The tumor microenvironment(TME)-activatable probes have proven effective in enhancing the signalto-background ratio(SBR)for precise fluorescence imaging in tumor diagnosis.However,many fluorophores have suboptimal emi...The tumor microenvironment(TME)-activatable probes have proven effective in enhancing the signalto-background ratio(SBR)for precise fluorescence imaging in tumor diagnosis.However,many fluorophores have suboptimal emission spectra and a short Stokes shift,which may lead to overlap with bioautofluorescence,excitation,and emission spectra,limiting their use in intraoperative guidance.Herein,aγ-glutathione(GSH)responsive near-infrared(NIR)BODIPY probe,named“Pro-Dye”was synthesized with a large Stokes shift of 91 nm.The Pro-Dye can be rapidly and specifically activated by high concentrations of GSH both in solution and inside cancer cells,while remaining inactive in normal cells(Human umbilical vein endothelial cells,HUVECs).The Pro-Dye was further encapsulated by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-5000(DSPE-PEG5000)to form Pro-Dye nanoparticles(NPs),making it water-dispersible for in vivo application.In vivo fluorescence imaging demonstrated that Pro-Dye NPs can accumulate at the tumor and exhibit an improved SBR compared to the“alwayson”probe(Dye NPs).Moreover,the tumor can be precisely resected under the real-time guidance of fluorescence imaging of Pro-Dye NPs,showing a well-defined tumor margin.展开更多
Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials prov...Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.展开更多
Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for di...Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for diabetic patients.Most of the activated dual-modal probes are usually activated by single factor stimulation,which greatly reduces the diagnostic accuracy of liver injury.Here,a novel cysteine(Cys)/homocysteine(Hcy)and viscosity-enhanced dual-modal probe DAL was developed for the first time to monitor diabetic liver injury and its repair process.In the presence of Cys/Hcy,the near-infrared fluorescence(NIRF)and photoacoustic(PA)signals of the probe DAL were activated,with further signal enhancement in high viscosity environments.This Cys/Hcy and viscosity cascade probe exhibits heightened sensitivity and enhanced anti-interference capabilities,contributing to the advancement of liver injury diagnosis accuracy.In addition,the probe DAL shows exceptional mitochondrial targeting ability,enabling sensitive monitoring of Cys/Hcy and viscosity alterations within mitochondria.Based on NIRF/PA dual-modal imaging technology,the probe was successfully used for the first time in a mouse diabetic liver injury model to evaluate the extent of liver damage and the repair process by tracking the levels of Cys/Hcy and viscosity.Therefore,the two-factor activated dual-modal probe developed in this study provides a powerful instrument for accurate diagnosis and efficacy evaluation of complications related to diabetes.展开更多
Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapi...Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.展开更多
A novel[3]rotaxane,featuring two hydrogen-bonded aramide azo-macrocycles mechanically interlocked on a dumbbell with distinct recognition sites,a secondary dialkylammonium(AM)unit and a 4,4'-bipyridinium(BP)unit,h...A novel[3]rotaxane,featuring two hydrogen-bonded aramide azo-macrocycles mechanically interlocked on a dumbbell with distinct recognition sites,a secondary dialkylammonium(AM)unit and a 4,4'-bipyridinium(BP)unit,has been synthesized.This multi-stimuli-responsive[3]rotaxane exhibits unique molecular motion,with the macrocycles shuttling along the axle in response to acid-base reactions,temperature changes,solvent variations,and light irradiation.The molecular shuttle and reversibility were investigated by^(1)H NMR,2D NOESY,HRESI-MS,and UV-vis spectroscopy.This study provides a rare example of a higher order rotaxane with multi-stimuli responsiveness,highlighting its potential for multi-state control over the motion of interlocked rings on an axle.The ability to manipulate the molecular motion of the macrocycles through various external triggers offers insights for future developments in molecular machinery and adaptive materials.展开更多
Black wings of butterfly Ornithoptera goliath and infrared-band radiative cooling function of Rapala dioetas butterfly wings are associated with black pigment(e.g.,melanin)and unique hierarchical micro/nanostructures,...Black wings of butterfly Ornithoptera goliath and infrared-band radiative cooling function of Rapala dioetas butterfly wings are associated with black pigment(e.g.,melanin)and unique hierarchical micro/nanostructures,greatly stimulating biomimetic fabrication of functional photonic structures but mainly targeted to one prototype.Targeted at two-prototype integrated biomimetic fabrication from fully compositional/structural/functional aspects,femtosecond(fs)laser subtractive/additive-integrated hierarchical micro/nano-manufacturing technique is proposed in this work.This technique can one-step transfer refractory metals(e.g.,W,Mo,Nb,Ta)into black non-stoichiometric oxide nanomaterials with abundant oxygen vacancies and simultaneously enable the realization of in situ quasi-controllable micro/nanoscale hierarchical aggregation and assembly,all displaying black color but with tunable infrared emission.Adjusting the scan interval for biomimetic manufacturing can tailor the structural oxidation degree,the emission in the long-wave infrared(LWIR)band while keeping the blackness of hierarchical aggregates,and the confined height between the covering quartz plate and the ablated sample.The blackening efficiency of this technique can reach∼11.25 cm^(2)·min^(−1),opening opportunities for high-throughput optical/thermal applications.Selectively patterned Chinese characters,Arabic numbers,and English letters are easily fabricable,which are intrinsically invisible-infrared dual-band encrypted but decryptable via static/dynamic environment stimuli(e.g.,sample heating/cooling,introducing external hot/cold sources including human hands).The self-evolution from‘orderless’structuring to‘ordered’functionalization is validated for the proposed fs laser subtractive/additive-integrated biomimetic manufacturing,specifically from the synthesis of diverse black nanomaterials and the seemingly disordered micro/nano-aggregates to the ordered optical/thermal regulation capacities for a delicate modulation of information encryption and decryption,unveiling a new concept for future exploration and extension.展开更多
Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections.Herein,we developed a close-packed and ordered Au@AgPt array coupled with a cas...Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections.Herein,we developed a close-packed and ordered Au@AgPt array coupled with a cascade triggering strategy for surface-enhanced Raman scattering(SERS)and colorimetric identification of the Staphylococcus aureus biomarker micrococcal nuclease(MNase)in serum samples.The trimetallic Au@AgPt nanozymes can catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)molecules to SERS-enhanced oxidized TMB(oxTMB),accompanied by the color change from colorless to blue.In the presence of S.aureus,the secreted MNase preferentially cut the nucleobase AT-rich regions of DNA sequences on magnetic beads(MBs)to release alkaline phosphatase(ALP),which subsequently mediated the oxTMB reduction for inducing the colorimetric/SERS signal fade away.Using this“on-to-off”triggering strategy,the target S.aureus can be recorded in a wide linear range with a limit of detection of 38 CFU/mL in the colorimetric mode and 6 CFU/mL in the SERS mode.Meanwhile,the MNase-mediated strategy characterized by high specificity and sensitivity successfully discriminated between patients with sepsis(n=7)and healthy participants(n=3),as well as monitored the prognostic progression of the disease(n=2).Overall,benefiting from highly active and dense“hot spot”substrate,MNase-mediated cascade response strategy,and colorimetric/SERS dual-signal output,this methodology will offer a promising avenue for the early diagnosis of S.aureus infection.展开更多
Superhydrophobic/superhydrophilic antifouling materials are widely used to solve the severe water pollution and bio-adhesion of marine equipment.However,conventional antifouling materials rely on the static superwetta...Superhydrophobic/superhydrophilic antifouling materials are widely used to solve the severe water pollution and bio-adhesion of marine equipment.However,conventional antifouling materials rely on the static superwettability of surfaces,which suffer from poorly sustained antifouling effects.Inspired by the unique dynamic antifouling strategies of Calliphora Vicina wing surface based on the hydrophobic micro-cilia arrays,a Biomimetic Magnetic-Responsive Antifouling Surface(BMRAS)is designed and fabricated using a method combining UV lithography and an inverse molding.The BMRAS is coated by high-aspect-ratio micro-cilia,which are filled with synthesized magnetic Fe3O4 nanoparticles.The bioinspired hydrophobic micro-cilia arrays endow the BMRAS with excellent intrinsic superhydrophobicity,benefiting from the high-aspect-ratio feature and roughness effect.Remarkably,the static contact angle is more than 156.9±1.6°and the rolling angle is less than 2.3±0.3°.The synthesized magnetic nanomaterials play a key role in implementing dynamic antifouling strategies.On the one hand,the surface tension can be adjusted as required under magnetically controlled oscillations.On the other hand,the doping of magnetic nanomaterials can enhance mechanical properties and reduce capillary force-induced aggregation of high-aspect-ratio micro-cilia.The antifouling tests demonstrate that the chemically modified micro-cilia can effectively expel gravels under the stimulation of an external magnetic field and enable the BMRAS to achieve dynamic self-cleaning.Specifically,0.17 g gravel distributed on BMRAS can be completely cleaned up within 0.296 s,which improved by 14.2%compared with the flat materials.This work provides a brief and effective strategy for designing dynamic antifouling surfaces with excellent physicochemical durability and great potential value in the applications of marine fouling.展开更多
In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain sta...In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.展开更多
Glycyrrhetinic acid(GA)sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver,however,the limitation of commonly used macromolecular GA modification approaches as well as ...Glycyrrhetinic acid(GA)sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver,however,the limitation of commonly used macromolecular GA modification approaches as well as the application gap across various vector have constrained its use.In this study,we proposed a novel perspective to break out,disulfide bonds(SS)were employed as linkage to facilitate GA modification,which allowed further connections with various carriers,while provided additional glutathione(GSH)-responsive property.The superiority of GA-disulfide conjunction was validated using mesoporous silica nanoparticles(MSN)as model carriers,chemotherapeutic drug(doxorubicin)and photosensitizer(indocyanine green)were loaded into MSN-SS-GA to further achieve chemo-photothermal synergistic anti-tumor therapy.Based on results from multiple evaluations,the GA-disulfide drafted MSN(DI/MSN-SS-GA)demonstrated expected liver tumor targeting effect and exhibited GSH-stimuli release property to reduce preleakage.Taken together,this study presents an effective chemo-photothermal therapy for liver cancer(88.26%),offers a potential,robust and straightforward strategy on GA application for enhancing liver targeting therapy.展开更多
Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials...Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials(PCMs).Magnetically-responsive phase change thermal storage materials are considered an emerging concept for energy storage systems,enabling PCMs to perform unprecedented functions(such as green energy utilization,magnetic thermotherapy,drug release,etc.).The combination of multifunctional magnetic nanomaterials and PCMs is a milestone in the creation of advanced multifunctional composite PCMs.However,a timely and comprehensive review of composite PCMs based on magnetic nanoparticle modification is still missing.Herein,we furnish an exhaustive exposition elucidating the cutting-edge advancements in magnetically responsive composite PCMs.We delve deeply into the multifarious roles assumed by distinct nanoparticles within composite PCMs of varying dimensions,meticulously scrutinizing the intricate interplay between their architectures and thermophysical attributes.Moreover,we prognosticate future research trajectories,delineate alternative stratagems,and illuminate prospective avenues.This review is intended to stimulate broader academic interest in interdisciplinary fields and provide valuable insights into the development of next-generation magnetically-responsive composite PCMs.展开更多
Control crosslink network and chain connectivity are essential to develop shape memory polymers(SMPs)with high shape memory capabilities,adjustable response temperature,and satisfying mechanistical properties.In this ...Control crosslink network and chain connectivity are essential to develop shape memory polymers(SMPs)with high shape memory capabilities,adjustable response temperature,and satisfying mechanistical properties.In this study,novel poly(ε-caprolactone)(PCL)-poly(2-vinyl)ethylene glycol(PVEG)copolymers bearing multi-pendant vinyl groups is synthesized by branched-selective allylic etherification polymerization of vinylethylene carbonate(VEC)with linear and tetra-arm PCLs under a synergistic catalysis of palladium complex and boron reagent.Facile thiol-ene photo-click reaction of PCL-PVEG copolymers with multifunctional thiols can rapidly access a serious crosslinked SMPs with high shape memory performance.The thermal properties,mechanical properties and response temperature of the obtained SMPs are tunable by the variation of PCL prepolymers,vinyl contents and functionality of thiols.Moreover,high elastic modulus in the rubbery plateau region can be maintained effectively owing to high-density topological networks of the PCL materials.In addition,the utility of the present SMPs is further demonstrated by the post-functionalization via thiol-ene photo-click chemistry.展开更多
Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs t...Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs to form amphiphilic prodrug molecules with self-assembly characteristics.Upon stimulation by specific factors in the tumor microenvironment,these amphiphilic prodrug molecules can release drugs at precise sites within the tumor.These strategies significantly increase the drug concentration at the tumor site while effectively reducing the damage of anti-cancer drugs to normal tissues.Owing to the advanced delivery strategies such as synergistic administration and controlled drug release,tumor microenvironment-responsive drug self-delivery systems hold great potential for treating malignant tumors with multidrug resistance(MDR).At the same time,the stimulus-reactivity of metal complexes provides an important opportunity to design site-specific prodrugs that can maximize therapeutic efficacy while minimizing adverse side effects of metal drugs.This innovative drug design complements the tumor microenvironment-responsive self-delivery system,providing more feasible therapeutic strategies and possibilities in the field of cancer therapy and drug delivery.This work provides a comprehensive review of recent advancements in drug self-delivery systems,offering insights into their potential applications in cancer therapy and MDR reversal.展开更多
Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of tran...Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional devices.Herein,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is proposed.The TMN consisted of a bilayer microneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and SOS.PNIPAM accelerates drug release by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regeneration and epithelial formation.The results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80% in the 10th h,and the antibacterial rate of TMN could reach 800%.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.展开更多
Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been re...Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been revealed in the past ten years,it is still unclear if the pH-responsive properties of SPBs are affected by the brush thickness.In this study,we employed the positively charged poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride(PMETAC)and negatively charged sodium poly(styrenesulfonate)(NaPSS)brushes as model systems to explore the effect of thickness on the pH-responsive properties of SPBs.The results demonstrate that the pH-responsive properties of SPBs manifest different dependences on the brush thickness.Specifically,for both PMETAC and NaPSS brushes,the pH-responsive hydration and stiffness are influenced by the thickness,and the pH-responsive wettability and adhesion are almost unaffected by the thickness.This work not only provides a clear understanding of the relationship between the brush thickness and the pH responsiveness of SPBs,but also offers a new method to control the pH-responsive properties of SPBs.展开更多
