期刊文献+
共找到44,545篇文章
< 1 2 250 >
每页显示 20 50 100
Information Diffusion Models and Fuzzing Algorithms for a Privacy-Aware Data Transmission Scheduling in 6G Heterogeneous ad hoc Networks
1
作者 Borja Bordel Sánchez Ramón Alcarria Tomás Robles 《Computer Modeling in Engineering & Sciences》 2026年第2期1214-1234,共21页
In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic h... In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic heterogeneous infrastructures,unstable links and non-uniform hardware capabilities create critical issues regarding security and privacy.Traditional protocols are often too computationally heavy to allow 6G services to achieve their expected Quality-of-Service(QoS).As the transport network is built of ad hoc nodes,there is no guarantee about their trustworthiness or behavior,and transversal functionalities are delegated to the extreme nodes.However,while security can be guaranteed in extreme-to-extreme solutions,privacy cannot,as all intermediate nodes still have to handle the data packets they are transporting.Besides,traditional schemes for private anonymous ad hoc communications are vulnerable against modern intelligent attacks based on learning models.The proposed scheme fulfills this gap.Findings show the probability of a successful intelligent attack reduces by up to 65%compared to ad hoc networks with no privacy protection strategy when used the proposed technology.While congestion probability can remain below 0.001%,as required in 6G services. 展开更多
关键词 6G networks ad hoc networks PRIVACY scheduling algorithms diffusion models fuzzing algorithms
在线阅读 下载PDF
Multi-Label Classification Model Using Graph Convolutional Neural Network for Social Network Nodes
2
作者 Junmin Lyu Guangyu Xu +4 位作者 Feng Bao Yu Zhou Yuxin Liu Siyu Lu Wenfeng Zheng 《Computer Modeling in Engineering & Sciences》 2026年第2期1235-1256,共22页
Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relati... Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks. 展开更多
关键词 GNN social networks nodes multi-label classification model graphic convolution neural network coupling principle
在线阅读 下载PDF
Collision risk assessment for constellation satellites based on a space debris environment topological network model
3
作者 Yurun YUAN Jingrui ZHANG +2 位作者 Keying YANG Lincheng LI Hao WU 《Chinese Journal of Aeronautics》 2026年第2期472-484,共13页
In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This s... In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This study aims to explore the complex evolution of the space debris environment and assess the collision risks associated with spacecraft.First,a space debris environment topological network model is proposed,which incorporates interdisciplinary methods from topological networks,fluid mechanics,and spacecraft dynamics.This model enables a structured representation of the relationships among space objects and provides rapid predictions of the space debris environment.Then,a collision probability algorithm based on the topological network model is introduced.This algorithm inherits the efficiency advantages of the topological network model and has been validated for reliability through comparison with the classical ESA’s DRAMA software.Finally,based on the above models,the collision risks of constellation satellites in Low Earth Orbit(LEO)are analyzed,including both operational and deorbit processes.The study reveals that constellation satellites face a much higher risk of internal collisions with satellites from the same constellation during operations than that with other space objects.Additionally,during the satellite deorbit process,the collision risk peaks when satellites traverse the operational region of Starlink satellites. 展开更多
关键词 Collision probability Computing resource CONSTELLATION Space debris Topological network model
原文传递
Dual Layer Source Grid Load Storage Collaborative Planning Model Based on Benders Decomposition: Distribution Network Optimization Considering Low-Carbon and Economy
4
作者 Jun Guo Maoyuan Chen +2 位作者 Yuyang Li Sibo Feng Guangyu Fu 《Energy Engineering》 2026年第2期104-133,共30页
