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CNN-ALSTM Soft-Sensing Model for Resistivity Gradient in CZ Monocrystalline Silicon Wafers 被引量:1
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作者 Zhiheng Zhang Zengguo Tian 《Instrumentation》 2025年第2期71-79,共9页
This study addresses the challenge of real-time resistivity gradient measurement in the Czochralski(CZ)silicon production process.Due to the inability to directly measure this parameter,we propose a Long Short-Term Me... This study addresses the challenge of real-time resistivity gradient measurement in the Czochralski(CZ)silicon production process.Due to the inability to directly measure this parameter,we propose a Long Short-Term Memory soft-sensing model based on Convolutional Neural Network(CNN)and attention mechanism(CNN-ALSTM)that enhances traditional LSTM by integrating CNN and attention mechanism to overcome time lag variations during silicon pulling.The CNN module extracts spatial features from multi-source sensor data,while the attention-enhanced LSTM(ALSTM)dynamically adjusts historical parameter weights,enabling accurate resistivity gradient prediction.Experiments with real production data show that CNN-ALSTM outperforms SVR,FNN,RNN,XGBoost,and GRU,improving prediction accuracy by 11.76%,16.67%,21.05%,30.23%,and 9.09%,respectively.This soft-sensing approach enhances real-time monitoring and optimization of monocrystalline silicon growth. 展开更多
关键词 CZ monocrystalline silicon soft-sensing model CNN-ALSTM resistivity gradient
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Evaluation of electrical resistivity of lead-contaminated soils stabilized by electrolytic manganese residue-based binder
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作者 Chaoliu Tu Yuan Li +2 位作者 Chen Wang Lei Liu Yi Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第10期6621-6635,共15页
Evaluating the stabilized lead(Pb)-contaminated soils through sampling and laboratory testing involves costly and time-consuming processes.Therefore,this study employed a low-cost and non-destructive resistivity tool ... Evaluating the stabilized lead(Pb)-contaminated soils through sampling and laboratory testing involves costly and time-consuming processes.Therefore,this study employed a low-cost and non-destructive resistivity tool to evaluate the Pb-contaminated soils stabilized by electrolytic manganese residue(EMR)-based geopolymer(EG-OPC)from the strength and environmental benefits perspective.First,unconfined compressive strength(UCS)and leaching tests were conducted to study the stabilization effectiveness of EG-OPC.Results indicated that the UCS values of soil(5000 mg/kg of pollutants)stabilized by 20%EG-OPC were 4.87 MPa and 8.13 MPa after 7 d and 60 d of curing,respectively.After 60 d of curing,the Pb concentration in the leachate reached 44 mg/L,far lower than the control group(321 mg/L).Second,soil,pore water,and leachate resistivity(ERS,ERW,and ERL)were measured to establish fitting relationships with strength parameters and pollution risk.The good fitting results(e.g.ERS/ERW versus UCS/secant modulus(E50):correlation coefficient R2 z 0.9,ERS/ERW versus Pb contents:R2 z 0.9,and ERL versus Pb2þconcentration:R2¼0.92)and well used Archie's law(ERS versus ERW:R2>0.9)indicate that the resistivity can be used to evaluate the stabilization effectiveness.Furthermore,the microscopic results revealed two behaviors,demonstrating the reliability of resistivity:(1)with the hydration process,resistivity increases due to a denser structure and lower amounts of free water and Pb ions,and(2)the addition of Pb reduces resistivity due to its inhibition or even destructive effects on cementation and formation of hydration products. 展开更多
关键词 Stabilization effectiveness resistivity Lead leaching Stabilization mechanism Soil structure
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Experimental Analysis of Resistivity Logging Response of Marine Gas Hydrate Reservoirs
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作者 CHEN Qiang LI Chengfeng +5 位作者 WANG Hongbin LIU Changling BU Qingtao SUN Jianye WEI Jiangong KOU Beibei 《Journal of Ocean University of China》 2025年第1期85-94,共10页
