A new chemically mutagenic mutant of Synechococcus PCC7942 named high-CO2 re-quiring mutant, which could grow at 4% CO2 but could not grow at air levels of CO2, was isolated. Com-parative studies on some physiological...A new chemically mutagenic mutant of Synechococcus PCC7942 named high-CO2 re-quiring mutant, which could grow at 4% CO2 but could not grow at air levels of CO2, was isolated. Com-parative studies on some physiological aspects of the mutant and high-cO2 growing cells (growing at 4%CO2 ) were conducted. The result showed that the mutant had lower growing rate, about 1/40th photosyn-thetic affinity to inorganic carbon, 25% lower carbonic anhydrase (CA) activity, lower quenching rate ofchlorophyll fluoresence, and about 1/2 alkalinization rate of the medium. The CA activity responses ofthe two types of cells to different concentrations of CO2 were determined. Upon the addition of inorganiccarbon (Ci), the rate of active Ci uptake described by the rate of chlorophyll fluorescence quenching ofthe mutant was obviously lower compared with that of the high-CO2 growing cells; the size of the internalinorganic carbon pool size determined by the extent of fluorescence quenching Of the mutant was alsosmaller.展开更多
A sign pattern(matrix)is a matrix whose entries are the symbols+,-and 0.Foran n×n sign pattern matrix A,the sign pattern class of A,denoted by Q(A),is the set ofall n×n real matrices whose entries have signs...A sign pattern(matrix)is a matrix whose entries are the symbols+,-and 0.Foran n×n sign pattern matrix A,the sign pattern class of A,denoted by Q(A),is the set ofall n×n real matrices whose entries have signs indicated by the corresponding entries of A.We say that a sign pattern matrix A requires a matrix property P if every real matrix in Q(A)has the property P.A matrix with all distinct eigenvalues has many nice展开更多
The tryptophan-requiring auxotrophs escherichia coliWP2A and Cm891 strains wrer used in the work.Thesestrains are sensitive to base pair substitutionmutagens.These strain have been indentified beforeexperiment.The est...The tryptophan-requiring auxotrophs escherichia coliWP2A and Cm891 strains wrer used in the work.Thesestrains are sensitive to base pair substitutionmutagens.These strain have been indentified beforeexperiment.The estimated dose rate of tritid展开更多
Objective To evaluate risk factors for postoperative acute renal failure requiring dialysis (ARF-D) after hear valve surgery. Methods Adult patients (age≤18 years) underwent valve surgery with preoperative serum crea...Objective To evaluate risk factors for postoperative acute renal failure requiring dialysis (ARF-D) after hear valve surgery. Methods Adult patients (age≤18 years) underwent valve surgery with preoperative serum creati nine 【 300 μmol / L were included between January 2005 and December 2008. Fifty patients developed ARF-D展开更多
Vitamin B(VB1),including thiamin,thiamin monophosphate(TMP),and thiamin pyrophosphate(TPP),is an essential micronutrient for all living organisms.Nevertheless,the precise function of VB1 in rice remains unclear.Here,w...Vitamin B(VB1),including thiamin,thiamin monophosphate(TMP),and thiamin pyrophosphate(TPP),is an essential micronutrient for all living organisms.Nevertheless,the precise function of VB1 in rice remains unclear.Here,we described a VB1 auxotrophic mutant,chlorotic lethal seedling(cles)from the mutation of OsTH1,which displayed collapsed chloroplast membrane system and decreased pigment content.OsTH1 encoded a phosphomethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase,and was expressed in various tissues,especially in seedlings,leaves,and young panicles.The VB1 content in cles was markedly reduced,despite an increase in the expression of VB1 synthesis genes.The decreased TPP content affected the tricarboxylic acid cycle,pentose phosphate pathway,and de novo fatty acid synthesis,leading to a reduction in fatty acids(C16:0 and C18:0)and sugars(sucrose and glucose)of cles.Additionally,irregular expression of chloroplast membrane synthesis genes led to membrane collapse.We also found that alternative splicing and translation allowed OsTH1 to be localized to both chloroplast and cytosol.Our study revealed that OsTH1 was an essential enzyme in VB1 biosynthesis and played crucial roles in seedling growth and development by participating in fatty acid and sugar metabolism,providing new perspectives on VB1 function in rice.展开更多
Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between...Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between adjacent filled drifts,which can weaken the integrity of the backfill roof.These interfaces also lead to two common drift layouts:aligned drifts and staggered drifts.However,less attention has been paid to the interfaces and the two drift layouts were not adequately distinguished in previous studies.In this paper,the interfaces between filled drifts were firstly considered to investigate the stability of backfill roof.Failure modes and strength requirements of backfill roof in aligned and staggered drifts are comprehensively investigated by FLAC3D,with a focus on considerations of varied shear parameters of the interfaces.Results show that failure modes in aligned drifts transition from block sliding to top caving,bottom caving or sloughing as the interface cohesion increases from zero to at least half of the backfill cohesion.Further increases in interface cohesion allow aligned drifts to behave as if there are no interfaces between them.The critical stability conditions of backfill roof in aligned drifts were mostly determined by the interface strength instead of the backfill strength.However,the stability of backfill roof in staggered drifts is barely affected by the interface strength.The outcomes are expected to provide references for mining engineers to optimize drift layouts and perform cost-effective backfill roof strength design at mines using underhand drift-and-fill mining method.展开更多
We now differentiate between the requirements for new and revised submissions.You may choose to submit your manuscript as a single Word or PDF file to be used in the refereeing process.Only when your paper is at the r...We now differentiate between the requirements for new and revised submissions.You may choose to submit your manuscript as a single Word or PDF file to be used in the refereeing process.Only when your paper is at the revision stage,will you be requested to put your paper into a'correct format'for acceptance and provide the items required for the publication of your article.展开更多
Objective To study the role of inositol requiring enzyme 1(IRE1)-mediated endoplasmic reticulum stress on hepatocyte apoptosis of experimental fulminant hepatic failure(FHF). Methods Thirty male depuratory
To meet the challenge of mismatches between power supply and demand,modern buildings must schedule flexible energy loads in order to improve the efficiency of power grids.Furthermore,it is essential to understand the ...To meet the challenge of mismatches between power supply and demand,modern buildings must schedule flexible energy loads in order to improve the efficiency of power grids.Furthermore,it is essential to understand the effectiveness of flexibility management strategies under different climate conditions and extreme weather events.Using both typical and extreme weather data from cities in five major climate zones of China,this study investigates the energy flexibility potential of an office building under three short-term HVAC management strategies in the context of different climates.The results show that the peak load flexibility and overall energy performance of the three short-term strategies were affected by the surrounding climate conditions.The peak load reduction rate of the pre-cooling and zone temperature reset strategies declined linearly as outdoor temperature increased.Under extreme climate conditions,the daily peak-load time was found to be over two hours earlier than under typical conditions,and the intensive solar radiation found in the extreme conditions can weaken the correlation between peak load reduction and outdoor temperature,risking the ability of a building’s HVAC system to maintain a comfortable indoor environment.展开更多
Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery...Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery disease,stroke,peripheral artery disease,and heart failure.Despite advances in medicine and healthcare delivery,CVD continues to have a serious impact on individuals,families,and the healthcare system.This review begins by delineating the merits and demerits of commonly employed synthetic and natural materials for artificial blood vessels.It delves into various techniques commonly employed in the fabrication of artificial blood vessels,encompassing advanced textile technologies,electrospinning,ther-mally induced phase separation,and 3D printing.The review critically analyzes the attributes of different preparation methodologies alongside the latest advancements in research.The review also outlines the requisite performance requirements for artificial blood vessels,which encompass robust mechanical prop-erties,appropriate porosity,exceptional compatibility,and antibacterial attributes.It provides a succinct overview of ongoing effort s in vascular functionalization,particularly emphasizing thrombus mitigation,promotion of endothelialization,and enhancement of nitric oxide production.The review finally encap-sulates the primary challenges confronting vascular grafts and prospective avenues for future research.展开更多
Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen energy.Herein,Ru/NiMnB spherical cluster pillar(SCP),denoted as Ru/NiMnB,is synthesized using a combination of elect...Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen energy.Herein,Ru/NiMnB spherical cluster pillar(SCP),denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal reaction.Systematic investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic performance.The Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm^(2)in 1 M KOH,making them highly competitive with state-of-the-art electrocatalysts.Remarkably,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm^(2)in 1 M KOH,outperforming the standard benchmark electrodes of RuO_(2)||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional electrocatalysts.These SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm^(2)high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial conditions.Only a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction rates.Consequently,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H_(2)production.展开更多