Theauthor proposes a dual layer source grid load storage collaborative planning model based on Benders decomposition to optimize the low-carbon and economic performance of the distribution network.The model plans the ... Theauthor proposes a dual layer source grid load storage collaborative planning model based on Benders decomposition to optimize the low-carbon and economic performance of the distribution network.The model plans the configuration of photovoltaic(3.8 MW),wind power(2.5 MW),energy storage(2.2 MWh),and SVC(1.2 Mvar)through interaction between upper and lower layers,and modifies lines 2–3,8–9,etc.to improve transmission capacity and voltage stability.The author uses normal distribution and Monte Carlo method to model load uncertainty,and combines Weibull distribution to describe wind speed characteristics.Compared to the traditional three-layer model(TLM),Benders decomposition-based two-layer model(BLBD)has a 58.1%reduction in convergence time(5.36 vs.12.78 h),a 51.1%reduction in iteration times(23 vs.47 times),a 8.07%reduction in total cost(12.436 vs.13.528 million yuan),and a 9.62%reduction in carbon emissions(12,456 vs.13,782 t).After optimization,the peak valley difference decreased from4.1 to 2.9MW,the renewable energy consumption rate reached 93.4%,and the energy storage efficiency was 87.6%.Themodel has been validated in the IEEE 33 node system,demonstrating its superiority in terms of economy,low-carbon,and reliability. 展开更多
关键词 Benders decomposition source grid load storage distribution network planning low-carbon economy optimization model
在线阅读 下载PDF
Anisotropy of Phase Transformation in Aluminum and Copper under Shock Compression:Atomistic Simulations and Neural Network Model
5
作者 Evgenii V.Fomin Ilya A.Bryukhanov +1 位作者 Natalya A.Grachyova Alexander E.Mayer 《Computers, Materials & Continua》 2026年第4期548-577,共30页
It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range ... It is well known that aluminum and copper exhibit structural phase transformations in quasi-static and dynamic measurements,including shock wave loading.However,the dependence of phase transformations in a wide range of crystallographic directions of shock loading has not been revealed.In this work,we calculated the shock Hugoniot for aluminum and copper in different crystallographic directions([100],[110],[111],[112],[102],[114],[123],[134],[221]and[401])of shock compression using molecular dynamics(MD)simulations.The results showed a high pressure(>160 GPa for Cu and>40 GPa for Al)of the FCC-to-BCC transition.In copper,different characteristics of the phase transition are observed depending on the loading direction with the[100]compression direction being the weakest.The FCC-to-BCC transition for copper is in the range of 150–220 GPa,which is consistent with the existing experimental data.Due to the high transition pressure,the BCC phase transition in copper competes with melting.In aluminum,the FCC-to-BCC transition is observed for all studied directions at pressures between 40 and 50 GPa far beyond the melting.In all considered cases we observe the coexistence of HCP and BCC phases during the FCC-to-BCC transition,which is consistent with the experimental data and atomistic calculations;this HCP phase forms in the course of accompanying plastic deformation with dislocation activity in the parent FCC phase.The plasticity incipience is also anisotropic in bothmetals,which is due to the difference in the projections of stress on the slip plane for different orientations of the FCC crystal.MD modeling results demonstrate a strong dependence of the FCC-to-BCC transition on the crystallographic direction,in which the material is loaded in the copper crystals.However,MD simulations data can only be obtained for specific points in the stereographic direction space;therefore,for more comprehensive understanding of the phase transition process,a feed-forward neural network was trained using MD modeling data.The trained machine learning model allowed us to construct continuous stereographic maps of phase transitions as a function of stress in the shock-compressed state of metal.Due to appearance and growth of multiple centers of new phase,the FCC-to-BCC transition leads to formation of a polycrystalline structure from the parent single crystal. 展开更多
关键词 Molecular dynamics(MD) ALUMINUM COPPER shock wave polymorphic phase transformation polycrystalline structure neural network model
在线阅读 下载PDF
Neural networks and econometric models:Advancing brain connectivity for Alzheimer's drug development
6
作者 Lorenzo Pini Paolo Pigato +1 位作者 Gloria Menegaz Ilaria Boscolo Galazzo 《Neural Regeneration Research》 2026年第7期2928-2929,共2页
Advances in Alzheimer's disease(AD)research have deepened our understanding,yet the mechanisms driving its progression remain unclear.Although a range of in vivo biomarkers is now available(e.g.,measurements of am... Advances in Alzheimer's disease(AD)research have deepened our understanding,yet the mechanisms driving its progression remain unclear.Although a range of in vivo biomarkers is now available(e.g.,measurements of amyloidbeta(Aβ)and ta u accumulation-the molecular hallmarks of AD-structural magnetic resonance imaging(MRI),assessments of brain metabolism,and,more recently,blood-based markers),a definitive diagnosis of AD continues to be challenging.For example,Frisoni et al. 展开更多