Natural gas hydrates are widely distributed in marine and permafrost environments.As a novel energy resource,accurately describing reservoir characteristics and assessing energy potential is crucial for its commercial... Natural gas hydrates are widely distributed in marine and permafrost environments.As a novel energy resource,accurately describing reservoir characteristics and assessing energy potential is crucial for its commercial development.Resistivity logging serves as a valuable approach for achieving these goals.Nevertheless,due to inadequate comprehension of the electrical conductivity mechanism in hydrate-bearing sediments,existing data processing models still encounter certain challenges.This study conducts both core-scale and pore-scale simulation experiments to examine the relationship between resistivity variations and the distribution of gas hydrate porosity.The results indicate that the characteristics of resistivity variation is associated with the gas hydrate formation process,and the gas hydrate saturation index,denoted as‘n',varies between 0 and 3 depending on different gas hydrate distribution patterns.As the saturation increases,gas hydrate distribution in pore spaces transitions from floating to contacting and cementing patterns.It is proposed that the aqueous pore tortuosity can be utilized to correct the saturation index‘n'in Archie's equation.Based on the analysis of experimental data,a correction method for Archie's equation is suggested,and its effectiveness in controlling relative error has been validated. 展开更多
关键词 gas hydrate electrical resistivity Archie's equation pore connectivity micro distribution
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Shear characteristics and damage mechanism of carbonaceous mudstone soil-rock mixed fillers based on electrical resistivity
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作者 ZENG Ling TANG Jing +2 位作者 ZHANG Saize TANG Jing CHEN Jingcheng 《Journal of Mountain Science》 2025年第12期4737-4752,共16页
With carbonaceous mudstone increasingly employed as fill material for road embankments in areas of China such as Guangxi and Hunan,its longterm stability has become a significant engineering concern.This study adopted... With carbonaceous mudstone increasingly employed as fill material for road embankments in areas of China such as Guangxi and Hunan,its longterm stability has become a significant engineering concern.This study adopted a test method combining direct shear and resistivity measurements.The dynamic coupling mechanism of the mechanical properties and resistivity response of carbonaceous mudstone soil-rock mixed fillers during the shear process was systematically investigated by controlling the influencing factors of rock content and normal stress.The study indicates that the filler's shear failure mode gradually shifts from strain softening to plastic flow as the rock content increases,with shear strength and strength parameters exhibiting an initial increase followed by a subsequent decrease.When the rock content exceeds 60%,particle breakage is markedly intensified,and an increase in normal stress further facilitates the breakdown of coarse particles.The resistivity of the specimen demonstrates a strong positive correlation with shear displacement.The initial resistivity exhibits a rising trend with increasing rock content,and variations in rock content notably impact the resistivity's extreme differenceΔρ(Ω·m).60%rock content is the key critical point of the shear strength,Br,andΔρof the packing.At this point,the shear strength reaches the maximum value,the Br value undergoes a transition,andΔρis the lowest.In this study,the variation of resistivity is utilized to characterize the evolution law of internal structural damage during the shear process,with the aim of providing a theoretical basis for the long-term stability analysis of carbonaceous mudstone soil-rock mixed fill embankments. 展开更多
关键词 Carbonaceous mudstone Shear properties Electrical resistivity Particle breakage Damage evolution