App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While t...App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.展开更多
近日,东南大学计算机与科学工程学院白如帆在人工智能领域国际期刊《Artificial Intelligence》(AIJ,CCF A)上发表题为“On the Computation of Mixed Strategies for Security Games with General Defending Requirements”的论文,介...近日,东南大学计算机与科学工程学院白如帆在人工智能领域国际期刊《Artificial Intelligence》(AIJ,CCF A)上发表题为“On the Computation of Mixed Strategies for Security Games with General Defending Requirements”的论文,介绍该团队在智能体安全博弈领域内的最新研究成果,白如帆老师为论文唯一第一作者,这也是东南大学第二次以第一、通信单位身份在该期刊发表论文。展开更多
Objective To explore the effect of acupuncture on the endoplasmic reticulum stress IRE l-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes ...Objective To explore the effect of acupuncture on the endoplasmic reticulum stress IRE l-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes mellitus. Methods Eighty SD rats were selected, among which, 10 were fed with normal diet and taken as blank control group （＂blank group＂ for short）, the other 70 rats were fed with high fat and high glucose food and injected with small dosage of STZ intraperitoneally, and 30 models were established successfully. The models were randomly divided into acupuncture treatment group （~＇acupuncture group＂ for short）, model control group （＂model group＂ for short） and western medicine group （metformin） with 10 rats in each group. After treatment for 4 weeks, RBG, and the expression levels of CHOP, IRE 2, Bax, Bcl-2 protein and mRNA in pancreatic tissue of rats were determined. Result Compared with the conditions before treatment, RBG reduced obviously in the acupuncture group and western medicine group （P〈0.05）, and there was no statistical difference in RBG in the model group and blank group （P〉0.05）; the expression levels of CHOP, IRE 1 and Bax proteins in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly lower than those in model group （P〈0.05）; the expression levels of CHOP, IRE 1 and Bax mRNAs in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.01）, the expression results in the acupuncture group and western medicine group were significantly lower than those in the model group （P〈0.01）; the expression level of Bcl-2 protein in the model group was significantly lower than that in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly higher than that in the model group （P〈0.02）; there was no statistical difference between the acupuncture group and western medicine group （P〉0.05）; the expression level of Bcl-2 mRNA in the model group was significantly lower than that in the blank group （P〈0.02）, the expression results in the acupuncture group and western medicine group were significantly higher than that in the model group （P〈0.01）; there was no statistical difference between the acupuncture group and western medicine group （P〉0.05）. Conclusion There was endoplasmic reticulum stress in the pancreatic tissue of rats with STZ-induced diabetes mellitus, and IRE 1-CHOP signal pathway was the main pathway for inhibiting the endoplasmic reticulum stress in the pancreatic tissue. Acupuncture can improve the endoplasmic reticulum stress in pancreatic tissue, inhibit apoptosis genes, and protect the pancreatic tissue through IRE 1-CHOP signal pathway.展开更多
As the trend to use the latestmachine learning models to automate requirements engineering processes continues,security requirements classification is tuning into the most researched field in the software engineering ...As the trend to use the latestmachine learning models to automate requirements engineering processes continues,security requirements classification is tuning into the most researched field in the software engineering community.Previous literature studies have proposed numerousmodels for the classification of security requirements.However,adopting those models is constrained due to the lack of essential datasets permitting the repetition and generalization of studies employing more advanced machine learning algorithms.Moreover,most of the researchers focus only on the classification of requirements with security keywords.They did not consider other nonfunctional requirements(NFR)directly or indirectly related to security.This has been identified as a significant research gap in security requirements engineering.The major objective of this study is to propose a security requirements classification model that categorizes security and other relevant security requirements.We use PROMISE_exp and DOSSPRE,the two most commonly used datasets in the software engineering community.The