The development and commercialization of new technologies are important to the global economy. In this paper, the author first addresses Small Business Innovation Research （SBIR） background ; then, implicitly define...The development and commercialization of new technologies are important to the global economy. In this paper, the author first addresses Small Business Innovation Research （SBIR） background ; then, implicitly defines SBIR ; finally, I also analyze the impacts of smaU business innovation research programs. There are four aspects ： entrepreneurial orientation; environmental factors; organizational factors and performanee.展开更多
The mission of this program is to explore the spherical torus plasma with a SUNIST spherical tokamak. Main experiments in the start phase will be involved with breakdown and plasma current set-up with a mode of saving...The mission of this program is to explore the spherical torus plasma with a SUNIST spherical tokamak. Main experiments in the start phase will be involved with breakdown and plasma current set-up with a mode of saving volt-second and without ohmic heating system, equilibrium and instability, current driving, heating and profile modification. The SUNIST is a university-scale conceptual spherical tokamak, with R = 0.3 m, A 1.3, Ip - 50 kA, BT < 0.15 T, and PRF - 100 kW. The only peculiarity of SUNIST is that there is a toroidal insulating break along the outer wall of vacuum vessel. The expected that advantages of this arrangement are helpful not only for saving flux swing, but also for having a deep understanding of what will influence the discharge startup and globe performances of plasma under different conditions of strong vessel eddy and ECR power assistance. Of course, the vessel structure of cross seal will be at a great risk of controlling vacuum quality, although we have achieved positive results on simulation test and vacuum vessel test.展开更多
To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mashl and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examine...To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mashl and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examined astrocytes from 2-month-old Sprague-Dawley rats, and found that Brn2 was expressed, but Mashl was not detectable. Thus, we hypothesized that Mashl alone could be used to reprogram astrocytes into neurons. We transfected a recombinant MSCV-MASH1 plasmid into astrocytes for 72 hours, and saw that all cells expressed Mashl. One week later, we observed the changes in morphology of astrocytes, which showed typical neuro- nal characteristics. Moreover, β-tubulin expression levels were significantly higher in astrocytes expressing Mashl than in control cells. These results indicate that Mashl alone can reprogram astrocytes into neurons.展开更多
1 INTRODUCTION The tropical Indo-Pacific Oceans span over twothirds of the global tropical oceans.A major warm pool with the highest large-scale sea surface temperature of the global oceans is located in the western P...1 INTRODUCTION The tropical Indo-Pacific Oceans span over twothirds of the global tropical oceans.A major warm pool with the highest large-scale sea surface temperature of the global oceans is located in the western Pacific and eastern Indian Oceans.The climate systems over the tropical Pacific and Indian Oceans are subject to strong ocean-atmosphere coupling at multiple scales from intraseasonal to interannual,and to centennial.The展开更多
We sketch Friedrich Ackermann’s research program following the concept of Imre Lakatos,with some historical key developments in the theory and application of aerotriangulation and image matching.The research program,...We sketch Friedrich Ackermann’s research program following the concept of Imre Lakatos,with some historical key developments in the theory and application of aerotriangulation and image matching.The research program,with its core being statistical estimation theory,has decisively influenced photogrammetry since the 60s,is still fully alive,and a challenge for today’s methods of image interpretation.We describe(1)Lakatos’concept of a scientific research program,with its negative and positive heuristics and(2)Ackermann’s research program,clearly made explicit in his PhD,with its mathematical model,the ability to predict theoretical precision and reliability,the potential of analyzing rigorous and approximate method,and the role of testing.The development of aerotriangulation,later augmented by image matching techniques,is closely connected to Ackermann’s successful attempts to integrate basic research and practical applications.展开更多
