Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ...Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ground devices is generally determined by experience.However,too large reshaping force may destroy the deformed casing,and too small reshaping force may also prolong the construction period and affect the repairing effect.In this paper,based on Hertz contact theory and elastic-plastic theory,combined with the process parameters of shaping,and considering the structural characteristics of the deformed casing and reshaper,we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper.Meanwhile,the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method,and the reliability of the mathematical model is verified by several examples.On this basis,the control variable method is used to investigate the influence of each parameter on the reshaping force,and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis.The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction,but also provide a reference for the subsequent improvement of the shaping process.展开更多
From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions sugges...From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions suggest that in integrating into the East Asian production network,China has gradually emerged as the manufacturing center of East Asia,weakening the regional influence of the Four Asian Tigers.Meanwhile,the competitive effect of China's rise has helped promote the specialization levels of the network's members and even the network as a whole.With cooperation in various processes of intra-product specialization,internal connections of the East Asian production network were further strengthened.In addition,China became an export platform of East Asia,transforming the export pattern of the East Asian production network to world markets from "bilateral trade" into "triangular trade," trade via China.展开更多
This study focuses on the localized practice of the“Post-View-Purchase-Post”consumption loop(also referred to as the“Pretty Food Cycle”)driven by the Xiaohongshu platform within the context of Guangzhou’s food co...This study focuses on the localized practice of the“Post-View-Purchase-Post”consumption loop(also referred to as the“Pretty Food Cycle”)driven by the Xiaohongshu platform within the context of Guangzhou’s food consumption.By deconstructing the loop’s operational dynamics across three dimensions-power agents,behavioral logic,and spatial order-empirical analysis reveals a structural conflict between the standardized digital loop logic(visual-first and fast-paced)and the genetic traits of Cantonese food culture(“wok hei”authenticity and slow-paced social dining).On the one hand,the loop mechanism reshapes culinary authority through a value definition model led by KOLs/KOCs(Key Opinion Leaders/Consumers)and collectively scored by users.On the other hand,it encounters strong resistance and revision from local cultural genes.For instance,the cultural reverence for“wok hei”leads to collective downrating of photogenic dishes that lack authentic cooking essence,while pragmatic consumerism gives rise to phenomena such as the popularity of the“8-yuan pork knuckle rice,”which deconstructs the aesthetic elitism of food presentation.This research reveals the dual effects of the loop mechanism in both adapting to and dissolving regional cultural symbols(such as“yāt jūng léuhng gin”,i.e.,a pot of tea and two dim sum pieces).It also develops a“Cultural Discount Rate”evaluation model to assess cultural risks(mild symbolization≤20%,moderate authenticity loss 20-50%,severe alienation≥50%).Furthermore,it proposes three principles for building a sustainable consumption loop:authenticity anchoring,intergenerational permeability,and algorithmic fairness.The study argues that the“Pretty Food Cycle”essentially functions as a tool of digital colonization.Ignoring the cultural discount effect may lead to a spatial restructuring characterized by“digital eateries displacing wok hei small shops”-as seen in the wave of dessert shop closures on Baohua Road.However,through the assertion of user rating rights(e.g.,the 4.8 score comeback of“Ma Ji Store”),consumers demonstrate the counter-disciplinary potential of digital civic sovereignty against platform hegemony.展开更多
Sex determination is a complex biological process,through which the sex of an organism is established in a binary fate decision[1,2].There are two main determining mechanisms:1)genotypic sex determination(GSD),whereby...Sex determination is a complex biological process,through which the sex of an organism is established in a binary fate decision[1,2].There are two main determining mechanisms:1)genotypic sex determination(GSD),whereby the individual’s sex is determined by its genotype;and 2)environmental sex determination(ESD),where the sex is driven by different external factors,such as temperature,p H,and social interactions[1].展开更多
China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing ...China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing arts sector,as the industry evolved from a traditional entertainment field into a comprehensive engine of cultural consumption.展开更多
In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of p...In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of people’s behaviors,measurement of its scale,and architectural history.Besides,how urban renewal creates new urban vitality was demonstrated.It has certain guiding and reference significance for research on urban renewal.Remarkable results have been achieved,such as rationalizing the internal functions of old residential areas,improving circulation experience conditions,and promoting and recreating unique cultural features.It is a case of engineering innovation in urban renewal in the core areas of domestic cities.展开更多