Background:Nonsuicidal self-injury(NSSI)in adolescents with depression disorders often exhibits addictive patterns,potentially linked to serum beta-endorphin levels and neural reward responsiveness.Beta-endorphin,invo...Background:Nonsuicidal self-injury(NSSI)in adolescents with depression disorders often exhibits addictive patterns,potentially linked to serum beta-endorphin levels and neural reward responsiveness.Beta-endorphin,involved in reward processing,alongside dysregulated neural reward pathways,may reinforce self-injurious behaviors,highlighting the need to explore these mechanisms.Methods:Adolescents(aged 12-17 years)with depression disorders were divided into an NSSI group(21 subjects)and a control group(11 subjects)according to inclusion criteria.Serum beta-endorphin concentration was measured using the enzyme-linked immunosorbent assay method.The Addiction Factor Scale was used to assess addiction levels.Statistical analyses were con-ducted using SPSS 25.0.The oxygenated hemoglobin response signal was detected using functional near-infrared spectroscopy.Analyses were performed using NIRS_KIT 2.0.Results:Compared with the control group,the NSSI group exhibited lower serum beta-endorphin concentration.Additionally,85.7%of those in the NSSI group displayed addictive behaviors,and serum beta-endorphin concentration was negatively correlated with the Addiction Factor Scale score.The reward task activated channels 17,20,and 21(corresponding to the dorsolateral prefrontal cortex[PFC]and frontopolar PFC)in the gain condition and channels 20 and 21 in the loss condition.The oxygenated hemoglobin concentration of the differential waveform(Δ[oxy-Hb])of channel 12(corresponding to the frontopolar PFC)correlated positively with the Addiction Factor Scale score and negatively with the serum beta-endorphin concentration.展开更多
Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-in...Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma.Herein,we reported an infectious microenvironment responsive bimetallic sulfide(FeCuS_(x),FCS)combining with near infrared(NIR)irradiation for maxillofacial trauma therapy.In cellular levels,FCS exhibited the most efficient antioxidant and anti-inflammatory,cell migration,and angiogenesis behaviors through down-regulating the inflammatory factor(iNOS)expression level,up-regulating anti-inflammatory factors(Arg^(-1)and TGF-β)expression level,inducing macrophages M2 polarization(CD86down-regulation and CD206 up-regulation),and promoting tissue repair factors(CD31)expression level.Besides,it presented the excellent antibacterial ability of Escherichia coli(99.74%)and MRSA(99.78%)for FCS+NIR.Significantly,it also confirmed that FCS+NIR presented the excellent functions of inhibiting wound infections,decreasing wound inflammation,as well as promoting trauma tissue repairing.Altogether,it had developed the strategy of FCS+NIR for the synergistic enhancement of infectious maxillofacial trauma healing,could also serve as a promising therapeutic strategy for the treatment of infectious diseases.展开更多
The state-space neural network and extended Kalman filter model is used to directly predict the optimal timing plan that corresponds to futuristic traffic conditions in real time with the purposes of avoiding the lagg...The state-space neural network and extended Kalman filter model is used to directly predict the optimal timing plan that corresponds to futuristic traffic conditions in real time with the purposes of avoiding the lagging of the signal timing plans to traffic conditions. Utilizing the traffic conditions in current and former intervals, the network topology of the state-space neural network （SSNN）, which is derived from the geometry of urban arterial routes, is used to predict the optimal timing plan corresponding to the traffic conditions in the next time interval. In order to improve the effectiveness of the SSNN, the extended Kalman filter （EKF） is proposed to train the SSNN instead of conventional approaches. Raw traffic data of the Guangzhou Road, Nanjing and the optimal signal timing plan generated by a multi-objective optimization genetic algorithm are applied to test the performance of the proposed model. The results indicate that compared with the SSNN and the BP neural network, the proposed model can closely match the optimal timing plans in futuristic states with higher efficiency.展开更多
基金supported by the Natural Science Foundation of Shaanxi Province(Nos.2023-YBSF-270,2024SF-ZDCYL-02-08)Fundamental Research Funds for the Central Universities(No.xzy022024033)+2 种基金Horizontal Project of the First Affiliated Hospital of Xi’an Jiaotong University(No.202304174)supported by the Opening Project of Structural Optimization and Application of Functional Molecules Key Laboratory of Sichuan Province(No.2023GNFZ-03)The Key Laboratory for Screening and Diagnosis of Maternal and Child Genetic Disease of Health Commission of Jiangxi Province.
文摘The tumor microenvironment(TME)-activatable probes have proven effective in enhancing the signalto-background ratio(SBR)for precise fluorescence imaging in tumor diagnosis.However,many fluorophores have suboptimal emission spectra and a short Stokes shift,which may lead to overlap with bioautofluorescence,excitation,and emission spectra,limiting their use in intraoperative guidance.Herein,aγ-glutathione(GSH)responsive near-infrared(NIR)BODIPY probe,named“Pro-Dye”was synthesized with a large Stokes shift of 91 nm.The Pro-Dye can be rapidly and specifically activated by high concentrations of GSH both in solution and inside cancer cells,while remaining inactive in normal cells(Human umbilical vein endothelial cells,HUVECs).The Pro-Dye was further encapsulated by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-5000(DSPE-PEG5000)to form Pro-Dye nanoparticles(NPs),making it water-dispersible for in vivo application.In vivo fluorescence imaging demonstrated that Pro-Dye NPs can accumulate at the tumor and exhibit an improved SBR compared to the“alwayson”probe(Dye NPs).Moreover,the tumor can be precisely resected under the real-time guidance of fluorescence imaging of Pro-Dye NPs,showing a well-defined tumor margin.
基金supported by Natural Science Foundation of Jilin Province(No.SKL202302002)Key Research and Development project of Jilin Provincial Science and Technology Department(No.20210204142YY)+2 种基金The Science and Technology Development Program of Jilin Province(No.2020122256JC)Beijing Kechuang Medical Development Foundation Fund of China(No.KC2023-JX-0186BQ079)Talent Reserve Program(TRP),the First Hospital of Jilin University(No.JDYY-TRP-2024007)。
文摘Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.
