BACKGROUND Antibiotic resistance significantly impacts the treatment failure rates of Helicobacter pylori(H.pylori)infections.AIM To investigate the trends in primary antibiotic resistance of H.pylori in Taiwan of Chi...BACKGROUND Antibiotic resistance significantly impacts the treatment failure rates of Helicobacter pylori(H.pylori)infections.AIM To investigate the trends in primary antibiotic resistance of H.pylori in Taiwan of China over the past six years.METHODS We conducted a retrospective analysis of H.pylori isolates from Taiwan residents,China who had not undergone previous treatments(n=1408),collected between January 1,2019 and December 31,2024.Susceptibility of these strains to amoxicillin,clarithromycin,levofloxacin,metronidazole,and tetracycline was tested using the Epsilometer test.We analyzed the trends in single and dual resistance profiles over the study period,and compared antibiotic resistance across different regions(northern,southern and eastern areas)of Taiwan of China.RESULTS The overall resistance rates for H.pylori to amoxicillin,clarithromycin,metronidazole,tetracycline,and levofloxacin in Taiwan of China were 1.3%,18.0%,31.0%,0.8%,and 28.7%,respectively.Tetracycline resistance increased significantly from 0%in 2019 to 3.5%in 2024(P value inχ^(2)test for linear trend:<0.001),while metronidazole resistance declined from 35.5%to 13.0%(P value inχ^(2)test for linear trend:<0.001).No significant changes of amoxicillin,clarithromycin and levofloxacin resistances were observed.The dual resistances to clarithromycin plus tetracycline,and metronidazole plus tetracycline both increased significantly from 0%to 1.7%from 2019 to 2024(P value inχ^(2)test for linear trend:<0.05).Furthermore,no significant regional differences in resistance frequencies except for levofloxacin were detected.CONCLUSION Primary antibiotic resistance to tetracycline in H.pylori has increased in Taiwan of China from 2019 to 2024,while resistance to metronidazole has decreased during the same period.The dual resistance to clarithromycin plus tetracycline and metronidazole plus tetracycline both increased significantly.展开更多
Metal wear and corrosion require a protective coating with good corrosion and wear resistance.The inorganic adhesive of methyltriethoxysilane modified silica sol(SMP)was first synthesized by the dehydration condensati...Metal wear and corrosion require a protective coating with good corrosion and wear resistance.The inorganic adhesive of methyltriethoxysilane modified silica sol(SMP)was first synthesized by the dehydration condensation of silica sol(S30)with methyltriethoxysilane in propyl alcohol.Then,SMP was used to modify the organic polyurethane(PU)by adjusting the volume ratio.The optimal ratio of the organic–inorganic hybrid adhesive PU-SMP was obtained by measuring its film-forming,mechanical,and corrosion-resistant properties.Then,PU-SMP and zirconia nanoparticles(ZrO_(2))were used as an adhesive and functional filler to prepare the organic–inorganic composite coating of PU-SMP@ZrO_(2)via spraying on various substrates.The fabricated PU-SMP@ZrO_(2)performed superior mechanical strength,good wear performance,and excellent anti-corrosion property.The pencil hardness of the coating PU-SMP@2.5ZrO_(2)is 7H,the wear mass is reduced from 0.7 to 0.2 mg,and the impedance modulus reached 10^(7)Ωcm^(2).The synthesized organic–inorganic hybrid adhesive and its composite coatings provide a promising approach for constructing functional protective coatings on mechanical engineering material.展开更多
为满足海上深层超深层油气井压裂改造需要,保证压裂液的耐温和携砂能力,以丙烯酰胺、丙烯酸、2-丙烯酰胺-2-甲基丙磺酸以及疏水单体DM合成了一种耐高温高盐疏水缔合聚合物TH–200。采用红外光谱、核磁共振氢谱、热重对聚合物TH–200进...为满足海上深层超深层油气井压裂改造需要,保证压裂液的耐温和携砂能力,以丙烯酰胺、丙烯酸、2-丙烯酰胺-2-甲基丙磺酸以及疏水单体DM合成了一种耐高温高盐疏水缔合聚合物TH–200。采用红外光谱、核磁共振氢谱、热重对聚合物TH–200进行结构表征,并进一步评价了其作为压裂液稠化剂的主要性能。研究结果表明:聚合物TH–200为四元共聚合物,具有较好的热稳定性。该聚合物在海水中增黏速率达92%,具有较好的增黏抗盐性能,适合在海水等高矿化度水中使用,其分子间临界缔合质量分数在0.25%附近。分子动力学模拟显示AMPS单体浓度增加,聚合物链段的回转半径显著提升且受温度和矿化度的影响较小。海水配制0.1%溶液降阻率可达78%。1.0%聚合物TH–200+0.5%螯合调节剂+1.0%有机锆交联剂配制的海水基压裂液,在200℃、100 s^(-1)下剪切90 min后黏度为110 m Pa·s,表明其具有良好的延迟交联性能和耐温耐剪切性能,交联冻胶具有优异的携砂性能,可满足海上200℃储层压裂施工需求。展开更多
基金Supported by the An Nan Hospital,China Medical University,No.ANHRF114-20 and No.ANHRF114-21.