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Calculating Sound Absorption Coefficients of Sound-Absorbing Materials Using Flow Resistivity
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作者 ZHU Congyun SHAO Zhenya DING Guofang 《Journal of Donghua University(English Edition)》 2025年第2期197-203,共7页
To minimize the calculation errors in the sound absorption coefficient resulting from inaccurate measurements of flow resistivity,a simple method for determining the sound absorption coefficient of soundabsorbing mate... To minimize the calculation errors in the sound absorption coefficient resulting from inaccurate measurements of flow resistivity,a simple method for determining the sound absorption coefficient of soundabsorbing materials is proposed.Firstly,the sound absorption coefficients of a fibrous sound-absorbing material are measured at two different frequencies using the impedance tube method.Secondly,utilizing the empirical formulas for the wavenumber and acoustic impedance in the fibrous material,the flow resistivity and porosity of the sound-absorbing materials are calculated using the MATLAB cycle program.Thirdly,based on the values obtained through reverse calculations,the sound absorption coefficient,the real and the imaginary parts of the acoustic impedance of the sound-absorbing material at different frequencies are theoretically computed.Finally,the accuracy of these theoretical calculations is verified through experiments.The experimental results indicate that the calculated values are basically consistent with the measured values,demonstrating the feasibility and reliability of this method. 展开更多
关键词 sound-absorbing material sound absorption coefficient flow resistivity acoustic impedance
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Application of high-density electrical resistivity tomography in backfilling effectiveness of quarries:A case study of Liuyao Village quarry in Huaibei City,Anhui Province
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作者 XU Guangrui LIU Lijia HAN Jiangtao 《Global Geology》 2025年第4期231-239,共9页
Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfil... Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness. 展开更多
关键词 high-density electrical resistivity tomography Wenner array backfilling effectiveness backfill soil
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Fast Forward Modeling of Resistivity Method under Complex Topography Using Finite Element Method
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作者 Wang Zhan Li Chang-Wei +3 位作者 Lv Yu-Zeng Luo Run-Lin Cheng Bo Li Bo 《Applied Geophysics》 2025年第4期1271-1283,1498,共14页
A parallel finite element scheme for 3D resistivity method forward modeling is introduced in this article.The domain decomposition algorithm,along with a message passing interface,is used to implement parallelism.The ... A parallel finite element scheme for 3D resistivity method forward modeling is introduced in this article.The domain decomposition algorithm,along with a message passing interface,is used to implement parallelism.The computational domain is divided into subdomains,and mesh partitioning is combined with load balancing.Unstructured meshes and local mesh refinement strategies are used to realize high precision for complex topography models.Furthermore,an improved linear solver for multi-electrode resistivity method modeling is adopted.Recycling preconditioned conjugate gradient,which is a linear solver,is based on the similarity of linear systems between point sources.The multiple right-hand-side linear systems corresponding to different point source positions are constructed,and the accelerated convergence is obtained through recycling subspace using the linear solver.The computational accuracy and efficiency of the forward scheme for complex topography models are verified using the numerical test results. 展开更多
关键词 resistivity method parallel computing multiple linear systems recycling Krylov subspace
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Mechanism and Application of Dynamic Monitoring for Seepage Processes in Earth-Rock Dams Using the Time-Lapse Electrical Resistivity Method
