Aiming at the fact that traditional cache replacement strategy lacks pertinence to the semantic cache in the process of extensible markup language （XML） algebra query, a replacement strategy based on the semantic ca...Aiming at the fact that traditional cache replacement strategy lacks pertinence to the semantic cache in the process of extensible markup language （XML） algebra query, a replacement strategy based on the semantic cache contribution value is proposed. First, pattern matching rules for XML algebra query and semantic caches are given. Second, the method of calculating the semantic cache contribution value is proposed. In XML documents with four different sizes, the experimental results of time efficiency show that this strategy supports environment of the XML algebra query and it has better time efficiency than both least frequency used （LFU） and least recently used （LRU）.展开更多
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microglia play an important role in secondary injury and can be activated in response to traumatic brain injury.In this article,we review the origin and classification of microglia as well as the dynamic changes of microglia in traumatic brain injury.We also clarify the microglial polarization pathways and the therapeutic drugs targeting activated microglia.We found that regulating the signaling pathways involved in pro-inflammatory and anti-inflammatory microglia,such as the Toll-like receptor 4/nuclear factor-kappa B,mitogen-activated protein kinase,Janus kinase/signal transducer and activator of transcription,phosphoinositide 3-kinase/protein kinase B,Notch,and high mobility group box 1 pathways,can alleviate the inflammatory response triggered by microglia in traumatic brain injury,thereby exerting neuroprotective effects.We also reviewed the strategies developed on the basis of these pathways,such as drug and cell replacement therapies.Drugs that modulate inflammatory factors,such as rosuvastatin,have been shown to promote the polarization of antiinflammatory microglia and reduce the inflammatory response caused by traumatic brain injury.Mesenchymal stem cells possess anti-inflammatory properties,and clinical studies have confirmed their significant efficacy and safety in patients with traumatic brain injury.Additionally,advancements in mesenchymal stem cell-delivery methods—such as combinations of novel biomaterials,genetic engineering,and mesenchymal stem cell exosome therapy—have greatly enhanced the efficiency and therapeutic effects of mesenchymal stem cells in animal models.However,numerous challenges in the application of drug and mesenchymal stem cell treatment strategies remain to be addressed.In the future,new technologies,such as single-cell RNA sequencing and transcriptome analysis,can facilitate further experimental studies.Moreover,research involving non-human primates can help translate these treatment strategies to clinical practice.展开更多
Due to the explosion of network data traffic and IoT devices,edge servers are overloaded and slow to respond to the massive volume of online requests.A large number of studies have shown that edge caching can solve th...Due to the explosion of network data traffic and IoT devices,edge servers are overloaded and slow to respond to the massive volume of online requests.A large number of studies have shown that edge caching can solve this problem effectively.This paper proposes a distributed edge collaborative caching mechanism for Internet online request services scenario.It solves the problem of large average access delay caused by unbalanced load of edge servers,meets users’differentiated service demands and improves user experience.In particular,the edge cache node selection algorithm is optimized,and a novel edge cache replacement strategy considering the differentiated user requests is proposed.This mechanism can shorten the response time to a large number of user requests.Experimental results show that,compared with the current advanced online edge caching algorithm,the proposed edge collaborative caching strategy in this paper can reduce the average response delay by 9%.It also increases the user utility by 4.5 times in differentiated service scenarios,and significantly reduces the time complexity of the edge caching algorithm.展开更多
Spark,a distributed computing platform,has rapidly developed in the field of big data.Its in-memory computing feature reduces disk read overhead and shortens data processing time,making it have broad application prosp...Spark,a distributed computing platform,has rapidly developed in the field of big data.Its in-memory computing feature reduces disk read overhead and shortens data processing time,making it have broad application prospects in large-scale computing applications such as machine learning and image processing.However,the performance of the Spark platform still needs to be improved.When a large number of tasks are processed simultaneously,Spark’s cache replacementmechanismcannot identify high-value data partitions,resulting inmemory resources not being fully utilized and affecting the performance of the Spark platform.To address the problem that Spark’s default cache replacement algorithm cannot accurately evaluate high-value data partitions,firstly the weight influence factors of data partitions are modeled and evaluated.Then,based on this weighted model,a cache replacement algorithm based on dynamic weighted data value is proposed,which takes into account hit rate and data difference.Better integration and usage strategies are implemented based on LRU(LeastRecentlyUsed).Theweight update algorithm updates the weight value when the data partition information changes,accurately measuring the importance of the partition in the current job;the cache removal algorithm clears partitions without useful values in the cache to releasememory resources;the weight replacement algorithm combines partition weights and partition information to replace RDD partitions when memory remaining space is insufficient.Finally,by setting up a Spark cluster environment,the algorithm proposed in this paper is experimentally verified.Experiments have shown that this algorithmcan effectively improve cache hit rate,enhance the performance of the platform,and reduce job execution time by 7.61%compared to existing improved algorithms.展开更多
Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of ＂mi- to...Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of ＂mi- tochondrial medicine＂ is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.展开更多
The hit rate, a major metric for evaluating proxy caches, is mostly limited by the replacement strategy of proxy caches. However, in traditional proxy caches, the hit rate does not usually successfully predict how w...The hit rate, a major metric for evaluating proxy caches, is mostly limited by the replacement strategy of proxy caches. However, in traditional proxy caches, the hit rate does not usually successfully predict how well a proxy cache will perform because the proxy cache counts any hit in its caching space which has many pages without useful information, so its replacement strategy fails to determine which pages to keep and which to release. The proxy cache efficiency can be measured more accurately using the valid hit rate introduced in this paper. An efficient replacement strategy based on the Site Graph model for WWW (World Wide Web) documents is also discussed in this paper. The model analyzes user access behavior as a basis for the replacement strategy. Simulation results demonstrate that the replacement strategy improves proxy cache efficiency.展开更多
Cranial hemophilic pseudotumor(cHPT)is a very rare disease,which is easy to misdiagnose.It is also difficult to manage such patients.We reported the first case of occipital cHPT.Case presentation:Here,we presented a r...Cranial hemophilic pseudotumor(cHPT)is a very rare disease,which is easy to misdiagnose.It is also difficult to manage such patients.We reported the first case of occipital cHPT.Case presentation:Here,we presented a rare case of an occipital bone mass in a 3-year-old boy who was diagnosed with hemophilia A.The mass was misdiagnosed as an aneurysmal bone cyst by pathological examination.After resection,the patient underwent one-stage cranioplasty.However,the patient was admitted again for hematoma caused by an invasive procedure.A second surgery and one-stage cranioplasty were performed at the same time.A follow-up 3 months after discharging showed the patient was uneventful,and the titanium mesh was well fixed.Conclusion:The diagnosis of cHPT requires the combining of history,radiological examination,and pathological examination.Resection is the best choice for symptomatic cHPT.Replacement treatment and less invasive treatment can make perioperative management safer.One-stage cranioplasty for resection of an occipital cHPT can improve the quality of life.展开更多
基金Supported by the National Natural Science Foundation of China(60803160 and 61272110)the Key Projects of National Social Science Foundation of China(11&ZD189)+3 种基金the Natural Science Foundation of Hubei Province(2013CFB334)the Natural Science Foundation of Educational Agency of Hubei Province(Q20101110)the State Key Lab of Software Engineering Open Foundation of Wuhan University(SKLSE2012-09-07)the Wuhan Key Technology Support Program(2013010602010216)
文摘Aiming at the fact that traditional cache replacement strategy lacks pertinence to the semantic cache in the process of extensible markup language （XML） algebra query, a replacement strategy based on the semantic cache contribution value is proposed. First, pattern matching rules for XML algebra query and semantic caches are given. Second, the method of calculating the semantic cache contribution value is proposed. In XML documents with four different sizes, the experimental results of time efficiency show that this strategy supports environment of the XML algebra query and it has better time efficiency than both least frequency used （LFU） and least recently used （LRU）.
基金supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW)the National Key Research and Development Program of China,No.2018YFA0801403(to ZW)+1 种基金Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW)the Natural Science Foundation of China,No.31960120(to ZW)。
文摘Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microglia play an important role in secondary injury and can be activated in response to traumatic brain injury.In this article,we review the origin and classification of microglia as well as the dynamic changes of microglia in traumatic brain injury.We also clarify the microglial polarization pathways and the therapeutic drugs targeting activated microglia.We found that regulating the signaling pathways involved in pro-inflammatory and anti-inflammatory microglia,such as the Toll-like receptor 4/nuclear factor-kappa B,mitogen-activated protein kinase,Janus kinase/signal transducer and activator of transcription,phosphoinositide 3-kinase/protein kinase B,Notch,and high mobility group box 1 pathways,can alleviate the inflammatory response triggered by microglia in traumatic brain injury,thereby exerting neuroprotective effects.We also reviewed the strategies developed on the basis of these pathways,such as drug and cell replacement therapies.Drugs that modulate inflammatory factors,such as rosuvastatin,have been shown to promote the polarization of antiinflammatory microglia and reduce the inflammatory response caused by traumatic brain injury.Mesenchymal stem cells possess anti-inflammatory properties,and clinical studies have confirmed their significant efficacy and safety in patients with traumatic brain injury.Additionally,advancements in mesenchymal stem cell-delivery methods—such as combinations of novel biomaterials,genetic engineering,and mesenchymal stem cell exosome therapy—have greatly enhanced the efficiency and therapeutic effects of mesenchymal stem cells in animal models.However,numerous challenges in the application of drug and mesenchymal stem cell treatment strategies remain to be addressed.In the future,new technologies,such as single-cell RNA sequencing and transcriptome analysis,can facilitate further experimental studies.Moreover,research involving non-human primates can help translate these treatment strategies to clinical practice.
