With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold ...With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold War,showing instability and uncertainty.The type of order that can emerge in a region depends on the effectiveness of governance and the power structures and systems built upon it.The SCO advocates a brand new philosophy of cooperation that transcends the traditional mentality of international relations,forging a new model of multilateral collaboration.The SCO has vigorously participated in improving regional governance and is thus playing an increasingly important and unique role in reshaping the Eurasian regional order.展开更多
In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of p...In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of people’s behaviors,measurement of its scale,and architectural history.Besides,how urban renewal creates new urban vitality was demonstrated.It has certain guiding and reference significance for research on urban renewal.Remarkable results have been achieved,such as rationalizing the internal functions of old residential areas,improving circulation experience conditions,and promoting and recreating unique cultural features.It is a case of engineering innovation in urban renewal in the core areas of domestic cities.展开更多
China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing ...China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing arts sector,as the industry evolved from a traditional entertainment field into a comprehensive engine of cultural consumption.展开更多
An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this pa...An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.展开更多
The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA an...The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.展开更多
The transition from middle-income to high-income stage is fraught with risks of growth divergence. Economic transition is clouded by the following possibilities： （1）falling share of industrial seetor through indust...The transition from middle-income to high-income stage is fraught with risks of growth divergence. Economic transition is clouded by the following possibilities： （1）falling share of industrial seetor through industrial depression and weakening growth momentum caused by the large urbanization costs; （2） the subordination of service sector as a result of nearly irreversibly industrial professional, which falters the process of service sector transition and upgrading,＂ （3） inefficient knowledge production allocation and human capital upgrade due to the absence of incentivized compensation of knowledge consumption. We suggest that a country should reshape its efficiency model by upgrading knowledge factor and human capital as the pre-requisite. Given the dilemmas of transition, China should take the faetorization trend of service sector and reshape efficiency model through institutional reform, ensuring that service sector will develop in tandem with industrial sector.展开更多
Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,ai...Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,aiming to reshape the economic geography of China.This paper is based on the Belt and Road Initiative and the Yangtze River Economic Belt and outlines the pattern of opening up.To analyze the impact of the pattern of opening up on the regional integration of China's economic geography,this paper has developed a new economic geography model comprised of four regions and two countries.From this,it draws some conclusions.First,the change of pattern of opening up will lead to shifting centripetal and centrifugal forces from the international market.The greater the scale of neighboring markets,the stronger the agglomeration force will be; the more product varieties made in neighboring countries,the more potent its dispersion force.Second,developing an inland international trade corridor will decentralize industry distribution and reduce the impact of external market integration on home countries.Third,the inland international trade corridor could alter the effect of domestic market integration on the economic geography.When domestic integration occurs prior to international integration,further integration of a domestic market leads to greater industrial distribution along a bell-shaped curve,which describes economic activities from dispersion to agglomeration to decentralization.Therefore,developing an integrated market system of major countries and opening a corridor between China and Europe is not only the key to reshaping China's economic geography but also the path to solving the problems of the Heihe-Tengchong Line.展开更多
Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often o...Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often overlooking the revolutionary nature of digital media.Digital media has the sweeping potential to unify all forms of media and reshape social life,giving rise to new demands for a new generation of human rights.The concept of digital human rights can be defined as the legitimate rights of human's infinitely extended personalities through digital media.Its core characteristic is its transcendency,where every person lives in a networked space that surpasses physical boundaries,nations,and individual personalities.Human rights are generally considered the foundation for basic constitutional rights,which,in turn,form the basis for legislative acts across various sectors.In recent years,China has enacted numerous laws in the digital domain to keep pace with the times,but due to the lack of guidance on digital human rights,these laws tend to be fragmented and disjointed.It is urgent to unify digital legislation at all levels on the basis of reshaping basic constitutional rights.Thus,it is essential to reshape the basic rights based on the concept and characteristics of digital human rights and streamline legislation at all levels under the unified guidance of basic rights.This can help establish a comprehensive digital human rights protection system that meets the demands of the modern era.展开更多