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作者 Cai Zu-gen Yang Ming-sheng +1 位作者 Wang Jian-jun Xu Yao-hui 《Applied Geophysics》 2025年第4期1464-1474,1502,共12页
In the leakage detection of reservoir dam bodies,traditional geophysical methods can only achieve one-time detection.Meanwhile,due to the non-uniqueness of geophysicalin version,how to improve the fidelity of geophysi... In the leakage detection of reservoir dam bodies,traditional geophysical methods can only achieve one-time detection.Meanwhile,due to the non-uniqueness of geophysicalin version,how to improve the fidelity of geophysical detection inversion profiles has become a key challenge in the industry.This study aims to construct a long-term real-time monitoring system using the time-lapse resistivity method,reveal the spatiotemporal evolution law of dam leakage,and provide technical support for accurate treatment.By integrating the Internet of Things(IoT),5G technology,and AI technology,real-time data acquisition,real-time transmission,and automatic inversionare realized.Through dynamic imaging analysis of the electrical anomaly characteristics of the leakage area and comparison between corresponding rainfall events,the leakage range and resistivity changes,the reliability and efficiency of dam leakagedete ction are significantly improved.This achieves long-termdynamic monitoring of dam leakage and provides a new perspective for the safe operation and maintenance of reservoirs. 展开更多
关键词 geophysical detection time-lapse resistivity method IoT and 5G technologies dynamic monitoring
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Reducing specific contact resistivity of V/Al/Ti/Au n-electrode on n-AlGaN with Al content over 80%for far-UVC LEDs
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作者 Jiale Peng Ke Jiang +8 位作者 Shanli Zhang Jianwei Ben Kexi Liu Ziyue Qin Ruihua Chen Chunyue Zhang Shunpeng Lv Xiaojuan Sun Dabing Li 《Journal of Semiconductors》 2025年第9期42-49,共8页
AlGaN-based LEDs with peak wavelength below 240 nm(far-UVC)pose no significant harm to human health,thus highlighting their broader application potential.While,there is a significant Schottky barrier between the n-ele... AlGaN-based LEDs with peak wavelength below 240 nm(far-UVC)pose no significant harm to human health,thus highlighting their broader application potential.While,there is a significant Schottky barrier between the n-electrode and Alrich n-AlGaN,adversely impeding electron injection and resulting in considerable heat generation.Here,we fabricate V-based electrodes of V/Al/Ti/Au on n-AlGaN with Al content over 80%and investigate the relationship between the metal diffusion and contact properties during the high-temperature annealing process.Experiments reveal that decreasing V thickness in the electrode promotes the diffusion of Al towards the surface of n-AlGaN,which facilitates the formation of VN and thus the increase of local electron concentration,resulting in lower specific contact resistivity.Then,increasing the Al thickness inhibits the diffusion of Au to the n-AlGaN surface,suppressing the rise of Schottky barrier.Experimentally,an optimized n-electrode of V(10 nm)/Al(240 nm)/Ti(40 nm)/Au(50 nm)on n-Al_(0.81)Ga_(0.19)N is obtained,realizing an optimal specific contact resistivity of 7.30×10^(−4)Ω·cm^(2).Based on the optimal n-electrode preparation scheme for Al-rich n-AlGaN,the work voltage of a far-UVC LED with peak wavelength of 233.5 nm is effectively reduced. 展开更多
关键词 Al-rich n-AlGaN specific contact resistivity far-UVC LED
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玉米穗腐病的抗性遗传研究进展与育种应用
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作者 苏爱国 肖森林 +13 位作者 易红梅 段赛茹 王帅帅 张如养 邢锦丰 李春辉 孙轩 徐瑞斌 徐田军 李志勇 张勇 王荣焕 宋伟 赵久然 《作物学报》 北大核心 2026年第1期1-13,共13页
穗腐病是玉米生产中的一种主要病害,不仅影响产量和品质,病原菌产生的毒素还会危害人畜的健康安全。选育和种植玉米抗病品种,是防治玉米穗腐病最有效的途径之一。目前,国内外学者对优势病原菌的抗性候选基因和分子遗传机制进行了深入研... 穗腐病是玉米生产中的一种主要病害,不仅影响产量和品质,病原菌产生的毒素还会危害人畜的健康安全。选育和种植玉米抗病品种,是防治玉米穗腐病最有效的途径之一。目前,国内外学者对优势病原菌的抗性候选基因和分子遗传机制进行了深入研究。玉米的10条染色体上,均有穗腐病抗性相关QTL和显著关联的SNP位点报道。但病原菌侵染的复杂性,以及其抗性为微效多基因控制的数量性状,导致相关研究应用于抗病育种实践的实例并不多。本文介绍了玉米穗腐病的主要病原菌种类、地域分布、发病影响因素以及毒素危害,总结了近年来在拟轮枝穗腐病(fusarium ear rot,FER)和禾谷镰孢穗腐病(gibberella ear rot,GER)抗性基因挖掘和分子遗传机制方面取得的研究进展,并对抗病育种进行了展望。多组学交叉研究的深入和新生物技术的应用将加速穗腐病主效抗性基因的挖掘和抗病分子机制解析,进而促进玉米种质创制和穗腐病抗性品种选育。 展开更多