基金financially supported by the National Natural Science Foundation of China(Nos.21877048,22077048,and 22277014)Guangxi Natural Science Foundation(Nos.2021GXNSFDA075003,AD21220061)the Startup Fund of Guangxi University(No.A3040051003).
文摘Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for diabetic patients.Most of the activated dual-modal probes are usually activated by single factor stimulation,which greatly reduces the diagnostic accuracy of liver injury.Here,a novel cysteine(Cys)/homocysteine(Hcy)and viscosity-enhanced dual-modal probe DAL was developed for the first time to monitor diabetic liver injury and its repair process.In the presence of Cys/Hcy,the near-infrared fluorescence(NIRF)and photoacoustic(PA)signals of the probe DAL were activated,with further signal enhancement in high viscosity environments.This Cys/Hcy and viscosity cascade probe exhibits heightened sensitivity and enhanced anti-interference capabilities,contributing to the advancement of liver injury diagnosis accuracy.In addition,the probe DAL shows exceptional mitochondrial targeting ability,enabling sensitive monitoring of Cys/Hcy and viscosity alterations within mitochondria.Based on NIRF/PA dual-modal imaging technology,the probe was successfully used for the first time in a mouse diabetic liver injury model to evaluate the extent of liver damage and the repair process by tracking the levels of Cys/Hcy and viscosity.Therefore,the two-factor activated dual-modal probe developed in this study provides a powerful instrument for accurate diagnosis and efficacy evaluation of complications related to diabetes.
基金supported by the National Natural Science Foundation of China(Nos.52025132,U24A20205,52303373,21621091,22021001,and 22121001)the China Postdoctoral Science Foundation(No.2024M763174)+2 种基金the 111 Project(Nos.B17027,B16029)the Natural Science Foundation of Fujian Province of China(No.2022J02059)the New Cornerstone Science Foundation through the Xplorer Prize。
文摘Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.
基金supported by the National Natural Science Foundation of China(No.22271202 to L.Yuan,No.22201193 to X.Li)the Sichuan Science and Technology Program(No.2023NSFSC0109 to X.Li)+2 种基金the Fundamental Research Funds for the Central Universities and the Hundred Talent Program of Sichuan University(No.YJ2021158 to X.Li)Sichuan University Interdisciplinary Innovation Fund(X.Li)Open Project of State Key Laboratory of Supramolecular Structure and Materials(No.SKLSSM2024037)。
文摘A novel[3]rotaxane,featuring two hydrogen-bonded aramide azo-macrocycles mechanically interlocked on a dumbbell with distinct recognition sites,a secondary dialkylammonium(AM)unit and a 4,4'-bipyridinium(BP)unit,has been synthesized.This multi-stimuli-responsive[3]rotaxane exhibits unique molecular motion,with the macrocycles shuttling along the axle in response to acid-base reactions,temperature changes,solvent variations,and light irradiation.The molecular shuttle and reversibility were investigated by^(1)H NMR,2D NOESY,HRESI-MS,and UV-vis spectroscopy.This study provides a rare example of a higher order rotaxane with multi-stimuli responsiveness,highlighting its potential for multi-state control over the motion of interlocked rings on an axle.The ability to manipulate the molecular motion of the macrocycles through various external triggers offers insights for future developments in molecular machinery and adaptive materials.
基金financially supported by Shanghai Pujiang Program 23PJ1406500.
文摘Black wings of butterfly Ornithoptera goliath and infrared-band radiative cooling function of Rapala dioetas butterfly wings are associated with black pigment(e.g.,melanin)and unique hierarchical micro/nanostructures,greatly stimulating biomimetic fabrication of functional photonic structures but mainly targeted to one prototype.Targeted at two-prototype integrated biomimetic fabrication from fully compositional/structural/functional aspects,femtosecond(fs)laser subtractive/additive-integrated hierarchical micro/nano-manufacturing technique is proposed in this work.This technique can one-step transfer refractory metals(e.g.,W,Mo,Nb,Ta)into black non-stoichiometric oxide nanomaterials with abundant oxygen vacancies and simultaneously enable the realization of in situ quasi-controllable micro/nanoscale hierarchical aggregation and assembly,all displaying black color but with tunable infrared emission.Adjusting the scan interval for biomimetic manufacturing can tailor the structural oxidation degree,the emission in the long-wave infrared(LWIR)band while keeping the blackness of hierarchical aggregates,and the confined height between the covering quartz plate and the ablated sample.The blackening efficiency of this technique can reach∼11.25 cm^(2)·min^(−1),opening opportunities for high-throughput optical/thermal applications.Selectively patterned Chinese characters,Arabic numbers,and English letters are easily fabricable,which are intrinsically invisible-infrared dual-band encrypted but decryptable via static/dynamic environment stimuli(e.g.,sample heating/cooling,introducing external hot/cold sources including human hands).The self-evolution from‘orderless’structuring to‘ordered’functionalization is validated for the proposed fs laser subtractive/additive-integrated biomimetic manufacturing,specifically from the synthesis of diverse black nanomaterials and the seemingly disordered micro/nano-aggregates to the ordered optical/thermal regulation capacities for a delicate modulation of information encryption and decryption,unveiling a new concept for future exploration and extension.