文摘BACKGROUND Antibiotic resistance significantly impacts the treatment failure rates of Helicobacter pylori(H.pylori)infections.AIM To investigate the trends in primary antibiotic resistance of H.pylori in Taiwan of China over the past six years.METHODS We conducted a retrospective analysis of H.pylori isolates from Taiwan residents,China who had not undergone previous treatments(n=1408),collected between January 1,2019 and December 31,2024.Susceptibility of these strains to amoxicillin,clarithromycin,levofloxacin,metronidazole,and tetracycline was tested using the Epsilometer test.We analyzed the trends in single and dual resistance profiles over the study period,and compared antibiotic resistance across different regions(northern,southern and eastern areas)of Taiwan of China.RESULTS The overall resistance rates for H.pylori to amoxicillin,clarithromycin,metronidazole,tetracycline,and levofloxacin in Taiwan of China were 1.3%,18.0%,31.0%,0.8%,and 28.7%,respectively.Tetracycline resistance increased significantly from 0%in 2019 to 3.5%in 2024(P value inχ^(2)test for linear trend:<0.001),while metronidazole resistance declined from 35.5%to 13.0%(P value inχ^(2)test for linear trend:<0.001).No significant changes of amoxicillin,clarithromycin and levofloxacin resistances were observed.The dual resistances to clarithromycin plus tetracycline,and metronidazole plus tetracycline both increased significantly from 0%to 1.7%from 2019 to 2024(P value inχ^(2)test for linear trend:<0.05).Furthermore,no significant regional differences in resistance frequencies except for levofloxacin were detected.CONCLUSION Primary antibiotic resistance to tetracycline in H.pylori has increased in Taiwan of China from 2019 to 2024,while resistance to metronidazole has decreased during the same period.The dual resistance to clarithromycin plus tetracycline and metronidazole plus tetracycline both increased significantly.
基金supported by National Key R&D Project of China(No.2024YFB4600167)the National Natural Science Foundation of China(No.52205313)+1 种基金Natural Science Foundation of Shandong Province(Nos.ZR2022ZD07 and ZR2022QE161)China Postdoctoral Science Foundation(No.2023M734093).
文摘Metal wear and corrosion require a protective coating with good corrosion and wear resistance.The inorganic adhesive of methyltriethoxysilane modified silica sol(SMP)was first synthesized by the dehydration condensation of silica sol(S30)with methyltriethoxysilane in propyl alcohol.Then,SMP was used to modify the organic polyurethane(PU)by adjusting the volume ratio.The optimal ratio of the organic–inorganic hybrid adhesive PU-SMP was obtained by measuring its film-forming,mechanical,and corrosion-resistant properties.Then,PU-SMP and zirconia nanoparticles(ZrO_(2))were used as an adhesive and functional filler to prepare the organic–inorganic composite coating of PU-SMP@ZrO_(2)via spraying on various substrates.The fabricated PU-SMP@ZrO_(2)performed superior mechanical strength,good wear performance,and excellent anti-corrosion property.The pencil hardness of the coating PU-SMP@2.5ZrO_(2)is 7H,the wear mass is reduced from 0.7 to 0.2 mg,and the impedance modulus reached 10^(7)Ωcm^(2).The synthesized organic–inorganic hybrid adhesive and its composite coatings provide a promising approach for constructing functional protective coatings on mechanical engineering material.
文摘为满足海上深层超深层油气井压裂改造需要,保证压裂液的耐温和携砂能力,以丙烯酰胺、丙烯酸、2-丙烯酰胺-2-甲基丙磺酸以及疏水单体DM合成了一种耐高温高盐疏水缔合聚合物TH–200。采用红外光谱、核磁共振氢谱、热重对聚合物TH–200进行结构表征,并进一步评价了其作为压裂液稠化剂的主要性能。研究结果表明:聚合物TH–200为四元共聚合物,具有较好的热稳定性。该聚合物在海水中增黏速率达92%,具有较好的增黏抗盐性能,适合在海水等高矿化度水中使用,其分子间临界缔合质量分数在0.25%附近。分子动力学模拟显示AMPS单体浓度增加,聚合物链段的回转半径显著提升且受温度和矿化度的影响较小。海水配制0.1%溶液降阻率可达78%。1.0%聚合物TH–200+0.5%螯合调节剂+1.0%有机锆交联剂配制的海水基压裂液,在200℃、100 s^(-1)下剪切90 min后黏度为110 m Pa·s,表明其具有良好的延迟交联性能和耐温耐剪切性能,交联冻胶具有优异的携砂性能,可满足海上200℃储层压裂施工需求。