关键词 econometric models amyloidbeta alzheimers disease ad research drug development neural networks vivo biomarkers Alzheimers disease brain connectivity
暂未订购
The Interaction Mechanism Between Urban Scale Hierarchy and Urban Networks in China:An Analysis Based on A Spatial Simultaneous Equation Model
7
作者 ZHOU Ying ZHENG Wensheng WANG Xiaofang 《Chinese Geographical Science》 2026年第1期19-33,共15页
Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefor... Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefore,this paper analyzes the spatial interaction between urban scale hierarchy and urban networks in China from 2019 to 2023,drawing on Baidu migration data and employing a spatial simultaneous equation model.The results reveal a significant positive spatial correlation between cities with higher hierarchy and those with greater network centrality.Within a static framework,we identify a positive interaction between urban scale hierarchy and urban network centrality,while their spatial cross-effects manifest as negative neighborhood interactions based on geographical distance and positive cross-scale interactions shaped by network connections.Within a dynamic framework,changes in urban scale hierarchy and urban networks are mutually reinforcing,thereby widening disparities within the urban hierarchy.Furthermore,an increase in a city’s network centrality had a dampening effect on the population growth of neighboring cities and network-connected cities.This study enhances understanding of the spatial organisation of urban systems and offers insights for coordinated regional development. 展开更多
关键词 urban scale hierarchy urban networks spatial interaction spatial spillover effect Baidu migration data spatial simultaneous equation model China
在线阅读 下载PDF
Multi-source and multi-attribute collaborative fracture network modeling of a sandstone reservoir in Ordos Basin
8
作者 Yinbang Zhou 《Energy Geoscience》 2026年第1期214-223,共10页
The effective channeling of fluid flow by fractures is a liability for enhanced oil recovery(EOR)methods like CO_(2) flooding or CO_(2) storage.Developing a distributed fracture model to understand the heterogeneity o... The effective channeling of fluid flow by fractures is a liability for enhanced oil recovery(EOR)methods like CO_(2) flooding or CO_(2) storage.Developing a distributed fracture model to understand the heterogeneity of the fracture network is essential in characterizing tight and low-permeability reservoirs.In the Ordos Basin,the Chang 8-1-2 layer of the Yanchang Formation is a typical tight and low permeability reservoir in the JH17 wellblock.The strong heterogeneity of distributed fractures,differing fracture scales and fracture types make it difficult to effectively characterize the fracture distribution within the Chang 8-1-2 layer.In this paper,multi-source and multi-attribute methods are used to integrate data into a neural network at different scales,and fuzzy logic control is used to judge the correlation of various attributes.The results suggest that attribute correlation between coherence and fracture indication is the best,followed by correlations with fault distance,north–south slope,and north–south curvature.Advantageous attributes from the target area are used to train the neural network,and the fracture density model and discrete fracture network(DFN)model are built at different scales.This method can be used to effectively predict the distribution characteristics of fractures in the study area.And any learning done by the neural network from this case study can be applied to fracture network modeling for reservoirs of the same type. 展开更多
关键词 Tight oil reservoir CO_(2)flooding CO_(2)storage Reservoir fracture Fracture network modeling Fracture density
在线阅读 下载PDF
An artificial neural network-based data-driven constitutive model of shape memory alloys 被引量:1
9
作者 Xingyu Zhou Ziang Liu +1 位作者 Chao Yu Guozheng Kang 《Acta Mechanica Sinica》 2025年第8期108-125,共18页
The constitutive models of shape memory alloys(SMAs)play an important role in facilitating the widespread application of such types of alloys in various engineering fields.However,to accurately describe the deformatio... The constitutive models of shape memory alloys(SMAs)play an important role in facilitating the widespread application of such types of alloys in various engineering fields.However,to accurately describe the deformation behaviors of SMAs,the concepts in classical plasticity are employed in the existing constitutive models,and a series of complex mathematical equations are involved.Such complexity brings inconvenience for the construction,implementation,and application of the constitutive models.To overcome these shortcomings,a data-driven constitutive model of