 2025年第4期170-173,共4页
随着电力行业的深化改革,火力发电具有良好的发展前景,它具有结构灵活、施工时间短等特点,但是对大气和环保造成了严重的影响。与此同时,在减少二氧化碳排放量的前提下,应针对不同时期的出力情况,需要进行火力发电优化。为此,提出了考... 随着电力行业的深化改革,火力发电具有良好的发展前景,它具有结构灵活、施工时间短等特点,但是对大气和环保造成了严重的影响。与此同时,在减少二氧化碳排放量的前提下,应针对不同时期的出力情况,需要进行火力发电优化。为此,提出了考虑碳排放时空演变特征的火力发电时序协调优化模型。计算碳排放时空演变特征,在考虑碳排放时空演变特征的基础上,将火力发电时碳排放量最小化和火力发电厂利润最大化作为目标函数,设置火力发电机组总发电负荷、某时间输出功率和爬坡约束条件,建立了火力发电时序协调优化模型,利用交互式极大极小的逐步宽容约束方法,对其进行了求解,以达到对火力发电的协同最优控制。实验结果表明,所提方法的火力发电时序协调优化效果较好,能够有效控制火力发电时碳排放量。 展开更多
关键词 碳排放 时空演变特征 火力发电 逐步宽容约束法 时序协调优化模型
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