Obesity is a chronic,multifactorial disease closely linked to a spectrum of cardiometabolic disorders,with its global prevalence rising at an alarming rate.In recent years,minimally invasive,safe,and effective endosco...Obesity is a chronic,multifactorial disease closely linked to a spectrum of cardiometabolic disorders,with its global prevalence rising at an alarming rate.In recent years,minimally invasive,safe,and effective endoscopic bariatric therapies have gained significant attention as alternatives to conventional surgical interventions.This review provides a comprehensive overview of various endoscopic weight-loss procedures,evaluating their advantages and limitations in comparison to surgical approaches to assist clinicians in optimizing patientspecific treatment strategies.Endoscopic bariatric therapies,including intragastric balloons,duodenal-jejunal bypass sleeves,endoscopic sleeve gastroplasty,gastric remodeling procedures,and interventions aimed at delaying gastric emptying are systematically reviewed.The efficacy,safety profiles,and clinical applicability are all synthesized.Endoscopic bariatric therapies exhibit distinct advantages and limitations,with varying indications and contraindications.As part of a multidisciplinary approach to obesity management,these procedures should be integrated with lifestyle modifications and nutritional counseling to maximize therapeutic benefits.Future research should focus on the long-term efficacy,safety,and patient-reported outcomes to refine clinical practice and optimize the role of endoscopic interventions in obesity treatment.展开更多
Gold prices have been more than usually volatile in recent months,with prices making multiple sharp swings since the start of 2026.In an environment of elevated uncertainty,these price movements are not simply a matte...Gold prices have been more than usually volatile in recent months,with prices making multiple sharp swings since the start of 2026.In an environment of elevated uncertainty,these price movements are not simply a matter of supply and demand;they signal a much broader shift toward the acceleration of de-dollarization and the reshaping of the global monetary system.展开更多
This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical ...This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.展开更多
The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscop...The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera? Intragastric Balloon System(Apollo Endosurgery Inc, Austin, TX, United States), the Re Shape? Integrated Dual Balloon System(Re Shape Medical, Inc., San Clemente, CA, United States), and the Obalon(Obalon? Therapeutics, Inc.). The individual features of each of these balloons, the method of introduction and removal, and the expected weight loss and possible complications are discussed. This review of the various balloons highlights the innovation in the field of weight loss.展开更多
Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ...Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ground devices is generally determined by experience.However,too large reshaping force may destroy the deformed casing,and too small reshaping force may also prolong the construction period and affect the repairing effect.In this paper,based on Hertz contact theory and elastic-plastic theory,combined with the process parameters of shaping,and considering the structural characteristics of the deformed casing and reshaper,we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper.Meanwhile,the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method,and the reliability of the mathematical model is verified by several examples.On this basis,the control variable method is used to investigate the influence of each parameter on the reshaping force,and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis.The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction,but also provide a reference for the subsequent improvement of the shaping process.展开更多
Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement tea...Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement teaching reform,and carry out teaching innovation.The article carries out blended teaching with deep integration of online and offline modes and within and outside of class,constructing innovative measures of“four integrations and four reshaping.”The article conducts diversified evaluations to stimulate learning motivation and help achieve talent cultivation goals.Through the close integration of probability theory and mathematical statistics course teaching with professional education and practical application,the“three-in-one”teaching goal of value shaping,ability cultivation,and knowledge exploration is achieved.The fundamental task of“cultivating morality and talents”is implemented.展开更多
The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequen...The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequences,some residues werechanged and the reshaping VL and VH genes were designed.The full VH gene was assem-bled in three steps with eight chemically synthesized oligonucleotide fragments using over-lapping PCR and sequenced.The VH gene was expressed as active protein and inclusion bod-ies in the vectors of pCOMB3 and pGEX-4T-1 by ELISA and Western blot analysis.展开更多
Anisotropic shapes of gold nanoparticles are prepared using a modified seed method in the presence of silver ions or clusters in order to study the thermal stability and the dynamics of the hot carriers induced by fem...Anisotropic shapes of gold nanoparticles are prepared using a modified seed method in the presence of silver ions or clusters in order to study the thermal stability and the dynamics of the hot carriers induced by femtosecond laser pulses. Although gold nanospheres are stable towards thermal treatment, the decomposition of the gold nanorods into spherical nanoparticle aggregates upon thermal treatment is mechanistically different from the case of nanoprisms. Great enhancement of thermal stability is achieved by modifying the surface of the nanoparticles by adding specific amounts of polyvinyl pyrrolidone (PVP) after preparation of gold particles of different shapes capped with cetyltrimethylammonium bromide (CTAB). The surface plasmon resonance spectra of the gold nanostructures are used to monitor their morphological changes. In regards to the hot carrier dynamics, it is found that the phonon-phonon (ph-ph) coupling is much slower in dots than in rods and prisms while electron-phonon (e-ph) coupling is almost the same in these particles.展开更多
