In this paper, we present numerically and experimentally the linear beam-optics distortion in the SSRF storage ring and the correction of optics by using a number of quadrupole magnets installed in the storage ring. T...In this paper, we present numerically and experimentally the linear beam-optics distortion in the SSRF storage ring and the correction of optics by using a number of quadrupole magnets installed in the storage ring. The measured orbit-response matrices were fitted to the model-response matrices to obtain the β and the dispersion functions in the storage ring. By readjusting the currents of quadrupole-magnet power supplies, we were able to successfully restore the optics parameters to values very close to the design ones, with rms deviations around 1%. This periodicity restoration is verified with the β function measurement.展开更多
In the management of unconfined aquifer systems, if the thickness of the aquifer is very small and the drawdown is relatively big, errors may arise when the superposition principle is adopted. directly. In allusion to...In the management of unconfined aquifer systems, if the thickness of the aquifer is very small and the drawdown is relatively big, errors may arise when the superposition principle is adopted. directly. In allusion to this limitation, a new management model for the management of unconfined aquifer systems called two-level response matrix method is put forward. This method is applied in groundwater resources management in Shenyang city. The managing results show that this method can, in some degree, increase the efficiency of management and decrease the risk of management.展开更多
In solving a response function by the boundary element method, the use of the singular valued method and the Laplace transform in a time domain makes the solving process be simplified and the result be accurate. The r...In solving a response function by the boundary element method, the use of the singular valued method and the Laplace transform in a time domain makes the solving process be simplified and the result be accurate. The restricted condition matrix formed by the response matrix method is much smaller than that by embedding method. In addition, the response function may realize directly the management decision making. So it is efficient for establishing and solving hydraulics management models.展开更多
Matrix metalloproteinase-9（MMP-9） plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier（BBB）,which has limited its use for the treatmen...Matrix metalloproteinase-9（MMP-9） plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier（BBB）,which has limited its use for the treatment of brain ischemia.In the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after stroke.Hypoxia response element（HRE）was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion.Lentiviruses were injected into the peri-infarct area on day 7 after transient ischemia.We found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV group.Furthermore,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT groups.Therefore,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke.展开更多
Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the A...Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the Asian yellow pond turtle Mauremys mutica（designated as MaMMP3）. The MaMMP3 cDNA is 1805 bp and consists of a 5＇-untranslated region（UTR） of 56 bp, a 3＇-UTR of 243 bp, and an open reading frame（ORF） of 1506 bp encoding 481 amino acids. Homology analysis of MaMMP3 revealed that the MaMMP3 shared 25%–63% similarity to other known MMP3 sequences. The genomic sequence covers 6007 bp. Comparative analysis of the cDNA sequence revealed that the Asian yellow pond turtle MMP3 has eight exons and seven introns. The phylogenetic tree showed that the MaMMP3 is closely related to Gallus gallus MMP3 and Taeniopygia guttata MMP3. The mRNA expression of the MaMMP3 in normal group without any bacterial challenge could be detected in all studied tissues including kidney, heart, live and spleen, with the highest level in the spleen. The results of immune challenge showed that the expression level of MaMMP3 was up-regulated in the spleen and liver. These results provided an important information for studying the roles of Asian yellow pond turtle MMP3 in immunity further.展开更多
Generally,to apply the MUltiple SIgnal Classification(MUSIC)algorithm for the rapid imaging of small objects,complete elements of the multi-static response(MSR)matrix must be collected.However,in some real-world appli...Generally,to apply the MUltiple SIgnal Classification(MUSIC)algorithm for the rapid imaging of small objects,complete elements of the multi-static response(MSR)matrix must be collected.However,in some real-world applications in microwave imaging,diagonal elements of theMSRmatrix are unknown.Nevertheless,it is possible to obtain imaging results using a traditional approach but theoretical reason of the applicability has not been investigated yet.In this paper,we consider the application of MUSIC for a fast identification of small objects from collected MSR matrix in both transverse magnetic(TM)and transverse electric(TE)polarizations.In order to examine the applicability,fundamental limitation,and various properties of MUSIC,we establish mathematical structure of the three imaging functions and explore that the main factors of the imaging functions are Bessel function of order zero,one,and two.The established structures demonstrate why the existence and location of small objects can be retrieved via MUSIC without the diagonal elements of the MSR matrix.Results of numerical simulations with noise-corrupted synthetic data are also provided to support the identified structures.展开更多