proposed methodology consists of two steps.In the first step,we analyze all the nonfunctional requirements and their relation with security requirements.We found 10 NFRs that have a strong relationship with security requirements.In the second step,we categorize those NFRs in the security requirements category.Our proposedmethodology is a hybridmodel based on the ConvolutionalNeural Network(CNN)and Extreme Gradient Boosting(XGBoost)models.Moreover,we evaluate the model by updating the requirement type column with a binary classification column in the dataset to classify the requirements into security and non-security categories.The performance is evaluated using four metrics:recall,precision,accuracy,and F1 Score with 20 and 28 epochs number and batch size of 32 for PROMISE_exp and DOSSPRE datasets and achieved 87.3%and 85.3%accuracy,respectively.The proposed study shows an enhancement in metrics values compared to the previous literature studies.This is a proof of concept for systematizing the evaluation of security recognition in software systems during the early phases of software development.展开更多
Objective This study aimed to reexplore minimum iodine excretion and to build a dietary iodine recommendation for Chinese adults using the obligatory iodine loss hypothesis.Methods Data from 171 Chinese adults(19–21 ...Objective This study aimed to reexplore minimum iodine excretion and to build a dietary iodine recommendation for Chinese adults using the obligatory iodine loss hypothesis.Methods Data from 171 Chinese adults(19–21 years old)were collected and analyzed based on three balance studies in Shenzhen,Yinchuan,and Changzhi.The single exponential equation was accordingly used to simulate the trajectory of 24 h urinary iodine excretion as the low iodine experimental diets offered(iodine intake:11-26μg/day)and to further deduce the dietary reference intakes(DRIs)for iodine,including estimated average requirement(EAR)and recommended nutrient intake(RNI).Results The minimum iodine excretion was estimated as 57,58,and 51μg/day in three balance studies,respectively.Moreover,it was further suggested as 57,58,and 51μg/day for iodine EAR,and 80,81,and 71μg/day for iodine RNI or expressed as 1.42,1.41,and 1.20μg/(day·kg)of body weight.Conclusion The iodine DRIs for Chinese adults were established based on the obligatory iodine loss hypothesis,which provides scientific support for the amendment of nutrient requirements.展开更多
Sessile oak(Quercus petraea(Matt.)Liebl.)is widely distributed across most of Europe particularly the hills and lower mountain ranges,so is considered“the oak of the mountains”.This species grows on a wide variety o...Sessile oak(Quercus petraea(Matt.)Liebl.)is widely distributed across most of Europe particularly the hills and lower mountain ranges,so is considered“the oak of the mountains”.This species grows on a wide variety of soils and at altitudes ranging from sea level to 2200 m,especially in Atlantic and sub-Mediterranean climates,and it is sensitive to low winter temperatures,early and late frosts,as well as high summer temperatures.Sessile oak forms both pure and mixed stands especially with broadleaves such as European beech,European hornbeam,small-leaved lime and Acer spp.These form the understorey of sessile oak stands,promoting the natural shedding of lower branches of the oak and protecting the trunk against epicormic branches.Sessile oak is a long-lived,light-demanding and wind-firm species,owing to its taproot and heart-shaped root system.Its timber,one of the most valuable in Europe,is important for fur-niture-making(both solid wood and veneer),construction,barrels,railway sleepers,and is also used as fuelwood.It is one of the few major tree species in Europe that is regener-ated by seed(naturally or artificially)and by stump shoots in high forest,coppice-with-standards and coppice forests.Sessile oak forests are treated in both regular and irregular systems involving silvicultural techniques such as uniform shelterwood,group shelterwood,irregular shelterwood,irregular high forest,coppice-with-standards and simple coppice.Young naturally regenerated stands are managed by weeding,release cutting and cleaning-respacing,keeping the stands quite dense for good natural pruning.Plantations are based on(1)2-4-year old bare-root or container-grown seedlings produced in nurseries using seeds from genetic resources,seed stands and seed orchards.The density of sessile oak plantations(mostly in rows,but also in clusters)is usually between 4000 and 6000 ind.ha^(−1).Sessile oak silviculture of mature stands includes crown thinning,focus-ing on final crop trees(usually a maximum of 100 ind.ha^(−1))and targeting the production of large-diameter and high quality trees at long rotation ages(mostly over 120 years,sometimes 250-300 years).In different parts of Europe,conversion of simple coppices and coppice-with-standards to high forests is continuing.Even though manage-ment of sessile oak forests is very intensive and expensive,requiring active human intervention,the importance of this species in future European forests will increase in the con-text of climate change due to its high resistance to distur-bance,superior drought tolerance and heat stress resistance.展开更多