基金supported by the National Natural Science Foundation of China(Grant Nos.:82373833,22177039,and 82304438)the National Key Research and Development Program of China(Grant No.:2021YFC2300400)Guangdong Basic and Applied Basic Research Foundation,China(Grant Nos.:2024A1515012204,2022A1515010300,and 2022A1515110618).
文摘Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections.Herein,we developed a close-packed and ordered Au@AgPt array coupled with a cascade triggering strategy for surface-enhanced Raman scattering(SERS)and colorimetric identification of the Staphylococcus aureus biomarker micrococcal nuclease(MNase)in serum samples.The trimetallic Au@AgPt nanozymes can catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)molecules to SERS-enhanced oxidized TMB(oxTMB),accompanied by the color change from colorless to blue.In the presence of S.aureus,the secreted MNase preferentially cut the nucleobase AT-rich regions of DNA sequences on magnetic beads(MBs)to release alkaline phosphatase(ALP),which subsequently mediated the oxTMB reduction for inducing the colorimetric/SERS signal fade away.Using this“on-to-off”triggering strategy,the target S.aureus can be recorded in a wide linear range with a limit of detection of 38 CFU/mL in the colorimetric mode and 6 CFU/mL in the SERS mode.Meanwhile,the MNase-mediated strategy characterized by high specificity and sensitivity successfully discriminated between patients with sepsis(n=7)and healthy participants(n=3),as well as monitored the prognostic progression of the disease(n=2).Overall,benefiting from highly active and dense“hot spot”substrate,MNase-mediated cascade response strategy,and colorimetric/SERS dual-signal output,this methodology will offer a promising avenue for the early diagnosis of S.aureus infection.
基金supported by the National Key Research and Development Program of China(2023YFB4605700)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52021003)+4 种基金the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(No.52222509)the Natural Science Foundation of Jilin Province(No.20220101220JC)the Defense Industrial Technology Development Program(JCKY2023130C001)Changbai Talents Plan of Jilin Province“Fundamental Research Funds for the Central Universities”.
文摘Superhydrophobic/superhydrophilic antifouling materials are widely used to solve the severe water pollution and bio-adhesion of marine equipment.However,conventional antifouling materials rely on the static superwettability of surfaces,which suffer from poorly sustained antifouling effects.Inspired by the unique dynamic antifouling strategies of Calliphora Vicina wing surface based on the hydrophobic micro-cilia arrays,a Biomimetic Magnetic-Responsive Antifouling Surface(BMRAS)is designed and fabricated using a method combining UV lithography and an inverse molding.The BMRAS is coated by high-aspect-ratio micro-cilia,which are filled with synthesized magnetic Fe3O4 nanoparticles.The bioinspired hydrophobic micro-cilia arrays endow the BMRAS with excellent intrinsic superhydrophobicity,benefiting from the high-aspect-ratio feature and roughness effect.Remarkably,the static contact angle is more than 156.9±1.6°and the rolling angle is less than 2.3±0.3°.The synthesized magnetic nanomaterials play a key role in implementing dynamic antifouling strategies.On the one hand,the surface tension can be adjusted as required under magnetically controlled oscillations.On the other hand,the doping of magnetic nanomaterials can enhance mechanical properties and reduce capillary force-induced aggregation of high-aspect-ratio micro-cilia.The antifouling tests demonstrate that the chemically modified micro-cilia can effectively expel gravels under the stimulation of an external magnetic field and enable the BMRAS to achieve dynamic self-cleaning.Specifically,0.17 g gravel distributed on BMRAS can be completely cleaned up within 0.296 s,which improved by 14.2%compared with the flat materials.This work provides a brief and effective strategy for designing dynamic antifouling surfaces with excellent physicochemical durability and great potential value in the applications of marine fouling.
基金supported by the General Program of the National Natural Science Foundation of China(52074335)the National Key Research and Development Program of China(2022YFE0129900 and 2019YFA0708700)+1 种基金the Fundamental Research Funds for the Central Universities(23CX07003A)the Special Funding Program for the Operational Expenses of National Research Institutions(SKLDOG2024-ZYRC-01).
文摘In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.
基金funded by Research Project of Department of Education of Liaoning Province(No.LJKMZ20221363,China)。
文摘Glycyrrhetinic acid(GA)sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver,however,the limitation of commonly used macromolecular GA modification approaches as well as the application gap across various vector have constrained its use.In this study,we proposed a novel perspective to break out,disulfide bonds(SS)were employed as linkage to facilitate GA modification,which allowed further connections with various carriers,while provided additional glutathione(GSH)-responsive property.The superiority of GA-disulfide conjunction was validated using mesoporous silica nanoparticles(MSN)as model carriers,chemotherapeutic drug(doxorubicin)and photosensitizer(indocyanine green)were loaded into MSN-SS-GA to further achieve chemo-photothermal synergistic anti-tumor therapy.Based on results from multiple evaluations,the GA-disulfide drafted MSN(DI/MSN-SS-GA)demonstrated expected liver tumor targeting effect and exhibited GSH-stimuli release property to reduce preleakage.Taken together,this study presents an effective chemo-photothermal therapy for liver cancer(88.26%),offers a potential,robust and straightforward strategy on GA application for enhancing liver targeting therapy.