In groundwater management,the exchanges between groundwater and other water such as surface water and spring water need to be considered.Some exchange is dependent on the ground-water level,which is called covariate.T...In groundwater management,the exchanges between groundwater and other water such as surface water and spring water need to be considered.Some exchange is dependent on the ground-water level,which is called covariate.The pumping rate,groundwater level,and covariate interact and the relation of mutual-feed joint-variation is used to describe their interaction.This article presents a new approach of dealing with the relation in groundwater management model.The mathematical for-mulation of the relation,as an additional equality constraint in the optimization model,is developed using response matrix method.Thereby the groundwater management model with covariate is set up.The code for the simulation and management of groundwater system with covariate is programmed with Fortran 90,and the optimal pumping rate,groundwater level,and covariate are obtained.The approach is verified with a hypothetical case.Finally,the approach is applied to the groundwater management of Qianguo（前郭） area in western Jilin（吉林） Province.The results indicate that the ap-proach is feasible.It provides a universal solution for various covariates and reduces the computational complexity compared to iteration method.The approach is proven to be very efficient to solve ground-water management problem with covariate.展开更多
Background Most of the global orbit feedback algorithms in storage rings are based on response matrix(RM)singular value decomposition method.Commonly,the RM is the orbit distortion along the ring responding to the ste...Background Most of the global orbit feedback algorithms in storage rings are based on response matrix(RM)singular value decomposition method.Commonly,the RM is the orbit distortion along the ring responding to the steering magnet changes.For those methods RF frequency feedback is in a separated process.Methods and Results In this paper,the response matrix is expanded to the orbit distortion caused by the RF frequency variation.With this expanded RM,the orbit correction via steering magnet changes and RF frequency adjustment can be accomplished in one step.The commissioning results are carried out showing that the algorithm works stably.展开更多
As the stiffness of the elastic support varies with the physical-chemical erosion and mechanical friction, model catastrophe of a single degree-of-freedom(DOF) isolation system may occur. A 3-DOF four-point-elastic-su...As the stiffness of the elastic support varies with the physical-chemical erosion and mechanical friction, model catastrophe of a single degree-of-freedom(DOF) isolation system may occur. A 3-DOF four-point-elastic-support rigid plate(FERP) structure is presented to describe the catastrophic isolation system. Based on the newly-established structure, theoretical derivation for stiffness matrix calculation by free response(SMCby FR) and the method of stiffness identification by stiffness matrix disassembly(SIby SMD)are proposed. By integrating the SMCby FR and the SIby SMD and defining the stiffness assurance criterion(SAC), the procedures for stiffness identification of a FERP structure(SIFERP) are summarized. Then, a numerical example is adopted for the SIFERP validation, in which the simulated tested free response data are generated by the numerical methods, and operation for filtering noise is conducted to imitate the practical application. Results in the numerical example demonstrate the feasibility and accuracy of the developed SIFERP for stiffness identification.展开更多
In this paper, we consider a MUSIC algorithm for locating point-like scatterers contained in a sample on flat substrate. Based on an asymptotic expansion of the scattering amplitude proposed by Ammari et al., the reco...In this paper, we consider a MUSIC algorithm for locating point-like scatterers contained in a sample on flat substrate. Based on an asymptotic expansion of the scattering amplitude proposed by Ammari et al., the reconstruction problem can be reduced to a calculation of Green function corresponding to the background medium. In addition, we use an explicit formulation of Green function in the MUSIC algorithm to simplify the calculation when the cross-section of sample is a half-disc. Numerical experiments are included to demonstrate the feasibility of this method.展开更多
Combining hyperthermia and chemotherapy for maximum anticancer efficacy remains a challenge because drugtolerant cancer cells often evade this synergistic treatment due to drug resistance and asynchronous drug release...Combining hyperthermia and chemotherapy for maximum anticancer efficacy remains a challenge because drugtolerant cancer cells often evade this synergistic treatment due to drug resistance and asynchronous drug release.In this study,multifunctional scaffolds were designed to efficiently treat drug-tolerant breast cancer by improving the sensitization of breast cancer cells and synchronizing anticancer drug release with magnetic hyperthermia.The scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes,doxorubicin-encapsulated thermoresponsive liposomes and Fe_(3)O_(4)nanoparticles.The scaffolds could release microRNA specifically to improve the sensitization of breast cancer cells to anticancer drugs.The scaffolds also showed excellent hyperthermia effects under alternating magnetic field irradiation.Moreover,doxorubicin release was synchronized with magnetic hyperthermia.In vitro and in vivo studies demonstrated that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant MDA-MB-231 cells through the syner-gistic effect of magnetic hyperthermia and sensitizing chemotherapy.Additionally,the scaffolds could support the proliferation and adipogenic differentiation of stem cells for adipose tissue regeneration after killing cancer cells at a late therapeutic stage.These composite scaffolds offer an innovative strategy for treating breast cancer,with synergistic anticancer effects and regenerative functions.展开更多