China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the ma...China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the market surged from 11.4 billion yuan in 2018 to 22.9 billion yuan in 2023,achieving a compound annual growth rate(CAGR) of 15%.With projections estimating a rise to 44 billion yuan by 2028 at a 14% CAGR,the sector's long-term growth prospects remain strong.展开更多
1Legal requirements.The author(s)guarantee(s)that the manuscript will not be published elsewhere in any language without the consent of the copyright holders,that the rights of third parties will not be violated,and t...1Legal requirements.The author(s)guarantee(s)that the manuscript will not be published elsewhere in any language without the consent of the copyright holders,that the rights of third parties will not be violated,and that the publisher will not be held legally responsible should there be any claims for compensation.Authors wishing to include figures or text passages that have already been published elsewhere are required to obtain permission from the copyright holder(s)and to include evidence that such permission has been granted when submitting their papers.Any material received without such evidence will be assumed to originate from the authors.展开更多
文摘A new chemically mutagenic mutant of Synechococcus PCC7942 named high-CO2 re-quiring mutant, which could grow at 4% CO2 but could not grow at air levels of CO2, was isolated. Com-parative studies on some physiological aspects of the mutant and high-cO2 growing cells (growing at 4%CO2 ) were conducted. The result showed that the mutant had lower growing rate, about 1/40th photosyn-thetic affinity to inorganic carbon, 25% lower carbonic anhydrase (CA) activity, lower quenching rate ofchlorophyll fluoresence, and about 1/2 alkalinization rate of the medium. The CA activity responses ofthe two types of cells to different concentrations of CO2 were determined. Upon the addition of inorganiccarbon (Ci), the rate of active Ci uptake described by the rate of chlorophyll fluorescence quenching ofthe mutant was obviously lower compared with that of the high-CO2 growing cells; the size of the internalinorganic carbon pool size determined by the extent of fluorescence quenching Of the mutant was alsosmaller.
文摘A sign pattern(matrix)is a matrix whose entries are the symbols+,-and 0.Foran n×n sign pattern matrix A,the sign pattern class of A,denoted by Q(A),is the set ofall n×n real matrices whose entries have signs indicated by the corresponding entries of A.We say that a sign pattern matrix A requires a matrix property P if every real matrix in Q(A)has the property P.A matrix with all distinct eigenvalues has many nice
文摘The tryptophan-requiring auxotrophs escherichia coliWP2A and Cm891 strains wrer used in the work.Thesestrains are sensitive to base pair substitutionmutagens.These strain have been indentified beforeexperiment.The estimated dose rate of tritid
文摘Objective To evaluate risk factors for postoperative acute renal failure requiring dialysis (ARF-D) after hear valve surgery. Methods Adult patients (age≤18 years) underwent valve surgery with preoperative serum creati nine 【 300 μmol / L were included between January 2005 and December 2008. Fifty patients developed ARF-D
基金supported by the National Natural Science Foundation of China(32170337,31870303)。
文摘Vitamin B(VB1),including thiamin,thiamin monophosphate(TMP),and thiamin pyrophosphate(TPP),is an essential micronutrient for all living organisms.Nevertheless,the precise function of VB1 in rice remains unclear.Here,we described a VB1 auxotrophic mutant,chlorotic lethal seedling(cles)from the mutation of OsTH1,which displayed collapsed chloroplast membrane system and decreased pigment content.OsTH1 encoded a phosphomethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase,and was expressed in various tissues,especially in seedlings,leaves,and young panicles.The VB1 content in cles was markedly reduced,despite an increase in the expression of VB1 synthesis genes.The decreased TPP content affected the tricarboxylic acid cycle,pentose phosphate pathway,and de novo fatty acid synthesis,leading to a reduction in fatty acids(C16:0 and C18:0)and sugars(sucrose and glucose)of cles.Additionally,irregular expression of chloroplast membrane synthesis genes led to membrane collapse.We also found that alternative splicing and translation allowed OsTH1 to be localized to both chloroplast and cytosol.Our study revealed that OsTH1 was an essential enzyme in VB1 biosynthesis and played crucial roles in seedling growth and development by participating in fatty acid and sugar metabolism,providing new perspectives on VB1 function in rice.
基金supported by Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2024ZD1003705)the Beijing Nova Program(Grant No.20220484057)support from China Scholarship Council under Grant CSC No.202110300001.