主题语境:“中国制造”新形象篇幅:370词建议用时:7分钟.1 Recently,Labubu,a toothy,fluffy figure toy from Chinese brand Pop Mart,has sparked a global hit.This phenomenon significantly demonstrates how Chinese enterprises ...主题语境:“中国制造”新形象篇幅:370词建议用时:7分钟.1 Recently,Labubu,a toothy,fluffy figure toy from Chinese brand Pop Mart,has sparked a global hit.This phenomenon significantly demonstrates how Chinese enterprises are reshaping their international image through innovation,cultural storytelling and the globalization of homegrown intellectual property.展开更多
With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold ...With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold War,showing instability and uncertainty.The type of order that can emerge in a region depends on the effectiveness of governance and the power structures and systems built upon it.The SCO advocates a brand new philosophy of cooperation that transcends the traditional mentality of international relations,forging a new model of multilateral collaboration.The SCO has vigorously participated in improving regional governance and is thus playing an increasingly important and unique role in reshaping the Eurasian regional order.展开更多
Obesity is a chronic,multifactorial disease closely linked to a spectrum of cardiometabolic disorders,with its global prevalence rising at an alarming rate.In recent years,minimally invasive,safe,and effective endosco...Obesity is a chronic,multifactorial disease closely linked to a spectrum of cardiometabolic disorders,with its global prevalence rising at an alarming rate.In recent years,minimally invasive,safe,and effective endoscopic bariatric therapies have gained significant attention as alternatives to conventional surgical interventions.This review provides a comprehensive overview of various endoscopic weight-loss procedures,evaluating their advantages and limitations in comparison to surgical approaches to assist clinicians in optimizing patientspecific treatment strategies.Endoscopic bariatric therapies,including intragastric balloons,duodenal-jejunal bypass sleeves,endoscopic sleeve gastroplasty,gastric remodeling procedures,and interventions aimed at delaying gastric emptying are systematically reviewed.The efficacy,safety profiles,and clinical applicability are all synthesized.Endoscopic bariatric therapies exhibit distinct advantages and limitations,with varying indications and contraindications.As part of a multidisciplinary approach to obesity management,these procedures should be integrated with lifestyle modifications and nutritional counseling to maximize therapeutic benefits.Future research should focus on the long-term efficacy,safety,and patient-reported outcomes to refine clinical practice and optimize the role of endoscopic interventions in obesity treatment.展开更多
Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infr...Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infrared spectroscopy,modification of chemical reactions,and exploration of nonlinear quantum effects.Surface plasmon resonance,excited on simple plasmonic resonators in the infrared,has been demonstrated as a means to realize VSC,but suffers from either limited quality factor for realizing large Rabi splitting or poor reconfigurability for precise detuning control.Here we propose and experimentally demonstrate,for the first time,an on-chip plasmonic resonator based on degeneracy breaking of Wood’s anomaly for VSC.Leveraging the low damping rate of the surface state induced by this degeneracy breaking,we achieve a plasmonic resonance with a high-Q factor exceeding~110,resulting in a Rabi splitting up to~112 cm^(-1) with a subwavelength molecular layer.Additionally,the dispersion of the surface state allows for precise control over VSC detuning by simply adjusting the incident angle of excitation light,even in the absence of photons,enabling a broad detuning range up to 300 cm^(-1).These experimental results align well with our analytical model and numerical simulation.This work provides a promising integrated platform for VSC,with various potential applications in on-chip spectroscopy,polariton chemistry,and polariton devices.展开更多
The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscop...The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera? Intragastric Balloon System(Apollo Endosurgery Inc, Austin, TX, United States), the Re Shape? Integrated Dual Balloon System(Re Shape Medical, Inc., San Clemente, CA, United States), and the Obalon(Obalon? Therapeutics, Inc.). The individual features of each of these balloons, the method of introduction and removal, and the expected weight loss and possible complications are discussed. This review of the various balloons highlights the innovation in the field of weight loss.展开更多
Obesity and its comorbidities- including diabetes and obstructive sleep apnea- have taken a large and increasing toll on the United States and the rest of the world. The availability of commercial, clinical, and opera...Obesity and its comorbidities- including diabetes and obstructive sleep apnea- have taken a large and increasing toll on the United States and the rest of the world. The availability of commercial, clinical, and operative therapies for weight management have not been effective at a societal level. Endoscopic bariatric therapy is gaining acceptance as more effective than diet and lifestyle measures, and less invasive than bariatric surgery. Various endoscopic therapies are analogues of the restrictive or bypass components of bariatric surgery, utilizing gastric remodeling or intestinal anastomosis to achieve proven weight loss and metabolic benefits. Others, such as aspiration therapy, employnovel mechanisms of action. Intragastric balloons have recently been approved by the United States Food and Drug Administration, and a number of other technologies have completed large multicenter trials(such as AspireA ssist aspiration therapy and Primary Obesity Surgery Endolumenal). Endoscopic sleeve gastroplasty and transoral outlet reduction for endoscopic revision of gastric bypass have proven safe and effective in a number of studies. As devices are approved for use, data will continue to accumulate for safety, effectiveness, and cost effectiveness. Bariatric endoscopists should be prepared to appropriately target and apply various endoscopic bariatric therapies in the context of a comprehensive long-term weight management program.展开更多
