Aiming at dealing with the difficulty for traditional emergency rescue vehicle(ECV)to enter into limited rescue scenes,the electro-hydraulic steer-by-wire(SBW)system is introduced to achieve the multi-mode steering of...Aiming at dealing with the difficulty for traditional emergency rescue vehicle(ECV)to enter into limited rescue scenes,the electro-hydraulic steer-by-wire(SBW)system is introduced to achieve the multi-mode steering of the ECV.The overall structure and mathematical model of the SBW system are described at length.The fractional order proportional-integral-derivative(FOPID)controller based on fractional calculus theory is designed to control the steering cylinder’s movement in SBW system.The anti-windup problem is considered in the FOPID controller design to reduce the bad influence of saturation.Five parameters of the FOPID controller are optimized using the genetic algorithm by maximizing the fitness function which involves integral of time by absolute value error(ITAE),peak overshoot,as well as settling time.The time-domain simulations are implemented to identify the performance of the raised FOPID controller.The simulation results indicate the presented FOPID controller possesses more effective control properties than classical proportional-integral-derivative(PID)controller on the part of transient response,tracking capability and robustness.展开更多
BACKGROUND Due to increasing resistance rates of Helicobacter pylori(H.pylori)to different antibiotics,failures in eradication therapies are becoming more frequent.Even though eradication criteria and treatment algori...BACKGROUND Due to increasing resistance rates of Helicobacter pylori(H.pylori)to different antibiotics,failures in eradication therapies are becoming more frequent.Even though eradication criteria and treatment algorithms for first-line and second-line therapy against H.pylori infection are well-established,there is no clear recommendation for third-line and rescue therapy in refractory H.pylori infection.AIM To perform a systematic review evaluating the efficacy and safety of rescue therapies against refractory H.pylori infection.METHODS A systematic search of available rescue treatments for refractory H.pylori infection was conducted on the National Library of Medicine’s PubMed search platform based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Randomized or non-randomized clinical trials and observational studies evaluating the effectiveness of H.pylori infection rescue therapies were included.RESULTS Twenty-eight studies were included in the analysis of mean eradication rates as rescue therapy,and 21 of these were selected for analysis of mean eradication rate as third-line treatment.For rifabutin-,sitafloxacin-,levofloxacin-,or metronidazole-based triple-therapy as third-line treatment,mean eradication rates of 81.6%and 84.4%,79.4%and 81.5%,55.7%and 60.6%,and 62.0%and 63.0%were found in intention-to-treat(ITT)and per-protocol(PP)analysis,respectively.For third-line quadruple therapy,mean eradication rates of 69.2%and 72.1%were found for bismuth quadruple therapy(BQT),88.9%and 90.9%for bismuth quadruple therapy,three-in-one,Pylera®(BQT-Pylera),and 61.3%and 64.2%for non-BQT)in ITT and PP analysis,respectively.For rifabutin-,sitafloxacin-,levofloxacin-,or metronidazole-based triple therapy as rescue therapy,mean eradication rates of 75.4%and 78.8%,79.4 and 81.5%,55.7%and 60.6%,and 62.0%and 63.0%were found in ITT and PP analysis,respectively.For quadruple therapy as rescue treatment,mean eradication rates of 76.7%and 79.2%for BQT,84.9%and 87.8%for BQT-Pylera,and 61.3%and 64.2%for non-BQT were found in ITT and PP analysis,respectively.For susceptibility-guided therapy,mean eradication rates as third-line and rescue treatment were 75.0%in ITT and 79.2%in PP analysis.CONCLUSION We recommend sitafloxacin-based triple therapy containing vonoprazan in regions with low macrolide resistance profile.In regions with known resistance to macrolides or unavailability of bismuth,rifabutin-based triple therapy is recommended.展开更多
Out-of-hospital cardiac arrest(OHCA)presents a significant public health challenge in China.A sharp contrast in survival rate after OHCA exists between China and more developed countries.Due to the short life-saving t...Out-of-hospital cardiac arrest(OHCA)presents a significant public health challenge in China.A sharp contrast in survival rate after OHCA exists between China and more developed countries.Due to the short life-saving time window,emergency medical services(EMS)and bystanders peripheral to EMS are key contributors to survival after OHCA.Here we discuss limitations and challenges for current EMS in rescuing OHCA by reviewing requirements for EMS in China.We call for an updated public health-based prehospital rescue system that includes establishing a cardiac arrest registry,promoting a“Three Early’s”campaign[early dialing of emergency hotline 120,early cardiopulmonary resuscitation(CPR),and early defibrillation],and operating a mechanism comprised of professional public health institutions(EMS,CDC,specialized disease prevention and control institutions,and health education institutions)as well as many governmental departments,such as healthcare,industry and information technology,and education,and non-governmental organizations,such as the Red Cross Society.Following the optimization of the prehospital rescue system and the participation of the whole population in self-rescue and mutual rescue,we believe that a dramatic improvement in OHCA survival will come about in China.展开更多
In recent years,geological and mineral resources exploration in China has expanded to deep hinterland of the Qinghai−Tibet Plateau and other regions with complex geological conditions.The special natural conditions of...In recent years,geological and mineral resources exploration in China has expanded to deep hinterland of the Qinghai−Tibet Plateau and other regions with complex geological conditions.The special natural conditions of Qinghai−Tibet Plateau determine the characteristics of“life-forbidden zone”that is characterized by alpine hypoxia,changeable weather,complex road conditions,and beast attack.In particular,the work in wild depopulated zones with severe environment and poor communications imposes serious threats to the life safety of geological personnel.Therefore,how to guarantee the safety of geological personnel working on the Qinghai−Tibet Plateau and how to reduce or even avoid casualty of geological personnel have currently become the urgent challenge.In this study,an emergency rescue information system for field geological survey is constructed based on BeiDou Navigation Satellite System.A case study of emergency rescue has been conducted in the depopulated zone of the Qinghai−Tibet Plateau and good effects have been achieved,providing security assurance for personnel engaged in field geological survey on the Qinghai−Tibet Plateau and technical support for the emergency rescue in case of natural hazards on the Qinghai−Tibet Plateau.The BeiDou Navigation Satellite System(BDS)can be effectively used to locate and communicate in the emergency rescue for rigorous Geological survey task where there is no network signal for the mobile phone,and the emergency rescue guarantee system is independent,reliable,and relatively cheap.The application value of BDS is demonstrated in the geological field.展开更多