文摘Stability of base-exposed backfill roof in underhand drift-and-fill mining is crucial for the safety of those working beneath.Given the commonly used primary-and-secondary mining sequence,interfaces are formed between adjacent filled drifts,which can weaken the integrity of the backfill roof.These interfaces also lead to two common drift layouts:aligned drifts and staggered drifts.However,less attention has been paid to the interfaces and the two drift layouts were not adequately distinguished in previous studies.In this paper,the interfaces between filled drifts were firstly considered to investigate the stability of backfill roof.Failure modes and strength requirements of backfill roof in aligned and staggered drifts are comprehensively investigated by FLAC3D,with a focus on considerations of varied shear parameters of the interfaces.Results show that failure modes in aligned drifts transition from block sliding to top caving,bottom caving or sloughing as the interface cohesion increases from zero to at least half of the backfill cohesion.Further increases in interface cohesion allow aligned drifts to behave as if there are no interfaces between them.The critical stability conditions of backfill roof in aligned drifts were mostly determined by the interface strength instead of the backfill strength.However,the stability of backfill roof in staggered drifts is barely affected by the interface strength.The outcomes are expected to provide references for mining engineers to optimize drift layouts and perform cost-effective backfill roof strength design at mines using underhand drift-and-fill mining method.
文摘We now differentiate between the requirements for new and revised submissions.You may choose to submit your manuscript as a single Word or PDF file to be used in the refereeing process.Only when your paper is at the revision stage,will you be requested to put your paper into a'correct format'for acceptance and provide the items required for the publication of your article.
文摘Objective To study the role of inositol requiring enzyme 1(IRE1)-mediated endoplasmic reticulum stress on hepatocyte apoptosis of experimental fulminant hepatic failure(FHF). Methods Thirty male depuratory
基金National Key R&D Program of China of the 13th Five-Year Plan(No.2018YFD1100704)。
文摘To meet the challenge of mismatches between power supply and demand,modern buildings must schedule flexible energy loads in order to improve the efficiency of power grids.Furthermore,it is essential to understand the effectiveness of flexibility management strategies under different climate conditions and extreme weather events.Using both typical and extreme weather data from cities in five major climate zones of China,this study investigates the energy flexibility potential of an office building under three short-term HVAC management strategies in the context of different climates.The results show that the peak load flexibility and overall energy performance of the three short-term strategies were affected by the surrounding climate conditions.The peak load reduction rate of the pre-cooling and zone temperature reset strategies declined linearly as outdoor temperature increased.Under extreme climate conditions,the daily peak-load time was found to be over two hours earlier than under typical conditions,and the intensive solar radiation found in the extreme conditions can weaken the correlation between peak load reduction and outdoor temperature,risking the ability of a building’s HVAC system to maintain a comfortable indoor environment.
基金the National Natural Science Foundation of China(No.82374295)the National Key R&D Program of China(No.2021YFE0111100)+1 种基金the Science and Technol-ogy Partnership Program by the Ministry of Science and Technol-ogy of China(No.KY202201002)the Jiangsu Provincial De-partment of Science and Technology(No.BZ2022017).
文摘Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery disease,stroke,peripheral artery disease,and heart failure.Despite advances in medicine and healthcare delivery,CVD continues to have a serious impact on individuals,families,and the healthcare system.This review begins by delineating the merits and demerits of commonly employed synthetic and natural materials for artificial blood vessels.It delves into various techniques commonly employed in the fabrication of artificial blood vessels,encompassing advanced textile technologies,electrospinning,ther-mally induced phase separation,and 3D printing.The review critically analyzes the attributes of different preparation methodologies alongside the latest advancements in research.The review also outlines the requisite performance requirements for artificial blood vessels,which encompass robust mechanical prop-erties,appropriate porosity,exceptional compatibility,and antibacterial attributes.It provides a succinct overview of ongoing effort s in vascular functionalization,particularly emphasizing thrombus mitigation,promotion of endothelialization,and enhancement of nitric oxide production.The review finally encap-sulates the primary challenges confronting vascular grafts and prospective avenues for future research.
基金Core Research Institute Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2018R1A6A1A03025242)in part by the research grant of Kwangwoon University in 2024。
文摘Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen energy.Herein,Ru/NiMnB spherical cluster pillar(SCP),denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal reaction.Systematic investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic performance.The Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm^(2)in 1 M KOH,making them highly competitive with state-of-the-art electrocatalysts.Remarkably,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm^(2)in 1 M KOH,outperforming the standard benchmark electrodes of RuO_(2)||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional electrocatalysts.These SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm^(2)high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial conditions.Only a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction rates.Consequently,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H_(2)production.