If H and G are the transfer function matrix and the free response matrix of a linear finite automaton,then G is called a free response matrix matched to H.Given H,let(H)be the set of all possible free response matrice...If H and G are the transfer function matrix and the free response matrix of a linear finite automaton,then G is called a free response matrix matched to H.Given H,let(H)be the set of all possible free response matrices matched to H.A classification and an enumeration on the set(H)are given in this paper.展开更多
The burgeoning field of computational spectrometers is rapidly advancing,providing a pathway to highly miniaturized,on-chip systems for in-situ or portable measurements.The performance of these systems is typically li...The burgeoning field of computational spectrometers is rapidly advancing,providing a pathway to highly miniaturized,on-chip systems for in-situ or portable measurements.The performance of these systems is typically limited in its encoder section.The response matrix is largely compromised with redundancies,due to the periodic intensity or overly smooth responses.As such,the inherent interdependence among the physical size,resolution,and bandwidth of spectral encoders poses a challenge to further miniaturization progress.Achieving high spectral resolution necessitates a long optical path length,leading to a larger footprint required for sufficient spectral decorrelation,resulting in a limited detectable free-spectral range(FSR).Here,we report a groundbreaking ultraminiaturized disordered photonic molecule spectrometer that surpasses the resolution-bandwidth-footprint metric of current spectrometers.This computational spectrometer utilizes complicated electromagnetic coupling to determinately generate quasi-random spectral response matrices,a feature absents in other state-of-the-art systems,fundamentally overcoming limitations present in the current technologies.This configuration yields an effectively infinite FSR while upholding a high Q-factor(>7.74×10^(5)).Through dynamic manipulation of photon frequency,amplitude,and phase,a broad operational bandwidth exceeding 100 nm can be attained with an ultra-high spectral resolution of 8 pm,all encapsulated within an ultra-compact footprint measuring 70×50μm^(2).The disordered photonic molecule spectrometer is constructed on a CMOS-compatible integrated photonics platform,presenting a pioneering approach for high-performance and highly manufacturable miniaturized spectroscopy.展开更多
文摘In this paper, we present numerically and experimentally the linear beam-optics distortion in the SSRF storage ring and the correction of optics by using a number of quadrupole magnets installed in the storage ring. The measured orbit-response matrices were fitted to the model-response matrices to obtain the β and the dispersion functions in the storage ring. By readjusting the currents of quadrupole-magnet power supplies, we were able to successfully restore the optics parameters to values very close to the design ones, with rms deviations around 1%. This periodicity restoration is verified with the β function measurement.
基金This work was supported partly by the National Plan for Basic Studies of China under Grant G1999043606 and National Social Science Foundation under Grant 03CJL006
文摘In the management of unconfined aquifer systems, if the thickness of the aquifer is very small and the drawdown is relatively big, errors may arise when the superposition principle is adopted. directly. In allusion to this limitation, a new management model for the management of unconfined aquifer systems called two-level response matrix method is put forward. This method is applied in groundwater resources management in Shenyang city. The managing results show that this method can, in some degree, increase the efficiency of management and decrease the risk of management.
文摘In solving a response function by the boundary element method, the use of the singular valued method and the Laplace transform in a time domain makes the solving process be simplified and the result be accurate. The restricted condition matrix formed by the response matrix method is much smaller than that by embedding method. In addition, the response function may realize directly the management decision making. So it is efficient for establishing and solving hydraulics management models.
基金supported by the grants from the National Natural Science Foundation of China (U1232205)the National Basic Research Development Program (973 Program) of China (2011CB504405)+2 种基金the Science and Technology Commission of Shanghai Municipality, China (13140903500 and 13ZR1422600)Shanghai Jiao Tong University Foundation for Technological Innovation in Major Projects (12X190030021)the KC Wong Foundation
文摘Matrix metalloproteinase-9（MMP-9） plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier（BBB）,which has limited its use for the treatment of brain ischemia.In the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after stroke.Hypoxia response element（HRE）was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion.Lentiviruses were injected into the peri-infarct area on day 7 after transient ischemia.We found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV group.Furthermore,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT groups.Therefore,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke.