From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions sugges...From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions suggest that in integrating into the East Asian production network,China has gradually emerged as the manufacturing center of East Asia,weakening the regional influence of the Four Asian Tigers.Meanwhile,the competitive effect of China's rise has helped promote the specialization levels of the network's members and even the network as a whole.With cooperation in various processes of intra-product specialization,internal connections of the East Asian production network were further strengthened.In addition,China became an export platform of East Asia,transforming the export pattern of the East Asian production network to world markets from "bilateral trade" into "triangular trade," trade via China.展开更多
The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism a...The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism and populism,the resurgent power politics and authoritarianism,theintensified competition in geopolitical and other new areas,and the incessant regional turmoil and conflicts.展开更多
The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensify...The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensifying global challenges in the security,political,economic,technological and other fields,the international community has a pressing need to reshape the international landscape at this critical moment of change.展开更多
Background Judkins catheter is widely used in recent years, for clinical angiography and intervention of most normal coronary arteries, but still incapable to deal with the problems caused by difficult coronary artery...Background Judkins catheter is widely used in recent years, for clinical angiography and intervention of most normal coronary arteries, but still incapable to deal with the problems caused by difficult coronary artery （DCA）. DCA may influence the procedure of diagnosis and intervention of ischemic heart disease （IHD）. To cope with different subtypes of DCA, catheters like Amplatz, EBU, Leya, etc. were born at that moment, but these stan- dard catheters are used just in special cases and have so many sequences that a local hospital may not be able to keep all of them available routinely at any time. To overcome this problem, some centers perform angiography and intervention using modified catheters based on their own condition and have obtained some experiences. Catheter modification techniques used in these years are reviewed, and are stated respectively based on dealing with different subtypes of DCA to provide practical guidance for clinical diagnosis and intervention for IHD patients having DCA.展开更多
文摘With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold War,showing instability and uncertainty.The type of order that can emerge in a region depends on the effectiveness of governance and the power structures and systems built upon it.The SCO advocates a brand new philosophy of cooperation that transcends the traditional mentality of international relations,forging a new model of multilateral collaboration.The SCO has vigorously participated in improving regional governance and is thus playing an increasingly important and unique role in reshaping the Eurasian regional order.
基金Sponsored by the General Project of the National Social Science Foundation of China(25BGL309).
文摘In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of people’s behaviors,measurement of its scale,and architectural history.Besides,how urban renewal creates new urban vitality was demonstrated.It has certain guiding and reference significance for research on urban renewal.Remarkable results have been achieved,such as rationalizing the internal functions of old residential areas,improving circulation experience conditions,and promoting and recreating unique cultural features.It is a case of engineering innovation in urban renewal in the core areas of domestic cities.
文摘China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing arts sector,as the industry evolved from a traditional entertainment field into a comprehensive engine of cultural consumption.
基金the National Natural Science Foundation of China(Nos.11772293 and12072312)Zhejiang Science and Technology Project(No.2019C03129)。
文摘An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.
基金Supported by the NSFC-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(No.U1809212)the Scientific and Technical Project of Zhejiang Province(Nos.2021C02055,2017C02013)+1 种基金the National Natural Science Foundation of China(No.31272642)the Healthy Aquaculture,the K.C.Wong Magna Fund in Ningbo University,and the Collaborative Innovation Center for Zhejiang Marine High-efficiency。
文摘The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.
基金sponsored by major tendering projects of National Social Sciences Foundation "Study on Accelerating Economic Adjustment and Coordinated Development"(Grant No.12&ZD084) and "Study on Contribution of Consumption to Economic Growth under Shifting Demand Structure"(Grant No.15ZDC011)projects of National Social Sciences Foundation "Study on China's Structural Growth Deceleration,Transition Risks and Efficiency Improvement Path"(Grant No.14AJL006) and "Study on the Scale,Spatial Clustering and Management Model of Chinese Cities"(Grant No.15ZDC011)
文摘The transition from middle-income to high-income stage is fraught with risks of growth divergence. Economic transition is clouded by the following possibilities： （1）falling share of industrial seetor through industrial depression and weakening growth momentum caused by the large urbanization costs; （2） the subordination of service sector as a result of nearly irreversibly industrial professional, which falters the process of service sector transition and upgrading,＂ （3） inefficient knowledge production allocation and human capital upgrade due to the absence of incentivized compensation of knowledge consumption. We suggest that a country should reshape its efficiency model by upgrading knowledge factor and human capital as the pre-requisite. Given the dilemmas of transition, China should take the faetorization trend of service sector and reshape efficiency model through institutional reform, ensuring that service sector will develop in tandem with industrial sector.