SMAs is developed in this work based on the artificial neural network(ANN).In the proposed model,the components of the strain tensor in principal space,ambient temperature,and the maximum equivalent strain in the deformation history from the initial state to the current loading state are chosen as the input features,and the components of the stress tensor in principal space are set as the output.The proposed ANN-based constitutive model is implemented into the finite element program ABAQUS by deriving its consistent tangent modulus and writing a user-defined material subroutine.The stress-strain responses of SMA material under various loading paths and at different ambient temperatures are used to train the ANN model,which is generated from the existing constitutive model(numerical experiments).To validate the capability of the proposed model,the predicted stress-strain responses of SMA material,and the global and local responses of two typical SMA structures are compared with the corresponding numerical experiments.This work demonstrates a good potential to obtain the constitutive model of SMAs by pure data and avoid the need for vast stores of knowledge for the construction of constitutive models. 展开更多
关键词 Shape memory alloys Constitutive model DATA-DRIVEN Artificial neural network
原文传递
A hybrid data-driven approach for rainfall-induced landslide susceptibility mapping:Physically-based probabilistic model with convolutional neural network 被引量:1
10
作者 Hong-Zhi Cui Bin Tong +2 位作者 Tao Wang Jie Dou Jian Ji 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期4933-4951,共19页
Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with region... Landslide susceptibility mapping(LSM)plays a crucial role in assessing geological risks.The current LSM techniques face a significant challenge in achieving accurate results due to uncertainties associated with regional-scale geotechnical parameters.To explore rainfall-induced LSM,this study proposes a hybrid model that combines the physically-based probabilistic model(PPM)with convolutional neural network(CNN).The PPM is capable of effectively capturing the spatial distribution of landslides by incorporating the probability of failure(POF)considering the slope stability mechanism under rainfall conditions.This significantly characterizes the variation of POF caused by parameter uncertainties.CNN was used as a binary classifier to capture the spatial and channel correlation between landslide conditioning factors and the probability of landslide occurrence.OpenCV image enhancement technique was utilized to extract non-landslide points based on the POF of landslides.The proposed model comprehensively considers physical mechanics when selecting non-landslide samples,effectively filtering out samples that do not adhere to physical principles and reduce the risk of overfitting.The results indicate that the proposed PPM-CNN hybrid model presents a higher prediction accuracy,with an area under the curve(AUC)value of 0.85 based on the landslide case of the Niangniangba area of Gansu Province,China compared with the individual CNN model(AUC=0.61)and the PPM(AUC=0.74).This model can also consider the statistical correlation and non-normal probability distributions of model parameters.These results offer practical guidance for future research on rainfall-induced LSM at the regional scale. 展开更多
关键词 Rainfall landslides Landslide susceptibility mapping Hybrid model Physically-based model Convolution neural network(CNN) Probability of failure(POF)
在线阅读 下载PDF
Regional Storm Surge Forecast Method Based on a Neural Network and the Coupled ADCIRC-SWAN Model 被引量:1
11
作者 Yuan SUN Po HU +2 位作者 Shuiqing LI Dongxue MO Yijun HOU 《Advances in Atmospheric Sciences》 2025年第1期129-145,共17页
Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many ... Timely and accurate forecasting of storm surges can effectively prevent typhoon storm surges from causing large economic losses and casualties in coastal areas.At present,numerical model forecasting consumes too many resources and takes too long to compute,while neural network forecasting lacks regional data to train regional forecasting models.In this study,we used the DUAL wind model to build typhoon wind fields,and constructed a typhoon database of 75 processes in the northern South China Sea using the coupled Advanced Circulation-Simulating Waves Nearshore(ADCIRC-SWAN)model.Then,a neural network with a Res-U-Net structure was trained using the typhoon database to forecast the typhoon processes in the validation dataset,and an excellent storm surge forecasting effect was achieved in the Pearl River Estuary region.The storm surge forecasting effect of stronger typhoons was improved by adding a branch structure and transfer learning. 展开更多