The major research program,"Catalysis science for carbon-based energy conversion",from the national science foundation of China(NSFC)answers to the main strategic needs of China for the efficien use of carbo...The major research program,"Catalysis science for carbon-based energy conversion",from the national science foundation of China(NSFC)answers to the main strategic needs of China for the efficien use of carbon-based energy and targets to address the key scientifi issues involved in the catalytic interfaces.The research program aims to improve the catalytic activation of C–H and C–O bonds and the C–C coupling process,展开更多
China will open part of its civil projects in national research program, including hi-tech development programs and major basic research programs to overseas scientists, said a senior official with the Ministry of Sci...China will open part of its civil projects in national research program, including hi-tech development programs and major basic research programs to overseas scientists, said a senior official with the Ministry of Science and Technology (MOST). Facing the globalization trend in terms of economy and S&T development, China will take a展开更多
Aproposal to carry out research into the chemistry of molecular agglomerate, jointly made by Tong Zhenhe with CAS Institute of Physical and Chemical Technologies, Jiang Xikui with Shanghai Institute of Organic Chemist...Aproposal to carry out research into the chemistry of molecular agglomerate, jointly made by Tong Zhenhe with CAS Institute of Physical and Chemical Technologies, Jiang Xikui with Shanghai Institute of Organic Chemistry, Shen Jiaocong of Jilin University, and two German and展开更多
This article gives a systematic and comprehensive summary of the marine research results ac complished by the Chinese Academy of Sciences (CAS) with the support of the National High-tech Research and Development Progr...This article gives a systematic and comprehensive summary of the marine research results ac complished by the Chinese Academy of Sciences (CAS) with the support of the National High-tech Research and Development Program during the period of the Ninth Five-year Plan (1996 - 2000). It includes achievements in the exploitation of marine resources, protection of the marine environment, reduction of marine disasters and the safeguarding of national marine sovereignty.展开更多
Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of r...Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson＇s disease rats. In the current study, we investigated the relationship between iron accumulation and transferrin expression in C6 cells, to explore the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson＇s disease rats. Iron content was detected using inductively coupled plasma-atomic emission spectroscopy. Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins. After treatment with ferric ammonium citrate of differing concentrations （10, 50, 100, 400 ktg/mL） in C6 glioma cells, cell survival rate and ferroportin 1 expression were negatively correlated with ferric ammonium citrate concentration, but divalent metal transporter 1 expression positively correlated with ferric ammonium citrate concentration. Baicalin or deferoxamine reduced divalent metal transporter 1 expression, but increased ferroportin 1 expression in the 100 μg/mL ferric ammonium citrate-loaded C6 cells. These results indicate that baicalin down-regulated iron concentration, which positively regulat- ed divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.展开更多
Eighty medical science research programs won national awards at the Great Hall of the People here Monday, with more than 2000 representatives from the sector attending the award ceremony.
Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and ...Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the elite strategies such as to discover the talents, to cultivate the elites and to establish the mechanism for the expert groups to work in team, echelon and vigor.展开更多
There are increasing calls for engaging citizens in the development of future outlooks. At the same time, large-scale public engagement activities warrant appropriate methods for analyzing their outcomes. This paper r...There are increasing calls for engaging citizens in the development of future outlooks. At the same time, large-scale public engagement activities warrant appropriate methods for analyzing their outcomes. This paper reviews how topic modeling could provide such a methodology, which both accounts for all textual data collected in public engagement activities, however large in scope, yet also allows for meaningful topical analysis. It compares topic modeling results concerning a corpus of 179 citizen visions from 30 European countries on desirable and sustainable futures to those acquired through deliberative analysis. While both methodologies contend that European citizens＇ outlook consists of education, sustainability in the economy, health concerns, and fairness in communities, and the particular strengths of topic modeling relate to its documentability, repeatability, cost efficiency, and scalability. Topic modeling can also be considered to support public engagement analytically from the perspective of knowledge formation rather than that of common sense.展开更多