A new explosion-proof walking system was designed for the coal mine rescue robot(CMRR) by optimizing the mechanical structure and control algorithm. The mechanical structure innovation lies mainly in the dual-motor dr...A new explosion-proof walking system was designed for the coal mine rescue robot(CMRR) by optimizing the mechanical structure and control algorithm. The mechanical structure innovation lies mainly in the dual-motor drive tracked unit used, which showed high dynamic performance compared with the conventional tracked unit. The control algorithm, developed based on decision trees and neural networking, facilitates autonomous switching between "Velocity-driven Mode" and "Torquedriven Mode". To verify the feasibility and effectiveness of the control strategy, we built a self-designed test platform and used it to debug the control program; we then made a robot prototype and conducted further experiments on single-step, ramp, and rubble terrains. The results show that the proposed walking system has excellent dynamic performance and the control strategy is very efficient, suggesting that a robot with this type of explosion-proof walking system can be successfully applied in Chinese coal mines.展开更多
Helicopters are often used in mountain rescue both for rescuers moving in the area of accidents and for evacuating victims, but in steep or forested terrain finding a landing place can be problematic. The main aim of ...Helicopters are often used in mountain rescue both for rescuers moving in the area of accidents and for evacuating victims, but in steep or forested terrain finding a landing place can be problematic. The main aim of this research is to use Digital Elevation Model(DEM) and cartographic database analysis to select locations that can be used as landing site for the rescue helicopters. Methods were based on GIS analysis;both raster and vector data were used for identifying touchdown points for rescue helicopters. Based on DEM data, locations with a low slope gradient were identified;topographic vector data were used for identifying unforested sites. Then buffer zones for buildings and power lines were excluded, and it was checked whether the areas had any topographic features that prevented helicopter landings. The findings were verified on an orthophotomap. In result, GIS analyses have selected 1232 polygons that fulfilled initial criteria. Their verification on orthophotomap has shown that only 55% of them could be potentially used as landing site. Landing sites can be found mainly on side ridges of mountain ranges and in valley beds, when those on ridges are most important in this research. The greatest difficulties and methodological challenges are posed by: identification of sites having a shape which prevents landing, the obsolescence of data due to environment dynamics, the presence of features that are not shown on maps but prevent helicopter landings. A map of landing sites is a very useful tool to conduct rescue operations, but each use of a given landing site requires both in-field and numerical verification. The analysis demonstrated that GIS toolsare useful in pre-planning of rescue missions, and also showed that such data must be kept up-to-date and in-field verification is needed continuously, the more so as it plays an important role in ensuring the safety of rescuers and victims.展开更多
Fire rescue challenges and solutions have evolved from straightfor-ward plane rescue to encompass 3D space due to the rise of high-rise city buildings.Hence,this study facilitates a system with quick and simplified on...Fire rescue challenges and solutions have evolved from straightfor-ward plane rescue to encompass 3D space due to the rise of high-rise city buildings.Hence,this study facilitates a system with quick and simplified on-site launching and generates real-time location data,enabling fire rescuers to arrive at the intended spot faster and correctly for effective and precise rescue.Auto-positioning with step-by-step instructions is proposed when launching the locating system,while no extra measuring instrument like Total Station(TS)is needed.Real-time location tracking is provided via a 3D space real-time locating system(RTLS)constructed using Ultra-wide Bandwidth technology(UWB),which requires electromagnetic waves to pass through concrete walls.A hybrid weighted least squares with a time difference of arrival(WLS/TDOA)positioning method is proposed to address real path-tracking issues in 3D space and to meet RTLS requirements for quick computing in real-world applications.The 3D WLS/TDOA algorithm is theoretically constructed with the Cramer-Rao lower bound(CRLB).The computing complexity is reduced to the lower bound for embedded hardware to directly compute the time differential of the arriving signals using the time-to-digital converter(TDC).The results of the experiments show that the errors are controlled when the positioning algorithm is applied in various complicated situations to fulfill the requirements of engineering applications.The statistical analysis of the data reveals that the proposed UWB RTLS auto-positioning system can track target tags with an accuracy of 0.20 m.展开更多
Dear Editor,De novo generation of negative-stranded RNA viruses(NSVs)requires efficient transcription of integral viral RNAs with precise termini from cloned plasmids.Studies during the past 25 years with animal NSVs ...Dear Editor,De novo generation of negative-stranded RNA viruses(NSVs)requires efficient transcription of integral viral RNAs with precise termini from cloned plasmids.Studies during the past 25 years with animal NSVs have established the bacteriophage T7 RNA polymerase(Pol)-and endogenous Pol I-based transcription systems as the most efficient platforms for recovery of recombinant NSVs(Bridgen 2012).Unfortunately.展开更多
By introdming a small-caliber deep well rescue robot, a hold-hug pattern rescue mechanism was brought forward. In order to reduce the volmne, the trader-well rescue imclmnism is modularizing designed. At the same tira...By introdming a small-caliber deep well rescue robot, a hold-hug pattern rescue mechanism was brought forward. In order to reduce the volmne, the trader-well rescue imclmnism is modularizing designed. At the same tirae, the audio and video systyems, the illumination system and the ventilation system are expatiated. The rescuing robot can rescue the falling person in the deep well, it can save much manateral resources and time. It＇s really an ideal rescue device for the small-caliber fall.展开更多
With the development of metropolitan regions and the appearance of urban agglomerations, cities have been more closely related. For the restricted emergency rescue resource in a single city, it has become more and mor...With the development of metropolitan regions and the appearance of urban agglomerations, cities have been more closely related. For the restricted emergency rescue resource in a single city, it has become more and more imminent for the demand of the intercity collaborative resistance to major accident, so as to improve the protection capacity of urban security. In order to find an effective intercity, emergency rescue collaborative system, this paper introduces the concept and analysis method of ecosystem theory into intercity emergency, rescue. Based on the analysis of the formation-process of emergency rescue individual, population and community： a throe-level intercity emergency rescue collaborative system is constructed according to the characteristics of dynamics and structure of intercity emergency rescue ecosystem then the collaboration mechanism of information, resource and process in the interceity emergency rescue ecosystem is also studied in this paper; so as to offer available strategy and method for the ecosystem theory applied to intercity, emergency rescue. Through the studies of intereity emergency rescue ecosystem. it illuminates that the proposed emergency system can not Only cope with the major accident more timely and effectively but also integrate the intercity information resources and emergency rescue resource and process optimization.展开更多