基金supported by the Ministry of Science and Technology funds (No. 2011GB23260021)Major State Basic Research Development Program of China (No. 2004CB117401)+1 种基金Science and Technology New Star from Guangzhou City (No. 2012089)Fundamental Research Funds from CAFS (No. 2012A0403)
文摘Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the Asian yellow pond turtle Mauremys mutica（designated as MaMMP3）. The MaMMP3 cDNA is 1805 bp and consists of a 5＇-untranslated region（UTR） of 56 bp, a 3＇-UTR of 243 bp, and an open reading frame（ORF） of 1506 bp encoding 481 amino acids. Homology analysis of MaMMP3 revealed that the MaMMP3 shared 25%–63% similarity to other known MMP3 sequences. The genomic sequence covers 6007 bp. Comparative analysis of the cDNA sequence revealed that the Asian yellow pond turtle MMP3 has eight exons and seven introns. The phylogenetic tree showed that the MaMMP3 is closely related to Gallus gallus MMP3 and Taeniopygia guttata MMP3. The mRNA expression of the MaMMP3 in normal group without any bacterial challenge could be detected in all studied tissues including kidney, heart, live and spleen, with the highest level in the spleen. The results of immune challenge showed that the expression level of MaMMP3 was up-regulated in the spleen and liver. These results provided an important information for studying the roles of Asian yellow pond turtle MMP3 in immunity further.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(NRF-2020R1A2C1A01005221).
文摘Generally,to apply the MUltiple SIgnal Classification(MUSIC)algorithm for the rapid imaging of small objects,complete elements of the multi-static response(MSR)matrix must be collected.However,in some real-world applications in microwave imaging,diagonal elements of theMSRmatrix are unknown.Nevertheless,it is possible to obtain imaging results using a traditional approach but theoretical reason of the applicability has not been investigated yet.In this paper,we consider the application of MUSIC for a fast identification of small objects from collected MSR matrix in both transverse magnetic(TM)and transverse electric(TE)polarizations.In order to examine the applicability,fundamental limitation,and various properties of MUSIC,we establish mathematical structure of the three imaging functions and explore that the main factors of the imaging functions are Bessel function of order zero,one,and two.The established structures demonstrate why the existence and location of small objects can be retrieved via MUSIC without the diagonal elements of the MSR matrix.Results of numerical simulations with noise-corrupted synthetic data are also provided to support the identified structures.
基金supported by the Special Fund for Basic Scientific Research of Central Colleges,South-Central University for Nationalities(No.CZY12021)the National Natural Science Foundation of China(No.40672157)the 863 Program of China(No.2007AA06Z337)
文摘In groundwater management,the exchanges between groundwater and other water such as surface water and spring water need to be considered.Some exchange is dependent on the ground-water level,which is called covariate.The pumping rate,groundwater level,and covariate interact and the relation of mutual-feed joint-variation is used to describe their interaction.This article presents a new approach of dealing with the relation in groundwater management model.The mathematical for-mulation of the relation,as an additional equality constraint in the optimization model,is developed using response matrix method.Thereby the groundwater management model with covariate is set up.The code for the simulation and management of groundwater system with covariate is programmed with Fortran 90,and the optimal pumping rate,groundwater level,and covariate are obtained.The approach is verified with a hypothetical case.Finally,the approach is applied to the groundwater management of Qianguo（前郭） area in western Jilin（吉林） Province.The results indicate that the ap-proach is feasible.It provides a universal solution for various covariates and reduces the computational complexity compared to iteration method.The approach is proven to be very efficient to solve ground-water management problem with covariate.
基金supported by the National Natural Science Foundation of China(No.11975298).
文摘Background Most of the global orbit feedback algorithms in storage rings are based on response matrix(RM)singular value decomposition method.Commonly,the RM is the orbit distortion along the ring responding to the steering magnet changes.For those methods RF frequency feedback is in a separated process.Methods and Results In this paper,the response matrix is expanded to the orbit distortion caused by the RF frequency variation.With this expanded RM,the orbit correction via steering magnet changes and RF frequency adjustment can be accomplished in one step.The commissioning results are carried out showing that the algorithm works stably.