China＇s Ministry of Science and Technology recently announced approval of China＇s National Basic Research Program （the 973 Program） and the Major Research Plan projects in 2008. Five Tsinghua research projects wil...China＇s Ministry of Science and Technology recently announced approval of China＇s National Basic Research Program （the 973 Program） and the Major Research Plan projects in 2008. Five Tsinghua research projects will be sponsored by the 973 Program and two by the Major Research Plan. Seven professors were appointed as chief scientists for the projects. Tsinghua has undertaken 28 projects since the 973 Program＇s inception involving 28 chief scientists and eight Major Research Plan projects involving eight chief scientists. Tsinghua is one of the country＇s leading institutions for supervision and conduct of the 973 Program projects.展开更多
The research priorities and drilling goals of Ocean Drilling Program are introduced from two scientific themes. The scientific theme of dynamics of earth’s environment try to understand earth’s changing climate, cau...The research priorities and drilling goals of Ocean Drilling Program are introduced from two scientific themes. The scientific theme of dynamics of earth’s environment try to understand earth’s changing climate, causes and effects of sea—level change, and other problems such as global carbon cycle, formation of gas hydrates and submarine展开更多
In partnership with Central University of Finance and Economics(CUFE)in Beijing and the University of Chicago,I had the unique privilege of traveling to China for the first time for a period of nine days.The purpose o...In partnership with Central University of Finance and Economics(CUFE)in Beijing and the University of Chicago,I had the unique privilege of traveling to China for the first time for a period of nine days.The purpose of the trip was to partake in an academic research program focused on public capital markets.展开更多
Aworld-renowned expert on non-conforming finite elementmethods,Prof.Zhong-Ci Shi,had left a lasting impact on the overarching development of Chinese computational mathematics and scientific computing as well as comput...Aworld-renowned expert on non-conforming finite elementmethods,Prof.Zhong-Ci Shi,had left a lasting impact on the overarching development of Chinese computational mathematics and scientific computing as well as computational mathematics worldwide through his tireless and visionary leadership.His dedication to developing academic programs in many leading Chinese universities and institutions,along with his stewardship in establishing national computational research programs,played a fundamental role in elevating Chinese computational research status to a global recognition.Several generations of Chinese scholars benefited from his guidance and teaching,and this focused issue of original research contributions from 33 Chinese and international scientist teams bears witness to the profound influence of Prof.Shi on their research careers by his lifetime of work spanning over six decades.Beyond being an accomplished mathematician,Prof.Shi had lived a life of a cultured man who radiated vigor and warmth,imbuing his life with heartiness,openness,and honesty.展开更多
国家自然科学基金:National Natural Science Foundation of China(NSFC)国家高技术研究发展计划(863计划):National High-tech R&D Program of China(863 Program)国家重点基础研究发展计划项目(973计划):National Program on Key ...国家自然科学基金:National Natural Science Foundation of China(NSFC)国家高技术研究发展计划(863计划):National High-tech R&D Program of China(863 Program)国家重点基础研究发展计划项目(973计划):National Program on Key Basic Research Project of China(973 Program)。展开更多
国家自然科学基金:National Natural Science Foundation of China(NSFC)国家高技术研究发展计划(863计划):National High-tech R&D Program of China(863 Program)国家重点基础研究发展计划项目(973计划):National Program on Key ...国家自然科学基金:National Natural Science Foundation of China(NSFC)国家高技术研究发展计划(863计划):National High-tech R&D Program of China(863 Program)国家重点基础研究发展计划项目(973计划):National Program on Key Basic Research Projeet of China(973 Program)。展开更多
文摘The development and commercialization of new technologies are important to the global economy. In this paper, the author first addresses Small Business Innovation Research （SBIR） background ; then, implicitly defines SBIR ; finally, I also analyze the impacts of smaU business innovation research programs. There are four aspects ： entrepreneurial orientation; environmental factors; organizational factors and performanee.
基金This work was supported by National Science Foundation of China No.19889506,Subject Derelopment Priject of TsinghuaUniversity,Innoration Fund of Institute of Physics,Chinese Academy of Science.