基金a staged research result of "Studies on New Strategic Regions Contributing to China’s Economic Growth in the Future"(14ZDA024)a major program of the National Social Science Fund of China+3 种基金"Studies on Regional Integration and Welfare Compensation on the Basis of Dynamic CGE and DCI Models"(71173101)a program funded by the National Natural Science Foundation of China"Studies on Path and Mechanism to Improve Economic Performance and Quality in Jiangsu Province from the Perspective of the Supply Side"(BRA2017358)a Jiangsu "333" High-level Cultivation Program
文摘Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,aiming to reshape the economic geography of China.This paper is based on the Belt and Road Initiative and the Yangtze River Economic Belt and outlines the pattern of opening up.To analyze the impact of the pattern of opening up on the regional integration of China's economic geography,this paper has developed a new economic geography model comprised of four regions and two countries.From this,it draws some conclusions.First,the change of pattern of opening up will lead to shifting centripetal and centrifugal forces from the international market.The greater the scale of neighboring markets,the stronger the agglomeration force will be; the more product varieties made in neighboring countries,the more potent its dispersion force.Second,developing an inland international trade corridor will decentralize industry distribution and reduce the impact of external market integration on home countries.Third,the inland international trade corridor could alter the effect of domestic market integration on the economic geography.When domestic integration occurs prior to international integration,further integration of a domestic market leads to greater industrial distribution along a bell-shaped curve,which describes economic activities from dispersion to agglomeration to decentralization.Therefore,developing an integrated market system of major countries and opening a corridor between China and Europe is not only the key to reshaping China's economic geography but also the path to solving the problems of the Heihe-Tengchong Line.
基金phased result of“Feasibility Demonstration of Basic Legislation on Artificial Intelligence”(Project No.2022K20263)a project of the Bureau of Law-based Cyberspace Governance at the Cyberspace Administration of China。
文摘Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often overlooking the revolutionary nature of digital media.Digital media has the sweeping potential to unify all forms of media and reshape social life,giving rise to new demands for a new generation of human rights.The concept of digital human rights can be defined as the legitimate rights of human's infinitely extended personalities through digital media.Its core characteristic is its transcendency,where every person lives in a networked space that surpasses physical boundaries,nations,and individual personalities.Human rights are generally considered the foundation for basic constitutional rights,which,in turn,form the basis for legislative acts across various sectors.In recent years,China has enacted numerous laws in the digital domain to keep pace with the times,but due to the lack of guidance on digital human rights,these laws tend to be fragmented and disjointed.It is urgent to unify digital legislation at all levels on the basis of reshaping basic constitutional rights.Thus,it is essential to reshape the basic rights based on the concept and characteristics of digital human rights and streamline legislation at all levels under the unified guidance of basic rights.This can help establish a comprehensive digital human rights protection system that meets the demands of the modern era.
基金Supported by National Natural Science Foundation of China,No.81602056 and No.82273393the Young Talents Promotion Project of Shandong Medical Association in 2023,No.2023-GJ-0087.
文摘Obesity is a chronic,multifactorial disease closely linked to a spectrum of cardiometabolic disorders,with its global prevalence rising at an alarming rate.In recent years,minimally invasive,safe,and effective endoscopic bariatric therapies have gained significant attention as alternatives to conventional surgical interventions.This review provides a comprehensive overview of various endoscopic weight-loss procedures,evaluating their advantages and limitations in comparison to surgical approaches to assist clinicians in optimizing patientspecific treatment strategies.Endoscopic bariatric therapies,including intragastric balloons,duodenal-jejunal bypass sleeves,endoscopic sleeve gastroplasty,gastric remodeling procedures,and interventions aimed at delaying gastric emptying are systematically reviewed.The efficacy,safety profiles,and clinical applicability are all synthesized.Endoscopic bariatric therapies exhibit distinct advantages and limitations,with varying indications and contraindications.As part of a multidisciplinary approach to obesity management,these procedures should be integrated with lifestyle modifications and nutritional counseling to maximize therapeutic benefits.Future research should focus on the long-term efficacy,safety,and patient-reported outcomes to refine clinical practice and optimize the role of endoscopic interventions in obesity treatment.
文摘Gold prices have been more than usually volatile in recent months,with prices making multiple sharp swings since the start of 2026.In an environment of elevated uncertainty,these price movements are not simply a matter of supply and demand;they signal a much broader shift toward the acceleration of de-dollarization and the reshaping of the global monetary system.
基金supported by the National Natural Science Foundation of China (Nos. 11402020 and 51407011)
文摘This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
文摘The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera? Intragastric Balloon System(Apollo Endosurgery Inc, Austin, TX, United States), the Re Shape? Integrated Dual Balloon System(Re Shape Medical, Inc., San Clemente, CA, United States), and the Obalon(Obalon? Therapeutics, Inc.). The individual features of each of these balloons, the method of introduction and removal, and the expected weight loss and possible complications are discussed. This review of the various balloons highlights the innovation in the field of weight loss.