This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical ...This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.展开更多
An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this pa...An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.展开更多
Over the past 40 years of reform and opening-up during 1978-2018, China ＇S rapid economic growth has become a miracle in world economic history and reshaped the world economy. In the 40 years, China has successfully ...Over the past 40 years of reform and opening-up during 1978-2018, China ＇S rapid economic growth has become a miracle in world economic history and reshaped the world economy. In the 40 years, China has successfully transformed from an isolated agricultural country into the world＇s largest industrial manufacturer. In 2018, China＇s urbanization rate is expected to reach 60% with per capita GDP expected to reach 9, 000 USD. After another 5 to 8 years, China will join the rank of high-income countries, successfully cross the middle-income trap and become a moderately prosperous economy in all respects. In its modernization drive, China will follow the new concept of ＂innovation, coordinated, green, open and shared development＂ and strive to achieve its ＂two centennial展开更多
Developmental dysplasia of hip seriously affects the health of children,and pelvic osteotomy is an important part of surgical treatment.Improving the shape of the acetabulum,preventing or delaying the progression of o...Developmental dysplasia of hip seriously affects the health of children,and pelvic osteotomy is an important part of surgical treatment.Improving the shape of the acetabulum,preventing or delaying the progression of osteoarthritis is the ultimate goal of pelvic osteotomies.Re-directional osteotomies,reshaping osteotomies and salvage osteotomies are the three most common types of pelvic osteotomy.The influence of different pelvic osteotomy on acetabular morphology is different,and the acetabular morphology after osteotomy is closely related to the prognosis of the patients.But there lacks comparison of acetabular morphology between different pelvic osteotomies,on the basis of retrospective analysis and measurable imaging indicators,this study predicted the acetabular shape after developmental dysplasia of the hip pelvic osteotomy in order to help clinicians make reasonable and correct decisions and improve the planning and performance of pelvic osteotomy.展开更多
The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA an...The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.展开更多
Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement tea...Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement teaching reform,and carry out teaching innovation.The article carries out blended teaching with deep integration of online and offline modes and within and outside of class,constructing innovative measures of“four integrations and four reshaping.”The article conducts diversified evaluations to stimulate learning motivation and help achieve talent cultivation goals.Through the close integration of probability theory and mathematical statistics course teaching with professional education and practical application,the“three-in-one”teaching goal of value shaping,ability cultivation,and knowledge exploration is achieved.The fundamental task of“cultivating morality and talents”is implemented.展开更多
Objective To explore the efficiency of endoscopic septoplasty with submucous resection for the treatment of 220 patients with deviated nasal septum and report our experience in this field.Methods From May 2006 to May ...Objective To explore the efficiency of endoscopic septoplasty with submucous resection for the treatment of 220 patients with deviated nasal septum and report our experience in this field.Methods From May 2006 to May 2010,220 patients with deviated nasal septum were treated by endoscopic septoplasty with submucous resection to decompress the stress points,resect the deviated parts and implant the reshaped bone of nasal septum,while retaining the normal structure of nasal septum with minimally invasive technique.Results Satisfactory effects were achieved in all the 220 patients,showing centered septal structure and disappeared symptoms such as nasal obstruction,headache and nasal hemorrhage,but no complications including perforation of nasal septum,depressed nasal bridge and septal chalasia and flaring.Conclusion Rhino-endoscopic septoplasty with submucous resection can substantially retain the original structure of nasal septum and thus is proven to be a desirable operation with multiple advantages including minimal invasiveness,quicker healing and fewer complications.展开更多
基金financially supported by the National Natural Science Foundation of China (51674088)Natural Science Foundation of Heilongjiang Province of China (LH 2021E011)。
文摘Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ground devices is generally determined by experience.However,too large reshaping force may destroy the deformed casing,and too small reshaping force may also prolong the construction period and affect the repairing effect.In this paper,based on Hertz contact theory and elastic-plastic theory,combined with the process parameters of shaping,and considering the structural characteristics of the deformed casing and reshaper,we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper.Meanwhile,the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method,and the reliability of the mathematical model is verified by several examples.On this basis,the control variable method is used to investigate the influence of each parameter on the reshaping force,and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis.The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction,but also provide a reference for the subsequent improvement of the shaping process.