关键词 玉米 穗腐病 病原菌 抗性基因 防御机制 抗病育种
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土石坝渗漏地-孔电阻率成像探测技术
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作者 谭磊 胡雄武 +5 位作者 张平松 江晓益 董亚 刘福达 李纯阳 徐虎 《煤田地质与勘探》 北大核心 2026年第2期203-213,共11页
【目的】电阻率法是水库堤坝渗漏探测的重要手段,但地表电阻率法探测隐患时存在两坝肩盲区与深部分辨率不足等问题,难以精准捕捉全坝段的薄弱区。【方法】提出大坝渗漏的地-孔电阻率探测方法,通过数值模拟分析渗漏区在横向与垂向变化过... 【目的】电阻率法是水库堤坝渗漏探测的重要手段,但地表电阻率法探测隐患时存在两坝肩盲区与深部分辨率不足等问题,难以精准捕捉全坝段的薄弱区。【方法】提出大坝渗漏的地-孔电阻率探测方法,通过数值模拟分析渗漏区在横向与垂向变化过程中的地-孔电阻率分布特征。以石壁水库大坝为例,利用地-孔电阻率观测系统获取电极电流以及近地表、跨孔、地-孔电阻率信息,并结合钻孔资料、水库水位、地质剖面和钻孔电视验证探测结果的可靠性。【结果和结论】随着预设渗漏区逐渐靠近坝肩山体,地表电阻率反映出的异常体深度与中心位置偏差逐渐增大,而地-孔电阻率成像受岸坡山体高阻区影响较小,探测结果与预设模型吻合较好;地表电阻率对浅部渗漏异常较为敏感,但随着深度增加,难以识别深部渗漏区,地-孔电阻率反演结果能清晰揭示不同深度的目标体,并对山体边界具有较强的刻画能力;在石壁水库渗漏区探测试验中,地表电阻率反映出的坝体段渗漏异常范围较大,难以全面揭示坝肩渗漏区,跨孔电阻率提高了钻孔间坝体段的探测精度,但覆盖范围有限,地-孔电阻率反演剖面勘探范围广,有效压制了坝体段的低阻异常,有助于降低地表电阻率的体积效应,实现对深部坝肩接触带低阻异常的精细圈定,为水库大坝隐患的定向处置提供了技术依据,也为土石坝的精准诊断与智能感知提供了新思路。 展开更多
关键词 电阻率法 土石坝 渗漏隐患 地-孔电阻率成像 电极电流 并行电法
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电阻型超导限流器的限流和恢复特性仿真分析研究
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作者 张琦 项彬 +5 位作者 马舒幸 邓朴达 袁仲滨 耿英三 刘志远 王建华 《西安交通大学学报》 北大核心 2026年第2期156-165,共10页
为进一步探索超导限流器的恢复性能,准确判断其恢复状态,对电阻型超导限流器的限流电阻和恢复特性进行了仿真分析研究。基于实验获得的ST-12-L超导带材单位电阻-单位热量(R-Q)拟合曲线,以及超导的电场强度-电流密度指数(E-J)公式,结合... 为进一步探索超导限流器的恢复性能,准确判断其恢复状态,对电阻型超导限流器的限流电阻和恢复特性进行了仿真分析研究。基于实验获得的ST-12-L超导带材单位电阻-单位热量(R-Q)拟合曲线,以及超导的电场强度-电流密度指数(E-J)公式,结合液氮相变传热方程,在SIMULINK中建立了电阻型超导限流器的R-Q恢复模型和E-J恢复模型;仿真分析了LC短路电流下ST-12-L超导带材的故障限流和恢复特性;基于LC源和恢复测试回路,搭建了并联超导带材的限流和恢复实验电路,进行了LC短路冲击下的超导带材的失超限流和恢复测试,并将实验结果和仿真结果进行了对比。对比发现:在限流效果仿真中,E-J恢复模型的电流正、负峰值与实验的最大误差分别为3.6%和15%,而R-Q恢复模型的电流正、负峰值与实验值的最大误差分别为2.3%和8.6%,R-Q恢复模型的限流仿真更为准确;在恢复时间仿真中,R-Q恢真模型的恢复时间最大误差仅为0.120 s,误差远小于E-J恢复模型的仿真结果。R-Q恢复仿真模型能有效模拟超导带材的失超和恢复,促进电阻型超导限流器在电力系统中的应用。 展开更多
关键词 电阻型超导限流器 超导仿真 限流电阻 恢复特性
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3D electrical resistivity inversion using prior spatial shape constraints 被引量:10
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作者 李术才 聂利超 +4 位作者 刘斌 宋杰 刘征宇 苏茂鑫 徐磊 《Applied Geophysics》 SCIE CSCD 2013年第4期361-372,510,共13页
To minimize the number of solutions in 3D resistivity inversion, an inherent problem in inversion, the amount of data considered have to be large and prior constraints need to be applied. Geological and geophysical da... To minimize the number of solutions in 3D resistivity inversion, an inherent problem in inversion, the amount of data considered have to be large and prior constraints need to be applied. Geological and geophysical data regarding the extent of a geological anomaly are important prior information. We propose the use of shape constraints in 3D electrical resistivity inversion, Three weighted orthogonal vectors (a normal and two tangent vectors) were used to control the resistivity differences at the boundaries of the anomaly. The spatial shape of the anomaly and the constraints on the boundaries of the anomaly are thus established. We incorporated the spatial shape constraints in the objective function of the 3D resistivity inversion and constructed the 3D resistivity inversion equation with spatial shape constraints. Subsequently, we used numerical modeling based on prior spatial shape data to constrain the direction vectors and weights of the 3D resistivity inversion. We established a reasonable range between the direction vectors and weights, and verified the feasibility and effectiveness of using spatial shape prior constraints in reducing excessive structures and the number of solutions. We applied the prior spatially shape-constrained inversion method to locate the aquifer at the Guangzhou subway. The spatial shape constraints were taken from ground penetrating radar data. The inversion results for the location and shape of the aquifer agree well with drilling data, and the number of inversion solutions is significantly reduced. 展开更多
关键词 electrical resistivity INVERSION prior spatial constraints direction vector GEOPHYSICS geotechnical engineering.