基金financially supported by the National Natural Science Foundation of China(No.51902025).
文摘Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials(PCMs).Magnetically-responsive phase change thermal storage materials are considered an emerging concept for energy storage systems,enabling PCMs to perform unprecedented functions(such as green energy utilization,magnetic thermotherapy,drug release,etc.).The combination of multifunctional magnetic nanomaterials and PCMs is a milestone in the creation of advanced multifunctional composite PCMs.However,a timely and comprehensive review of composite PCMs based on magnetic nanoparticle modification is still missing.Herein,we furnish an exhaustive exposition elucidating the cutting-edge advancements in magnetically responsive composite PCMs.We delve deeply into the multifarious roles assumed by distinct nanoparticles within composite PCMs of varying dimensions,meticulously scrutinizing the intricate interplay between their architectures and thermophysical attributes.Moreover,we prognosticate future research trajectories,delineate alternative stratagems,and illuminate prospective avenues.This review is intended to stimulate broader academic interest in interdisciplinary fields and provide valuable insights into the development of next-generation magnetically-responsive composite PCMs.
基金financially supported by the National Natural Science Foundation of China(No.22171182)Sichuan Tianfu Emei Plan.
文摘Control crosslink network and chain connectivity are essential to develop shape memory polymers(SMPs)with high shape memory capabilities,adjustable response temperature,and satisfying mechanistical properties.In this study,novel poly(ε-caprolactone)(PCL)-poly(2-vinyl)ethylene glycol(PVEG)copolymers bearing multi-pendant vinyl groups is synthesized by branched-selective allylic etherification polymerization of vinylethylene carbonate(VEC)with linear and tetra-arm PCLs under a synergistic catalysis of palladium complex and boron reagent.Facile thiol-ene photo-click reaction of PCL-PVEG copolymers with multifunctional thiols can rapidly access a serious crosslinked SMPs with high shape memory performance.The thermal properties,mechanical properties and response temperature of the obtained SMPs are tunable by the variation of PCL prepolymers,vinyl contents and functionality of thiols.Moreover,high elastic modulus in the rubbery plateau region can be maintained effectively owing to high-density topological networks of the PCL materials.In addition,the utility of the present SMPs is further demonstrated by the post-functionalization via thiol-ene photo-click chemistry.
基金supported by the National Natural Science Foundation of China(No.21907059)Shandong Province Chinese Medicine Science and Technology Development Project(No.M-2022258)+1 种基金the Young Scientist Development Foundation of Shandong First Medical University(No.202201-002)the Academic Promotion Program of Shandong First Medical University(Nos.2019LJ003 and 2019QL011).
文摘Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs to form amphiphilic prodrug molecules with self-assembly characteristics.Upon stimulation by specific factors in the tumor microenvironment,these amphiphilic prodrug molecules can release drugs at precise sites within the tumor.These strategies significantly increase the drug concentration at the tumor site while effectively reducing the damage of anti-cancer drugs to normal tissues.Owing to the advanced delivery strategies such as synergistic administration and controlled drug release,tumor microenvironment-responsive drug self-delivery systems hold great potential for treating malignant tumors with multidrug resistance(MDR).At the same time,the stimulus-reactivity of metal complexes provides an important opportunity to design site-specific prodrugs that can maximize therapeutic efficacy while minimizing adverse side effects of metal drugs.This innovative drug design complements the tumor microenvironment-responsive self-delivery system,providing more feasible therapeutic strategies and possibilities in the field of cancer therapy and drug delivery.This work provides a comprehensive review of recent advancements in drug self-delivery systems,offering insights into their potential applications in cancer therapy and MDR reversal.
基金supported by the Joint Funds of National Natural Science Foundation of China(No.U22A20162)the Natural Science Foundation of Hebei Province of China(No.C2021202002)+1 种基金the National Natural Science Foundation of China(No.52271245),the Natural Science Foundation of Tianjin(No.21JCQNJC01280)the financial support from the Danish Council for Independent Research(9040-00219B),European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement ENSIGN(Project ID:101086226),L4DNANO(Project ID:101086227).
文摘Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional devices.Herein,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is proposed.The TMN consisted of a bilayer microneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and SOS.PNIPAM accelerates drug release by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regeneration and epithelial formation.The results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80% in the 10th h,and the antibacterial rate of TMN could reach 800%.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.
基金financially supported by the National Natural Science Foundation of China(Nos.22273098,52033001 and 22303032)the Key Project of Anhui Province Science and Technology Innovation Platform(No.S202305a12020030)+1 种基金the Science and Technology Program Project of Zhejiang Province,China(No.2025ZY01057)partially carried out at the USTC Center for Micro and Nanoscale Research and Fabrication。
文摘Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been revealed in the past ten years,it is still unclear if the pH-responsive properties of SPBs are affected by the brush thickness.In this study,we employed the positively charged poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride(PMETAC)and negatively charged sodium poly(styrenesulfonate)(NaPSS)brushes as model systems to explore the effect of thickness on the pH-responsive properties of SPBs.The results demonstrate that the pH-responsive properties of SPBs manifest different dependences on the brush thickness.Specifically,for both PMETAC and NaPSS brushes,the pH-responsive hydration and stiffness are influenced by the thickness,and the pH-responsive wettability and adhesion are almost unaffected by the thickness.This work not only provides a clear understanding of the relationship between the brush thickness and the pH responsiveness of SPBs,but also offers a new method to control the pH-responsive properties of SPBs.