基金This research project received the support of "Research on the Creation of China Foreign Trade Innovation System" under the Research Program of Philosophical and Social Sciences of Shanghai (Approval No.:2007BJL009),together with Open Economy and Trade,which is a key research task of Shanghai Municipal Commission of Education.
文摘From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions suggest that in integrating into the East Asian production network,China has gradually emerged as the manufacturing center of East Asia,weakening the regional influence of the Four Asian Tigers.Meanwhile,the competitive effect of China's rise has helped promote the specialization levels of the network's members and even the network as a whole.With cooperation in various processes of intra-product specialization,internal connections of the East Asian production network were further strengthened.In addition,China became an export platform of East Asia,transforming the export pattern of the East Asian production network to world markets from "bilateral trade" into "triangular trade," trade via China.
文摘This study focuses on the localized practice of the“Post-View-Purchase-Post”consumption loop(also referred to as the“Pretty Food Cycle”)driven by the Xiaohongshu platform within the context of Guangzhou’s food consumption.By deconstructing the loop’s operational dynamics across three dimensions-power agents,behavioral logic,and spatial order-empirical analysis reveals a structural conflict between the standardized digital loop logic(visual-first and fast-paced)and the genetic traits of Cantonese food culture(“wok hei”authenticity and slow-paced social dining).On the one hand,the loop mechanism reshapes culinary authority through a value definition model led by KOLs/KOCs(Key Opinion Leaders/Consumers)and collectively scored by users.On the other hand,it encounters strong resistance and revision from local cultural genes.For instance,the cultural reverence for“wok hei”leads to collective downrating of photogenic dishes that lack authentic cooking essence,while pragmatic consumerism gives rise to phenomena such as the popularity of the“8-yuan pork knuckle rice,”which deconstructs the aesthetic elitism of food presentation.This research reveals the dual effects of the loop mechanism in both adapting to and dissolving regional cultural symbols(such as“yāt jūng léuhng gin”,i.e.,a pot of tea and two dim sum pieces).It also develops a“Cultural Discount Rate”evaluation model to assess cultural risks(mild symbolization≤20%,moderate authenticity loss 20-50%,severe alienation≥50%).Furthermore,it proposes three principles for building a sustainable consumption loop:authenticity anchoring,intergenerational permeability,and algorithmic fairness.The study argues that the“Pretty Food Cycle”essentially functions as a tool of digital colonization.Ignoring the cultural discount effect may lead to a spatial restructuring characterized by“digital eateries displacing wok hei small shops”-as seen in the wave of dessert shop closures on Baohua Road.However,through the assertion of user rating rights(e.g.,the 4.8 score comeback of“Ma Ji Store”),consumers demonstrate the counter-disciplinary potential of digital civic sovereignty against platform hegemony.
基金supported by grants from the National Key R&D Program of China(Grant No.2018YFA0800200)the Strategic Priority Research Program of the Chinese Academy of Sciences,China(Grant No.XDA16010207)+1 种基金the National Natural Science Foundation of China(Grant Nos.31830061,31425016,and 81530004)the State Key Laboratory of Membrane Biology,China
文摘Sex determination is a complex biological process,through which the sex of an organism is established in a binary fate decision[1,2].There are two main determining mechanisms:1)genotypic sex determination(GSD),whereby the individual’s sex is determined by its genotype;and 2)environmental sex determination(ESD),where the sex is driven by different external factors,such as temperature,p H,and social interactions[1].
文摘China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing arts sector,as the industry evolved from a traditional entertainment field into a comprehensive engine of cultural consumption.
基金Sponsored by the General Project of the National Social Science Foundation of China(25BGL309).
文摘In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of people’s behaviors,measurement of its scale,and architectural history.Besides,how urban renewal creates new urban vitality was demonstrated.It has certain guiding and reference significance for research on urban renewal.Remarkable results have been achieved,such as rationalizing the internal functions of old residential areas,improving circulation experience conditions,and promoting and recreating unique cultural features.It is a case of engineering innovation in urban renewal in the core areas of domestic cities.