The existing research on rescue robots has focused mainly on reconnaissance,detection,and firefighting,and a small number of robots that can achieve human rescue have problems such as poor safety and stability and ins...The existing research on rescue robots has focused mainly on reconnaissance,detection,and firefighting,and a small number of robots that can achieve human rescue have problems such as poor safety and stability and insufficient carrying capacity.This article addresses the above issues and cleverly combines the advantages of soft robotic arms,underactuated robotic arms,and suction cups based on the principles of bionics.A new design for a robotic arm was proposed,and its working principle was explained.Then,the human rescue process was divided into two stages,and the grasping force of the robotic arm in each stage was analyzed separately.Finally,a prototype of the principle was developed,and the feasibility of the design principle of the robotic arm was verified through grasping experiments on a cross-sectional contour model of the human chest.At the same time,grasping experiments were conducted on different objects to demonstrate the potential application of the robotic arm in grasping ground objects.This research proposes a stress envelope adsorption rescue robot arm inspired by the adhesion ability of the Drosera plant and the stress envelope effect,which can apply force to the entire surface of the human body,reduce local force on the human body,ensure load-bearing capacity and adaptability,and improve the safety and stability of rescue grasping.展开更多
More than eighty years ago,when the Nazis brutally persecuted and mass-murdered the Jews,and nearly every country in the world shut its door to them desperately seeking refuge,the Chinese people,especially those of th...More than eighty years ago,when the Nazis brutally persecuted and mass-murdered the Jews,and nearly every country in the world shut its door to them desperately seeking refuge,the Chinese people,especially those of the city of Shanghai,opened their arms to the European Jews at this critical moment.展开更多
Researchers have discovered that mice instinctively exhibit rescue-like behavior towards anesthetized companions-a finding that suggests a biological basis for prosociality.The study,published in PNAS on April 23,2025...Researchers have discovered that mice instinctively exhibit rescue-like behavior towards anesthetized companions-a finding that suggests a biological basis for prosociality.The study,published in PNAS on April 23,2025,was led by Dr.HU Li from the Institute of Psychology of the Chinese Academy of Sciences(IPCAS)and Dr.CHEN Zhoufeng from Washington University School of Medicine and the Shenzhen Medical Academy of Research and Translation.展开更多
Objectives:At the time of the bombing of the federal building in Oklahoma City,Oklahoma(OKC),it was the deadliest terrorist attack in the United States of America.Available research on this incident,and in general,has...Objectives:At the time of the bombing of the federal building in Oklahoma City,Oklahoma(OKC),it was the deadliest terrorist attack in the United States of America.Available research on this incident,and in general,has been quantitative,using deductive methods.The purpose of the current study was to systematically examine professional disaster response workers’emotions elicited spontaneously and in detail as they were experienced over time after a major disaster.This qualitative study will add to existing knowledge of psychopathology and the psychosocial effects of disasters on professional responders,which have not been explored by prior quantitative studies.Methods:A volunteer sample of 181 rescue and recovery workers for the 1995 bombing of the OKC Murrah Federal Building was interviewed approximately 3 years after the bombing.These responders were asked open-ended questions to elicit undirected responses in their own words.In these interviews,they were prompted to describe their feelings at 3 distinct time points:upon their arrival at the bombing scene(“immediately”),in the first 1 week following the bombing,and currently at the time of the interview(“now”).Results:Data items were coded into the 5 themes:Anticipation,Shock and awe,Negative reactions,Positive reactions,and Emotionally unengaged/unaffected.The emotional themes of the responders mapped into 2 conceptual domains.The first domain is related to common human responses to horrible events such as the bombing.The second domain is related to the professional identities of the disaster responders.Conclusions:Specific aspects of the professional responder roles asserted themselves,shaping their emotional responses distinctly from those of the bomb blast survivors.This study identified both negative and positive emotions,which may help identify risk for or resistance to posttraumatic stress disorder(PTSD).展开更多
Construction failures caused by unforeseen circumstances, such as natural disasters, environmental degradation, and structural weaknesses, present significant challenges in achieving durability, safety, and sustainabi...Construction failures caused by unforeseen circumstances, such as natural disasters, environmental degradation, and structural weaknesses, present significant challenges in achieving durability, safety, and sustainability. This research addresses these challenges through the development of advanced emergency rescue systems incorporating wood-derived nanomaterials and IoT-enabled Structural Health Monitoring (SHM) technologies. The use of nanocellulose which demonstrates outstanding mechanical capabilities and biodegradability alongside high resilience allowed developers to design modular rescue systems that function effectively even under challenging conditions while providing real-time failure protection. Experimental data from testing showed that the replacement system strengthened load-bearing limits by 20% while enhancing impact tolerance by 30% and decreasing lifecycle carbon footprints by 60% against conventional methods. FEA results alongside dynamic simulations established that the system maintains its strength across seismic events and thermal variations and environmental conditions. SHM systems that leverage the Internet of Things Platform revealed 95% accuracy rates in detecting anomalies while improving response speed by 30% for predictive maintenance operations. The innovative solutions support the special issue’s direction to push structural transformation through durable designs and creative materials with preventive failure solutions. The proposed solutions work together toward creating resilient infrastructure systems which resist unexpected stressors and environmental damage.展开更多
