Trained immunity confers innate immune memory through metabolic and epigenetic reprogramming,enabling innate immune cells to exhibit an enhanced immune response to secondary pathogenic stimulation.Although the epigene...Trained immunity confers innate immune memory through metabolic and epigenetic reprogramming,enabling innate immune cells to exhibit an enhanced immune response to secondary pathogenic stimulation.Although the epigenetic basis and functional changes underlying trained immunity in specific immune cell populations have been characterized,the intercellular communication mechanisms and master regulators that orchestrate multicellular immune coordination to establish system-wide trained immunity against infection remain incompletely understood.展开更多
文摘Trained immunity confers innate immune memory through metabolic and epigenetic reprogramming,enabling innate immune cells to exhibit an enhanced immune response to secondary pathogenic stimulation.Although the epigenetic basis and functional changes underlying trained immunity in specific immune cell populations have been characterized,the intercellular communication mechanisms and master regulators that orchestrate multicellular immune coordination to establish system-wide trained immunity against infection remain incompletely understood.