关键词 regional storm surge forecast coupled ADCIRC-SWAN model neural network Res-U-Net structure
在线阅读 下载PDF
Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach
12
作者 Ghaliah Alhamzi Badr Saad TAlkahtani +1 位作者 Ravi Shanker Dubey Mati ur Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期609-633,共25页
This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV i... This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately. 展开更多
关键词 HIV infection model qualitative scheme approximate solution piecewise global operator neural network
在线阅读 下载PDF
Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures
13
作者 Muhammad Qasim Khan Fazal Malik +1 位作者 Fahad Alturise Noor Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期123-153,共31页
Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important a... Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject. 展开更多
关键词 Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication
在线阅读 下载PDF
Diff-IDS:A Network Intrusion Detection Model Based on Diffusion Model for Imbalanced Data Samples 被引量:1
14
作者 Yue Yang Xiangyan Tang +3 位作者 Zhaowu Liu Jieren Cheng Haozhe Fang Cunyi Zhang 《Computers, Materials & Continua》 2025年第3期4389-4408,共20页
With the rapid development of Internet of Things technology,the sharp increase in network devices and their inherent security vulnerabilities present a stark contrast,bringing unprecedented challenges to the field of ... With the rapid development of Internet of Things technology,the sharp increase in network devices and their inherent security vulnerabilities present a stark contrast,bringing unprecedented challenges to the field of network security,especially in identifying malicious attacks.However,due to the uneven distribution of network traffic data,particularly the imbalance between attack traffic and normal traffic,as well as the imbalance between minority class attacks and majority class attacks,traditional machine learning detection algorithms have significant limitations when dealing with sparse network traffic data.To effectively tackle this challenge,we have designed a lightweight intrusion detection model based on diffusion mechanisms,named Diff-IDS,with the core objective of enhancing the model’s efficiency in parsing complex network traffic features,thereby significantly improving its detection speed and training efficiency.The model begins by finely filtering network traffic features and converting them into grayscale images,while also employing image-flipping techniques for data augmentation.Subsequently,these preprocessed images are fed into a diffusion model based on the Unet architecture for training.Once the model is trained,we fix the weights of the Unet network and propose a feature enhancement algorithm based on feature masking to further boost the model’s expressiveness.Finally,we devise an end-to-end lightweight detection strategy to streamline the model,enabling efficient lightweight detection of imbalanced samples.Our method has been subjected to multiple experimental tests on renowned network intrusion detection benchmarks,including CICIDS 2017,KDD 99,and NSL-KDD.The experimental results indicate that Diff-IDS leads in terms of detection accuracy,training efficiency,and lightweight metrics compared to the current state-of-the-art models,demonstrating exceptional detection capabilities and robustness. 展开更多
关键词 network traffic feature enhancement diffusion model multi-classification Algorithm 2(continued)13:end for 14:Return y
在线阅读 下载PDF
Age-and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging 被引量:1
15
作者 Dilara Yilmaz Francisco C.Marques +9 位作者 Lorena Gregorio Jérôme Schlatter Christian Gehre Thurgadevi Pararajasingam Wanwan Qiu Neashan Mathavan Xiao-Hua Qin Esther Wehrle Gisela A.Kuhn Ralph Müller 《Bone Research》 2025年第4期957-967,共11页
Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better under... Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms.Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss.Our study uses the prematurely aged PolgD257A/D257A(PolgA)mouse model to scrutinize age-and sex-related alterations in musculoskeletal health parameters(frailty,grip strength,gait data),bone and particularly the osteocyte lacuno-canalicular network(LCN).Moreover,a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging.Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters,bone,and osteocyte LCN in PolgA mice as early as 40 weeks,with more prominent alterations evident in aged males.Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss,given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans. 展开更多
关键词 molecular cellular mechanismsemerging osteocyte lacuno canalicular network bone remodeling therapeutic targets premature aging polgd d mouse model reduced bone density age related osteoporosis