Unlike other major crops,little research has been performed on tomato to reduce the generation time for speed breeding.We evaluated several agronomic treatments to reduce the generation time of tomato in the‘M82'...Unlike other major crops,little research has been performed on tomato to reduce the generation time for speed breeding.We evaluated several agronomic treatments to reduce the generation time of tomato in the‘M82'(determinate)and‘Moneymaker'(indeterminate)varieties and evaluated the best combination in conjunction with embryo rescue.Five container sizes with volumes of 0.2 L(XS),0.45 L(S),0.8 L(M),1.3 L(L),and6 L(XL),were evaluated in the first experiment under the autumn cycle.We found that plants grown in XL containers exhibited better development and required less time from sowing to anthesis(DSA)and from anthesis to fruit ripening(DAR).In the second experiment,using XL containers in the autumn-winter cycle,we evaluated the effects of cold priming at the cotyledonary stage,water stress,P supplementation,and K supplementation on generation time.Compared to the control,we found that cold priming significantly reduced the number of leaves,plant height to first the inflorescence,and DSA(2.7 d),whereas K supplementation reduced the DAR(8.8 d).In contrast,water stress and P supplementation did not significantly affect any of the measured traits like DAR,DSA or fruit set.To validate these data,in a third experiment with XL containers in the spring-summer cycle,the combination of cold priming and K supplementation was tested,confirming the significant effect of this combination on the reduction of generation time(2.9 d for DSA and 3.9 d for DAR)compared to the control.Embryo rescue during the cell expansion cycle(average of 22.0 d and 23.3 d after anthesis for‘M82'and‘Moneymaker',respectively)allowed the shortening of the generation time by 8.7 d in‘M82'and 11.6 d in‘Moneymaker'compared to the in planta fruit ripening.The combination of agronomic treatments with embryo rescue can effectively increase the number of generations per year from three to four for speed breeding of tomato.展开更多
Climate change exacerbates tourism emergencies, making it increasingly critical to enhance mitigation and adaptation capacity to alleviate extreme climate's impacts during tourism. Climate-induced impacts and thre...Climate change exacerbates tourism emergencies, making it increasingly critical to enhance mitigation and adaptation capacity to alleviate extreme climate's impacts during tourism. Climate-induced impacts and threats in mountainous tourism areas are more challenging given complex terrains and multiple risk sources. Prior studies have focused on assessing climate-related impacts in mountainous tourism areas, while limited studies have investigated the emergency rescue capacity of mountainous tourism areas. This largely constrains decision makers to adopt proper solutions to enhance emergency rescue capacity. To address this research challenges, this study aims to assess emergency rescue capability through an empirical study of the Wulong Karst Tourism Destination(WKTD) area in Chongqing, China. In particular, based on road network and emergency response facility data, the accessibility of road network was delineated by the Spatial Design Network Analysis(s DNA) model. The results indicate that fire and medical rescue facilities were extremely limited and their service coverage was irregular. Valleys significantly narrowed rescue facilities' service area and weakened their functional connection. With the vital 60-minute timeframe, the closeness and betweenness analyses revealed the low accessibility of global rescue roads, while relatively high accessibility of small-scale vehicle and pedestrian rescue roads. The Mean Crow Flight(MCF) and Diversion Ratio(DR) analyses verified that the accessibility of road rescue services was impeded by mountainous terrain. Overall, this study informs solutions pertaining to rescue and disaster mitigation in mountainous tourism areas.展开更多
Dear Editor,This letter is concerned with a coordinated path following control method for multiple unmanned underwater vehicles(UUVs)to carry out maritime search and rescue(MSR)missions.The kinetic model parameters of...Dear Editor,This letter is concerned with a coordinated path following control method for multiple unmanned underwater vehicles(UUVs)to carry out maritime search and rescue(MSR)missions.The kinetic model parameters of each UUV is totally unknown.Firstly,a kinematic control law is constructed by designing a vertical line-of-sight(LOS)guidance scheme.展开更多
Objective:To explore the application effect of emergency rescue capability intervention among students in a university in Beijing.Methods:A total of 900 students from a university in Beijing in 2023 were selected as t...Objective:To explore the application effect of emergency rescue capability intervention among students in a university in Beijing.Methods:A total of 900 students from a university in Beijing in 2023 were selected as the research objects.Emergency rescue capability training was conducted from March 2023 to June 2023,once a month.The students’mastery of emergency rescue before and after the intervention was analyzed.Survey questionnaires were distributed to all college students to understand their channels and willingness to acquire emergency rescue knowledge.Results:A total of 886 valid questionnaires were collected in this study.The highest proportion of knowledge about China’s general emergency telephone number and how to dial the emergency rescue hotline was 100.00%.Among the strategies for dealing with cardiac arrest in CPR,the highest proportion was 336.34%.Among the four major first aid techniques of hemostasis,bandaging,fixation,transportation,the highest proportion of knowledge about the use of rubber band signs was 31.71%.Among the first aid techniques for heatstroke,poisoning,fire,and sharp instrument injuries,the principle of emergency treatment for severe gas poisoning had the highest proportion of 41.42%,showing significant differences.College students mainly acquire knowledge of emergency rescue capability through TV programs,health education lectures,and the internet.Around 61.40%of college students hope to learn more about prevention and control knowledge.Conclusion:After the intervention of emergency rescue capability,the emergency rescue capability of college students in this university has been significantly improved,showing a strong training effect,which is worthy of promotion.展开更多
基金Project(2016YFC0802904)supported by the National Key Research and Development Program of China
文摘Aiming at dealing with the difficulty for traditional emergency rescue vehicle(ECV)to enter into limited rescue scenes,the electro-hydraulic steer-by-wire(SBW)system is introduced to achieve the multi-mode steering of the ECV.The overall structure and mathematical model of the SBW system are described at length.The fractional order proportional-integral-derivative(FOPID)controller based on fractional calculus theory is designed to control the steering cylinder’s movement in SBW system.The anti-windup problem is considered in the FOPID controller design to reduce the bad influence of saturation.Five parameters of the FOPID controller are optimized using the genetic algorithm by maximizing the fitness function which involves integral of time by absolute value error(ITAE),peak overshoot,as well as settling time.The time-domain simulations are implemented to identify the performance of the raised FOPID controller.The simulation results indicate the presented FOPID controller possesses more effective control properties than classical proportional-integral-derivative(PID)controller on the part of transient response,tracking capability and robustness.