文摘The mission of this program is to explore the spherical torus plasma with a SUNIST spherical tokamak. Main experiments in the start phase will be involved with breakdown and plasma current set-up with a mode of saving volt-second and without ohmic heating system, equilibrium and instability, current driving, heating and profile modification. The SUNIST is a university-scale conceptual spherical tokamak, with R = 0.3 m, A 1.3, Ip - 50 kA, BT < 0.15 T, and PRF - 100 kW. The only peculiarity of SUNIST is that there is a toroidal insulating break along the outer wall of vacuum vessel. The expected that advantages of this arrangement are helpful not only for saving flux swing, but also for having a deep understanding of what will influence the discharge startup and globe performances of plasma under different conditions of strong vessel eddy and ECR power assistance. Of course, the vessel structure of cross seal will be at a great risk of controlling vacuum quality, although we have achieved positive results on simulation test and vacuum vessel test.
基金supported by the National Basic Research Program of China(973 Program),No.2010CB530400the Key Project of National Natural Science Foundation of China,No.30930111
文摘To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mashl and Brn2 have been previously shown to cooperate to reprogram fibroblasts into neurons. In this study, we examined astrocytes from 2-month-old Sprague-Dawley rats, and found that Brn2 was expressed, but Mashl was not detectable. Thus, we hypothesized that Mashl alone could be used to reprogram astrocytes into neurons. We transfected a recombinant MSCV-MASH1 plasmid into astrocytes for 72 hours, and saw that all cells expressed Mashl. One week later, we observed the changes in morphology of astrocytes, which showed typical neuro- nal characteristics. Moreover, β-tubulin expression levels were significantly higher in astrocytes expressing Mashl than in control cells. These results indicate that Mashl alone can reprogram astrocytes into neurons.
文摘1 INTRODUCTION The tropical Indo-Pacific Oceans span over twothirds of the global tropical oceans.A major warm pool with the highest large-scale sea surface temperature of the global oceans is located in the western Pacific and eastern Indian Oceans.The climate systems over the tropical Pacific and Indian Oceans are subject to strong ocean-atmosphere coupling at multiple scales from intraseasonal to interannual,and to centennial.The
文摘We sketch Friedrich Ackermann’s research program following the concept of Imre Lakatos,with some historical key developments in the theory and application of aerotriangulation and image matching.The research program,with its core being statistical estimation theory,has decisively influenced photogrammetry since the 60s,is still fully alive,and a challenge for today’s methods of image interpretation.We describe(1)Lakatos’concept of a scientific research program,with its negative and positive heuristics and(2)Ackermann’s research program,clearly made explicit in his PhD,with its mathematical model,the ability to predict theoretical precision and reliability,the potential of analyzing rigorous and approximate method,and the role of testing.The development of aerotriangulation,later augmented by image matching techniques,is closely connected to Ackermann’s successful attempts to integrate basic research and practical applications.
文摘The major research program,"Catalysis science for carbon-based energy conversion",from the national science foundation of China(NSFC)answers to the main strategic needs of China for the efficien use of carbon-based energy and targets to address the key scientifi issues involved in the catalytic interfaces.The research program aims to improve the catalytic activation of C–H and C–O bonds and the C–C coupling process,
文摘China will open part of its civil projects in national research program, including hi-tech development programs and major basic research programs to overseas scientists, said a senior official with the Ministry of Science and Technology (MOST). Facing the globalization trend in terms of economy and S&T development, China will take a
文摘Aproposal to carry out research into the chemistry of molecular agglomerate, jointly made by Tong Zhenhe with CAS Institute of Physical and Chemical Technologies, Jiang Xikui with Shanghai Institute of Organic Chemistry, Shen Jiaocong of Jilin University, and two German and
文摘This article gives a systematic and comprehensive summary of the marine research results ac complished by the Chinese Academy of Sciences (CAS) with the support of the National High-tech Research and Development Program during the period of the Ninth Five-year Plan (1996 - 2000). It includes achievements in the exploitation of marine resources, protection of the marine environment, reduction of marine disasters and the safeguarding of national marine sovereignty.