文摘主题语境:“中国制造”新形象篇幅:370词建议用时:7分钟.1 Recently,Labubu,a toothy,fluffy figure toy from Chinese brand Pop Mart,has sparked a global hit.This phenomenon significantly demonstrates how Chinese enterprises are reshaping their international image through innovation,cultural storytelling and the globalization of homegrown intellectual property.
文摘With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold War,showing instability and uncertainty.The type of order that can emerge in a region depends on the effectiveness of governance and the power structures and systems built upon it.The SCO advocates a brand new philosophy of cooperation that transcends the traditional mentality of international relations,forging a new model of multilateral collaboration.The SCO has vigorously participated in improving regional governance and is thus playing an increasingly important and unique role in reshaping the Eurasian regional order.
基金Supported by National Natural Science Foundation of China,No.81602056 and No.82273393the Young Talents Promotion Project of Shandong Medical Association in 2023,No.2023-GJ-0087.
文摘Obesity is a chronic,multifactorial disease closely linked to a spectrum of cardiometabolic disorders,with its global prevalence rising at an alarming rate.In recent years,minimally invasive,safe,and effective endoscopic bariatric therapies have gained significant attention as alternatives to conventional surgical interventions.This review provides a comprehensive overview of various endoscopic weight-loss procedures,evaluating their advantages and limitations in comparison to surgical approaches to assist clinicians in optimizing patientspecific treatment strategies.Endoscopic bariatric therapies,including intragastric balloons,duodenal-jejunal bypass sleeves,endoscopic sleeve gastroplasty,gastric remodeling procedures,and interventions aimed at delaying gastric emptying are systematically reviewed.The efficacy,safety profiles,and clinical applicability are all synthesized.Endoscopic bariatric therapies exhibit distinct advantages and limitations,with varying indications and contraindications.As part of a multidisciplinary approach to obesity management,these procedures should be integrated with lifestyle modifications and nutritional counseling to maximize therapeutic benefits.Future research should focus on the long-term efficacy,safety,and patient-reported outcomes to refine clinical practice and optimize the role of endoscopic interventions in obesity treatment.
基金supported by the National Key Research and Development Program of China(Grant No.2024YFE0105200)the National Nature Science Foundation of China(Grant No.62405284)+2 种基金the Key Research and Development Program of Henan Province(Grant No.241111220600)the JSPS KAKENHI(Grant No.JP20K14785)the Murata Science Foundation.
文摘Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infrared spectroscopy,modification of chemical reactions,and exploration of nonlinear quantum effects.Surface plasmon resonance,excited on simple plasmonic resonators in the infrared,has been demonstrated as a means to realize VSC,but suffers from either limited quality factor for realizing large Rabi splitting or poor reconfigurability for precise detuning control.Here we propose and experimentally demonstrate,for the first time,an on-chip plasmonic resonator based on degeneracy breaking of Wood’s anomaly for VSC.Leveraging the low damping rate of the surface state induced by this degeneracy breaking,we achieve a plasmonic resonance with a high-Q factor exceeding~110,resulting in a Rabi splitting up to~112 cm^(-1) with a subwavelength molecular layer.Additionally,the dispersion of the surface state allows for precise control over VSC detuning by simply adjusting the incident angle of excitation light,even in the absence of photons,enabling a broad detuning range up to 300 cm^(-1).These experimental results align well with our analytical model and numerical simulation.This work provides a promising integrated platform for VSC,with various potential applications in on-chip spectroscopy,polariton chemistry,and polariton devices.
文摘The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera? Intragastric Balloon System(Apollo Endosurgery Inc, Austin, TX, United States), the Re Shape? Integrated Dual Balloon System(Re Shape Medical, Inc., San Clemente, CA, United States), and the Obalon(Obalon? Therapeutics, Inc.). The individual features of each of these balloons, the method of introduction and removal, and the expected weight loss and possible complications are discussed. This review of the various balloons highlights the innovation in the field of weight loss.
文摘Obesity and its comorbidities- including diabetes and obstructive sleep apnea- have taken a large and increasing toll on the United States and the rest of the world. The availability of commercial, clinical, and operative therapies for weight management have not been effective at a societal level. Endoscopic bariatric therapy is gaining acceptance as more effective than diet and lifestyle measures, and less invasive than bariatric surgery. Various endoscopic therapies are analogues of the restrictive or bypass components of bariatric surgery, utilizing gastric remodeling or intestinal anastomosis to achieve proven weight loss and metabolic benefits. Others, such as aspiration therapy, employnovel mechanisms of action. Intragastric balloons have recently been approved by the United States Food and Drug Administration, and a number of other technologies have completed large multicenter trials(such as AspireA ssist aspiration therapy and Primary Obesity Surgery Endolumenal). Endoscopic sleeve gastroplasty and transoral outlet reduction for endoscopic revision of gastric bypass have proven safe and effective in a number of studies. As devices are approved for use, data will continue to accumulate for safety, effectiveness, and cost effectiveness. Bariatric endoscopists should be prepared to appropriately target and apply various endoscopic bariatric therapies in the context of a comprehensive long-term weight management program.