文摘BACKGROUND Due to increasing resistance rates of Helicobacter pylori(H.pylori)to different antibiotics,failures in eradication therapies are becoming more frequent.Even though eradication criteria and treatment algorithms for first-line and second-line therapy against H.pylori infection are well-established,there is no clear recommendation for third-line and rescue therapy in refractory H.pylori infection.AIM To perform a systematic review evaluating the efficacy and safety of rescue therapies against refractory H.pylori infection.METHODS A systematic search of available rescue treatments for refractory H.pylori infection was conducted on the National Library of Medicine’s PubMed search platform based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Randomized or non-randomized clinical trials and observational studies evaluating the effectiveness of H.pylori infection rescue therapies were included.RESULTS Twenty-eight studies were included in the analysis of mean eradication rates as rescue therapy,and 21 of these were selected for analysis of mean eradication rate as third-line treatment.For rifabutin-,sitafloxacin-,levofloxacin-,or metronidazole-based triple-therapy as third-line treatment,mean eradication rates of 81.6%and 84.4%,79.4%and 81.5%,55.7%and 60.6%,and 62.0%and 63.0%were found in intention-to-treat(ITT)and per-protocol(PP)analysis,respectively.For third-line quadruple therapy,mean eradication rates of 69.2%and 72.1%were found for bismuth quadruple therapy(BQT),88.9%and 90.9%for bismuth quadruple therapy,three-in-one,Pylera®(BQT-Pylera),and 61.3%and 64.2%for non-BQT)in ITT and PP analysis,respectively.For rifabutin-,sitafloxacin-,levofloxacin-,or metronidazole-based triple therapy as rescue therapy,mean eradication rates of 75.4%and 78.8%,79.4 and 81.5%,55.7%and 60.6%,and 62.0%and 63.0%were found in ITT and PP analysis,respectively.For quadruple therapy as rescue treatment,mean eradication rates of 76.7%and 79.2%for BQT,84.9%and 87.8%for BQT-Pylera,and 61.3%and 64.2%for non-BQT were found in ITT and PP analysis,respectively.For susceptibility-guided therapy,mean eradication rates as third-line and rescue treatment were 75.0%in ITT and 79.2%in PP analysis.CONCLUSION We recommend sitafloxacin-based triple therapy containing vonoprazan in regions with low macrolide resistance profile.In regions with known resistance to macrolides or unavailability of bismuth,rifabutin-based triple therapy is recommended.
基金The Special Foundation for National Science and Technology Basic Resource Survey Program of China(2018FY10060002).
文摘Out-of-hospital cardiac arrest(OHCA)presents a significant public health challenge in China.A sharp contrast in survival rate after OHCA exists between China and more developed countries.Due to the short life-saving time window,emergency medical services(EMS)and bystanders peripheral to EMS are key contributors to survival after OHCA.Here we discuss limitations and challenges for current EMS in rescuing OHCA by reviewing requirements for EMS in China.We call for an updated public health-based prehospital rescue system that includes establishing a cardiac arrest registry,promoting a“Three Early’s”campaign[early dialing of emergency hotline 120,early cardiopulmonary resuscitation(CPR),and early defibrillation],and operating a mechanism comprised of professional public health institutions(EMS,CDC,specialized disease prevention and control institutions,and health education institutions)as well as many governmental departments,such as healthcare,industry and information technology,and education,and non-governmental organizations,such as the Red Cross Society.Following the optimization of the prehospital rescue system and the participation of the whole population in self-rescue and mutual rescue,we believe that a dramatic improvement in OHCA survival will come about in China.
基金This study was supported by the Public Beneficial Industrial Funds by the Ministry of Land and Resources of China[grant number 201011010].
文摘In recent years,geological and mineral resources exploration in China has expanded to deep hinterland of the Qinghai−Tibet Plateau and other regions with complex geological conditions.The special natural conditions of Qinghai−Tibet Plateau determine the characteristics of“life-forbidden zone”that is characterized by alpine hypoxia,changeable weather,complex road conditions,and beast attack.In particular,the work in wild depopulated zones with severe environment and poor communications imposes serious threats to the life safety of geological personnel.Therefore,how to guarantee the safety of geological personnel working on the Qinghai−Tibet Plateau and how to reduce or even avoid casualty of geological personnel have currently become the urgent challenge.In this study,an emergency rescue information system for field geological survey is constructed based on BeiDou Navigation Satellite System.A case study of emergency rescue has been conducted in the depopulated zone of the Qinghai−Tibet Plateau and good effects have been achieved,providing security assurance for personnel engaged in field geological survey on the Qinghai−Tibet Plateau and technical support for the emergency rescue in case of natural hazards on the Qinghai−Tibet Plateau.The BeiDou Navigation Satellite System(BDS)can be effectively used to locate and communicate in the emergency rescue for rigorous Geological survey task where there is no network signal for the mobile phone,and the emergency rescue guarantee system is independent,reliable,and relatively cheap.The application value of BDS is demonstrated in the geological field.
