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WTAP-mediated m6A modification of JUNB contributes to poor prognosis of HCC patients through the NLRP3-GSDMD pathway 被引量:1
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作者 Zhijia Sun Jiangbo Li +7 位作者 Zheng Zhang Pu Liu Ruiguan Wang Zhuo Song Yuzhu Tang Chenhui Wang Liang Guo Yingjie Wang 《Chinese Medical Journal》 2025年第5期622-624,共3页
To the Editor:Hepatocellular carcinoma(HCC)is a prominent contributor to cancer-related mortality on a global scale.While therapeutic approaches,such as surgical resection,liver transplantation,and radiofrequency abla... To the Editor:Hepatocellular carcinoma(HCC)is a prominent contributor to cancer-related mortality on a global scale.While therapeutic approaches,such as surgical resection,liver transplantation,and radiofrequency ablation,have demonstrated effectiveness for specific patient populations,the 5-year overall survival(OS)rate in HCC is discouragingly low,estimated at only 18%.This unfavorable outcome can primarily be attributed to the high recurrence and metastasis rates.[1]Therefore,there is an urgent need for novel therapeutic strategies or targets to surmount the challenges in treating HCC. 展开更多
关键词 therapeutic approachessuch m modification WTAP HCC JUNB surgical resectionliver transplantationand radiofrequency ablationhave recurrence metastasis
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