基金This work is supported by the National Natural Science Foundation of China(62072465)the Key-Area Research and Development Program of Guang Dong Province(2019B010107001).
文摘Due to the explosion of network data traffic and IoT devices,edge servers are overloaded and slow to respond to the massive volume of online requests.A large number of studies have shown that edge caching can solve this problem effectively.This paper proposes a distributed edge collaborative caching mechanism for Internet online request services scenario.It solves the problem of large average access delay caused by unbalanced load of edge servers,meets users’differentiated service demands and improves user experience.In particular,the edge cache node selection algorithm is optimized,and a novel edge cache replacement strategy considering the differentiated user requests is proposed.This mechanism can shorten the response time to a large number of user requests.Experimental results show that,compared with the current advanced online edge caching algorithm,the proposed edge collaborative caching strategy in this paper can reduce the average response delay by 9%.It also increases the user utility by 4.5 times in differentiated service scenarios,and significantly reduces the time complexity of the edge caching algorithm.
基金the National Natural Science Foundation of China(61872284)Key Research and Development Program of Shaanxi(2023-YBGY-203,2023-YBGY-021)+3 种基金Industrialization Project of Shaanxi ProvincialDepartment of Education(21JC017)“Thirteenth Five-Year”National Key R&D Program Project(Project Number:2019YFD1100901)Natural Science Foundation of Shannxi Province,China(2021JLM-16,2023-JC-YB-825)Key R&D Plan of Xianyang City(L2023-ZDYF-QYCX-021)。
文摘Spark,a distributed computing platform,has rapidly developed in the field of big data.Its in-memory computing feature reduces disk read overhead and shortens data processing time,making it have broad application prospects in large-scale computing applications such as machine learning and image processing.However,the performance of the Spark platform still needs to be improved.When a large number of tasks are processed simultaneously,Spark’s cache replacementmechanismcannot identify high-value data partitions,resulting inmemory resources not being fully utilized and affecting the performance of the Spark platform.To address the problem that Spark’s default cache replacement algorithm cannot accurately evaluate high-value data partitions,firstly the weight influence factors of data partitions are modeled and evaluated.Then,based on this weighted model,a cache replacement algorithm based on dynamic weighted data value is proposed,which takes into account hit rate and data difference.Better integration and usage strategies are implemented based on LRU(LeastRecentlyUsed).Theweight update algorithm updates the weight value when the data partition information changes,accurately measuring the importance of the partition in the current job;the cache removal algorithm clears partitions without useful values in the cache to releasememory resources;the weight replacement algorithm combines partition weights and partition information to replace RDD partitions when memory remaining space is insufficient.Finally,by setting up a Spark cluster environment,the algorithm proposed in this paper is experimentally verified.Experiments have shown that this algorithmcan effectively improve cache hit rate,enhance the performance of the platform,and reduce job execution time by 7.61%compared to existing improved algorithms.
基金funded by NIH R21NS096670(AGR)University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment(AGR),NIH/NINDS 2P30NS051220
文摘Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of ＂mi- tochondrial medicine＂ is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.
基金the State High- Tech Developments Planof China (No.86 3- 30 6 - ZT0 1- 0 3- 1) IBM China Research Lab Huawei Enterprise Funding onScience and Technology
文摘The hit rate, a major metric for evaluating proxy caches, is mostly limited by the replacement strategy of proxy caches. However, in traditional proxy caches, the hit rate does not usually successfully predict how well a proxy cache will perform because the proxy cache counts any hit in its caching space which has many pages without useful information, so its replacement strategy fails to determine which pages to keep and which to release. The proxy cache efficiency can be measured more accurately using the valid hit rate introduced in this paper. An efficient replacement strategy based on the Site Graph model for WWW (World Wide Web) documents is also discussed in this paper. The model analyzes user access behavior as a basis for the replacement strategy. Simulation results demonstrate that the replacement strategy improves proxy cache efficiency.
基金supported by“Major special projects in the 13th five-year plan”(Grant No.2016YFC1301800)
文摘Cranial hemophilic pseudotumor(cHPT)is a very rare disease,which is easy to misdiagnose.It is also difficult to manage such patients.We reported the first case of occipital cHPT.Case presentation:Here,we presented a rare case of an occipital bone mass in a 3-year-old boy who was diagnosed with hemophilia A.The mass was misdiagnosed as an aneurysmal bone cyst by pathological examination.After resection,the patient underwent one-stage cranioplasty.However,the patient was admitted again for hematoma caused by an invasive procedure.A second surgery and one-stage cranioplasty were performed at the same time.A follow-up 3 months after discharging showed the patient was uneventful,and the titanium mesh was well fixed.Conclusion:The diagnosis of cHPT requires the combining of history,radiological examination,and pathological examination.Resection is the best choice for symptomatic cHPT.Replacement treatment and less invasive treatment can make perioperative management safer.One-stage cranioplasty for resection of an occipital cHPT can improve the quality of life.