基金Project(2012AA041504)supported by the National High-Tech Research and Development Program of ChinaProject(KYLX15_1418)supported by the 2015 Annual General University Graduate Research and Innovation Program of Jiangsu Province,ChinaProject supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),China
文摘A new explosion-proof walking system was designed for the coal mine rescue robot(CMRR) by optimizing the mechanical structure and control algorithm. The mechanical structure innovation lies mainly in the dual-motor drive tracked unit used, which showed high dynamic performance compared with the conventional tracked unit. The control algorithm, developed based on decision trees and neural networking, facilitates autonomous switching between "Velocity-driven Mode" and "Torquedriven Mode". To verify the feasibility and effectiveness of the control strategy, we built a self-designed test platform and used it to debug the control program; we then made a robot prototype and conducted further experiments on single-step, ramp, and rubble terrains. The results show that the proposed walking system has excellent dynamic performance and the control strategy is very efficient, suggesting that a robot with this type of explosion-proof walking system can be successfully applied in Chinese coal mines.
文摘Helicopters are often used in mountain rescue both for rescuers moving in the area of accidents and for evacuating victims, but in steep or forested terrain finding a landing place can be problematic. The main aim of this research is to use Digital Elevation Model(DEM) and cartographic database analysis to select locations that can be used as landing site for the rescue helicopters. Methods were based on GIS analysis;both raster and vector data were used for identifying touchdown points for rescue helicopters. Based on DEM data, locations with a low slope gradient were identified;topographic vector data were used for identifying unforested sites. Then buffer zones for buildings and power lines were excluded, and it was checked whether the areas had any topographic features that prevented helicopter landings. The findings were verified on an orthophotomap. In result, GIS analyses have selected 1232 polygons that fulfilled initial criteria. Their verification on orthophotomap has shown that only 55% of them could be potentially used as landing site. Landing sites can be found mainly on side ridges of mountain ranges and in valley beds, when those on ridges are most important in this research. The greatest difficulties and methodological challenges are posed by: identification of sites having a shape which prevents landing, the obsolescence of data due to environment dynamics, the presence of features that are not shown on maps but prevent helicopter landings. A map of landing sites is a very useful tool to conduct rescue operations, but each use of a given landing site requires both in-field and numerical verification. The analysis demonstrated that GIS toolsare useful in pre-planning of rescue missions, and also showed that such data must be kept up-to-date and in-field verification is needed continuously, the more so as it plays an important role in ensuring the safety of rescuers and victims.
文摘Fire rescue challenges and solutions have evolved from straightfor-ward plane rescue to encompass 3D space due to the rise of high-rise city buildings.Hence,this study facilitates a system with quick and simplified on-site launching and generates real-time location data,enabling fire rescuers to arrive at the intended spot faster and correctly for effective and precise rescue.Auto-positioning with step-by-step instructions is proposed when launching the locating system,while no extra measuring instrument like Total Station(TS)is needed.Real-time location tracking is provided via a 3D space real-time locating system(RTLS)constructed using Ultra-wide Bandwidth technology(UWB),which requires electromagnetic waves to pass through concrete walls.A hybrid weighted least squares with a time difference of arrival(WLS/TDOA)positioning method is proposed to address real path-tracking issues in 3D space and to meet RTLS requirements for quick computing in real-world applications.The 3D WLS/TDOA algorithm is theoretically constructed with the Cramer-Rao lower bound(CRLB).The computing complexity is reduced to the lower bound for embedded hardware to directly compute the time differential of the arriving signals using the time-to-digital converter(TDC).The results of the experiments show that the errors are controlled when the positioning algorithm is applied in various complicated situations to fulfill the requirements of engineering applications.The statistical analysis of the data reveals that the proposed UWB RTLS auto-positioning system can track target tags with an accuracy of 0.20 m.
基金supported by National Natural Science Foundation of China(Grant No.31671996)Natural Science Foundation of Zhejiang Province,China(Grant No.LZ20C140004)National Key R&D Program of China(No.2019YFD1001800)。
文摘Dear Editor,De novo generation of negative-stranded RNA viruses(NSVs)requires efficient transcription of integral viral RNAs with precise termini from cloned plasmids.Studies during the past 25 years with animal NSVs have established the bacteriophage T7 RNA polymerase(Pol)-and endogenous Pol I-based transcription systems as the most efficient platforms for recovery of recombinant NSVs(Bridgen 2012).Unfortunately.
基金supported by the Graduate Science and Technology Innovation Fund(YCB100150)
文摘By introdming a small-caliber deep well rescue robot, a hold-hug pattern rescue mechanism was brought forward. In order to reduce the volmne, the trader-well rescue imclmnism is modularizing designed. At the same tirae, the audio and video systyems, the illumination system and the ventilation system are expatiated. The rescuing robot can rescue the falling person in the deep well, it can save much manateral resources and time. It＇s really an ideal rescue device for the small-caliber fall.