暂未订购
Genome-scale metabolic network model-guided genetic modification of Escherichia coli for pyruvate accumulation
16
作者 LI Xuefei GUO Chaohao +4 位作者 TONG Wenyue YANG Sen LIU Xiaoyun LI Jingchen KANG Ming 《微生物学报》 北大核心 2025年第10期4374-4391,共18页
[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a... [Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a guide,we simulated pyruvate production of E.coli,screened key genes in metabolic pathways,and developed gene editing procedures accordingly.We knocked out the acetate kinase gene ackA,phosphate acetyltransferase gene pta,alcohol dehydrogenase adhE,glycogen synthase gene glgA,glycogen phosphorylase gene glgP,phosphoribosyl pyrophosphate(PRPP)synthase gene prs,ribose 1,5-bisphosphate phosphokinase gene phnN,and transporter encoding gene proP.Furthermore,we knocked in the transporter encoding gene ompC,flavonoid toxin gene fldA,and D-serine ammonia lyase gene dsdA.[Results]A shake flask process with the genetically edited mutant strain MG1655-6-2 under anaerobic conditions produced pyruvate at a titer of 10.46 g/L and a yield of 0.69 g/g.Metabolomic analysis revealed a significant increase in the pyruvate level in the fermentation broth,accompanied by notable decreases in the levels of certain related metabolic byproducts.Through 5 L fed-batch fermentation and an adaptive laboratory evolution,the strain finally achieved a pyruvate titer of 45.86 g/L.[Conclusion]This study illustrated the efficacy of a gene editing strategy predicted by a genome-scale metabolic network model in enhancing pyruvate accumulation in E.coli under anaerobic conditions and provided novel insights for microbial metabolic engineering. 展开更多
关键词 Escherichia coli PYRUVATE genome-scale metabolic network model CRISPR-Cas9 adaptive laboratory evolution
原文传递
A method for modeling and evaluating the interoperability of multi-agent systems based on hierarchical weighted networks
17
作者 DONG Jingwei TANG Wei YU Minggang 《Journal of Systems Engineering and Electronics》 2025年第3期754-767,共14页
Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weight... Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weighted scale-free community network and susceptible-infected-recovered(SIR)model.To solve the problem of difficulty in describing the changes in the structure and collaboration mode of the system under external factors,a two-dimensional Monte Carlo method and an improved dynamic Bayesian network are used to simulate the impact of external environmental factors on multi-agent systems.A collaborative information flow path optimization algorithm for agents under environmental factors is designed based on the Dijkstra algorithm.A method for evaluating system interoperability is designed based on simulation experiments,providing reference for the construction planning and optimization of organizational application of the system.Finally,the feasibility of the method is verified through case studies. 展开更多
关键词 complex network agent INTEROPERABILITY susceptible-infected-recovered model dynamic Bayesian network
在线阅读 下载PDF
Data Gathering Based on Hybrid Energy Efficient Clustering Algorithm and DCRNN Model in Wireless Sensor Network
18
作者 Li Cuiran Liu Shuqi +1 位作者 Xie Jianli Liu Li 《China Communications》 2025年第3期115-131,共17页
In order to solve the problems of short network lifetime and high data transmission delay in data gathering for wireless sensor network(WSN)caused by uneven energy consumption among nodes,a hybrid energy efficient clu... In order to solve the problems of short network lifetime and high data transmission delay in data gathering for wireless sensor network(WSN)caused by uneven energy consumption among nodes,a hybrid energy efficient clustering routing base on firefly and pigeon-inspired algorithm(FF-PIA)is proposed to optimise the data transmission path.After having obtained the optimal number of cluster head node(CH),its result might be taken as the basis of producing the initial population of FF-PIA algorithm.The L′evy flight mechanism and adaptive inertia weighting are employed in the algorithm iteration to balance the contradiction between the global search and the local search.Moreover,a Gaussian perturbation strategy is applied to update the optimal solution,ensuring the algorithm can jump out of the local optimal solution.And,in the WSN data gathering,a onedimensional signal reconstruction algorithm model is developed by dilated convolution and residual neural networks(DCRNN).We conducted experiments on the National Oceanic and Atmospheric Administration(NOAA)dataset.It shows that the DCRNN modeldriven data reconstruction algorithm improves the reconstruction accuracy as well as the reconstruction time performance.FF-PIA and DCRNN clustering routing co-simulation reveals that the proposed algorithm can effectively improve the performance in extending the network lifetime and reducing data transmission delay. 展开更多