基金supported by the National Natural Science Foundation of China(No.82260878)Guizhou Medical University Affiliated Hospital Doctoral Research Initiation Fund Project(gyfybsky-2021-44)+3 种基金Guizhou Provincial Science and Technology Plan Project(Qiankehe Achievements LC[2022]014)High-level Innovative Talents Cultivation Program of Guizhou Province(QianKeHe[2016]5679)Province Guiyang City Science and Technology Projects,Zhu Subjects Contract([2022]4-2-5)Guizhou Science and Technology Planning Project(QianKeHe[2020]4Y198).
文摘Background:Nonsuicidal self-injury(NSSI)in adolescents with depression disorders often exhibits addictive patterns,potentially linked to serum beta-endorphin levels and neural reward responsiveness.Beta-endorphin,involved in reward processing,alongside dysregulated neural reward pathways,may reinforce self-injurious behaviors,highlighting the need to explore these mechanisms.Methods:Adolescents(aged 12-17 years)with depression disorders were divided into an NSSI group(21 subjects)and a control group(11 subjects)according to inclusion criteria.Serum beta-endorphin concentration was measured using the enzyme-linked immunosorbent assay method.The Addiction Factor Scale was used to assess addiction levels.Statistical analyses were con-ducted using SPSS 25.0.The oxygenated hemoglobin response signal was detected using functional near-infrared spectroscopy.Analyses were performed using NIRS_KIT 2.0.Results:Compared with the control group,the NSSI group exhibited lower serum beta-endorphin concentration.Additionally,85.7%of those in the NSSI group displayed addictive behaviors,and serum beta-endorphin concentration was negatively correlated with the Addiction Factor Scale score.The reward task activated channels 17,20,and 21(corresponding to the dorsolateral prefrontal cortex[PFC]and frontopolar PFC)in the gain condition and channels 20 and 21 in the loss condition.The oxygenated hemoglobin concentration of the differential waveform(Δ[oxy-Hb])of channel 12(corresponding to the frontopolar PFC)correlated positively with the Addiction Factor Scale score and negatively with the serum beta-endorphin concentration.
基金financially supported by the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(Nos.2025GXNSFAA069283 and 2023GXNSFAA026264)Guangxi Science and Technology Base and Talent Special Project(No.GuikeAD21220008)+3 种基金the National Natural Science Foundation of China(No.82060195)Guangxi Medical and Health Suitable Technology Development and Popularization Applications Project(No.S2023093)the Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening,the Education Department of Guangxi Zhuang Autonomous Region(No.GXYWSX202404)the Major Talent Project of Guangxi Autonomous Region
文摘Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma.Herein,we reported an infectious microenvironment responsive bimetallic sulfide(FeCuS_(x),FCS)combining with near infrared(NIR)irradiation for maxillofacial trauma therapy.In cellular levels,FCS exhibited the most efficient antioxidant and anti-inflammatory,cell migration,and angiogenesis behaviors through down-regulating the inflammatory factor(iNOS)expression level,up-regulating anti-inflammatory factors(Arg^(-1)and TGF-β)expression level,inducing macrophages M2 polarization(CD86down-regulation and CD206 up-regulation),and promoting tissue repair factors(CD31)expression level.Besides,it presented the excellent antibacterial ability of Escherichia coli(99.74%)and MRSA(99.78%)for FCS+NIR.Significantly,it also confirmed that FCS+NIR presented the excellent functions of inhibiting wound infections,decreasing wound inflammation,as well as promoting trauma tissue repairing.Altogether,it had developed the strategy of FCS+NIR for the synergistic enhancement of infectious maxillofacial trauma healing,could also serve as a promising therapeutic strategy for the treatment of infectious diseases.
基金The National Natural Science Foundation of China (No.50422283)the Soft Science Research Project of Ministry of Housing and Urban-Rural Development of China (No.2008-K5-14)
文摘The state-space neural network and extended Kalman filter model is used to directly predict the optimal timing plan that corresponds to futuristic traffic conditions in real time with the purposes of avoiding the lagging of the signal timing plans to traffic conditions. Utilizing the traffic conditions in current and former intervals, the network topology of the state-space neural network （SSNN）, which is derived from the geometry of urban arterial routes, is used to predict the optimal timing plan corresponding to the traffic conditions in the next time interval. In order to improve the effectiveness of the SSNN, the extended Kalman filter （EKF） is proposed to train the SSNN instead of conventional approaches. Raw traffic data of the Guangzhou Road, Nanjing and the optimal signal timing plan generated by a multi-objective optimization genetic algorithm are applied to test the performance of the proposed model. The results indicate that compared with the SSNN and the BP neural network, the proposed model can closely match the optimal timing plans in futuristic states with higher efficiency.