基金supported by the National Natural Science Foundation of China (Nos. 11402020 and 51407011)
文摘This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
基金the National Natural Science Foundation of China(Nos.11772293 and12072312)Zhejiang Science and Technology Project(No.2019C03129)。
文摘An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.
基金This study is supported by key projects of the National Social Science Fund of China （NSSFC） ＂Study on Accelerating Economic Restructuring and Promoting Indigenous and Coordinated Economic Development＂ （Grant No. 12＆ZD084）, and ＂Strategic Adjustment of China＇s Economic Structure and Transformation of Growth Pattern＂ （Grant No. 06＆ZD004）.
文摘Over the past 40 years of reform and opening-up during 1978-2018, China ＇S rapid economic growth has become a miracle in world economic history and reshaped the world economy. In the 40 years, China has successfully transformed from an isolated agricultural country into the world＇s largest industrial manufacturer. In 2018, China＇s urbanization rate is expected to reach 60% with per capita GDP expected to reach 9, 000 USD. After another 5 to 8 years, China will join the rank of high-income countries, successfully cross the middle-income trap and become a moderately prosperous economy in all respects. In its modernization drive, China will follow the new concept of ＂innovation, coordinated, green, open and shared development＂ and strive to achieve its ＂two centennial
基金Supported by Scientific Research Project of Hunan Education Department,No.21A0054.
文摘Developmental dysplasia of hip seriously affects the health of children,and pelvic osteotomy is an important part of surgical treatment.Improving the shape of the acetabulum,preventing or delaying the progression of osteoarthritis is the ultimate goal of pelvic osteotomies.Re-directional osteotomies,reshaping osteotomies and salvage osteotomies are the three most common types of pelvic osteotomy.The influence of different pelvic osteotomy on acetabular morphology is different,and the acetabular morphology after osteotomy is closely related to the prognosis of the patients.But there lacks comparison of acetabular morphology between different pelvic osteotomies,on the basis of retrospective analysis and measurable imaging indicators,this study predicted the acetabular shape after developmental dysplasia of the hip pelvic osteotomy in order to help clinicians make reasonable and correct decisions and improve the planning and performance of pelvic osteotomy.
基金Supported by the NSFC-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(No.U1809212)the Scientific and Technical Project of Zhejiang Province(Nos.2021C02055,2017C02013)+1 种基金the National Natural Science Foundation of China(No.31272642)the Healthy Aquaculture,the K.C.Wong Magna Fund in Ningbo University,and the Collaborative Innovation Center for Zhejiang Marine High-efficiency。
文摘The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.
文摘Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement teaching reform,and carry out teaching innovation.The article carries out blended teaching with deep integration of online and offline modes and within and outside of class,constructing innovative measures of“four integrations and four reshaping.”The article conducts diversified evaluations to stimulate learning motivation and help achieve talent cultivation goals.Through the close integration of probability theory and mathematical statistics course teaching with professional education and practical application,the“three-in-one”teaching goal of value shaping,ability cultivation,and knowledge exploration is achieved.The fundamental task of“cultivating morality and talents”is implemented.
文摘Objective To explore the efficiency of endoscopic septoplasty with submucous resection for the treatment of 220 patients with deviated nasal septum and report our experience in this field.Methods From May 2006 to May 2010,220 patients with deviated nasal septum were treated by endoscopic septoplasty with submucous resection to decompress the stress points,resect the deviated parts and implant the reshaped bone of nasal septum,while retaining the normal structure of nasal septum with minimally invasive technique.Results Satisfactory effects were achieved in all the 220 patients,showing centered septal structure and disappeared symptoms such as nasal obstruction,headache and nasal hemorrhage,but no complications including perforation of nasal septum,depressed nasal bridge and septal chalasia and flaring.Conclusion Rhino-endoscopic septoplasty with submucous resection can substantially retain the original structure of nasal septum and thus is proven to be a desirable operation with multiple advantages including minimal invasiveness,quicker healing and fewer complications.