基金Project(51221462)supported by the National Natural Science Foundation of ChinaProject(20120095110001)supported by the PhD Programs Foundation of Ministry of Education of ChinaProject(CXZZ13_0927)supported by Research and Innovation Project for College Graduates of Jiangsu Province,China
文摘As the stiffness of the elastic support varies with the physical-chemical erosion and mechanical friction, model catastrophe of a single degree-of-freedom(DOF) isolation system may occur. A 3-DOF four-point-elastic-support rigid plate(FERP) structure is presented to describe the catastrophic isolation system. Based on the newly-established structure, theoretical derivation for stiffness matrix calculation by free response(SMCby FR) and the method of stiffness identification by stiffness matrix disassembly(SIby SMD)are proposed. By integrating the SMCby FR and the SIby SMD and defining the stiffness assurance criterion(SAC), the procedures for stiffness identification of a FERP structure(SIFERP) are summarized. Then, a numerical example is adopted for the SIFERP validation, in which the simulated tested free response data are generated by the numerical methods, and operation for filtering noise is conducted to imitate the practical application. Results in the numerical example demonstrate the feasibility and accuracy of the developed SIFERP for stiffness identification.
基金supported by the National Natural Science Foundation of China (10971083, 10801063)the School of Mathematical Sciences Foundation of Jilin University
文摘In this paper, we consider a MUSIC algorithm for locating point-like scatterers contained in a sample on flat substrate. Based on an asymptotic expansion of the scattering amplitude proposed by Ammari et al., the reconstruction problem can be reduced to a calculation of Green function corresponding to the background medium. In addition, we use an explicit formulation of Green function in the MUSIC algorithm to simplify the calculation when the cross-section of sample is a half-disc. Numerical experiments are included to demonstrate the feasibility of this method.
基金supported by JSPS KAKENHI Grant Number 19H04475,21H03830,22K19926 and 24K03289.
文摘Combining hyperthermia and chemotherapy for maximum anticancer efficacy remains a challenge because drugtolerant cancer cells often evade this synergistic treatment due to drug resistance and asynchronous drug release.In this study,multifunctional scaffolds were designed to efficiently treat drug-tolerant breast cancer by improving the sensitization of breast cancer cells and synchronizing anticancer drug release with magnetic hyperthermia.The scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes,doxorubicin-encapsulated thermoresponsive liposomes and Fe_(3)O_(4)nanoparticles.The scaffolds could release microRNA specifically to improve the sensitization of breast cancer cells to anticancer drugs.The scaffolds also showed excellent hyperthermia effects under alternating magnetic field irradiation.Moreover,doxorubicin release was synchronized with magnetic hyperthermia.In vitro and in vivo studies demonstrated that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant MDA-MB-231 cells through the syner-gistic effect of magnetic hyperthermia and sensitizing chemotherapy.Additionally,the scaffolds could support the proliferation and adipogenic differentiation of stem cells for adipose tissue regeneration after killing cancer cells at a late therapeutic stage.These composite scaffolds offer an innovative strategy for treating breast cancer,with synergistic anticancer effects and regenerative functions.
基金Supported by National Natural Science Foundation
文摘If H and G are the transfer function matrix and the free response matrix of a linear finite automaton,then G is called a free response matrix matched to H.Given H,let(H)be the set of all possible free response matrices matched to H.A classification and an enumeration on the set(H)are given in this paper.
基金supports from National Key R&D Program of China(2021YFB2800404)Natural Science Foundation of China(62175151,62341508)+1 种基金Shanghai Municipal Science and Technology Major Project(BH0300071)a Leverhulme Trust Early Career Fellowship grant,reference ECF-2022-711.
文摘The burgeoning field of computational spectrometers is rapidly advancing,providing a pathway to highly miniaturized,on-chip systems for in-situ or portable measurements.The performance of these systems is typically limited in its encoder section.The response matrix is largely compromised with redundancies,due to the periodic intensity or overly smooth responses.As such,the inherent interdependence among the physical size,resolution,and bandwidth of spectral encoders poses a challenge to further miniaturization progress.Achieving high spectral resolution necessitates a long optical path length,leading to a larger footprint required for sufficient spectral decorrelation,resulting in a limited detectable free-spectral range(FSR).Here,we report a groundbreaking ultraminiaturized disordered photonic molecule spectrometer that surpasses the resolution-bandwidth-footprint metric of current spectrometers.This computational spectrometer utilizes complicated electromagnetic coupling to determinately generate quasi-random spectral response matrices,a feature absents in other state-of-the-art systems,fundamentally overcoming limitations present in the current technologies.This configuration yields an effectively infinite FSR while upholding a high Q-factor(>7.74×10^(5)).Through dynamic manipulation of photon frequency,amplitude,and phase,a broad operational bandwidth exceeding 100 nm can be attained with an ultra-high spectral resolution of 8 pm,all encapsulated within an ultra-compact footprint measuring 70×50μm^(2).The disordered photonic molecule spectrometer is constructed on a CMOS-compatible integrated photonics platform,presenting a pioneering approach for high-performance and highly manufacturable miniaturized spectroscopy.