基金supported by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant no.(GPIP:13-612-2024).
文摘App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.
文摘近日,东南大学计算机与科学工程学院白如帆在人工智能领域国际期刊《Artificial Intelligence》(AIJ,CCF A)上发表题为“On the Computation of Mixed Strategies for Security Games with General Defending Requirements”的论文,介绍该团队在智能体安全博弈领域内的最新研究成果,白如帆老师为论文唯一第一作者,这也是东南大学第二次以第一、通信单位身份在该期刊发表论文。
基金Supported by National Natural Science Foundation for Youth of China:81202769Construction project"Innovation team of acupuncture theory,technology and application"of the platform for research and innovation in colleges and universitiesin Anhui:2015 TD 033
文摘Objective To explore the effect of acupuncture on the endoplasmic reticulum stress IRE l-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes mellitus. Methods Eighty SD rats were selected, among which, 10 were fed with normal diet and taken as blank control group （＂blank group＂ for short）, the other 70 rats were fed with high fat and high glucose food and injected with small dosage of STZ intraperitoneally, and 30 models were established successfully. The models were randomly divided into acupuncture treatment group （~＇acupuncture group＂ for short）, model control group （＂model group＂ for short） and western medicine group （metformin） with 10 rats in each group. After treatment for 4 weeks, RBG, and the expression levels of CHOP, IRE 2, Bax, Bcl-2 protein and mRNA in pancreatic tissue of rats were determined. Result Compared with the conditions before treatment, RBG reduced obviously in the acupuncture group and western medicine group （P〈0.05）, and there was no statistical difference in RBG in the model group and blank group （P〉0.05）; the expression levels of CHOP, IRE 1 and Bax proteins in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly lower than those in model group （P〈0.05）; the expression levels of CHOP, IRE 1 and Bax mRNAs in pancreatic tissue of rats in the model group were significantly higher than those in the blank group （P〈0.01）, the expression results in the acupuncture group and western medicine group were significantly lower than those in the model group （P〈0.01）; the expression level of Bcl-2 protein in the model group was significantly lower than that in the blank group （P〈0.05）, the expression results in the acupuncture group and western medicine group were significantly higher than that in the model group （P〈0.02）; there was no statistical difference between the acupuncture group and western medicine group （P〉0.05）; the expression level of Bcl-2 mRNA in the model group was significantly lower than that in the blank group （P〈0.02）, the expression results in the acupuncture group and western medicine group were significantly higher than that in the model group （P〈0.01）; there was no statistical difference between the acupuncture group and western medicine group （P〉0.05）. Conclusion There was endoplasmic reticulum stress in the pancreatic tissue of rats with STZ-induced diabetes mellitus, and IRE 1-CHOP signal pathway was the main pathway for inhibiting the endoplasmic reticulum stress in the pancreatic tissue. Acupuncture can improve the endoplasmic reticulum stress in pancreatic tissue, inhibit apoptosis genes, and protect the pancreatic tissue through IRE 1-CHOP signal pathway.
基金The authors of this study extend their appreciation to the Researchers Supporting Project number(RSPD2025R544),King Saud University,Riyadh,Saudia Arabia.
文摘As the trend to use the latestmachine learning models to automate requirements engineering processes continues,security requirements classification is tuning into the most researched field in the software engineering community.Previous literature studies have proposed numerousmodels for the classification of security requirements.However,adopting those models is constrained due to the lack of essential datasets permitting the repetition and generalization of studies employing more advanced machine learning algorithms.Moreover,most of the researchers focus only on the classification of requirements with security keywords.They did not consider other nonfunctional requirements(NFR)directly or indirectly related to security.This has been identified as a significant research gap in security requirements engineering.The major objective of this study is to propose a security requirements classification model that categorizes security and other relevant security requirements.We use PROMISE_exp and DOSSPRE,the two most commonly used datasets in the software engineering community.The proposed methodology consists of two steps.In the first step,we analyze all the nonfunctional requirements and their relation with security requirements.We found 10 NFRs that have a strong relationship with security requirements.In the second step,we categorize those NFRs in the security requirements category.Our proposedmethodology is a hybridmodel based on the ConvolutionalNeural Network(CNN)and Extreme Gradient Boosting(XGBoost)models.Moreover,we evaluate the model by updating the requirement type column with a binary classification column in the dataset to classify the requirements into security and non-security categories.The performance is evaluated using four metrics:recall,precision,accuracy,and F1 Score with 20 and 28 epochs number and batch size of 32 for PROMISE_exp and DOSSPRE datasets and achieved 87.3%and 85.3%accuracy,respectively.The proposed study shows an enhancement in metrics values compared to the previous literature studies.This is a proof of concept for systematizing the evaluation of security recognition in software systems during the early phases of software development.