关键词 CLUSTERING data gathering DCRNN model network lifetime wireless sensor network
在线阅读 下载PDF
Discrete neuron models and memristive neural network mapping:A comprehensive review
19
作者 Fei Yu Xuqi Wang +3 位作者 Rongyao Guo Zhijie Ying Yan He Qiong Zou 《Chinese Physics B》 2025年第12期76-89,共14页
In recent years,discrete neuron and discrete neural network models have played an important role in the development of neural dynamics.This paper reviews the theoretical advantages of well-known discrete neuron models... In recent years,discrete neuron and discrete neural network models have played an important role in the development of neural dynamics.This paper reviews the theoretical advantages of well-known discrete neuron models,some existing discretized continuous neuron models,and discrete neural networks in simulating complex neural dynamics.It places particular emphasis on the importance of memristors in the composition of neural networks,especially their unique memory and nonlinear characteristics.The integration of memristors into discrete neural networks,including Hopfield networks and their fractional-order variants,cellular neural networks and discrete neuron models has enabled the study and construction of various neural models with memory.These models exhibit complex dynamic behaviors,including superchaotic attractors,hidden attractors,multistability,and synchronization transitions.Furthermore,the present paper undertakes an analysis of more complex dynamical properties,including synchronization,speckle patterns,and chimera states in discrete coupled neural networks.This research provides new theoretical foundations and potential applications in the fields of brain-inspired computing,artificial intelligence,image encryption,and biological modeling. 展开更多
关键词 discrete neuron discrete neural network model MEMRISTOR chaotic dynamics memristive neural network
原文传递
Wireless Sensor Network Modeling and Analysis for Attack Detection
20
作者 Tamara Zhukabayeva Vasily Desnitsky Assel Abdildayeva 《Computer Modeling in Engineering & Sciences》 2025年第8期2591-2625,共35页
Wireless Sensor Networks(WSN)have gained significant attention over recent years due to their extensive applications in various domains such as environmentalmonitoring,healthcare systems,industrial automation,and smar... Wireless Sensor Networks(WSN)have gained significant attention over recent years due to their extensive applications in various domains such as environmentalmonitoring,healthcare systems,industrial automation,and smart cities.However,such networks are inherently vulnerable to different types of attacks because they operate in open environments with limited resources and constrained communication capabilities.Thepaper addresses challenges related to modeling and analysis of wireless sensor networks and their susceptibility to attacks.Its objective is to create versatile modeling tools capable of detecting attacks against network devices and identifying anomalies caused either by legitimate user errors or malicious activities.A proposed integrated approach for data collection,preprocessing,and analysis in WSN outlines a series of steps applicable throughout both the design phase and operation stage.This ensures effective detection of attacks and anomalies within WSNs.An introduced attackmodel specifies potential types of unauthorized network layer attacks targeting network nodes,transmitted data,and services offered by the WSN.Furthermore,a graph-based analytical framework was designed to detect attacks by evaluating real-time events from network nodes and determining if an attack is underway.Additionally,a simulation model based on sequences of imperative rules defining behaviors of both regular and compromised nodes is presented.Overall,this technique was experimentally verified using a segment of a WSN embedded in a smart city infrastructure,simulating a wormhole attack.Results demonstrate the viability and practical significance of the technique for enhancing future information security measures.Validation tests confirmed high levels of accuracy and efficiency when applied specifically to detecting wormhole attacks targeting routing protocols in WSNs.Precision and recall rates averaged above the benchmark value of 0.95,thus validating the broad applicability of the proposed models across varied scenarios. 展开更多
关键词 Wireless sensor network modelING SECURITY ATTACK DETECTION MONITORING
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部