基金supported by National Natural Science Foundation of China (Grant No.70671021)National Social Science Fund of China (Grant No.06BZZ019)Emergency Rescue Decision-Making Mechanism of Outsize Accidents in Nanjing (Grant No.200702011)
文摘With the development of metropolitan regions and the appearance of urban agglomerations, cities have been more closely related. For the restricted emergency rescue resource in a single city, it has become more and more imminent for the demand of the intercity collaborative resistance to major accident, so as to improve the protection capacity of urban security. In order to find an effective intercity, emergency rescue collaborative system, this paper introduces the concept and analysis method of ecosystem theory into intercity emergency, rescue. Based on the analysis of the formation-process of emergency rescue individual, population and community： a throe-level intercity emergency rescue collaborative system is constructed according to the characteristics of dynamics and structure of intercity emergency rescue ecosystem then the collaboration mechanism of information, resource and process in the interceity emergency rescue ecosystem is also studied in this paper; so as to offer available strategy and method for the ecosystem theory applied to intercity, emergency rescue. Through the studies of intereity emergency rescue ecosystem. it illuminates that the proposed emergency system can not Only cope with the major accident more timely and effectively but also integrate the intercity information resources and emergency rescue resource and process optimization.
基金Supported by National Natural Science Foundation of China(Grant No.52475032)Central Government Guides Local Science and Technology Development Fund Projects(Grant No.246Z2001G)Hebei Provincial Natural Science Foundation Key Projects(Grant No.E2021203125).
文摘The existing research on rescue robots has focused mainly on reconnaissance,detection,and firefighting,and a small number of robots that can achieve human rescue have problems such as poor safety and stability and insufficient carrying capacity.This article addresses the above issues and cleverly combines the advantages of soft robotic arms,underactuated robotic arms,and suction cups based on the principles of bionics.A new design for a robotic arm was proposed,and its working principle was explained.Then,the human rescue process was divided into two stages,and the grasping force of the robotic arm in each stage was analyzed separately.Finally,a prototype of the principle was developed,and the feasibility of the design principle of the robotic arm was verified through grasping experiments on a cross-sectional contour model of the human chest.At the same time,grasping experiments were conducted on different objects to demonstrate the potential application of the robotic arm in grasping ground objects.This research proposes a stress envelope adsorption rescue robot arm inspired by the adhesion ability of the Drosera plant and the stress envelope effect,which can apply force to the entire surface of the human body,reduce local force on the human body,ensure load-bearing capacity and adaptability,and improve the safety and stability of rescue grasping.
文摘More than eighty years ago,when the Nazis brutally persecuted and mass-murdered the Jews,and nearly every country in the world shut its door to them desperately seeking refuge,the Chinese people,especially those of the city of Shanghai,opened their arms to the European Jews at this critical moment.
文摘Researchers have discovered that mice instinctively exhibit rescue-like behavior towards anesthetized companions-a finding that suggests a biological basis for prosociality.The study,published in PNAS on April 23,2025,was led by Dr.HU Li from the Institute of Psychology of the Chinese Academy of Sciences(IPCAS)and Dr.CHEN Zhoufeng from Washington University School of Medicine and the Shenzhen Medical Academy of Research and Translation.
文摘Objectives:At the time of the bombing of the federal building in Oklahoma City,Oklahoma(OKC),it was the deadliest terrorist attack in the United States of America.Available research on this incident,and in general,has been quantitative,using deductive methods.The purpose of the current study was to systematically examine professional disaster response workers’emotions elicited spontaneously and in detail as they were experienced over time after a major disaster.This qualitative study will add to existing knowledge of psychopathology and the psychosocial effects of disasters on professional responders,which have not been explored by prior quantitative studies.Methods:A volunteer sample of 181 rescue and recovery workers for the 1995 bombing of the OKC Murrah Federal Building was interviewed approximately 3 years after the bombing.These responders were asked open-ended questions to elicit undirected responses in their own words.In these interviews,they were prompted to describe their feelings at 3 distinct time points:upon their arrival at the bombing scene(“immediately”),in the first 1 week following the bombing,and currently at the time of the interview(“now”).Results:Data items were coded into the 5 themes:Anticipation,Shock and awe,Negative reactions,Positive reactions,and Emotionally unengaged/unaffected.The emotional themes of the responders mapped into 2 conceptual domains.The first domain is related to common human responses to horrible events such as the bombing.The second domain is related to the professional identities of the disaster responders.Conclusions:Specific aspects of the professional responder roles asserted themselves,shaping their emotional responses distinctly from those of the bomb blast survivors.This study identified both negative and positive emotions,which may help identify risk for or resistance to posttraumatic stress disorder(PTSD).
文摘Construction failures caused by unforeseen circumstances, such as natural disasters, environmental degradation, and structural weaknesses, present significant challenges in achieving durability, safety, and sustainability. This research addresses these challenges through the development of advanced emergency rescue systems incorporating wood-derived nanomaterials and IoT-enabled Structural Health Monitoring (SHM) technologies. The use of nanocellulose which demonstrates outstanding mechanical capabilities and biodegradability alongside high resilience allowed developers to design modular rescue systems that function effectively even under challenging conditions while providing real-time failure protection. Experimental data from testing showed that the replacement system strengthened load-bearing limits by 20% while enhancing impact tolerance by 30% and decreasing lifecycle carbon footprints by 60% against conventional methods. FEA results alongside dynamic simulations established that the system maintains its strength across seismic events and thermal variations and environmental conditions. SHM systems that leverage the Internet of Things Platform revealed 95% accuracy rates in detecting anomalies while improving response speed by 30% for predictive maintenance operations. The innovative solutions support the special issue’s direction to push structural transformation through durable designs and creative materials with preventive failure solutions. The proposed solutions work together toward creating resilient infrastructure systems which resist unexpected stressors and environmental damage.