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Landslide monitoring in southwestern China via time-lapse electrical resistivity tomography 被引量:14
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作者 徐冬 胡祥云 +1 位作者 单春玲 李睿恒 《Applied Geophysics》 SCIE CSCD 2016年第1期1-12,217,共13页
The dynamic monitoring of landslides in engineering geology has focused on the correlation among landslide stability,rainwater infiltration,and subsurface hydrogeology.However,the understanding of this complicated cor... The dynamic monitoring of landslides in engineering geology has focused on the correlation among landslide stability,rainwater infiltration,and subsurface hydrogeology.However,the understanding of this complicated correlation is still poor and inadequate.Thus,in this study,we investigated a typical landslide in southwestern China via time-lapse electrical resistivity tomography(TLERT) in November 2013 and August 2014.We studied landslide mechanisms based on the spatiotemporal characteristics of surface water infiltration and flow within the landslide body.Combined with borehole data,inverted resistivity models accurately defined the interface between Quaternary sediments and bedrock.Preferential flow pathways attributed to fracture zones and fissures were also delineated.In addition,we found that surface water permeates through these pathways into the slipping mass and drains away as fissure water in the fractured bedrock,probably causing the weakly weathered layer to gradually soften and erode,eventually leading to a landslide.Clearly,TLERT dynamic monitoring can provide precursory information of critical sliding and can be used in landslide stability analysis and prediction. 展开更多
关键词 time-lapse electrical resistivity tomography LANDSLIDE HYDROGEOPHYSICS MONITORING preferential flow
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350株耐碳青霉烯类肺炎克雷伯菌耐药特征及基于头孢他啶/阿维巴坦的联合药敏试验报告
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作者 孙淑红 胡晓峰 +2 位作者 李春芝 彭善鑫 高春海 《中华医院感染学杂志》 北大核心 2026年第1期6-10,共5页
目的 了解医院耐碳青霉烯肺炎克雷伯菌(CRKP)耐药情况,探索CRKP联合药敏方式。方法 收集临沂市人民医院临床标本中分离的350株CRKP菌株,采用全自动微生物分析仪、改良碳青霉烯灭活试验(mCIM)和乙二胺四乙酸(EDTA)协同碳青霉烯灭活试验(e... 目的 了解医院耐碳青霉烯肺炎克雷伯菌(CRKP)耐药情况,探索CRKP联合药敏方式。方法 收集临沂市人民医院临床标本中分离的350株CRKP菌株,采用全自动微生物分析仪、改良碳青霉烯灭活试验(mCIM)和乙二胺四乙酸(EDTA)协同碳青霉烯灭活试验(eCIM)、免疫层析法及聚合酶链反应分析其耐药特征,采用常规纸片扩散法、纸片优加法和微量肉汤稀释棋盘法对产NDM菌株进行基于头孢他啶/阿维巴坦的联合药敏试验。结果 CRKP对替加环素和多黏菌素耐药率较低(0.57%,2.44%);285株携带bla_(KPC)耐药基因的CRKP对头孢他啶/阿维巴坦耐药率0.35%,12株携带bla_(OXA)基因菌株对其完全敏感,而53株携带blaNDM基因菌株对其完全耐药;与携带bla_(KPC)耐药基因菌株相比,携带blaNDM基因菌株对阿米卡星、氨曲南、环丙沙星、庆大霉素、左氧氟沙星等耐药率较低(P<0.05)。联合药敏结果显示,头孢他啶/阿维巴坦与氨曲南联合时全部具有协同作用,与磷霉素联合仅有1株有协同作用,与左氧氟沙星、替加环素、阿米卡星和美罗培南联合时均无协同作用。结论 CRKP抗感染治疗的抗菌药物选择有限,产丝氨酸酶菌株感染可选择头孢他啶/阿维巴坦,产金属酶的菌株感染建议选择头孢他啶/阿维巴坦联合氨曲南;用药过程中应根据实验室结果精准治疗、及时调整用药。 展开更多
关键词 耐碳青霉烯肺炎克雷伯菌 耐药基因 头孢他啶/阿维巴坦 联合药敏试验
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Analysis and application of the response characteristics of DLL and LWD resistivity in horizontal well 被引量:9
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作者 胡松 李军 +1 位作者 郭洪波 王昌学 《Applied Geophysics》 SCIE CSCD 2017年第3期351-362,459,460,共14页