基金supported by the National Natural Science Foundation of China(Grant No.81872624)Fundamental Research Program of Shanxi Province(Grant No.202403021211139).
文摘Objective This study aimed to reexplore minimum iodine excretion and to build a dietary iodine recommendation for Chinese adults using the obligatory iodine loss hypothesis.Methods Data from 171 Chinese adults(19–21 years old)were collected and analyzed based on three balance studies in Shenzhen,Yinchuan,and Changzhi.The single exponential equation was accordingly used to simulate the trajectory of 24 h urinary iodine excretion as the low iodine experimental diets offered(iodine intake:11-26μg/day)and to further deduce the dietary reference intakes(DRIs)for iodine,including estimated average requirement(EAR)and recommended nutrient intake(RNI).Results The minimum iodine excretion was estimated as 57,58,and 51μg/day in three balance studies,respectively.Moreover,it was further suggested as 57,58,and 51μg/day for iodine EAR,and 80,81,and 71μg/day for iodine RNI or expressed as 1.42,1.41,and 1.20μg/(day·kg)of body weight.Conclusion The iodine DRIs for Chinese adults were established based on the obligatory iodine loss hypothesis,which provides scientific support for the amendment of nutrient requirements.
文摘Sessile oak(Quercus petraea(Matt.)Liebl.)is widely distributed across most of Europe particularly the hills and lower mountain ranges,so is considered“the oak of the mountains”.This species grows on a wide variety of soils and at altitudes ranging from sea level to 2200 m,especially in Atlantic and sub-Mediterranean climates,and it is sensitive to low winter temperatures,early and late frosts,as well as high summer temperatures.Sessile oak forms both pure and mixed stands especially with broadleaves such as European beech,European hornbeam,small-leaved lime and Acer spp.These form the understorey of sessile oak stands,promoting the natural shedding of lower branches of the oak and protecting the trunk against epicormic branches.Sessile oak is a long-lived,light-demanding and wind-firm species,owing to its taproot and heart-shaped root system.Its timber,one of the most valuable in Europe,is important for fur-niture-making(both solid wood and veneer),construction,barrels,railway sleepers,and is also used as fuelwood.It is one of the few major tree species in Europe that is regener-ated by seed(naturally or artificially)and by stump shoots in high forest,coppice-with-standards and coppice forests.Sessile oak forests are treated in both regular and irregular systems involving silvicultural techniques such as uniform shelterwood,group shelterwood,irregular shelterwood,irregular high forest,coppice-with-standards and simple coppice.Young naturally regenerated stands are managed by weeding,release cutting and cleaning-respacing,keeping the stands quite dense for good natural pruning.Plantations are based on(1)2-4-year old bare-root or container-grown seedlings produced in nurseries using seeds from genetic resources,seed stands and seed orchards.The density of sessile oak plantations(mostly in rows,but also in clusters)is usually between 4000 and 6000 ind.ha^(−1).Sessile oak silviculture of mature stands includes crown thinning,focus-ing on final crop trees(usually a maximum of 100 ind.ha^(−1))and targeting the production of large-diameter and high quality trees at long rotation ages(mostly over 120 years,sometimes 250-300 years).In different parts of Europe,conversion of simple coppices and coppice-with-standards to high forests is continuing.Even though manage-ment of sessile oak forests is very intensive and expensive,requiring active human intervention,the importance of this species in future European forests will increase in the con-text of climate change due to its high resistance to distur-bance,superior drought tolerance and heat stress resistance.
文摘China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the market surged from 11.4 billion yuan in 2018 to 22.9 billion yuan in 2023,achieving a compound annual growth rate(CAGR) of 15%.With projections estimating a rise to 44 billion yuan by 2028 at a 14% CAGR,the sector's long-term growth prospects remain strong.
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