基金supported by the Scientific Research Common Program of Beijing Municipal Commission of Education,No.KM20110025010
文摘Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson＇s disease rats. In the current study, we investigated the relationship between iron accumulation and transferrin expression in C6 cells, to explore the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson＇s disease rats. Iron content was detected using inductively coupled plasma-atomic emission spectroscopy. Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins. After treatment with ferric ammonium citrate of differing concentrations （10, 50, 100, 400 ktg/mL） in C6 glioma cells, cell survival rate and ferroportin 1 expression were negatively correlated with ferric ammonium citrate concentration, but divalent metal transporter 1 expression positively correlated with ferric ammonium citrate concentration. Baicalin or deferoxamine reduced divalent metal transporter 1 expression, but increased ferroportin 1 expression in the 100 μg/mL ferric ammonium citrate-loaded C6 cells. These results indicate that baicalin down-regulated iron concentration, which positively regulat- ed divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.
文摘Eighty medical science research programs won national awards at the Great Hall of the People here Monday, with more than 2000 representatives from the sector attending the award ceremony.
基金the High Technology Research and Development Progam of China.
文摘Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the elite strategies such as to discover the talents, to cultivate the elites and to establish the mechanism for the expert groups to work in team, echelon and vigor.
文摘There are increasing calls for engaging citizens in the development of future outlooks. At the same time, large-scale public engagement activities warrant appropriate methods for analyzing their outcomes. This paper reviews how topic modeling could provide such a methodology, which both accounts for all textual data collected in public engagement activities, however large in scope, yet also allows for meaningful topical analysis. It compares topic modeling results concerning a corpus of 179 citizen visions from 30 European countries on desirable and sustainable futures to those acquired through deliberative analysis. While both methodologies contend that European citizens＇ outlook consists of education, sustainability in the economy, health concerns, and fairness in communities, and the particular strengths of topic modeling relate to its documentability, repeatability, cost efficiency, and scalability. Topic modeling can also be considered to support public engagement analytically from the perspective of knowledge formation rather than that of common sense.
文摘China＇s Ministry of Science and Technology recently announced approval of China＇s National Basic Research Program （the 973 Program） and the Major Research Plan projects in 2008. Five Tsinghua research projects will be sponsored by the 973 Program and two by the Major Research Plan. Seven professors were appointed as chief scientists for the projects. Tsinghua has undertaken 28 projects since the 973 Program＇s inception involving 28 chief scientists and eight Major Research Plan projects involving eight chief scientists. Tsinghua is one of the country＇s leading institutions for supervision and conduct of the 973 Program projects.
文摘The research priorities and drilling goals of Ocean Drilling Program are introduced from two scientific themes. The scientific theme of dynamics of earth’s environment try to understand earth’s changing climate, causes and effects of sea—level change, and other problems such as global carbon cycle, formation of gas hydrates and submarine
文摘In partnership with Central University of Finance and Economics(CUFE)in Beijing and the University of Chicago,I had the unique privilege of traveling to China for the first time for a period of nine days.The purpose of the trip was to partake in an academic research program focused on public capital markets.
文摘Aworld-renowned expert on non-conforming finite elementmethods,Prof.Zhong-Ci Shi,had left a lasting impact on the overarching development of Chinese computational mathematics and scientific computing as well as computational mathematics worldwide through his tireless and visionary leadership.His dedication to developing academic programs in many leading Chinese universities and institutions,along with his stewardship in establishing national computational research programs,played a fundamental role in elevating Chinese computational research status to a global recognition.Several generations of Chinese scholars benefited from his guidance and teaching,and this focused issue of original research contributions from 33 Chinese and international scientist teams bears witness to the profound influence of Prof.Shi on their research careers by his lifetime of work spanning over six decades.Beyond being an accomplished mathematician,Prof.Shi had lived a life of a cultured man who radiated vigor and warmth,imbuing his life with heartiness,openness,and honesty.
文摘国家自然科学基金:National Natural Science Foundation of China(NSFC)国家高技术研究发展计划(863计划):National High-tech R&D Program of China(863 Program)国家重点基础研究发展计划项目(973计划):National Program on Key Basic Research Project of China(973 Program)。
文摘国家自然科学基金:National Natural Science Foundation of China(NSFC)国家高技术研究发展计划(863计划):National High-tech R&D Program of China(863 Program)国家重点基础研究发展计划项目(973计划):National Program on Key Basic Research Projeet of China(973 Program)。