There exist different response characteristics in the resistivity measurements of dual laterolog (DLL) and logging while drilling (LWD) electromagnetic wave propagation logging in highly deviated and horizontal we... There exist different response characteristics in the resistivity measurements of dual laterolog (DLL) and logging while drilling (LWD) electromagnetic wave propagation logging in highly deviated and horizontal wells due to the difference in their measuring principles. In this study, we first use the integral equation method simulated the response characteristics of LWD resistivity and use the three dimensional finite element method (3D-FEM) simulated the response characteristics of DLL resistivity in horizontal wells, and then analyzed the response differences between the DLL and LWD resistivity. The comparative analysis indicated that the response differences may be caused by different factors such as differences in the angle of instrument inclination, anisotropy, formation interface, and mud intrusion. In the interface, the curves of the LWD resistivity become sharp with increases in the deviation while those of the DLL resistivity gradually become smooth. Both curves are affected by the anisotropy although the effect on DLL resistivity is lower than the LWD resistivity. These differences aid in providing a reasonable explanation in the horizontal well. However, this can also simultaneously lead to false results. At the end of the study, we explain the effects of the differences in the interpretation of the horizontal well based on the results and actual data analysis. 展开更多
关键词 response characteristic dual laterolog LWD resistivity horizontal well numerical modeling
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新型铁载体偶联头孢菌素——Cefiderocol
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作者 赵世峰 曹恒斌 +1 位作者 汪荣华 袁玉梅 《中国临床药理学与治疗学》 北大核心 2026年第1期133-144,共12页
Cefiderocol为全球首个铁载体偶联头孢菌素,凭借独特的作用机制和不依赖β-内酰胺酶抑制剂的高稳定性,Cefiderocol展现了对多重耐药革兰氏阴性菌或碳青霉烯类耐药革兰氏阴性菌的强大活性,是当前临床上治疗此类病原体的重要选择。本文对... Cefiderocol为全球首个铁载体偶联头孢菌素,凭借独特的作用机制和不依赖β-内酰胺酶抑制剂的高稳定性,Cefiderocol展现了对多重耐药革兰氏阴性菌或碳青霉烯类耐药革兰氏阴性菌的强大活性,是当前临床上治疗此类病原体的重要选择。本文对其作用机制、抗菌活性、药动学/药效学、临床研究、安全性及耐药机制等方面进行综述,以期为临床抗耐药革兰氏阴性菌感染提供参考。 展开更多
关键词 Cefiderocol 铁载体 Β-内酰胺类 多重耐药革兰氏阴性菌 碳青霉烯类耐药革兰氏阴性菌
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机器学习辅助耐磨耐腐蚀高熵合金设计的现状与展望
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作者 谢芋江 漆俊杰 +3 位作者 蒋文宇 文雄 温飞娟 黄本生 《材料导报》 北大核心 2026年第3期164-171,共8页
高熵合金(HEAs)具有高强度、高硬度、高耐磨性、高耐腐蚀性等优异的性能,广泛应用于石油工程和航空航天等领域。但是高熵合金的成分空间复杂,设计难度极大。以往高熵合金的设计主要依赖试错法和模拟计算法等,这些方法既耗时又浪费资源... 高熵合金(HEAs)具有高强度、高硬度、高耐磨性、高耐腐蚀性等优异的性能,广泛应用于石油工程和航空航天等领域。但是高熵合金的成分空间复杂,设计难度极大。以往高熵合金的设计主要依赖试错法和模拟计算法等,这些方法既耗时又浪费资源。近年来,机器学习(ML)作为研究高熵合金的强大工具逐渐崭露头角,通过训练模型和识别关键特征来推动研究。本文首先介绍了机器学习的基本原理,之后在广泛收集了机器学习辅助高熵合金设计的研究成果的基础上综述了机器学习在高熵合金设计中的最新应用,特别是相结构、耐磨性以及耐蚀性方面的研究。 展开更多
关键词 机器学习 高熵合金 相结构 耐磨性 耐蚀性
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Numerical simulation of LWD resistivity response of carbonate formation using self-adaptive hp-FEM 被引量:4
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作者 刘得军 马中华 +2 位作者 邢晓楠 李辉 郭智勇 《Applied Geophysics》 SCIE CSCD 2013年第1期97-108,119,120,共14页