基金financially supported by the National Natural Science Foundation of China (51674088)Natural Science Foundation of Heilongjiang Province of China (LH 2021E011)。
文摘Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ground devices is generally determined by experience.However,too large reshaping force may destroy the deformed casing,and too small reshaping force may also prolong the construction period and affect the repairing effect.In this paper,based on Hertz contact theory and elastic-plastic theory,combined with the process parameters of shaping,and considering the structural characteristics of the deformed casing and reshaper,we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper.Meanwhile,the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method,and the reliability of the mathematical model is verified by several examples.On this basis,the control variable method is used to investigate the influence of each parameter on the reshaping force,and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis.The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction,but also provide a reference for the subsequent improvement of the shaping process.
文摘Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement teaching reform,and carry out teaching innovation.The article carries out blended teaching with deep integration of online and offline modes and within and outside of class,constructing innovative measures of“four integrations and four reshaping.”The article conducts diversified evaluations to stimulate learning motivation and help achieve talent cultivation goals.Through the close integration of probability theory and mathematical statistics course teaching with professional education and practical application,the“three-in-one”teaching goal of value shaping,ability cultivation,and knowledge exploration is achieved.The fundamental task of“cultivating morality and talents”is implemented.
基金Supported by National Natural Science Foundation of Chinathe High Technology Research and Development Programme of China.
文摘The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequences,some residues werechanged and the reshaping VL and VH genes were designed.The full VH gene was assem-bled in three steps with eight chemically synthesized oligonucleotide fragments using over-lapping PCR and sequenced.The VH gene was expressed as active protein and inclusion bod-ies in the vectors of pCOMB3 and pGEX-4T-1 by ELISA and Western blot analysis.
文摘Anisotropic shapes of gold nanoparticles are prepared using a modified seed method in the presence of silver ions or clusters in order to study the thermal stability and the dynamics of the hot carriers induced by femtosecond laser pulses. Although gold nanospheres are stable towards thermal treatment, the decomposition of the gold nanorods into spherical nanoparticle aggregates upon thermal treatment is mechanistically different from the case of nanoprisms. Great enhancement of thermal stability is achieved by modifying the surface of the nanoparticles by adding specific amounts of polyvinyl pyrrolidone (PVP) after preparation of gold particles of different shapes capped with cetyltrimethylammonium bromide (CTAB). The surface plasmon resonance spectra of the gold nanostructures are used to monitor their morphological changes. In regards to the hot carrier dynamics, it is found that the phonon-phonon (ph-ph) coupling is much slower in dots than in rods and prisms while electron-phonon (e-ph) coupling is almost the same in these particles.
基金This research project received the support of "Research on the Creation of China Foreign Trade Innovation System" under the Research Program of Philosophical and Social Sciences of Shanghai (Approval No.:2007BJL009),together with Open Economy and Trade,which is a key research task of Shanghai Municipal Commission of Education.
文摘From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions suggest that in integrating into the East Asian production network,China has gradually emerged as the manufacturing center of East Asia,weakening the regional influence of the Four Asian Tigers.Meanwhile,the competitive effect of China's rise has helped promote the specialization levels of the network's members and even the network as a whole.With cooperation in various processes of intra-product specialization,internal connections of the East Asian production network were further strengthened.In addition,China became an export platform of East Asia,transforming the export pattern of the East Asian production network to world markets from "bilateral trade" into "triangular trade," trade via China.
文摘The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism and populism,the resurgent power politics and authoritarianism,theintensified competition in geopolitical and other new areas,and the incessant regional turmoil and conflicts.
文摘The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensifying global challenges in the security,political,economic,technological and other fields,the international community has a pressing need to reshape the international landscape at this critical moment of change.
基金supported by National Natural Science Foundation of China(No.81641058)
文摘Background Judkins catheter is widely used in recent years, for clinical angiography and intervention of most normal coronary arteries, but still incapable to deal with the problems caused by difficult coronary artery （DCA）. DCA may influence the procedure of diagnosis and intervention of ischemic heart disease （IHD）. To cope with different subtypes of DCA, catheters like Amplatz, EBU, Leya, etc. were born at that moment, but these stan- dard catheters are used just in special cases and have so many sequences that a local hospital may not be able to keep all of them available routinely at any time. To overcome this problem, some centers perform angiography and intervention using modified catheters based on their own condition and have obtained some experiences. Catheter modification techniques used in these years are reviewed, and are stated respectively based on dealing with different subtypes of DCA to provide practical guidance for clinical diagnosis and intervention for IHD patients having DCA.