基金funded by the European Commission H2020 Research and Innovation Programme through the HARNESSTOM innovation action(Grant No.101000716)Grant CIPROM/2021/020(project SOLECO)funded by Conselleria d’Innovació,Universitats,Ciència i Societat Digital(Generalitat Valenciana,Spain)Pietro Gramazio received a post-doctoral fellowship(Grant No.RYC2021-031999-I)funded by MCIN/AEI/10.13039/501100011033 and by“European Union NextGenerationEU/PRTR”。
文摘Unlike other major crops,little research has been performed on tomato to reduce the generation time for speed breeding.We evaluated several agronomic treatments to reduce the generation time of tomato in the‘M82'(determinate)and‘Moneymaker'(indeterminate)varieties and evaluated the best combination in conjunction with embryo rescue.Five container sizes with volumes of 0.2 L(XS),0.45 L(S),0.8 L(M),1.3 L(L),and6 L(XL),were evaluated in the first experiment under the autumn cycle.We found that plants grown in XL containers exhibited better development and required less time from sowing to anthesis(DSA)and from anthesis to fruit ripening(DAR).In the second experiment,using XL containers in the autumn-winter cycle,we evaluated the effects of cold priming at the cotyledonary stage,water stress,P supplementation,and K supplementation on generation time.Compared to the control,we found that cold priming significantly reduced the number of leaves,plant height to first the inflorescence,and DSA(2.7 d),whereas K supplementation reduced the DAR(8.8 d).In contrast,water stress and P supplementation did not significantly affect any of the measured traits like DAR,DSA or fruit set.To validate these data,in a third experiment with XL containers in the spring-summer cycle,the combination of cold priming and K supplementation was tested,confirming the significant effect of this combination on the reduction of generation time(2.9 d for DSA and 3.9 d for DAR)compared to the control.Embryo rescue during the cell expansion cycle(average of 22.0 d and 23.3 d after anthesis for‘M82'and‘Moneymaker',respectively)allowed the shortening of the generation time by 8.7 d in‘M82'and 11.6 d in‘Moneymaker'compared to the in planta fruit ripening.The combination of agronomic treatments with embryo rescue can effectively increase the number of generations per year from three to four for speed breeding of tomato.
基金supported by the State Key Laboratory of Subtropical Building and Urban Science (No.2024KA03)Southwest University Graduate Research Innovation Project (Grant No.SWUB23043)+1 种基金the China Meteorological Administration “Research on value realization of climate ecological products” Youth Innovation Team Project (No.CMA2024QN15)Chongqing Natural Science(No.CSTB2024NSCQ-MSX0670)。
文摘Climate change exacerbates tourism emergencies, making it increasingly critical to enhance mitigation and adaptation capacity to alleviate extreme climate's impacts during tourism. Climate-induced impacts and threats in mountainous tourism areas are more challenging given complex terrains and multiple risk sources. Prior studies have focused on assessing climate-related impacts in mountainous tourism areas, while limited studies have investigated the emergency rescue capacity of mountainous tourism areas. This largely constrains decision makers to adopt proper solutions to enhance emergency rescue capacity. To address this research challenges, this study aims to assess emergency rescue capability through an empirical study of the Wulong Karst Tourism Destination(WKTD) area in Chongqing, China. In particular, based on road network and emergency response facility data, the accessibility of road network was delineated by the Spatial Design Network Analysis(s DNA) model. The results indicate that fire and medical rescue facilities were extremely limited and their service coverage was irregular. Valleys significantly narrowed rescue facilities' service area and weakened their functional connection. With the vital 60-minute timeframe, the closeness and betweenness analyses revealed the low accessibility of global rescue roads, while relatively high accessibility of small-scale vehicle and pedestrian rescue roads. The Mean Crow Flight(MCF) and Diversion Ratio(DR) analyses verified that the accessibility of road rescue services was impeded by mountainous terrain. Overall, this study informs solutions pertaining to rescue and disaster mitigation in mountainous tourism areas.
基金supported by the National Science and Technology Major Project(2022ZD0119902)the Doctoral Scientific Research Foundation of Liaoning Province(2023-BS-077)+2 种基金the Postdoctoral Research Foundation of China(2024M751980)the Open Project of State Key Laboratory of Maritime Technology and Safety(SKLMTA-DMU2024Y3)Bolian Research Funds of Dalian Maritime University/Fundamental Research Funds for the Central Universities(3132023616).
文摘Dear Editor,This letter is concerned with a coordinated path following control method for multiple unmanned underwater vehicles(UUVs)to carry out maritime search and rescue(MSR)missions.The kinetic model parameters of each UUV is totally unknown.Firstly,a kinematic control law is constructed by designing a vertical line-of-sight(LOS)guidance scheme.
文摘Objective:To explore the application effect of emergency rescue capability intervention among students in a university in Beijing.Methods:A total of 900 students from a university in Beijing in 2023 were selected as the research objects.Emergency rescue capability training was conducted from March 2023 to June 2023,once a month.The students’mastery of emergency rescue before and after the intervention was analyzed.Survey questionnaires were distributed to all college students to understand their channels and willingness to acquire emergency rescue knowledge.Results:A total of 886 valid questionnaires were collected in this study.The highest proportion of knowledge about China’s general emergency telephone number and how to dial the emergency rescue hotline was 100.00%.Among the strategies for dealing with cardiac arrest in CPR,the highest proportion was 336.34%.Among the four major first aid techniques of hemostasis,bandaging,fixation,transportation,the highest proportion of knowledge about the use of rubber band signs was 31.71%.Among the first aid techniques for heatstroke,poisoning,fire,and sharp instrument injuries,the principle of emergency treatment for severe gas poisoning had the highest proportion of 41.42%,showing significant differences.College students mainly acquire knowledge of emergency rescue capability through TV programs,health education lectures,and the internet.Around 61.40%of college students hope to learn more about prevention and control knowledge.Conclusion:After the intervention of emergency rescue capability,the emergency rescue capability of college students in this university has been significantly improved,showing a strong training effect,which is worthy of promotion.