Most of the carbonate formation are highly heterogeneous with cavities of different sizes, which makes the prediction of cavity-filled reservoir in carbonate rocks difficult. Large cavities in carbonate formations pos... Most of the carbonate formation are highly heterogeneous with cavities of different sizes, which makes the prediction of cavity-filled reservoir in carbonate rocks difficult. Large cavities in carbonate formations pose serious threat to drilling operations. Logging-whiledrilling (LWD) is currently used to accurately identify and evaluate cavities in reservoirs during drilling. In this study, we use the self-adaptive hp-FEM algorithm simulate and calculate the LWD resistivity responses of fracture-cavity reservoir cavities. Compared with the traditional h-FEM method, the self-adaptive hp-FEM algorithm has the characteristics of the self-adaptive mesh refinement and the calculations exponentially converge to highly accurate solutions. Using numerical simulations, we investigated the effect of the cavity size, distance between cavity and borehole, and transmitted frequency on the LWD resistivity response. Based on the results, a method for recognizing cavities is proposed. This research can provide the theoretical basis for the accurate identification and quantitative evaluation of various carbonate reservoirs with cavities encountered in practice. 展开更多
关键词 LWD resistivity HP-FEM SELF-ADAPTIVE exponential convergence numerical simulation cavity RESERVOIRS
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Three-dimensional forward modeling of DC resistivity using the aggregation-based algebraic multigrid method 被引量:5
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作者 陈辉 邓居智 +2 位作者 尹敏 殷长春 汤文武 《Applied Geophysics》 SCIE CSCD 2017年第1期154-164,192,共12页
To speed up three-dimensional (3D) DC resistivity modeling, we present a new multigrid method, the aggregation-based algebraic multigrid method (AGMG). We first discretize the differential equation of the secondar... To speed up three-dimensional (3D) DC resistivity modeling, we present a new multigrid method, the aggregation-based algebraic multigrid method (AGMG). We first discretize the differential equation of the secondary potential field with mixed boundary conditions by using a seven-point finite-difference method to obtain a large sparse system of linear equations. Then, we introduce the theory behind the pairwise aggregation algorithms for AGMG and use the conjugate-gradient method with the V-cycle AGMG preconditioner (AGMG-CG) to solve the linear equations. We use typical geoelectrical models to test the proposed AGMG-CG method and compare the results with analytical solutions and the 3DDCXH algorithm for 3D DC modeling (3DDCXH). In addition, we apply the AGMG-CG method to different grid sizes and geoelectrical models and compare it to different iterative methods, such as ILU-BICGSTAB, ILU-GCR, and SSOR-CG. The AGMG-CG method yields nearly linearly decreasing errors, whereas the number of iterations increases slowly with increasing grid size. The AGMG-CG method is precise and converges fast, and thus can improve the computational efficiency in forward modeling of three-dimensional DC resistivity. 展开更多
关键词 AGMG DC resistivity method 3D modeling finite difference method
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